R Dingledine

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Ann Neurol 60:223-35. 2006
  2. ncbi Ionotropic glutamate receptors: regulation by G-protein-coupled receptors
    Asheebo Rojas
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Mol Pharmacol 83:746-52. 2013
  3. ncbi The glutamate receptor ion channels
    R Dingledine
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pharmacol Rev 51:7-61. 1999
  4. ncbi Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes
    Y Huang
    Department of Pharmacology and Biochemistry, Cell and Developmental Biology Graduate Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Neurosci 2:867-72. 1999
  5. ncbi Reduced excitatory drive onto interneurons in the dentate gyrus after status epilepticus
    J Doherty
    Department of Pharmacology, Emory University Medical School, Atlanta, Georgia 30322, USA
    J Neurosci 21:2048-57. 2001
  6. ncbi Subunit-dependent modulation of kainate receptors by extracellular protons and polyamines
    David D Mott
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:1179-88. 2003
  7. ncbi Medial perforant path inhibition mediated by mGluR7 is reduced after status epilepticus
    Kristopher J Bough
    School of Medicine, Dept of Pharmacology, Emory University, Rollins Research Center, Rm 5002, 1510 Clifton Road, Atlanta, GA 30322 3090, USA
    J Neurophysiol 92:1549-57. 2004
  8. ncbi Subunit-dependent modulation of kainate receptors by muscarinic acetylcholine receptors
    Morris Benveniste
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Brain Res 1352:61-9. 2010
  9. ncbi pH-dependent inhibition of kainate receptors by zinc
    David D Mott
    Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
    J Neurosci 28:1659-71. 2008
  10. ncbi Genetic regulation of glutamate receptor ion channels
    S J Myers
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 39:221-41. 1999

Research Grants

  1. FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPES
    Raymond Dingledine; Fiscal Year: 2002
  2. MODULATION OF KAINATE RECEPTORS
    Raymond Dingledine; Fiscal Year: 2003
  3. GENETIC CONTROL OF GLUTAMATE RECEPTOR FUNCTION
    Raymond Dingledine; Fiscal Year: 2004
  4. High content cell-based assay system
    Raymond Dingledine; Fiscal Year: 2004
  5. GENETIC CONTROL OF GLUTAMATE RECEPTOR FUNCTION
    Raymond Dingledine; Fiscal Year: 2007
  6. Prostanoid modulators that reduce brain injury and inflammation after seizures
    Raymond Dingledine; Fiscal Year: 2007
  7. MOLECULAR STUDIES OF THE NMDA-GLYCINE RECEPTOR
    Raymond Dingledine; Fiscal Year: 1993
  8. MICROARRAY SCANNING SYSTEM
    Raymond Dingledine; Fiscal Year: 2001

Detail Information

Publications17

  1. ncbi Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet
    Kristopher J Bough
    Department of Pharmacology, Emory University, Atlanta, GA, USA
    Ann Neurol 60:223-35. 2006
    ..The KD typically is used in pediatric epilepsies, but is effective also in adolescents and adults. Our goal was to use microarray and complementary technologies in adolescent rats to understand its anticonvulsant effect...
  2. ncbi Ionotropic glutamate receptors: regulation by G-protein-coupled receptors
    Asheebo Rojas
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Mol Pharmacol 83:746-52. 2013
    ..The details of GPCR-iGlu receptor cross-talk should inform a better understanding of how synaptic transmission is regulated and lead to new therapeutic strategies for neuropsychiatric disorders...
  3. ncbi The glutamate receptor ion channels
    R Dingledine
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pharmacol Rev 51:7-61. 1999
  4. ncbi Transcriptional repression by REST: recruitment of Sin3A and histone deacetylase to neuronal genes
    Y Huang
    Department of Pharmacology and Biochemistry, Cell and Developmental Biology Graduate Program, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Neurosci 2:867-72. 1999
    ..These results identify a general mechanism for controlling the neuronal expression pattern of a specific set of genes via the RE1 silencer element...
  5. ncbi Reduced excitatory drive onto interneurons in the dentate gyrus after status epilepticus
    J Doherty
    Department of Pharmacology, Emory University Medical School, Atlanta, Georgia 30322, USA
    J Neurosci 21:2048-57. 2001
    ..These results indicate that, in the SE-experienced rat, excitatory drive to hilar border inhibitory interneurons is weakened through a use-dependent mechanism involving group II metabotropic glutamate receptors...
  6. ncbi Subunit-dependent modulation of kainate receptors by extracellular protons and polyamines
    David D Mott
    Department of Pharmacology, Rollins Research Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 23:1179-88. 2003
    ..Furthermore, they suggest that fluctuations in brain pH during both normal and pathological processes could regulate synaptic transmission and plasticity mediated by kainate receptors...
  7. ncbi Medial perforant path inhibition mediated by mGluR7 is reduced after status epilepticus
    Kristopher J Bough
    School of Medicine, Dept of Pharmacology, Emory University, Rollins Research Center, Rm 5002, 1510 Clifton Road, Atlanta, GA 30322 3090, USA
    J Neurophysiol 92:1549-57. 2004
    ..These data suggest that reduced presynaptic inhibition mediated by mGluR7, but not mGluR2/3 or mGluR8, may play a role during the latent period in generating hyperexcitability in the dentate and thereby contribute to epileptogenesis...
  8. ncbi Subunit-dependent modulation of kainate receptors by muscarinic acetylcholine receptors
    Morris Benveniste
    Neuroscience Institute, Morehouse School of Medicine, Atlanta, GA 30310, USA
    Brain Res 1352:61-9. 2010
    ..We conclude that KARs are modulated in a subunit dependent manner by mAChRs. We suggest that ACh may induce long lasting alterations in neuronal excitability and enhance excitotoxicity in part by potentiating KAR function...
  9. ncbi pH-dependent inhibition of kainate receptors by zinc
    David D Mott
    Department of Pharmacology, Physiology, and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina 29208, USA
    J Neurosci 28:1659-71. 2008
    ..We conclude that zinc modulation of kainate receptors serves an important role in shaping kainate neurotransmission in the CA3 region...
  10. ncbi Genetic regulation of glutamate receptor ion channels
    S J Myers
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Annu Rev Pharmacol Toxicol 39:221-41. 1999
    ..Neuron-specific glutamate receptor promoter fragments may be employed in the design of novel gene-targeting constructs to deliver future experimental transgene and therapeutic agents to selected neurons in the brain...
  11. ncbi Ablation of cyclooxygenase-2 in forebrain neurons is neuroprotective and dampens brain inflammation after status epilepticus
    G E Serrano
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 31:14850-60. 2011
    ..These findings point to a profound role of seizure-induced neuronal COX-2 expression in neuropathologies that accompany epileptogenesis...
  12. ncbi Sequential and concerted gene expression changes in a chronic in vitro model of parkinsonism
    J G Greene
    Department of Neurology, Emory University School of Medicine, 505 Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    Neuroscience 152:198-207. 2008
    ..These experiments provide the first transcriptional analysis of a rotenone model of Parkinson's disease and insight into which mechanisms of neurodegeneration may be targeted for therapeutic intervention...
  13. ncbi Transcriptional regulation of the GluR2 gene: neural-specific expression, multiple promoters, and regulatory elements
    S J Myers
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 18:6723-39. 1998
    ..These results indicate that GluR2 transcription initiates from multiple sites, is highly neuronal selective, and is regulated by three regulatory elements in the 5' proximal promoter region...
  14. ncbi Subunit-specific desensitization of heteromeric kainate receptors
    David D Mott
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina, School of Medicine, Columbia, SC 29208, USA
    J Physiol 588:683-700. 2010
    ....
  15. ncbi Functional organization of the GluR1 glutamate receptor promoter
    K Borges
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 276:25929-38. 2001
    ..In contrast to the GluR2 promoter the regulatory regions are mainly located outside of the GluR1 initiation region...
  16. ncbi Phenylethanolamines inhibit NMDA receptors by enhancing proton inhibition
    D D Mott
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Nat Neurosci 1:659-67. 1998
    ....
  17. ncbi Neurological disease: listening to gene silencers
    A Roopra
    Department of Pharmacology, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    Mol Interv 1:219-28. 2001
    ....

Research Grants32

  1. FUNCTIONS OF METABOTROPIC GLUTAMATE RECEPTOR SUBTYPES
    Raymond Dingledine; Fiscal Year: 2002
    ..abstract_text> ..
  2. MODULATION OF KAINATE RECEPTORS
    Raymond Dingledine; Fiscal Year: 2003
    ....
  3. GENETIC CONTROL OF GLUTAMATE RECEPTOR FUNCTION
    Raymond Dingledine; Fiscal Year: 2004
    ....
  4. High content cell-based assay system
    Raymond Dingledine; Fiscal Year: 2004
    ..The requested system will greatly facilitate studies supported by NIH. ..
  5. GENETIC CONTROL OF GLUTAMATE RECEPTOR FUNCTION
    Raymond Dingledine; Fiscal Year: 2007
    ....
  6. Prostanoid modulators that reduce brain injury and inflammation after seizures
    Raymond Dingledine; Fiscal Year: 2007
    ....
  7. MOLECULAR STUDIES OF THE NMDA-GLYCINE RECEPTOR
    Raymond Dingledine; Fiscal Year: 1993
    ....
  8. MICROARRAY SCANNING SYSTEM
    Raymond Dingledine; Fiscal Year: 2001
    ..The requested system will facilitate our participation in this new and exciting direction of biomedical research. ..