Sergey Dikalov

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress
    Angelike Triantafyllou
    Medical School of Athens, Athens, Greece
    Nutr J 10:64. 2011
  2. ncbi Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase
    Sergey Dikalov
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Georgia 30322, USA
    J Biol Chem 277:25480-5. 2002
  3. pmc Honokiol is a potent scavenger of superoxide and peroxyl radicals
    Sergey Dikalov
    Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, Suite 319 WMB, Atlanta, GA 30322, United States
    Biochem Pharmacol 76:589-96. 2008
  4. ncbi Characterization of the high resolution ESR spectra of the methoxyl radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO)
    Sergey Dikalov
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, 111 Alexander Drive, PO Box 12233, Research Triangle Park, NC 27709, USA
    Free Radic Res 37:705-12. 2003
  5. pmc Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production
    Sergey I Dikalov
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Free Radic Biol Med 45:1340-51. 2008
  6. pmc Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay
    Sergey I Dikalov
    Free Radical in Medicine CORE, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Biochem Pharmacol 73:972-80. 2007
  7. ncbi Role of extracellular superoxide dismutase in hypertension
    Maria Carolina Gongora
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 48:473-81. 2006
  8. ncbi Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation
    Sumitra Miriyala
    Division of Cardiology, Emory University, Emory University, Atlanta, GA 30322, USA
    Circulation 113:2818-25. 2006
  9. pmc Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
  10. pmc Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling
    Anna E Dikalova
    Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Heart Circ Physiol 299:H673-9. 2010

Collaborators

Detail Information

Publications56

  1. pmc Anti-inflammatory activity of Chios mastic gum is associated with inhibition of TNF-alpha induced oxidative stress
    Angelike Triantafyllou
    Medical School of Athens, Athens, Greece
    Nutr J 10:64. 2011
    ..The molecular mechanisms of its anti-inflammatory activity, however, are not clear. In this work, the potential role of antioxidant activity of Chios mastic gum has been evaluated...
  2. ncbi Geldanamycin leads to superoxide formation by enzymatic and non-enzymatic redox cycling. Implications for studies of Hsp90 and endothelial cell nitric-oxide synthase
    Sergey Dikalov
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Georgia 30322, USA
    J Biol Chem 277:25480-5. 2002
    ..In light of these findings, the studies using geldanamycin as an inhibitor of Hsp90 should be interpreted with caution...
  3. pmc Honokiol is a potent scavenger of superoxide and peroxyl radicals
    Sergey Dikalov
    Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, Suite 319 WMB, Atlanta, GA 30322, United States
    Biochem Pharmacol 76:589-96. 2008
    ..5x10(6)M(-1)s(-1)). Therefore, honokiol is an effective scavenger of both superoxide and peroxyl radicals, which may be important for physiological activity of honokiol...
  4. ncbi Characterization of the high resolution ESR spectra of the methoxyl radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO)
    Sergey Dikalov
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, 111 Alexander Drive, PO Box 12233, Research Triangle Park, NC 27709, USA
    Free Radic Res 37:705-12. 2003
    ..We suggest that the analysis of high resolution ESR spectra can be used for the unambiguous characterization of DEPMPO radical adducts...
  5. pmc Distinct roles of Nox1 and Nox4 in basal and angiotensin II-stimulated superoxide and hydrogen peroxide production
    Sergey I Dikalov
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Free Radic Biol Med 45:1340-51. 2008
    ..These findings also provide important insight into the origin of H2O2 in vascular cells, and may partially account for the limited pharmacological effect of antioxidant treatments with O2*- scavengers that do not affect H2O2...
  6. pmc Production of extracellular superoxide by human lymphoblast cell lines: comparison of electron spin resonance techniques and cytochrome C reduction assay
    Sergey I Dikalov
    Free Radical in Medicine CORE, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Biochem Pharmacol 73:972-80. 2007
    ..A highly sensitive in vitro measurement of O(2)(-) in human cell lines would allow investigators to study genotype/phenotype interactions in translational studies...
  7. ncbi Role of extracellular superoxide dismutase in hypertension
    Maria Carolina Gongora
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 48:473-81. 2006
    ..These compensatory mechanisms preserve large vessel function when ecSOD is absent in hypertension...
  8. ncbi Bone morphogenic protein-4 induces hypertension in mice: role of noggin, vascular NADPH oxidases, and impaired vasorelaxation
    Sumitra Miriyala
    Division of Cardiology, Emory University, Emory University, Atlanta, GA 30322, USA
    Circulation 113:2818-25. 2006
    ....
  9. pmc Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Clin Invest 111:1201-9. 2003
    ..Treatment strategies that increase tetrahydrobiopterin or prevent its oxidation may prove useful in preventing vascular complications of this common disease...
  10. pmc Upregulation of Nox1 in vascular smooth muscle leads to impaired endothelium-dependent relaxation via eNOS uncoupling
    Anna E Dikalova
    Department of Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Heart Circ Physiol 299:H673-9. 2010
    ....
  11. ncbi Bone morphogenic protein 4 produced in endothelial cells by oscillatory shear stress induces monocyte adhesion by stimulating reactive oxygen species production from a nox1-based NADPH oxidase
    George P Sorescu
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    Circ Res 95:773-9. 2004
    ..Together, these results suggest that BMP4 produced in ECs by OS stimulates ROS release from the nox1-dependent NADPH oxidase leading to inflammation, a critical early atherogenic step...
  12. pmc Vascular oxidative stress and nitric oxide depletion in HIV-1 transgenic rats are reversed by glutathione restoration
    Erik R Kline
    Division of Pulmonary, Allergy and Critical Care Medicine, Free Radicals in Medicine Core, Emory University School of Medicine Atlanta Veterans Affairs Medical Center, Atlanta, Georgia, USA
    Am J Physiol Heart Circ Physiol 294:H2792-804. 2008
    ..Restoring glutathione levels reverses HIV-1 protein-mediated effects on superoxide, NO, and vasorelaxation...
  13. ncbi Hemodynamic and biochemical adaptations to vascular smooth muscle overexpression of p22phox in mice
    Karine Laude
    Division of Cardiology, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Am J Physiol Heart Circ Physiol 288:H7-12. 2005
    ..NO in turn increases ecSOD protein expression and counterbalances increased ROS production leading to the maintenance of normal vascular function and hemodynamics...
  14. pmc Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction
    Erik R Kline
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine Atlanta VA Medical Center, Atlanta, GA 30033, USA
    Cardiovasc Toxicol 9:1-12. 2009
    ..Endothelial cells are more susceptible to AZT-induced toxicity than HepG2 cells, and AZT caused greater endothelial dysfunction than d4T because of its pro-oxidative effects...
  15. ncbi NAD(P)H oxidase-derived hydrogen peroxide mediates endothelial nitric oxide production in response to angiotensin II
    Hua Cai
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 277:48311-7. 2002
    ..Because angiotensin II also stimulates O(2)() production from the NAD(P)H oxidase, the H(2)O(2) stimulation of NO(.) may facilitate peroxynitrite formation in response to this octapeptide...
  16. ncbi Characterization of the high-resolution ESR spectra of superoxide radical adducts of 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline N-oxide (DEPMPO) and 5,5-dimethyl-1-pyrroline N-oxide (DMPO). Analysis of conformational exchange
    Sergey Dikalov
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Free Radic Res 39:825-36. 2005
    ..It is clear that to correctly interpret DEPMPO spin trapping of superoxide radicals, one must carefully consider formation of secondary radical adducts...
  17. ncbi Nox1 overexpression potentiates angiotensin II-induced hypertension and vascular smooth muscle hypertrophy in transgenic mice
    Anna Dikalova
    Division of Cardiology, Emory University, Atlanta, GA 30322, USA
    Circulation 112:2668-76. 2005
    ..Nox1 upregulation has been implicated in cardiovascular pathologies such as hypertension and restenosis...
  18. ncbi Functional association of nox1 with p22phox in vascular smooth muscle cells
    Ibrahim R Hanna
    Division of Cardiology, Department of Medicine, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Free Radic Biol Med 37:1542-9. 2004
    ....
  19. pmc Cross talk between mitochondria and NADPH oxidases
    Sergey Dikalov
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Free Radic Biol Med 51:1289-301. 2011
    ..It is conceivable that the use of mitochondria-targeted treatments would be effective in these conditions...
  20. pmc Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation
    Wei Chen
    Cardiology Division and Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 286:13846-51. 2011
    ..These studies identify a previously unidentified consequence of T cell activation, promoting BH(4) levels, NO production, and modulating T cell cytokine production...
  21. pmc Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction
    GAD A SILBERMAN
    Department of Medicine Division of Cardiology, Emory University School of Medicine, Atlanta, GA, USA
    Circulation 121:519-28. 2010
    ..Similar events may occur in the heart that lead to uncoupled NOS and diastolic dysfunction...
  22. pmc The delivery of superoxide dismutase encapsulated in polyketal microparticles to rat myocardium and protection from myocardial ischemia-reperfusion injury
    Gokulakrishnan Seshadri
    Wallace H Coulter Department of Biomedical Engineering at Emory University and Georgia Institute of Technology, Atlanta, GA 30322, USA
    Biomaterials 31:1372-9. 2010
    ..These data demonstrate that delivery of SOD1 with polyketals is superior to free SOD1 protein therapy and may have potential clinical implications...
  23. pmc Calcium-dependent NOX5 nicotinamide adenine dinucleotide phosphate oxidase contributes to vascular oxidative stress in human coronary artery disease
    Tomasz J Guzik
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Coll Cardiol 52:1803-9. 2008
    ..This study sought to examine the expression and activity of the calcium-dependent nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX) in human atherosclerotic coronary arteries...
  24. pmc Folate receptor-targeted antioxidant therapy ameliorates renal ischemia-reperfusion injury
    Sarah F Knight
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Am Soc Nephrol 23:793-800. 2012
    ..Conjugation of other pharmaceuticals to folate may also facilitate the development of treatments for other kidney diseases...
  25. ncbi Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation
    Stephan Spiekermann
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Atlanta, GA, USA
    Circulation 107:1383-9. 2003
    ..We therefore characterized the vascular activities of xanthine oxidase and NAD(P)H oxidase, 2 major O2*--producing enzyme systems, and their relationship with flow-dependent, endothelium-mediated vasodilation (FDD) in patients with CAD...
  26. ncbi Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase
    Nermin Kuzkaya
    Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:22546-54. 2003
    ..We confirmed that ONOO- uncouples eNOS by oxidation of tetrahydrobiopterin and that ascorbate does not fully protect BH4 from oxidation but recycles BH3. radical back to BH4...
  27. ncbi Regulation of xanthine oxidoreductase protein expression by hydrogen peroxide and calcium
    J Scott McNally
    Division of Cardiology, Emory University, 101 Woodruff Cir, WMB 319, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 25:1623-8. 2005
    ..We postulated that H2O2 may modulate the irreversible conversion of xanthine dehydrogenase (XDH) to XO and sought to examine mechanisms involved...
  28. ncbi Role of p47(phox) in vascular oxidative stress and hypertension caused by angiotensin II
    Ulf Landmesser
    Division of Cardiology, Emory University School of Medicine and Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Hypertension 40:511-5. 2002
    ..These results suggest a pivotal role of the NAD(P)H oxidase and its subunit p47(phox) in the vascular oxidant stress and the blood pressure response to angiotensin II in vivo...
  29. pmc Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction
    Tomasz J Guzik
    Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30033, USA
    J Exp Med 204:2449-60. 2007
    ..T cells might represent a novel therapeutic target for the treatment of high blood pressure...
  30. ncbi IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation
    Minako Yamaoka-Tojo
    Division of Cardiology Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 95:276-83. 2004
    ....
  31. ncbi Detection of intracellular superoxide formation in endothelial cells and intact tissues using dihydroethidium and an HPLC-based assay
    Bruno Fink
    FRIMCORE, Division of Cardiology, Emory Univ School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Am J Physiol Cell Physiol 287:C895-902. 2004
    ..Detection of oxyethidium using HPLC represents a new, convenient, quantitative method for the detection of superoxide in intact cells and tissues...
  32. pmc Redox signaling in an in vivo murine model of low magnitude oscillatory wall shear stress
    Nick J Willett
    The Wallace H Coulter Department of Biomedical Engineering, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Antioxid Redox Signal 15:1369-78. 2011
    ..These results suggest that although the redox state is important to the overall pathogenesis of atherosclerosis, the initial WSS-dependent inflammatory response leading to lesion localization is not dependent on ROS...
  33. pmc Ascorbic acid efficiently enhances neuronal synthesis of norepinephrine from dopamine
    James M May
    Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 6303, USA
    Brain Res Bull 90:35-42. 2013
    ....
  34. doi Regulation of endothelial cell tetrahydrobiopterin pathophysiological and therapeutic implications
    David G Harrison
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta Veterans Administration Medical Center, Decatur, Georgia, USA
    Adv Pharmacol 60:107-32. 2010
    ..Whether BH(4) or related agents will be useful in treatment of human diseases needs additional study...
  35. ncbi Novel role of ARF6 in vascular endothelial growth factor-induced signaling and angiogenesis
    Satoshi Ikeda
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 96:467-75. 2005
    ..Thus, ARF6 is involved in the temporal-spatial organization of caveolae/lipid rafts- and ROS-dependent VEGF signaling in ECs as well as in angiogenesis in vivo...
  36. ncbi Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide
    Roy L Sutliff
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA
    Am J Physiol Heart Circ Physiol 283:H2363-70. 2002
    ..These results indicate that NRTIs impair endothelium-dependent relaxation by increasing superoxide levels and suggest that NRTI therapy contributes to cardiovascular complications in acquired immunodeficiency syndrome...
  37. ncbi ESR techniques for the detection of nitric oxide in vivo and in tissues
    Sergey Dikalov
    Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Methods Enzymol 396:597-610. 2005
    ..These data suggest that HbNO can be used as a noninvasive marker of endothelial NO* production in vivo...
  38. ncbi Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis
    Abdulrahman K Doughan
    Free Radical in Medicine CORE, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Antioxid Redox Signal 9:1825-36. 2007
    ..In light of these results, studies using mitoquinone as an antioxidant should be interpreted with caution...
  39. ncbi Role of the multidrug resistance protein-1 in hypertension and vascular dysfunction caused by angiotensin II
    Julian D Widder
    Emory University, Division of Cardiology, Department of Medicine and the Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 27:762-8. 2007
    ..This can promotes thiol loss during states of increased glutathione oxidation. We investigated how MRP1 modulates blood pressure and vascular function during angiotensin II-induced hypertension...
  40. pmc Determination of ebselen-sensitive reactive oxygen metabolites (ebROM) in human serum based upon N,N'-diethyl-1,4-phenylenediamine oxidation
    Yongliang Liang
    Clinical Biomarkers Laboratory, Allergy and Critical Care Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, United States
    Clin Chim Acta 414:1-6. 2012
    ..A convenient assay for oxidants in human serum is based upon the Fe(2+)-dependent decomposition of peroxides to oxidize N,N'-diethyl-1,4-phenylenediamine (DEPPD) to a stable radical cation which can be measured spectrophotometrically...
  41. ncbi NAD(P)H oxidase 4 mediates transforming growth factor-beta1-induced differentiation of cardiac fibroblasts into myofibroblasts
    Ioan Cucoranu
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA, USA
    Circ Res 97:900-7. 2005
    ..Thus, Nox4 may play a critical role in the pathological activation of cardiac fibroblasts in cardiac fibrosis associated with human heart failure...
  42. ncbi Regulation of tetrahydrobiopterin biosynthesis by shear stress
    Julian D Widder
    Division of Cardiology, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Circ Res 101:830-8. 2007
    ..These findings illustrate a new function of casein kinase 2 in the endothelium and provide insight into regulation of GTPCH-1 activity...
  43. ncbi Atrial fibrillation increases production of superoxide by the left atrium and left atrial appendage: role of the NADPH and xanthine oxidases
    Samuel C Dudley
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Circulation 112:1266-73. 2005
    ..We hypothesized that reduced LAA NO* levels observed in AF may be associated with increased superoxide (O2*-) production...
  44. ncbi Novel role of gp91(phox)-containing NAD(P)H oxidase in vascular endothelial growth factor-induced signaling and angiogenesis
    Masuko Ushio-Fukai
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circ Res 91:1160-7. 2002
    ....
  45. pmc Early determinants of H2O2-induced endothelial dysfunction
    Beth M Boulden
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30322, USA
    Free Radic Biol Med 41:810-7. 2006
    ..Dysfunction required O(2)(*-), ONOO(-), or a functional NADPH oxidase. Repeated activation of the NADPH oxidase by ROS may act as a feed forward system to promote endothelial dysfunction...
  46. pmc Measurement of reactive oxygen species in cardiovascular studies
    Sergey Dikalov
    Division of Cardiology, Department of Medicine, Emory University, Atlanta, GA 30322, USA
    Hypertension 49:717-27. 2007
  47. pmc Sustained release of a p38 inhibitor from non-inflammatory microspheres inhibits cardiac dysfunction
    Jay C Sy
    Wallace H Coulter Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, Georgia 30322, USA
    Nat Mater 7:863-8. 2008
    ..PCADK holds great promise for treating myocardial infarction and other inflammatory diseases given its neutral, biocompatible degradation products and its ability to deliver a wide range of therapeutics...
  48. ncbi Vascular oxidant stress enhances progression and angiogenesis of experimental atheroma
    Jaikirshan J Khatri
    Division of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Circulation 109:520-5. 2004
    ..Although multiple pathological processes have been associated with oxidative stress, the causative relation between oxidative stress and arterial lesion progression remains unclear...
  49. ncbi Noninvasive diagnostic tool for inflammation-induced oxidative stress using electron spin resonance spectroscopy and an extracellular cyclic hydroxylamine
    Sergey I Dikalov
    Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences, National Institutes of Health, 111 Alexander Drive, Research Triangle Park, NC 27709, USA
    Arch Biochem Biophys 402:218-26. 2002
    ..Diphenyleneiodonium (0.1 mM) inhibited formation of LPS-stimulated reactive oxidant species by 80%. We suggest that this test could be used as a noninvasive diagnostic tool for inflammation-induced oxidative stress...
  50. ncbi Molecular mechanisms of angiotensin II-mediated mitochondrial dysfunction: linking mitochondrial oxidative damage and vascular endothelial dysfunction
    Abdulrahman K Doughan
    Division of Cardiology and Department of Medicine, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Circ Res 102:488-96. 2008
    ..Furthermore, mitochondrial dysfunction in response to Ang II modulates endothelial NO. and generation, which in turn has ramifications for development of endothelial dysfunction...
  51. ncbi Cupric-amyloid beta peptide complex stimulates oxidation of ascorbate and generation of hydroxyl radical
    Sergey I Dikalov
    FRIMCORE, Division of Cardiology, Emory Medical School, Atlanta, GA 30322, USA
    Free Radic Biol Med 36:340-7. 2004
    ..Therefore, cupric-amyloid beta peptide-stimulated free radical generation may be involved in the pathogenesis of Alzheimer's disease...
  52. ncbi Peroxidase properties of extracellular superoxide dismutase: role of uric acid in modulating in vivo activity
    H Ulrich Hink
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arterioscler Thromb Vasc Biol 22:1402-8. 2002
    ..We examined peroxidase properties of the extracellular form of SOD (SOD3), a major isoform of SOD in the vessel wall, by using recombinant SOD3 and an in vivo model of atherosclerosis...
  53. ncbi C242T CYBA polymorphism of the NADPH oxidase is associated with reduced respiratory burst in human neutrophils
    Keith E Wyche
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hypertension 43:1246-51. 2004
    ..Because p22phox exists in both the neutrophil and vessel wall, vascular oxidative stress is likely diminished in individuals with this polymorphism...
  54. pmc Therapeutic targeting of mitochondrial superoxide in hypertension
    Anna E Dikalova
    Division of Cardiology, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Circ Res 107:106-16. 2010
    ..It is possible that these agents are not adequately delivered to the subcellular sites of superoxide production...
  55. ncbi The measurement of nitric oxide production by cultured endothelial cells
    C Michael Hart
    Department of Medicine, Emory University, Atlanta VA Medical Center, Decatur, Georgia 30033, USA
    Methods Enzymol 396:502-14. 2005
    ..In this chapter, we describe three protocols that employ chemiluminescence, electron spin resonance, or electrochemical techniques to permit the reliable detection of EC NO production...
  56. pmc Chronic ethanol ingestion increases aortic endothelial nitric oxide synthase expression and nitric oxide production in the rat
    Dean J Kleinhenz
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Atlanta, Georgia 30033, USA
    Alcohol Clin Exp Res 32:148-54. 2008
    ..The mechanisms for these vascular effects of chronic alcohol ingestion continue to be defined and constitute the focus of this study...

Research Grants1

  1. Mitochondrial Oxidative Stress In Angiotensis II Induced Endothelial Dysfunction
    Sergey Dikalov; Fiscal Year: 2010
    ..This work will study the role of mitochondrial oxidative stress in endothelial dysfunction and provide a novel therapeutic target to treat and prevent hypertension. ..