Joe Cubells

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)
    Joseph F Cubells
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT 06516, USA
    Drug Alcohol Depend 80:23-33. 2005
  2. ncbi request reprint Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology
    J F Cubells
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 174:463-76. 2004
  3. ncbi request reprint Clinical genomic psychiatry comes of age in the evaluation and treatment of developmental disabilities: is our nation prepared to make the benefits available to all who need them?
    Joseph F Cubells
    Departments of Human Genetics and Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 9:81-2. 2007
  4. pmc Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP)
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, Connecticut, USA
    Am J Addict 18:339-45. 2009
  5. pmc Genetic research on nicotine dependence will facilitate public health
    Joe Cubells
    Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Med 2:e396. 2005
  6. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
  7. ncbi request reprint Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT, USA
    Am J Addict 16:343-51. 2007
  8. pmc Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Am J Med Genet B Neuropsychiatr Genet 153:812-24. 2010
  9. ncbi request reprint A review of neurocognitive and behavioral profiles associated with 22q11 deletion syndrome: implications for clinical evaluation and treatment
    Opal Ousley
    Department of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 9:148-58. 2007
  10. ncbi request reprint Opiate addiction in China: current situation and treatments
    Yi lang Tang
    Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China
    Addiction 101:657-65. 2006

Detail Information

Publications35

  1. ncbi request reprint Rating the severity and character of transient cocaine-induced delusions and hallucinations with a new instrument, the Scale for Assessment of Positive Symptoms for Cocaine-Induced Psychosis (SAPS-CIP)
    Joseph F Cubells
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT 06516, USA
    Drug Alcohol Depend 80:23-33. 2005
    ..We examined the phenomenology of such cocaine-induced psychosis (CIP) using a modified version of the Scale for Assessment of Positive Symptoms (SAPS), a well-validated instrument for the assessment of schizophrenic psychosis...
  2. ncbi request reprint Human genetics of plasma dopamine beta-hydroxylase activity: applications to research in psychiatry and neurology
    J F Cubells
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 174:463-76. 2004
    ..Dopamine beta-hydroxylase (DbetaH) catalyzes the synthesis of NE from dopamine (DA) and occurs in the plasma as a stable heritable trait. Studies of this trait have been useful in psychiatric and neurological research...
  3. ncbi request reprint Clinical genomic psychiatry comes of age in the evaluation and treatment of developmental disabilities: is our nation prepared to make the benefits available to all who need them?
    Joseph F Cubells
    Departments of Human Genetics and Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 9:81-2. 2007
  4. pmc Transient cocaine-associated behavioral symptoms rated with a new instrument, the scale for assessment of positive symptoms for cocaine-induced psychosis (SAPS-CIP)
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, Connecticut, USA
    Am J Addict 18:339-45. 2009
    ..CRBs also correlate with hallucinations and delusions induced by cocaine, but to a lesser degree. Our findings suggest that there may be some common vulnerability factors that contribute to both cocaine-induced psychosis and CRBs...
  5. pmc Genetic research on nicotine dependence will facilitate public health
    Joe Cubells
    Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Med 2:e396. 2005
  6. pmc Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor gene
    Rebekah G Bradley
    Atlanta VA Medical Center, Georgia, USA
    Arch Gen Psychiatry 65:190-200. 2008
    ..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression...
  7. ncbi request reprint Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Health Care System, West Haven, CT, USA
    Am J Addict 16:343-51. 2007
    ..Comorbid substance use and psychiatric disorders are very common among individuals with cocaine dependence. Comorbid ADHD increases the odds of an individual endorsing CIP, suggesting some common basis for these phenomena...
  8. pmc Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptoms
    Kerry J Ressler
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, GA 30329, USA
    Am J Med Genet B Neuropsychiatr Genet 153:812-24. 2010
    ....
  9. ncbi request reprint A review of neurocognitive and behavioral profiles associated with 22q11 deletion syndrome: implications for clinical evaluation and treatment
    Opal Ousley
    Department of Psychiatry and Behavioral Sciences, Emory Autism Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 9:148-58. 2007
    ....
  10. ncbi request reprint Opiate addiction in China: current situation and treatments
    Yi lang Tang
    Beijing Anding Hospital, Capital University of Medical Sciences, Beijing, China
    Addiction 101:657-65. 2006
    ..Historically, China has had extraordinarily high rates of opiate dependence. These rates declined drastically following the 1949 revolution; however, opiate abuse has re-emerged in the late 1980's and has spread quickly since then...
  11. pmc Association study of the CNR1 gene exon 3 alternative promoter region polymorphisms and substance dependence
    Aryeh I Herman
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut, USA
    Am J Med Genet B Neuropsychiatr Genet 141:499-503. 2006
    ..These findings fail to replicate the original report of an association between SNPs adjacent to an alternative CNR1 exon 3 transcription start site and polysubstance abuse...
  12. ncbi request reprint Diagnostic reliability of the Semi-structured Assessment for Drug Dependence and Alcoholism (SSADDA)
    Amira Pierucci-Lagha
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Drug Alcohol Depend 80:303-12. 2005
    ..This study examines the diagnostic reliability of the SSADDA for substance use disorders and for other DSM-IV disorders that are commonly associated with substance use disorders...
  13. ncbi request reprint Genotypic and haplotypic associations of the DBH gene with plasma dopamine beta-hydroxylase activity in African Americans
    Yi lang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, New Haven, CT, USA
    Eur J Hum Genet 15:878-83. 2007
    ..0025 and 0.0036, respectively). The data support the validity of prior reported associations and underscore the importance of analyzing multiple SNPs across DBH in future association studies examining disease and biochemical phenotypes...
  14. pmc Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults
    Elisabeth B Binder
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
    JAMA 299:1291-305. 2008
    ..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability...
  15. ncbi request reprint Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 61:1310-3. 2007
    ..Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively...
  16. ncbi request reprint Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence
    John P Dahl
    Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
    Addict Biol 11:76-83. 2006
    ..This work suggests that variations in the TPH2 gene are not a risk factor for the development of cocaine dependence, but these findings require confirmation in larger, independent samples of cocaine-dependent and control subjects...
  17. pmc Sex differences in cocaine-dependent individuals' response to disulfiram treatment
    Charla Nich
    Yale University School of Medicine, VA Connecticut Health Care System, West Haven, USA
    Addict Behav 29:1123-8. 2004
    ..Reasons for this apparent sex-based response are not clear, but possible mechanisms worthy of greater study include differences in alcohol use by sex as well as differences in dopamine-mediated responses to cocaine and disulfiram...
  18. pmc Trauma exposure and stress-related disorders in inner city primary care patients
    Charles F Gillespie
    Departments of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Gen Hosp Psychiatry 31:505-14. 2009
    ..This study was undertaken to increase understanding of environmental risk factors for posttraumatic stress disorder (PTSD) and major depressive disorder (MDD) within an urban, impoverished, population...
  19. pmc A serotonin transporter gene polymorphism predicts peripartum depressive symptoms in an at-risk psychiatric cohort
    Elisabeth B Binder
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA
    J Psychiatr Res 44:640-6. 2010
    ..The aim of this study was to investigate associations of the serotonin-transporter linked polymorphic region (5-HTTLPR) genotype with peripartum MDD in an at-risk population...
  20. ncbi request reprint Haplotype-controlled analysis of the association of a non-synonymous single nucleotide polymorphism at DBH (+ 1603C --> T) with plasma dopamine beta-hydroxylase activity
    Yilang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, West Haven, Connecticut
    Am J Med Genet B Neuropsychiatr Genet 139:88-90. 2005
    ..These results suggest that altered homospecific activity of the enzyme can contribute to variation in pDbetaH. This conclusion informs how associations between DBH and psychiatric disorders should be approached. (c) 2005 Wiley-Liss, Inc...
  21. pmc The structure of linkage disequilibrium at the DBH locus strongly influences the magnitude of association between diallelic markers and plasma dopamine beta-hydroxylase activity
    Cyrus P Zabetian
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Hum Genet 72:1389-400. 2003
    ..These results provide a direct example of the potential value of constructing a haplotype map of the human genome prior to embarking on large-scale association studies...
  22. ncbi request reprint A single nucleotide polymorphism at DBH, possibly associated with attention-deficit/hyperactivity disorder, associates with lower plasma dopamine beta-hydroxylase activity and is in linkage disequilibrium with two putative functional single nucleotide pol
    Yilang Tang
    Department of Psychiatry, Yale University School of Medicine and VA Connecticut Healthcare System, New Haven, Connecticut, USA
    Biol Psychiatry 60:1034-8. 2006
    ..We tested whether 1) SNP2 associates with pDbetaH; and 2) whether linkage disequilibrium (LD) between SNP2 and the other SNPs explains that association...
  23. ncbi request reprint Self-reported paranoia during laboratory "binge" cocaine self-administration in humans
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 83:249-56. 2006
    ..Such methods may facilitate our understanding of the vulnerability to CIP in humans...
  24. ncbi request reprint Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression
    Joseph F Cubells
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 51:358-64. 2002
    ..Plasma DbetaH is under genetic control by the structural locus encoding DbetaH protein, DBH. This study tested the hypothesis that diagnosis-specific allelic variation at DBH accounts for lower plasma DbetaH in UDPF...
  25. pmc Sources of unreliability in the diagnosis of substance dependence
    Richard Feinn
    Clinical Epidemiology Research Center, Veterans Affairs Connecticut Healthcare Center and Yale University School of Medicine, West Haven, Connecticut 06516, USA
    J Stud Alcohol Drugs 70:475-81. 2009
    ..Using generalizability theory, we sought to ascertain the sources of unreliability for DSM-IV substance-dependence diagnoses and their criterion counts...
  26. ncbi request reprint A genotype-controlled analysis of plasma dopamine beta-hydroxylase in healthy and alcoholic subjects: evidence for alcohol-related differences in noradrenergic function
    Michael D Köhnke
    University Hospital of Psychiatry and Psychotherapy, Tubingen University Hospital, Tubingen, Germany
    Biol Psychiatry 52:1151-8. 2002
    ..A recent study demonstrated a strong association between variance in plasma DbetaH activity and a novel polymorphism (DBH-1021C-->T) at the structural locus (DBH) encoding DbetaH protein...
  27. ncbi request reprint Dopamine beta-hydroxylase (DBH) activity and -1021C/T polymorphism of DBH gene in combat-related post-traumatic stress disorder
    Maja Mustapic
    Division of Molecular Medicine, Rudjer Boskovic Institute, Zagreb, Croatia
    Am J Med Genet B Neuropsychiatr Genet 144:1087-9. 2007
    ....
  28. ncbi request reprint Setting priorities for genomic research
    Wade Berrettini
    Science 304:1445-7; author reply 1445-7. 2004
  29. ncbi request reprint A revised allele frequency estimate and haplotype analysis of the DBH deficiency mutation IVS1+2T --> C in African- and European-Americans
    Cyrus P Zabetian
    Am J Med Genet A 123:190-2. 2003
  30. ncbi request reprint Variations in the dopamine beta-hydroxylase gene are not associated with the autonomic disorders, pure autonomic failure, or multiple system atrophy
    Sonhae Cho
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts 02478, USA
    Am J Med Genet A 120:234-6. 2003
    ..In addition, no DBH mutation was found that distinguished autonomic disease patients from controls, suggesting that genetic variants of the DBH gene are not associated with the autonomic diseases OI, PAF, and MSA...
  31. pmc Reliability of DSM-IV diagnostic criteria using the semi-structured assessment for drug dependence and alcoholism (SSADDA)
    Amira Pierucci-Lagha
    Alcohol Research Center, Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, United States
    Drug Alcohol Depend 91:85-90. 2007
    ..This study examines the reliability of individual DSM-IV criteria for lifetime substance dependence diagnoses and the impact of those criteria on diagnostic reliability...
  32. ncbi request reprint Dopamine beta-hydroxylase (DBH) gene and schizophrenia phenotypic variability: a genetic association study
    Kenji Yamamoto
    Douglas Hospital Research Centre 6875 Boulevard LaSalle, Verdun H4H 1R3, Canada
    Am J Med Genet B Neuropsychiatr Genet 117:33-8. 2003
    ..These results suggest that the DBH gene is not a causative factor in schizophrenia but that it may be a modulator of psychotic symptoms, severity of the disorder and therapeutic response to neuroleptic drugs...
  33. pmc High-resolution mapping of DNA copy alterations in human chromosome 22 using high-density tiling oligonucleotide arrays
    Alexander Eckehart Urban
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 103:4534-9. 2006
    ..Our results demonstrate that HR-CGH allows the detection of copy number changes in the human genome at an unprecedented level of resolution...
  34. ncbi request reprint Genetic research and smoking behavior
    Laura Jean Bierut
    JAMA 297:809; author reply 810. 2007
  35. ncbi request reprint Mutations in the dopamine beta-hydroxylase gene are associated with human norepinephrine deficiency
    Chun Hyung Kim
    Molecular Neurobiology Laboratory, McLean Hospital, Harvard Medical School, Belmont, Massachusetts, USA
    Am J Med Genet 108:140-7. 2002
    ..Patient 2 carries missense mutations in exons 1 and 6 residing in cis. We propose that NE deficiency is an autosomal recessive disorder resulting from heterogeneous molecular lesions at DBH...

Research Grants9

  1. GENETICS OF COCAINE INDUCED PSYCHOSIS
    Joseph Cubells; Fiscal Year: 2002
    ..This program of research will improve our understanding of the genetics underlying human brain responses to chronic cocaine exposure, thus leading to better diagnosis and treatments for cocaine dependence and other addictive disorders. ..
  2. Genetics of plasma dopamine beta-hydroxylase activity in schizophrenia
    Joseph Cubells; Fiscal Year: 2007
    ..Identifying predictors of varying outcomes in SCZ would open new avenues for development of targeted interventions that could significantly ameliorate the impact of SCZ on individuals and society. ..
  3. Human Genetics of Drug-Abuse Related Phenotypes
    Joseph Cubells; Fiscal Year: 2007
    ..The latter goal will be accomplished by the candidate directing the newly-established Yale Human Behavioral Genetics Clinic, which offers psychiatric and substance-abuse services to patients with genetic illnesses. ..
  4. Genetics of plasma dopamine beta-hydroxylase activity in schizophrenia
    Joseph Cubells; Fiscal Year: 2009
    ..Identifying predictors of varying outcomes in SCZ would open new avenues for development of targeted interventions that could significantly ameliorate the impact of SCZ on individuals and society. ..