Lih Shen Chin

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Ubiquitin C-terminal hydrolase l1 in tumorigenesis
    Jennifer Hurst-Kennedy
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Res Int 2012:123706. 2012
  2. pmc Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
    James A Olzmann
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 178:1025-38. 2007
  3. pmc Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking
    Samuel M Lee
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 199:799-816. 2012
  4. pmc Parkin-mediated ubiquitin signalling in aggresome formation and autophagy
    Lih Shen Chin
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Soc Trans 38:144-9. 2010
  5. ncbi request reprint Regulation of synaptophysin degradation by mammalian homologues of seven in absentia
    Tiffany C Wheeler
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:10273-82. 2002
  6. ncbi request reprint Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
    James A Olzmann
    Departments of Pharmacology, Biochemistry, and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 279:8506-15. 2004
  7. ncbi request reprint Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Biol Chem 279:13256-64. 2004
  8. pmc Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways
    Samuel M Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Sci 124:3319-31. 2011
  9. pmc Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking
    Bong Yoon Kim
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 18:1129-42. 2007
  10. pmc Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
    Di Sha
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 19:352-63. 2010

Collaborators

Detail Information

Publications29

  1. pmc Ubiquitin C-terminal hydrolase l1 in tumorigenesis
    Jennifer Hurst-Kennedy
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Res Int 2012:123706. 2012
    ..In this paper, we provide an overview of the evidence supporting the involvement of UCH-L1 in tumor development and discuss the potential mechanisms of action of UCH-L1 in oncogenesis...
  2. pmc Parkin-mediated K63-linked polyubiquitination targets misfolded DJ-1 to aggresomes via binding to HDAC6
    James A Olzmann
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 178:1025-38. 2007
    ....
  3. pmc Charcot-Marie-Tooth disease-linked protein SIMPLE functions with the ESCRT machinery in endosomal trafficking
    Samuel M Lee
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Biol 199:799-816. 2012
    ..Our findings indicate a function of SIMPLE as a regulator of endosomal trafficking and provide evidence linking dysregulated endosomal trafficking to CMT pathogenesis...
  4. pmc Parkin-mediated ubiquitin signalling in aggresome formation and autophagy
    Lih Shen Chin
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochem Soc Trans 38:144-9. 2010
    ..The present review summarizes the current knowledge of the aggresome-autophagy pathway, its regulation by parkin-mediated Lys(63)-linked polyubiquitination, and its dysfunction in neurodegenerative diseases...
  5. ncbi request reprint Regulation of synaptophysin degradation by mammalian homologues of seven in absentia
    Tiffany C Wheeler
    Department of Pharmacology, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    J Biol Chem 277:10273-82. 2002
    ..Our findings indicate that Siah proteins function as E3 ubiquitin-protein ligases to regulate the ubiquitination and degradation of synaptophysin...
  6. ncbi request reprint Familial Parkinson's disease-associated L166P mutation disrupts DJ-1 protein folding and function
    James A Olzmann
    Departments of Pharmacology, Biochemistry, and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 279:8506-15. 2004
    ..Together these findings provide insights into the molecular mechanism by which loss-of-function mutations in DJ-1 lead to Parkinson's disease...
  7. ncbi request reprint Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, 1510 Clifton Road, Atlanta, GA 30322, USA
    J Biol Chem 279:13256-64. 2004
    ..Together, these results provide evidence supporting a direct link between oxidative damage to the neuronal ubiquitination/de-ubiquitination machinery and the pathogenesis of sporadic AD and PD...
  8. pmc Mutations associated with Charcot-Marie-Tooth disease cause SIMPLE protein mislocalization and degradation by the proteasome and aggresome-autophagy pathways
    Samuel M Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Sci 124:3319-31. 2011
    ....
  9. pmc Spongiform neurodegeneration-associated E3 ligase Mahogunin ubiquitylates TSG101 and regulates endosomal trafficking
    Bong Yoon Kim
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 18:1129-42. 2007
    ..Our findings support a role for Mahogunin in a proteasome-independent ubiquitylation pathway and suggest a link between dysregulation of endosomal trafficking and spongiform neurodegeneration...
  10. pmc Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling
    Di Sha
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 19:352-63. 2010
    ..Our findings support a direct link between PINK1-mediated phosphorylation and parkin-mediated ubiquitin signaling and implicate the deregulation of the PINK1/parkin/NF-kappaB neuroprotective signaling pathway in the pathogenesis of PD...
  11. ncbi request reprint Huntingtin-associated protein 1 interacts with hepatocyte growth factor-regulated tyrosine kinase substrate and functions in endosomal trafficking
    Yankun Li
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 277:28212-21. 2002
    ..These findings implicate, for the first time, the involvement of HAP1 in the regulation of vesicular trafficking from early endosomes to the late endocytic compartments...
  12. ncbi request reprint GRIF1 binds Hrs and is a new regulator of endosomal trafficking
    Elizabeth Kirk
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Cell Sci 119:4689-701. 2006
    ..Our findings suggest that GRIF1 may also participate in microtubule-based transport of early endosomes by acting as an adaptor linking Hrs-containing endosomes to kinesin...
  13. pmc Hypertonia-associated protein Trak1 is a novel regulator of endosome-to-lysosome trafficking
    Elizabeth Webber
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 4218, USA
    J Mol Biol 382:638-51. 2008
    ..Our findings support a role for Trak1 in the regulation of Hrs-mediated endosomal sorting and have important implications for understanding hypertonia associated with neurological disorders...
  14. pmc Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 281:10816-24. 2006
    ..Our study provides new insights into the oxidative modifications of DJ-1 and indicates association of oxidative damage to DJ-1 with sporadic PD and AD...
  15. ncbi request reprint Ubiquitination of alpha-synuclein by Siah-1 promotes alpha-synuclein aggregation and apoptotic cell death
    James T Lee
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Hum Mol Genet 17:906-17. 2008
    ..Our findings suggest that Siah-1-mediated alpha-synuclein ubiquitination may play a critical role in Lewy body formation and PD pathogenesis...
  16. pmc Parkinson disease protein DJ-1 converts from a zymogen to a protease by carboxyl-terminal cleavage
    Jue Chen
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Hum Mol Genet 19:2395-408. 2010
    ..Our findings support a role for DJ-1 protease in cellular defense against oxidative stress and have important implications for understanding and treating PD...
  17. pmc Printor, a novel torsinA-interacting protein implicated in dystonia pathogenesis
    Lisa M Giles
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 284:21765-75. 2009
    ..Our findings suggest that printor is a new component of the DYT1 pathogenic pathway and provide a potential molecular target for therapeutic intervention in dystonia...
  18. pmc Parkin-mediated K63-linked polyubiquitination: a signal for targeting misfolded proteins to the aggresome-autophagy pathway
    James A Olzmann
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    Autophagy 4:85-7. 2008
    ..Our findings provide insight into the mechanisms underlying aggresome formation and suggest that parkin and K63-linked polyubiquitination may play a role in the autophagic clearance of misfolded proteins...
  19. ncbi request reprint Oxidative modifications and aggregation of Cu,Zn-superoxide dismutase associated with Alzheimer and Parkinson diseases
    Joungil Choi
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 280:11648-55. 2005
    ..This work suggests that AD, PD, and ALS may share a common or overlapping pathogenic mechanism(s) that could potentially be targeted by similar therapeutic strategies...
  20. pmc TorsinA protein degradation and autophagy in DYT1 dystonia
    Lisa M Giles
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Autophagy 5:82-4. 2009
    ....
  21. ncbi request reprint Staring, a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation
    Lih Shen Chin
    Department of Pharmacology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, Georgia 30322 3090, USA
    J Biol Chem 277:35071-9. 2002
    ..These findings suggest that Staring is a novel E3 ubiquitin-protein ligase that targets syntaxin 1 for degradation by the ubiquitin-proteasome pathway...
  22. pmc Selective enrichment of DJ-1 protein in primate striatal neuronal processes: implications for Parkinson's disease
    James A Olzmann
    Department of Pharmacology, Emory University, Atlanta, Georgia 30322, USA
    J Comp Neurol 500:585-99. 2007
    ..Together, these findings indicate neuronal and synaptic expression of DJ-1 in primate subcortical brain regions and suggest a physiological role for DJ-1 in the survival and/or function of nigral-striatal neurons...
  23. pmc Motor and sensory neuropathy due to myelin infolding and paranodal damage in a transgenic mouse model of Charcot-Marie-Tooth disease type 1C
    Samuel M Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Mol Genet 22:1755-70. 2013
    ..The results from this study suggest that myelin infolding and paranodal damage may represent pathogenic precursors preceding demyelination and axonal degeneration in CMT1C patients...
  24. pmc PINK1 protects against oxidative stress by phosphorylating mitochondrial chaperone TRAP1
    Julia W Pridgeon
    Department of Pharmacology, Emory University School of Medicine, Atlanta, Georgia, United States of America
    PLoS Biol 5:e172. 2007
    ..Our findings suggest a novel pathway by which PINK1 phosphorylates downstream effector TRAP1 to prevent oxidative-stress-induced apoptosis and implicate the dysregulation of this mitochondrial pathway in PD pathogenesis...
  25. pmc Proteomic analysis reveals Hrs ubiquitin-interacting motif-mediated ubiquitin signaling in multiple cellular processes
    Julia W Pridgeon
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    FEBS J 276:118-31. 2009
    ....
  26. pmc The ubiquitin-proteasome system in spongiform degenerative disorders
    BRANDI R WHATLEY
    Department of Pharmacology and Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biochim Biophys Acta 1782:700-12. 2008
    ....
  27. pmc Dystonia-associated mutations cause premature degradation of torsinA protein and cell-type-specific mislocalization to the nuclear envelope
    Lisa M Giles
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322 3090, USA
    Hum Mol Genet 17:2712-22. 2008
    ....
  28. pmc Protein misfolding and clearance in demyelinating peripheral neuropathies: Therapeutic implications
    Samuel M Lee
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA USA
    Commun Integr Biol 5:107-10. 2012
    ..These studies suggest that targeting protein quality control systems involved in cytoprotection against CMT-associated misfolded proteins could have therapeutic benefits for treating demyelinating CMT...
  29. ncbi request reprint Conditional knock-out of Kir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation
    Biljana Djukic
    Department of Pharmacology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    J Neurosci 27:11354-65. 2007
    ..1 cKO hippocampus. Our findings implicate a role for glial Kir4.1 channel subunit in the modulation of synaptic strength...

Research Grants7

  1. Molecular analysis of DJ-1 function and dysfunction
    Lih Shen Chin; Fiscal Year: 2007
    ..Completion of the proposed project should advance our understanding of PD pathogenesis, and accelerate the efforts to discover curative therapies for PD and related neurodegenerative disorders. ..
  2. Molecular analysis of DJ-1 function and dysfunction
    Lih Shen Chin; Fiscal Year: 2010
    ..Completion of the proposed project should advance our understanding of PD pathogenesis, and accelerate the efforts to discover curative therapies for PD and related neurodegenerative disorders. ..
  3. A Novel Ubiquitin-Dependent Pathogenic Pathway in Spongiform Neurodegeneration
    Lih Shen Chin; Fiscal Year: 2010
    ..The results of the proposed studies will provide fundamental information needed for the development of effective therapeutics to combat age-related neurodegenerative diseases. ..