Research Topics
Genomes and Genes
| Jing ChenSummaryAffiliation: Emory University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expressionNaoko Masumoto
Program in Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
Gene 291:169-76. 2002..This is an interesting finding in light of our earlier results which located promoter B and two associated alternates of exon 1 of this gene on chromosome 17...
Mobilization as a preparative regimen for hematopoietic stem cell transplantationJing Chen
Medicine/Hematology, University of Washington, Box 357710, Seattle, 98195, USA
Blood 107:3764-71. 2006..These results indicate that the number of available niches regulates the number of HSCs. In addition, mobilization with AMD3100 may provide a safer preparative approach for HSC transplantation in genetic and other nonmalignant disorders...- FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathwaySumin Kang
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Cancer Cell 12:201-14. 2007..Our findings suggest that FGFR3 mediates hematopoietic transformation by activating RSK2 in a two-step fashion, promoting both the ERK-RSK2 interaction and subsequent phosphorylation of RSK2 by ERK... - Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformationJing Chen
Howard Hughes Medical Institute, Harvard Medical Scgool, Boston, MA, USA
Blood 106:328-37. 2005..These data indicate that engagement of multiple signaling pathways, including PLCgamma-dependent and PLCgamma-independent pathways, is required for full hematopoietic transformation by constitutively activated FGFR3 mutants... - Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cellsJun Fan
Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Cell Biol 31:4938-50. 2011.... - Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathyAndreas Stahl
Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Mass 02115, USA
Circ Res 107:495-500. 2010..Omega3 long-chain polyunsaturated fatty acids (omega3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing omega3-PUFA-dependent attenuation of angiogenesis... - Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growthTaro Hitosugi
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Sci Signal 2:ra73. 2009..Our findings suggest that tyrosine phosphorylation regulates PKM2 to provide a metabolic advantage to tumor cells, thereby promoting tumor growth... 
5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acidsPrzemyslaw Sapieha
Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Sci Transl Med 3:69ra12. 2011..It also suggests that cyclooxygenase inhibitors such as aspirin and ibuprofen (but not lipoxygenase inhibitors such as zileuton) might be used without losing the beneficial effect of dietary ω-3 PUFA...- Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529Sumin Kang
Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Biol Chem 283:4652-7. 2008..Together, our findings suggest that Src-dependent phosphorylation at Tyr-529 facilitates inactive ERK binding to RSK2, which might be a general requirement for RSK2 activation by EGF through the MEK/ERK pathway... - Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformationSumin Kang
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Cell Biol 29:2105-17. 2009..Our current and previous findings represent a paradigm for tyrosine phosphorylation-dependent regulation of serine-threonine kinases... - Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathyJing Chen
Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 50:1329-35. 2009..The authors investigated the inhibition of retinal EPO mRNA expression with RNA interference as a potential strategy to suppress retinal neovascularization and to prevent proliferative retinopathy... - Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolismTaro Hitosugi
Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Cell 44:864-77. 2011..Together, tyrosine phosphorylation activates PDHK1 to promote the Warburg effect and tumor growth... - FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignanciesJing Chen
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Oncogene 24:8259-67. 2005..These data indicate that PKC412 may be a useful molecularly targeted therapy for MM associated with overexpression of FGFR3, and perhaps other diseases associated with dysregulation of FGFR3 or related mutants... - The mouse retina as an angiogenesis modelAndreas Stahl
Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 51:2813-26. 2010..From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis... - Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) miceJing Hua
Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
Invest Ophthalmol Vis Sci 52:2809-16. 2011..In this study, the authors evaluate the therapeutic potential of resveratrol, a plant polyphenol, in Vldlr(-/-) mice as a model for MacTel... - Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathyAndreas Stahl
Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Am J Pathol 177:2715-23. 2010.... - p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cellsSumin Kang
Winship Cancer Institute of Emory University, Atlanta, Georgia 30322, USA
J Clin Invest 120:1165-77. 2010..Moreover, targeting RSK2 markedly attenuates in vitro invasion and in vivo metastasis of HNSCC cells, suggesting that RSK2 may represent a therapeutic target in the treatment of metastatic HNSCC... - Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesisKip M Connor
Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Nat Protoc 4:1565-73. 2009..In this protocol we describe standards for mouse size, sample size, retinal preparation, quantification of vascular loss, vascular regrowth, NV and neovascular regression... - SOCS3 is an endogenous inhibitor of pathologic angiogenesisAndreas Stahl
Department of Ophthalmology, Harvard Medical School, Boston Children s Hospital, Boston, MA 02115, USA
Blood 120:2925-9. 2012..These results identify SOCS3 as a pivotal endogenous feedback inhibitor of pathologic angiogenesis and a potential therapeutic target acting at the converging crossroads of growth factor- and cytokine-induced vessel growth... - Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cellsWinnie F Tam
Hematology Division, Brigham and Women s Hospital, Boston, MA 02115, USA
Blood 112:1981-92. 2008..These findings indicate that Id1 is an important target of constitutively activated tyrosine kinases and may be a therapeutic target for leukemias associated with oncogenic tyrosine kinases... - Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independentElizabeth H Stover
Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:8078-83. 2006..These results suggest that disruption of the autoinhibitory JM domain is an alternative, dimerization-independent mechanism by which chimeric tyrosine kinases are constitutively activated and induce leukemogenesis... - The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivoElizabeth H Stover
Division of Hematology, Brigham and Women's Hospital, 75 Francis St, Boston, MA 02115, USA
Blood 106:3206-13. 2005..In summary, AMN107 can inhibit myeloid proliferation driven by TEL-PDGFRbeta and FIP1L1-PDGFRalpha and may be a useful drug for treatment of patients with myeloproliferative disease who harbor these kinase fusions... - Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomesEbenezer David
Winship Cancer Institute of Emory University, Department of Hematology and Medical Oncology, School of Medicine, Atlanta, GA, USA
Blood 116:5285-8. 2010..Together, these data demonstrate that tipifarnib synergizes with bortezomib by inducing protein accumulation as a result of the uncoupling of the aggresome and autophagy pathways... - 14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cellsShaozhong Dong
Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
Blood 110:360-9. 2007..Our findings suggest that 14-3-3 integrates prosurvival signals in FGFR1 fusion-transformed hematopoietic cells. Disrupting 14-3-3-ligand association may represent an effective therapeutic strategy to treat 8p11 stem cell MPD... - Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1Sung Wuk Jang
Department of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
Cancer Res 68:4559-70. 2008..Thus, our findings establish a molecular mechanism by which SR splicing machinery regulates cell cycle and contributes to leukemia tumorigenesis... - Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptorsEbenezer David
Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
Clin Cancer Res 14:5090-8. 2008..The aim of this study is to investigate the efficacy of a novel Akt inhibitor, perifosine, in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human myeloma cells and primary patient samples... - Erythropoietin deficiency decreases vascular stability in miceJing Chen
Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 118:526-33. 2008..Understanding the role of Epo in angiogenesis is critical to timing its intervention in patients with retinopathy or other diseases in which pathological angiogenesis plays a significant role... - The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1RDiansheng Zhong
Department of Hematology, Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 284:23225-33. 2009..Our in vitro analysis demonstrated that treatment with a combination of subtoxic doses of 2-DG and the IGF1R inhibitor II reduced cancer cell proliferation 90% and promoted significant apoptosis... - Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survivalXia Liu
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:9679-84. 2007..Surprisingly, K230R mutant strongly binds to phosphatidylinositol-3,4,5-trisphosphate and suppresses DNA fragmentation. Thus, B23 sumoylation regulates its subcellular localization, cell proliferation, and survival activities... - PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorderJing Chen
Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:14479-84. 2004..Therefore, PKC412 may be a useful therapy for treatment of human stem cell leukemia-lymphoma syndrome... - Targeting RSK2 in human malignanciesSumin Kang
Emory University School of Medicine, Winship Cancer Institute of Emory, Department of Hematology and Medical Oncology, Atlanta, GA 30322, USA
Expert Opin Ther Targets 15:11-20. 2011..Recent advances reveal a crucial role of RSK2 in oncogenesis and tumor progression, making RSK2 an attractive therapeutic target for cancer treatment... - Lipid metabolites in the pathogenesis and treatment of neovascular eye diseaseAndreas Stahl
Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
Br J Ophthalmol 95:1496-501. 2011.... - ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1You Take Oh
Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA
J Biol Chem 285:41310-9. 2010..Collectively, we conclude that small molecules such as celecoxib induce DR5 expression through activating ERK/RSK signaling and subsequent Elk1 activation and ATF4-dependent CHOP induction... - IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowthChatarina Lofqvist
Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:10589-94. 2007.... - An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complexLai Xu
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
Mol Biol Cell 19:5059-71. 2008..These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the HOPS complex... - Positive and negative regulatory roles of the WW-like domain in TEL-PDGFbetaR transformationJing Chen
Division of Hematology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
Blood 104:535-42. 2004..Therefore, the WW-like domain in the context of TELPDGFbetaR may have both positive and negative regulatory roles in kinase activation... - Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycinJing Chen
Howard Hughes Medical Institute, Division of Hematology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Clin Invest 113:1784-91. 2004..Although siRNA delivery in vivo is a challenging problem, stable expression of siRNA, which targets oncogenic fusion genes, may potentiate the effects of conventional therapy for hematologic malignancies... - The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKTEbenezer David
Winship Cancer Institute, Emory University, 1365 Clifton Rd, Building C, Rm 4004, Atlanta, GA 30322, USA
Blood 106:4322-9. 2005..The combination of a proteasome inhibitor and farnesyl transferase inhibitor demonstrates synergistic myeloma-cell death and warrants further preclinical and clinical studies... - Current update on retinopathy of prematurity: screening and treatmentJing Chen
Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
Curr Opin Pediatr 23:173-8. 2011..This review summarizes the recent literature on ROP with a special focus on recent advances in treatment options as well as newly developed methods for disease screening... - Overstaying their welcome: defective CX3CR1 microglia eyed in macular degenerationJing Chen
Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
J Clin Invest 117:2758-62. 2007..In this issue of the JCI, the study by Combadière and colleagues shows that CX3C chemokine receptor 1-deficient (CX3CR1-deficient) mice have abnormal microglia that accumulate beneath the retina and contribute to the progression of AMD... - Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesisKip M Connor
Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Med 13:868-73. 2007..Supplementing omega-3-PUFA intake may be of benefit in preventing retinopathy... - Protective inflammasome activation in AMDJing Chen
Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
Nat Med 18:658-60. 2012..A new study identifies a protective role for inflammasomes in AMD, suggesting that inflammasome activation might be manipulated as a potential therapeutic strategy for this condition (pages 791-798)... - Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034Katsunori Fujii
Department of Pharmacology, Emory University School of Medicine, Atlanta GA 30322, USA
Oncogene 23:5099-104. 2004..Thus, the proapoptotic function of ASK1 is suppressed in part by phosphorylation at its C-terminal regulatory domain, which may couple upstream survival kinases to the death regulatory machinery... - Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cellsJing Chen
Integrated Cancer Research Center, School of Biology and Parker H Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
Gynecol Oncol 121:200-5. 2011..Members of the miR200 family of microRNAs have been implicated in EMT in other cancers. Our purpose was to determine if miR200 family microRNAs may be involved in EMT in OC and of potential therapeutic value in reducing OC metastasis... - SIRT1 is essential for normal cognitive function and synaptic plasticityShaday Michan
Paul F Glenn Laboratories, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
J Neurosci 30:9695-707. 2010..In contrast, mice with high levels of SIRT1 expression in brain exhibited regular synaptic plasticity and memory. We conclude that SIRT1 is indispensable for normal learning, memory, and synaptic plasticity in mice... - Light-induced translocation of cyclic-GMP phosphodiesterase on rod disc membranes in rat retinaJing Chen
Department of Biomedical Engineering, College of Engineering, Boston University, Boston, MA, USA
Mol Vis 14:2509-17. 2008..This study investigated the effects of light on the subcellular localization of PDE in ROS... - Retinopathy of prematurityJing Chen
Department of Ophthalmology, Harvard Medical School and Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
Angiogenesis 10:133-40. 2007..As infants mature, rising levels of IGF-1 in phase II of ROP allows VEGF stimulated pathological neovascularization. These findings suggest that restoration of IGF-1 to normal levels might be useful in preventing ROP in preterm infants... - Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cellsRobert S Ohgami
Department of Pathology Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
Nat Genet 37:1264-9. 2005..Taken together, these findings indicate that Steap3 is an endosomal ferrireductase required for efficient Tf-dependent iron uptake in erythroid cells... - A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1Jianping Jin
Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
Mol Cell 23:709-21. 2006..These studies uncover diverse substrate receptors for Cul4 and identify Cdt2 as a conserved component of the Cul4-Ddb1 E3 that is essential to destroy Cdt1 and ensure proper cell cycle regulation of DNA replication... - Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cellsRegina A Oyesanya
Virginia Commonwealth University, Department of Biochemistry and Molecular Biology, 1101 East Marshall St, Richmond, VA 23298, USA
FASEB J 22:2639-51. 2008..In addition to the transcriptional activation, the RNA stabilization protein HuR bound to and protected Cox-2 mRNA in LPA-stimulated cells, indicating an active role for HuR in sustaining Cox-2 induction during physiological responses... - The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expressionZhen Biao Xia
Department of Medicine, Molecular Biology Program, and Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
Proc Natl Acad Sci U S A 102:14028-33. 2005..This finding may have implications in terms of leukemia stem cell resistance to chemotherapy in MLL-AF4 leukemias... - Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalizationJing Chen
Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago Medical Center, University of Chicago, Chicago, Illinois, USA
Cancer Res 68:6199-207. 2008..This leads to constitutive overexpression of MLL target genes that block stem cell commitment and promote stem cell renewal, probably the first step in MLL-related leukemogenesis... - Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer techniqueShuai Chen
Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China
Acta Pharmacol Sin 26:99-106. 2005..This FRET-based assay might supply an ideal approach for the exploration SARS-CoV 3CL(pro) putative inhibitors... - A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonistQing Chen
Drug Discovery Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China
Anal Biochem 335:253-9. 2004.... - Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin ACheng Luo
Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
Biochem Biophys Res Commun 321:557-65. 2004..Such presently observed SARS_NP-hCypA interaction model might provide a new hint for facilitating the understanding of another possible SARS-CoV infection pathway against human cell... - Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive systemEmmanouil Karteris
Biomedical Research Institute, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL
J Clin Endocrinol Metab 89:1957-62. 2004.... - Association of an aminoacyl-tRNA synthetase with a putative metabolic protein in archaeaRichard S A Lipman
Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 233 South 10th Street, BLSB 220, Philadelphia, Pennsylvania 19107, USA
Biochemistry 42:7487-96. 2003..The association of Mj1338 with ProRS, and with other components of the protein synthesis machinery, thus suggests the possibility of a closer link between metabolism and decoding in archaea than in eukarya or bacteria... - [Asparagine synthetase activity in pediatric acute lymphoblastic leukemia]Hua Jiang
Department of Hematology Oncology, Shanghai Children s Medical Center Affiliated to Medical College of Shanghai Jiaotong University, Shanghai 200127, China
Zhongguo Dang Dai Er Ke Za Zhi 8:272-4. 2006..To study the cellular activity of asparagine synthetase in different types of childhood acute lymphoblastic leukemia (ALL)... - [Prognostic factors for childhood acute non-mature B-lymphoblastic leukemia]Hua Jiang
Department of Hematology Oncology, Shanghai Children s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
Zhongguo Dang Dai Er Ke Za Zhi 10:290-4. 2008..To study the prognostic factors for events-free survival (EFS) in children with acute non-mature B-lymphoblastic leukemia... - Construction and characterization of the HMGB1 mutant as a competitive antagonist to HMGB1 induced cytokines releaseZhiqiang Yuan
Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China
Biochem Biophys Res Commun 372:703-7. 2008..This may be of significant importance in providing a new anti-inflammatory strategy for the treatment of severe sepsis and other inflammatory disorders... - The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysisTiancen Hu
Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
J Biol Chem 283:21284-93. 2008..Our work is expected to provide clues for designing specific inhibitors of DAPDC... - Selective expression of progesterone receptor in malignant melanoma was inversely correlated with PCNAJiawen Li
Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
J Huazhong Univ Sci Technolog Med Sci 28:216-8. 2008..Selective expression of progesterone receptor in malignant melanoma might be correlated with inhibited tumor growth... - KLF4 is a FOXO target gene that suppresses B cell proliferationIsharat Yusuf
Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA
Int Immunol 20:671-81. 2008..Collectively, our findings indicate that KLF4 has growth-suppressive properties in B cells but might be redundant with other members of the KLF family in maintaining B cell quiescence... - Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding siteLi Du
Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
ChemMedChem 3:173-80. 2008.... - Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behaviorManjari Dimri
Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
Cancer Res 67:4164-72. 2007.... - SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-AblJing Chen
Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
Blood 109:778-85. 2007..These studies identified a novel function of SHP-2 and suggest that SHP-2 might be a useful target for controlling Bcr-Abl-positive leukemias... - Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposureJanis L Abkowitz
Department of Medicine, Division of Hematology, University of Washington, Box 357710, Seattle, WA 98195 7710, USA
Blood 102:1249-53. 2003....
Research Grants
- Signaling and targeting of FGFR1 fusions in 8p11 myeloproliferative syndromeJing Chen; Fiscal Year: 2007..In summary, this proposal will provide detailed information about signaling and transforming properties of FGFR1 fusions, and explore therapeutic strategies to treat FGFR1-associated malignancies. ..
- Signaling and targeting of FGFR1 fusions in 8p11 myeloproliferative syndromeJing Chen; Fiscal Year: 2009..In summary, this proposal will provide detailed information about signaling and transforming properties of FGFR1 fusions, and explore therapeutic strategies to treat FGFR1-associated malignancies. ..
- Signaling and targeting of FGFR1 fusions in 8p11 myeloproliferative syndromeJing Chen; Fiscal Year: 2010..In summary, this proposal will provide detailed information about signaling and transforming properties of FGFR1 fusions, and explore therapeutic strategies to treat FGFR1-associated malignancies. ..
- Tyrosine Kinase Signaling in Cancer Cell MetabolismJing Chen; Fiscal Year: 2010..Our overall hypothesis is that oncogenic FGFR1 programs cancer cell metabolism through tyrosine phosphorylation of metabolic enzymes including PKM2, PDHK1 and LDH-A to promote the Warburg effect and tumor growth. ..