Jing Chen

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression
    Naoko Masumoto
    Program in Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 291:169-76. 2002
  2. pmc Mobilization as a preparative regimen for hematopoietic stem cell transplantation
    Jing Chen
    Medicine Hematology, University of Washington, Box 357710, Seattle, 98195, USA
    Blood 107:3764-71. 2006
  3. pmc FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Cell 12:201-14. 2007
  4. pmc Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation
    Jing Chen
    Howard Hughes Medical Institute, Harvard Medical Scgool, Boston, MA, USA
    Blood 106:328-37. 2005
  5. pmc Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells
    Jun Fan
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell Biol 31:4938-50. 2011
  6. pmc Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy
    Andreas Stahl
    Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Mass 02115, USA
    Circ Res 107:495-500. 2010
  7. pmc Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
    Taro Hitosugi
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Sci Signal 2:ra73. 2009
  8. pmc 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids
    Przemyslaw Sapieha
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Sci Transl Med 3:69ra12. 2011
  9. pmc Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell Biol 29:2105-17. 2009
  10. pmc Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:4652-7. 2008

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression
    Naoko Masumoto
    Program in Molecular Pharmacology and Experimental Therapeutics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Gene 291:169-76. 2002
    ..This is an interesting finding in light of our earlier results which located promoter B and two associated alternates of exon 1 of this gene on chromosome 17...
  2. pmc Mobilization as a preparative regimen for hematopoietic stem cell transplantation
    Jing Chen
    Medicine Hematology, University of Washington, Box 357710, Seattle, 98195, USA
    Blood 107:3764-71. 2006
    ..These results indicate that the number of available niches regulates the number of HSCs. In addition, mobilization with AMD3100 may provide a safer preparative approach for HSC transplantation in genetic and other nonmalignant disorders...
  3. pmc FGFR3 activates RSK2 to mediate hematopoietic transformation through tyrosine phosphorylation of RSK2 and activation of the MEK/ERK pathway
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cancer Cell 12:201-14. 2007
    ..Our findings suggest that FGFR3 mediates hematopoietic transformation by activating RSK2 in a two-step fashion, promoting both the ERK-RSK2 interaction and subsequent phosphorylation of RSK2 by ERK...
  4. pmc Constitutively activated FGFR3 mutants signal through PLCgamma-dependent and -independent pathways for hematopoietic transformation
    Jing Chen
    Howard Hughes Medical Institute, Harvard Medical Scgool, Boston, MA, USA
    Blood 106:328-37. 2005
    ..These data indicate that engagement of multiple signaling pathways, including PLCgamma-dependent and PLCgamma-independent pathways, is required for full hematopoietic transformation by constitutively activated FGFR3 mutants...
  5. pmc Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH/NAD(+) redox homeostasis in cancer cells
    Jun Fan
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell Biol 31:4938-50. 2011
    ....
  6. pmc Short communication: PPAR gamma mediates a direct antiangiogenic effect of omega 3-PUFAs in proliferative retinopathy
    Andreas Stahl
    Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Mass 02115, USA
    Circ Res 107:495-500. 2010
    ..Omega3 long-chain polyunsaturated fatty acids (omega3-PUFAs) are powerful modulators of angiogenesis. However, little is known about the mechanisms governing omega3-PUFA-dependent attenuation of angiogenesis...
  7. pmc Tyrosine phosphorylation inhibits PKM2 to promote the Warburg effect and tumor growth
    Taro Hitosugi
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Sci Signal 2:ra73. 2009
    ..Our findings suggest that tyrosine phosphorylation regulates PKM2 to provide a metabolic advantage to tumor cells, thereby promoting tumor growth...
  8. pmc 5-Lipoxygenase metabolite 4-HDHA is a mediator of the antiangiogenic effect of ω-3 polyunsaturated fatty acids
    Przemyslaw Sapieha
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Sci Transl Med 3:69ra12. 2011
    ..It also suggests that cyclooxygenase inhibitors such as aspirin and ibuprofen (but not lipoxygenase inhibitors such as zileuton) might be used without losing the beneficial effect of dietary ω-3 PUFA...
  9. pmc Fibroblast growth factor receptor 3 associates with and tyrosine phosphorylates p90 RSK2, leading to RSK2 activation that mediates hematopoietic transformation
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell Biol 29:2105-17. 2009
    ..Our current and previous findings represent a paradigm for tyrosine phosphorylation-dependent regulation of serine-threonine kinases...
  10. pmc Epidermal growth factor stimulates RSK2 activation through activation of the MEK/ERK pathway and src-dependent tyrosine phosphorylation of RSK2 at Tyr-529
    Sumin Kang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 283:4652-7. 2008
    ..Together, our findings suggest that Src-dependent phosphorylation at Tyr-529 facilitates inactive ERK binding to RSK2, which might be a general requirement for RSK2 activation by EGF through the MEK/ERK pathway...
  11. pmc Suppression of retinal neovascularization by erythropoietin siRNA in a mouse model of proliferative retinopathy
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 50:1329-35. 2009
    ..The authors investigated the inhibition of retinal EPO mRNA expression with RNA interference as a potential strategy to suppress retinal neovascularization and to prevent proliferative retinopathy...
  12. pmc Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism
    Taro Hitosugi
    Department of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Cell 44:864-77. 2011
    ..Together, tyrosine phosphorylation activates PDHK1 to promote the Warburg effect and tumor growth...
  13. ncbi request reprint FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies
    Jing Chen
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Oncogene 24:8259-67. 2005
    ..These data indicate that PKC412 may be a useful molecularly targeted therapy for MM associated with overexpression of FGFR3, and perhaps other diseases associated with dysregulation of FGFR3 or related mutants...
  14. pmc Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice
    Jing Hua
    Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 52:2809-16. 2011
    ..In this study, the authors evaluate the therapeutic potential of resveratrol, a plant polyphenol, in Vldlr(-/-) mice as a model for MacTel...
  15. pmc The mouse retina as an angiogenesis model
    Andreas Stahl
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Invest Ophthalmol Vis Sci 51:2813-26. 2010
    ..From the multitude of studies performed in the mouse retina, a selection of representative works is discussed in more detail regarding their role in advancing the understanding of both the ocular and general mechanisms of angiogenesis...
  16. pmc Quantification of oxygen-induced retinopathy in the mouse: a model of vessel loss, vessel regrowth and pathological angiogenesis
    Kip M Connor
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Protoc 4:1565-73. 2009
    ..In this protocol we describe standards for mouse size, sample size, retinal preparation, quantification of vascular loss, vascular regrowth, NV and neovascular regression...
  17. pmc p90 ribosomal S6 kinase 2 promotes invasion and metastasis of human head and neck squamous cell carcinoma cells
    Sumin Kang
    Winship Cancer Institute of Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 120:1165-77. 2010
    ..Moreover, targeting RSK2 markedly attenuates in vitro invasion and in vivo metastasis of HNSCC cells, suggesting that RSK2 may represent a therapeutic target in the treatment of metastatic HNSCC...
  18. pmc Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy
    Andreas Stahl
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Am J Pathol 177:2715-23. 2010
    ....
  19. pmc SOCS3 is an endogenous inhibitor of pathologic angiogenesis
    Andreas Stahl
    Department of Ophthalmology, Harvard Medical School, Boston Children s Hospital, Boston, MA 02115, USA
    Blood 120:2925-9. 2012
    ..These results identify SOCS3 as a pivotal endogenous feedback inhibitor of pathologic angiogenesis and a potential therapeutic target acting at the converging crossroads of growth factor- and cytokine-induced vessel growth...
  20. pmc Id1 is a common downstream target of oncogenic tyrosine kinases in leukemic cells
    Winnie F Tam
    Hematology Division, Brigham and Women s Hospital, Boston, MA 02115, USA
    Blood 112:1981-92. 2008
    ..These findings indicate that Id1 is an important target of constitutively activated tyrosine kinases and may be a therapeutic target for leukemias associated with oncogenic tyrosine kinases...
  21. pmc The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo
    Elizabeth H Stover
    Division of Hematology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Blood 106:3206-13. 2005
    ..In summary, AMN107 can inhibit myeloid proliferation driven by TEL-PDGFRbeta and FIP1L1-PDGFRalpha and may be a useful drug for treatment of patients with myeloproliferative disease who harbor these kinase fusions...
  22. pmc 14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells
    Shaozhong Dong
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 110:360-9. 2007
    ..Our findings suggest that 14-3-3 integrates prosurvival signals in FGFR1 fusion-transformed hematopoietic cells. Disrupting 14-3-3-ligand association may represent an effective therapeutic strategy to treat 8p11 stem cell MPD...
  23. doi request reprint Tipifarnib sensitizes cells to proteasome inhibition by blocking degradation of bortezomib-induced aggresomes
    Ebenezer David
    Winship Cancer Institute of Emory University, Department of Hematology and Medical Oncology, School of Medicine, Atlanta, GA, USA
    Blood 116:5285-8. 2010
    ..Together, these data demonstrate that tipifarnib synergizes with bortezomib by inducing protein accumulation as a result of the uncoupling of the aggresome and autophagy pathways...
  24. pmc Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent
    Elizabeth H Stover
    Division of Hematology, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:8078-83. 2006
    ..These results suggest that disruption of the autoinhibitory JM domain is an alternative, dimerization-independent mechanism by which chimeric tyrosine kinases are constitutively activated and induce leukemogenesis...
  25. pmc Serine/arginine protein-specific kinase 2 promotes leukemia cell proliferation by phosphorylating acinus and regulating cyclin A1
    Sung Wuk Jang
    Department of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 68:4559-70. 2008
    ..Thus, our findings establish a molecular mechanism by which SR splicing machinery regulates cell cycle and contributes to leukemia tumorigenesis...
  26. pmc Erythropoietin deficiency decreases vascular stability in mice
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:526-33. 2008
    ..Understanding the role of Epo in angiogenesis is critical to timing its intervention in patients with retinopathy or other diseases in which pathological angiogenesis plays a significant role...
  27. doi request reprint Perifosine synergistically enhances TRAIL-induced myeloma cell apoptosis via up-regulation of death receptors
    Ebenezer David
    Department of Hematology and Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Clin Cancer Res 14:5090-8. 2008
    ..The aim of this study is to investigate the efficacy of a novel Akt inhibitor, perifosine, in combination with tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in human myeloma cells and primary patient samples...
  28. pmc Sumoylation of nucleophosmin/B23 regulates its subcellular localization, mediating cell proliferation and survival
    Xia Liu
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:9679-84. 2007
    ..Surprisingly, K230R mutant strongly binds to phosphatidylinositol-3,4,5-trisphosphate and suppresses DNA fragmentation. Thus, B23 sumoylation regulates its subcellular localization, cell proliferation, and survival activities...
  29. pmc The glycolytic inhibitor 2-deoxyglucose activates multiple prosurvival pathways through IGF1R
    Diansheng Zhong
    Department of Hematology, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 284:23225-33. 2009
    ..Our in vitro analysis demonstrated that treatment with a combination of subtoxic doses of 2-DG and the IGF1R inhibitor II reduced cancer cell proliferation 90% and promoted significant apoptosis...
  30. doi request reprint Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy
    Jing Chen
    Department of Ophthalmology, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA
    Angiogenesis 16:985-92. 2013
    ....
  31. pmc PKC412 inhibits the zinc finger 198-fibroblast growth factor receptor 1 fusion tyrosine kinase and is active in treatment of stem cell myeloproliferative disorder
    Jing Chen
    Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:14479-84. 2004
    ..Therefore, PKC412 may be a useful therapy for treatment of human stem cell leukemia-lymphoma syndrome...
  32. doi request reprint Targeting RSK2 in human malignancies
    Sumin Kang
    Emory University School of Medicine, Winship Cancer Institute of Emory, Department of Hematology and Medical Oncology, Atlanta, GA 30322, USA
    Expert Opin Ther Targets 15:11-20. 2011
    ..Recent advances reveal a crucial role of RSK2 in oncogenesis and tumor progression, making RSK2 an attractive therapeutic target for cancer treatment...
  33. pmc Lipid metabolites in the pathogenesis and treatment of neovascular eye disease
    Andreas Stahl
    Department of Ophthalmology, Harvard Medical School, Children s Hospital, Boston, Massachusetts 02115, USA
    Br J Ophthalmol 95:1496-501. 2011
    ....
  34. pmc An FTS/Hook/p107(FHIP) complex interacts with and promotes endosomal clustering by the homotypic vacuolar protein sorting complex
    Lai Xu
    Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Mol Biol Cell 19:5059-71. 2008
    ..These data suggest that the FTS/Hook/FHIP complex functions to promote vesicle trafficking and/or fusion via the HOPS complex...
  35. pmc ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1
    You Take Oh
    Department of Hematology and Medical Oncology, Emory University School of Medicine and Winship Cancer Institute, Atlanta, Georgia 30322, USA
    J Biol Chem 285:41310-9. 2010
    ..Collectively, we conclude that small molecules such as celecoxib induce DR5 expression through activating ERK/RSK signaling and subsequent Elk1 activation and ATF4-dependent CHOP induction...
  36. pmc IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth
    Chatarina Lofqvist
    Department of Ophthalmology, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:10589-94. 2007
    ....
  37. ncbi request reprint Positive and negative regulatory roles of the WW-like domain in TEL-PDGFbetaR transformation
    Jing Chen
    Division of Hematology, Brigham and Women s Hospital, 75 Francis St, Boston, MA 02115, USA
    Blood 104:535-42. 2004
    ..Therefore, the WW-like domain in the context of TELPDGFbetaR may have both positive and negative regulatory roles in kinase activation...
  38. pmc Stable expression of small interfering RNA sensitizes TEL-PDGFbetaR to inhibition with imatinib or rapamycin
    Jing Chen
    Howard Hughes Medical Institute, Division of Hematology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 113:1784-91. 2004
    ..Although siRNA delivery in vivo is a challenging problem, stable expression of siRNA, which targets oncogenic fusion genes, may potentiate the effects of conventional therapy for hematologic malignancies...
  39. ncbi request reprint The combination of the farnesyl transferase inhibitor lonafarnib and the proteasome inhibitor bortezomib induces synergistic apoptosis in human myeloma cells that is associated with down-regulation of p-AKT
    Ebenezer David
    Winship Cancer Institute, Emory University, 1365 Clifton Rd, Building C, Rm 4004, Atlanta, GA 30322, USA
    Blood 106:4322-9. 2005
    ..The combination of a proteasome inhibitor and farnesyl transferase inhibitor demonstrates synergistic myeloma-cell death and warrants further preclinical and clinical studies...
  40. ncbi request reprint Increased dietary intake of omega-3-polyunsaturated fatty acids reduces pathological retinal angiogenesis
    Kip M Connor
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Med 13:868-73. 2007
    ..Supplementing omega-3-PUFA intake may be of benefit in preventing retinopathy...
  41. pmc Current update on retinopathy of prematurity: screening and treatment
    Jing Chen
    Department of Ophthalmology, Harvard Medical School, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    Curr Opin Pediatr 23:173-8. 2011
    ..This review summarizes the recent literature on ROP with a special focus on recent advances in treatment options as well as newly developed methods for disease screening...
  42. pmc Overstaying their welcome: defective CX3CR1 microglia eyed in macular degeneration
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 117:2758-62. 2007
    ..In this issue of the JCI, the study by Combadière and colleagues shows that CX3C chemokine receptor 1-deficient (CX3CR1-deficient) mice have abnormal microglia that accumulate beneath the retina and contribute to the progression of AMD...
  43. pmc Protective inflammasome activation in AMD
    Jing Chen
    Department of Ophthalmology, Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 18:658-60. 2012
    ..A new study identifies a protective role for inflammasomes in AMD, suggesting that inflammasome activation might be manipulated as a potential therapeutic strategy for this condition (pages 791-798)...
  44. ncbi request reprint Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034
    Katsunori Fujii
    Department of Pharmacology, Emory University School of Medicine, Atlanta GA 30322, USA
    Oncogene 23:5099-104. 2004
    ..Thus, the proapoptotic function of ASK1 is suppressed in part by phosphorylation at its C-terminal regulatory domain, which may couple upstream survival kinases to the death regulatory machinery...
  45. pmc SIRT1 is essential for normal cognitive function and synaptic plasticity
    Shaday Michan
    Paul F Glenn Laboratories, Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 30:9695-707. 2010
    ..In contrast, mice with high levels of SIRT1 expression in brain exhibited regular synaptic plasticity and memory. We conclude that SIRT1 is indispensable for normal learning, memory, and synaptic plasticity in mice...
  46. doi request reprint Overexpression of miR-429 induces mesenchymal-to-epithelial transition (MET) in metastatic ovarian cancer cells
    Jing Chen
    Integrated Cancer Research Center, School of Biology and Parker H Petit Institute of Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, GA 30332 0363, USA
    Gynecol Oncol 121:200-5. 2011
    ..Members of the miR200 family of microRNAs have been implicated in EMT in other cancers. Our purpose was to determine if miR200 family microRNAs may be involved in EMT in OC and of potential therapeutic value in reducing OC metastasis...
  47. pmc Altered cholesterol homeostasis in aged macrophages linked to neovascular macular degeneration
    Jing Chen
    Department of Ophthalmology, Boston Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Cell Metab 17:471-2. 2013
    ..Sene et al. (2013) now demonstrate that in aged macrophages decreased ABCA1 expression, regulated by liver X receptor and miR-33, impairs export of intracellular cholesterol, which promotes neovascular AMD...
  48. pmc Light-induced translocation of cyclic-GMP phosphodiesterase on rod disc membranes in rat retina
    Jing Chen
    Department of Biomedical Engineering, College of Engineering, Boston University, Boston, MA, USA
    Mol Vis 14:2509-17. 2008
    ..This study investigated the effects of light on the subcellular localization of PDE in ROS...
  49. ncbi request reprint Retinopathy of prematurity
    Jing Chen
    Department of Ophthalmology, Harvard Medical School and Children s Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA
    Angiogenesis 10:133-40. 2007
    ..As infants mature, rising levels of IGF-1 in phase II of ROP allows VEGF stimulated pathological neovascularization. These findings suggest that restoration of IGF-1 to normal levels might be useful in preventing ROP in preterm infants...
  50. ncbi request reprint A family of diverse Cul4-Ddb1-interacting proteins includes Cdt2, which is required for S phase destruction of the replication factor Cdt1
    Jianping Jin
    Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell 23:709-21. 2006
    ..These studies uncover diverse substrate receptors for Cul4 and identify Cdt2 as a conserved component of the Cul4-Ddb1 E3 that is essential to destroy Cdt1 and ensure proper cell cycle regulation of DNA replication...
  51. pmc Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells
    Robert S Ohgami
    Department of Pathology Children s Hospital and Harvard Medical School, 300 Longwood Avenue, Boston, Massachusetts 02115, USA
    Nat Genet 37:1264-9. 2005
    ..Taken together, these findings indicate that Steap3 is an endosomal ferrireductase required for efficient Tf-dependent iron uptake in erythroid cells...
  52. ncbi request reprint Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system
    Emmanouil Karteris
    Biomedical Research Institute, Department of Biological Sciences, University of Warwick, Coventry, United Kingdom CV4 7AL
    J Clin Endocrinol Metab 89:1957-62. 2004
    ....
  53. ncbi request reprint Nucleocapsid protein of SARS coronavirus tightly binds to human cyclophilin A
    Cheng Luo
    Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Biochem Biophys Res Commun 321:557-65. 2004
    ..Such presently observed SARS_NP-hCypA interaction model might provide a new hint for facilitating the understanding of another possible SARS-CoV infection pathway against human cell...
  54. ncbi request reprint A yeast two-hybrid technology-based system for the discovery of PPARgamma agonist and antagonist
    Qing Chen
    Drug Discovery Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    Anal Biochem 335:253-9. 2004
    ....
  55. ncbi request reprint Enzymatic activity characterization of SARS coronavirus 3C-like protease by fluorescence resonance energy transfer technique
    Shuai Chen
    Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 201203, China
    Acta Pharmacol Sin 26:99-106. 2005
    ..To characterize enzymatic activity of severe acute respiratory syndrome (SARS) coronavirus (CoV) 3C-like protease (3CL(pro)) and its four site-directed mutants...
  56. ncbi request reprint Association of an aminoacyl-tRNA synthetase with a putative metabolic protein in archaea
    Richard S A Lipman
    Department of Biochemistry and Molecular Pharmacology, Thomas Jefferson University, 233 South 10th Street, BLSB 220, Philadelphia, Pennsylvania 19107, USA
    Biochemistry 42:7487-96. 2003
    ..The association of Mj1338 with ProRS, and with other components of the protein synthesis machinery, thus suggests the possibility of a closer link between metabolism and decoding in archaea than in eukarya or bacteria...
  57. pmc Transcriptional and post-transcriptional mechanisms for lysophosphatidic acid-induced cyclooxygenase-2 expression in ovarian cancer cells
    Regina A Oyesanya
    Virginia Commonwealth University, Department of Biochemistry and Molecular Biology, 1101 East Marshall St, Richmond, VA 23298, USA
    FASEB J 22:2639-51. 2008
    ..In addition to the transcriptional activation, the RNA stabilization protein HuR bound to and protected Cox-2 mRNA in LPA-stimulated cells, indicating an active role for HuR in sustaining Cox-2 induction during physiological responses...
  58. pmc The MLL fusion gene, MLL-AF4, regulates cyclin-dependent kinase inhibitor CDKN1B (p27kip1) expression
    Zhen Biao Xia
    Department of Medicine, Molecular Biology Program, and Oncology Institute, Cardinal Bernardin Cancer Center, Loyola University Medical Center, Maywood, IL 60153, USA
    Proc Natl Acad Sci U S A 102:14028-33. 2005
    ..This finding may have implications in terms of leukemia stem cell resistance to chemotherapy in MLL-AF4 leukemias...
  59. doi request reprint Selective expression of progesterone receptor in malignant melanoma was inversely correlated with PCNA
    Jiawen Li
    Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 28:216-8. 2008
    ..Selective expression of progesterone receptor in malignant melanoma might be correlated with inhibited tumor growth...
  60. pmc The catalytic intermediate stabilized by a "down" active site loop for diaminopimelate decarboxylase from Helicobacter pylori. Enzymatic characterization with crystal structure analysis
    Tiancen Hu
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China
    J Biol Chem 283:21284-93. 2008
    ..Our work is expected to provide clues for designing specific inhibitors of DAPDC...
  61. doi request reprint Construction and characterization of the HMGB1 mutant as a competitive antagonist to HMGB1 induced cytokines release
    Zhiqiang Yuan
    Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combined Injury, Third Military Medical University, 30 Gaotanyan Street, Chongqing 400038, China
    Biochem Biophys Res Commun 372:703-7. 2008
    ..This may be of significant importance in providing a new anti-inflammatory strategy for the treatment of severe sepsis and other inflammatory disorders...
  62. ncbi request reprint [Prognostic factors for childhood acute non-mature B-lymphoblastic leukemia]
    Hua Jiang
    Department of Hematology Oncology, Shanghai Children s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China
    Zhongguo Dang Dai Er Ke Za Zhi 10:290-4. 2008
    ..To study the prognostic factors for events-free survival (EFS) in children with acute non-mature B-lymphoblastic leukemia...
  63. ncbi request reprint Hyrtiosal, from the marine sponge Hyrtios erectus, inhibits HIV-1 integrase binding to viral DNA by a new inhibitor binding site
    Li Du
    Drug Discovery and Design Center, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201203, China
    ChemMedChem 3:173-80. 2008
    ....
  64. pmc Loss of MLL PHD finger 3 is necessary for MLL-ENL-induced hematopoietic stem cell immortalization
    Jing Chen
    Department of Microbiology and Immunology, Stritch School of Medicine, Loyola University of Chicago Medical Center, University of Chicago, Chicago, Illinois, USA
    Cancer Res 68:6199-207. 2008
    ..This leads to constitutive overexpression of MLL target genes that block stem cell commitment and promote stem cell renewal, probably the first step in MLL-related leukemogenesis...
  65. doi request reprint KLF4 is a FOXO target gene that suppresses B cell proliferation
    Isharat Yusuf
    Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA, USA
    Int Immunol 20:671-81. 2008
    ..Collectively, our findings indicate that KLF4 has growth-suppressive properties in B cells but might be redundant with other members of the KLF family in maintaining B cell quiescence...
  66. ncbi request reprint Modeling breast cancer-associated c-Src and EGFR overexpression in human MECs: c-Src and EGFR cooperatively promote aberrant three-dimensional acinar structure and invasive behavior
    Manjari Dimri
    Division of Molecular Oncology, Evanston Northwestern Healthcare Research Institute, Evanston, IL 60201, USA
    Cancer Res 67:4164-72. 2007
    ....
  67. pmc SHP-2 phosphatase is required for hematopoietic cell transformation by Bcr-Abl
    Jing Chen
    Department of Medicine, Case Comprehensive Cancer Center, Case Western Reserve University, 10900 Euclid Ave, Cleveland, OH 44106, USA
    Blood 109:778-85. 2007
    ..These studies identified a novel function of SHP-2 and suggest that SHP-2 might be a useful target for controlling Bcr-Abl-positive leukemias...
  68. ncbi request reprint [Asparagine synthetase activity in pediatric acute lymphoblastic leukemia]
    Hua Jiang
    Department of Hematology Oncology, Shanghai Children s Medical Center Affiliated to Medical College of Shanghai Jiaotong University, Shanghai 200127, China
    Zhongguo Dang Dai Er Ke Za Zhi 8:272-4. 2006
    ..To study the cellular activity of asparagine synthetase in different types of childhood acute lymphoblastic leukemia (ALL)...
  69. ncbi request reprint Mobilization of hematopoietic stem cells during homeostasis and after cytokine exposure
    Janis L Abkowitz
    Department of Medicine, Division of Hematology, University of Washington, Box 357710, Seattle, WA 98195 7710, USA
    Blood 102:1249-53. 2003
    ....

Research Grants6

  1. Signaling and targeting of FGFR1 fusions in 8p11 myeloproliferative syndrome
    Jing Chen; Fiscal Year: 2010
    ..In summary, this proposal will provide detailed information about signaling and transforming properties of FGFR1 fusions, and explore therapeutic strategies to treat FGFR1-associated malignancies. ..
  2. Signaling and targeting of FGFR1 fusions in 8p11 myeloproliferative syndrome
    Jing Chen; Fiscal Year: 2007
    ..In summary, this proposal will provide detailed information about signaling and transforming properties of FGFR1 fusions, and explore therapeutic strategies to treat FGFR1-associated malignancies. ..
  3. Signaling and targeting of FGFR1 fusions in 8p11 myeloproliferative syndrome
    Jing Chen; Fiscal Year: 2009
    ..In summary, this proposal will provide detailed information about signaling and transforming properties of FGFR1 fusions, and explore therapeutic strategies to treat FGFR1-associated malignancies. ..
  4. Tyrosine Kinase Signaling in Cancer Cell Metabolism
    Jing Chen; Fiscal Year: 2010
    ..Our overall hypothesis is that oncogenic FGFR1 programs cancer cell metabolism through tyrosine phosphorylation of metabolic enzymes including PKM2, PDHK1 and LDH-A to promote the Warburg effect and tumor growth. ..