Arlene B Chapman

Summary

Affiliation: Emory University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Predictors of blood pressure response to the angiotensin receptor blocker candesartan in essential hypertension
    Vincent J Canzanello
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Am J Hypertens 21:61-6. 2008
  2. pmc Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide
    Julio D Duarte
    Center for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 10:56. 2012
  3. pmc Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease
    Arlene B Chapman
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin J Am Soc Nephrol 7:479-86. 2012
  4. ncbi request reprint Predictors of antihypertensive response to a standard dose of hydrochlorothiazide for essential hypertension
    Arlene B Chapman
    Renal Division, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Kidney Int 61:1047-55. 2002
  5. pmc The HALT polycystic kidney disease trials: design and implementation
    Arlene B Chapman
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin J Am Soc Nephrol 5:102-9. 2010
  6. ncbi request reprint Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort
    Arlene B Chapman
    Department of Medicine Renal Division, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Kidney Int 64:1035-45. 2003
  7. ncbi request reprint Cystic disease in women: clinical characteristics and medical management
    Arlene B Chapman
    Department of Medicine Renal Division, Emory University School of Medicine, Atlanta, GA, USA
    Adv Ren Replace Ther 10:24-30. 2003
  8. pmc Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure response
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Transl Med 10:47. 2012
  9. pmc Plasma renin activity predicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Hypertens 23:1014-22. 2010
  10. ncbi request reprint Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease: the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP)
    W CHARLES O'NEILL
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Am J Kidney Dis 46:1058-64. 2005

Research Grants

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Predictors of blood pressure response to the angiotensin receptor blocker candesartan in essential hypertension
    Vincent J Canzanello
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Am J Hypertens 21:61-6. 2008
    ..Response to antihypertensive drugs varies widely among individuals...
  2. pmc Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide
    Julio D Duarte
    Center for Pharmacogenomics and Department of Pharmacotherapy and Translational Research, University of Florida, Gainesville, FL 32610, USA
    J Transl Med 10:56. 2012
    ..This study aimed to determine the role of variation in these regulatory genes on blood pressure response to HCTZ, and secondarily, untreated blood pressure...
  3. pmc Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease
    Arlene B Chapman
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin J Am Soc Nephrol 7:479-86. 2012
    ..Autosomal dominant polycystic kidney disease (ADPKD) is characterized by increased total kidney volume (TKV) and renal failure. This study aimed to determine if height-adjusted TKV (htTKV) predicts the onset of renal insufficiency...
  4. ncbi request reprint Predictors of antihypertensive response to a standard dose of hydrochlorothiazide for essential hypertension
    Arlene B Chapman
    Renal Division, Department of Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Kidney Int 61:1047-55. 2002
    ....
  5. pmc The HALT polycystic kidney disease trials: design and implementation
    Arlene B Chapman
    Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin J Am Soc Nephrol 5:102-9. 2010
    ..Primary outcomes of studies A and B are MR-based percent change kidney volume and a composite endpoint of time to 50% reduction of baseline estimated eGFR, ESRD, or death, respectively...
  6. ncbi request reprint Renal structure in early autosomal-dominant polycystic kidney disease (ADPKD): The Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease (CRISP) cohort
    Arlene B Chapman
    Department of Medicine Renal Division, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Kidney Int 64:1035-45. 2003
    ....
  7. ncbi request reprint Cystic disease in women: clinical characteristics and medical management
    Arlene B Chapman
    Department of Medicine Renal Division, Emory University School of Medicine, Atlanta, GA, USA
    Adv Ren Replace Ther 10:24-30. 2003
    ..Finally, increasing pregnancy number has minimal or no effect on renal outcome in ADPKD women...
  8. pmc Power to identify a genetic predictor of antihypertensive drug response using different methods to measure blood pressure response
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA
    J Transl Med 10:47. 2012
    ....
  9. pmc Plasma renin activity predicts blood pressure responses to beta-blocker and thiazide diuretic as monotherapy and add-on therapy for hypertension
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota, USA
    Am J Hypertens 23:1014-22. 2010
    ..Whether these or other characteristics predict blood pressure responses when the drugs are administered as add-on therapy is uncertain...
  10. ncbi request reprint Sonographic assessment of the severity and progression of autosomal dominant polycystic kidney disease: the Consortium of Renal Imaging Studies in Polycystic Kidney Disease (CRISP)
    W CHARLES O'NEILL
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Am J Kidney Dis 46:1058-64. 2005
    ..The accuracy and precision of ultrasonography (US) in assessing the severity of autosomal dominant polycystic kidney disease (ADPKD) is unknown...
  11. pmc Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, College of Medicine, Rochester, MN 55905, USA
    Hypertension 59:1204-11. 2012
    ....
  12. ncbi request reprint Magnetic resonance measurements of renal blood flow as a marker of disease severity in autosomal-dominant polycystic kidney disease
    Bernard F King
    Department of Medicine Renal Division, University of Alabama, Birmingham, Alabama, USA
    Kidney Int 64:2214-21. 2003
    ..Despite evidence for the importance of nephroangiosclerosis in the progression of renal insufficiency in ADPKD, evaluation of renal blood flow (RBF) as a surrogate marker of disease severity has received little attention...
  13. ncbi request reprint Comparison of methods for determining renal function decline in early autosomal dominant polycystic kidney disease: the consortium of radiologic imaging studies of polycystic kidney disease cohort
    Andrew D Rule
    Division of Nephrology, Mayo Foundation, 200 First Street SW, Rochester, MN 55905, and University of Alabama, Birmingham, USA
    J Am Soc Nephrol 17:854-62. 2006
    ..Misclassification from changes in non-GFR factors (e.g., creatinine production, tubular secretion) conservatively biased associations with eGFR. Misclassification from method imprecision attenuated associations with creatinine clearance...
  14. pmc Quality of life in autosomal dominant polycystic kidney disease patients not yet on dialysis
    Dana Rizk
    Departments of Medicine and Radiology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin J Am Soc Nephrol 4:560-6. 2009
    ..This study determined the impact of pain medication use and other clinical, biochemical and genetic characteristics on the physical and mental well being of predialysis ADPKD patients using the Short Form 36 (SF-36) questionnaire...
  15. pmc Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, MN 55905
    Hypertension 62:391-7. 2013
    ....
  16. pmc Renal arterial blood flow measurement by breath-held MRI: Accuracy in phantom scans and reproducibility in healthy subjects
    Samuel Dambreville
    Georgia Institute of Technology, Atlanta, Georgia, USA
    Magn Reson Med 63:940-50. 2010
    ..8 mL/min (4.21%) for immediate repetition of the breath-held flow scan, 39.13 mL/min (6.90%) for repeated plane scouting, and 40.76 mL/min (7.20%) for weekly fluctuations in renal blood flow...
  17. pmc Renal CD14 expression correlates with the progression of cystic kidney disease
    Juling Zhou
    Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Kidney Int 78:550-60. 2010
    ..But the association was significant when the analysis was confined to males. Clearly more studies need to be done to evaluate the utility of CD14 as a marker for outcomes in ADPKD...
  18. doi request reprint Approaches to testing new treatments in autosomal dominant polycystic kidney disease: insights from the CRISP and HALT-PKD studies
    Arlene B Chapman
    Emory University School of Medicine, 1364 Clifton Road, Room GG23, Atlanta, GA 30322, USA
    Clin J Am Soc Nephrol 3:1197-204. 2008
    ..Findings from CRISP and the rationale for interventions in ADPKD are described, and the design of the HALT-PKD clinical trial is outlined...
  19. pmc Comparison of office, ambulatory, and home blood pressure antihypertensive response to atenolol and hydrochlorthiazide
    Amber L Beitelshees
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA
    J Clin Hypertens (Greenwich) 12:14-21. 2010
    ..58) than with OBP response (r=0.47; P=.04). In the context of a randomized clinical trial, the authors have identified significant differences in HBP, OBP, and ABP methods of measuring BP response to atenolol and HCTZ monotherapy...
  20. pmc Hypertension in autosomal dominant polycystic kidney disease
    Arlene B Chapman
    Emory University School of Medicine, Atlanta, GA, USA
    Adv Chronic Kidney Dis 17:153-63. 2010
    ..Currently, large multicenter studies are being performed to determine the beneficial effects of RAAS inhibition both early and late in ADPKD...
  21. ncbi request reprint Cystic and inherited kidney diseases
    Dana Rizk
    Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Kidney Dis 42:1305-17. 2003
  22. ncbi request reprint Autosomal dominant polycystic kidney disease: time for a change?
    Arlene B Chapman
    Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    J Am Soc Nephrol 18:1399-407. 2007
    ....
  23. pmc Improving clinical trial design for inquiries into the mechanisms of cyst growth in ADPKD
    Arlene B Chapman
    Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Kidney Int 75:139-41. 2009
    ..These powerful and exciting tools make it possible to consider both short and long term randomized clinical trials in ADPKD at various stages of disease. Highlights of the work by Kistler and colleagues are now provided...
  24. ncbi request reprint The role of parental hypertension in the frequency and age of diagnosis of hypertension in offspring with autosomal-dominant polycystic kidney disease
    Robert W Schrier
    Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA
    Kidney Int 64:1792-9. 2003
    ..The present study was undertaken to examine the role of parental hypertension in the occurrence of hypertension in 475 ADPKD offspring...
  25. pmc Imaging approaches to patients with polycystic kidney disease
    Arlene B Chapman
    Department of Medicine, Renal Division, Emory University School of Medicine, Atlanta, GA, USA
    Semin Nephrol 31:237-44. 2011
    ..Renal blood flow and a novel approach to interpreting noncystic renal parenchyma by computed tomography images are other innovative imaging approaches described...
  26. pmc Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-enhanced MRI protocols
    Diego R Martin
    Department of Radiology, Emory University, Atlanta, Georgia, USA
    J Magn Reson Imaging 31:440-6. 2010
    ....
  27. pmc Characterization of large rearrangements in autosomal dominant polycystic kidney disease and the PKD1/TSC2 contiguous gene syndrome
    Mark B Consugar
    Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Kidney Int 74:1468-79. 2008
    ..Our assay improves detection levels and the reliability of molecular testing of patients with ADPKD...
  28. ncbi request reprint Recurrence of intracranial aneurysms in autosomal-dominant polycystic kidney disease
    Mark M Belz
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Kidney Int 63:1824-30. 2003
    ..The natural history of intracranial aneurysms (ICAs) in individuals with autosomal-dominant polycystic kidney disease (ADPKD) is poorly defined...
  29. ncbi request reprint Reproducibility of blood pressure response to hydrochlorothiazide
    Javier D Finkielman
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA
    J Clin Hypertens (Greenwich) 4:408-12. 2002
    ..These results show that the average systolic and diastolic blood pressure responses to hydrochlorothiazide for a group of subjects are reproducible; however, the responses for individual subjects are unpredictable...
  30. ncbi request reprint Effects of endothelial nitric oxide synthase, alpha-adducin, and other candidate gene polymorphisms on blood pressure response to hydrochlorothiazide
    Stephen T Turner
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Am J Hypertens 16:834-9. 2003
    ....
  31. ncbi request reprint Lack of agreement between office and ambulatory blood pressure responses to hydrochlorothiazide
    Javier Daniel Finkielman
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA
    Am J Hypertens 18:398-402. 2005
    ..We studied whether the OBP and 24-h ABPM responses to hydrochlorothiazide differ and, if so, the relevance of these differences...
  32. ncbi request reprint A multilocus approach to the antihypertensive pharmacogenetics of hydrochlorothiazide
    Anke Hilse Maitland-van der Zee
    Human Genetics Center, University of Texas Health Science Center, Houston, TX 77030, USA
    Pharmacogenet Genomics 15:287-93. 2005
    ..To assess the influence of variations in multiple candidate genes on inter-individual variation in diastolic blood pressure (DBP) response to hydrochlorothiazide...
  33. ncbi request reprint Demographic, environmental, and genetic predictors of metabolic side effects of hydrochlorothiazide treatment in hypertensive subjects
    Anke Hilse Maitland-van der Zee
    Human Genetics Center, University of Texas Health Science Centre, Houston, TX 77030, USA
    Am J Hypertens 18:1077-83. 2005
    ..The aim of this study was to characterize interindividual variation in glucose and lipid responses to hydrochlorothiazide and to identify demographic, environmental, and genetic predictors associated with this variation...
  34. ncbi request reprint WNK1 kinase polymorphism and blood pressure response to a thiazide diuretic
    Stephen T Turner
    Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, MN, USA
    Hypertension 46:758-65. 2005
    ..Polymorphisms in genes regulating renal sodium transport, in particular WNK1, predict interindividual differences in antihypertensive responses to hydrochlorothiazide...
  35. ncbi request reprint Magnetic resonance measurements of renal blood flow and disease progression in autosomal dominant polycystic kidney disease
    Vicente E Torres
    Mayo Clinic College of Medicine, Rochester, MN 55901, USA
    Clin J Am Soc Nephrol 2:112-20. 2007
    ..TKV and RBF were independent predictors of GFR decline (functional disease progression). In ADPKD, RBF reduction (1) parallels TKV increase, (2) precedes GFR decline, and (3) predicts structural and functional disease progression...
  36. ncbi request reprint Volume progression in polycystic kidney disease
    Jared J Grantham
    Kidney Institute and the Department of Internal Medicine, Kansas University Medical Center, Kansas City, KS 66160, USA
    N Engl J Med 354:2122-30. 2006
    ..Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of cyst-filled kidneys...
  37. ncbi request reprint Cyst number but not the rate of cystic growth is associated with the mutated gene in autosomal dominant polycystic kidney disease
    Peter C Harris
    Division of Nephrology and Hypertension, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Am Soc Nephrol 17:3013-9. 2006
    ..These insights will inform the development of targeted therapies in autosomal dominant PKD...
  38. ncbi request reprint Comprehensive molecular diagnostics in autosomal dominant polycystic kidney disease
    Sandro Rossetti
    Division of Nephrology, Mayo Clinic, Rochester, MN 55905, USA
    J Am Soc Nephrol 18:2143-60. 2007
    ..Although nondefinite mutation data must be treated with care in the clinical setting, this study shows the potential for molecular diagnostics in ADPKD that is likely to become increasingly important as therapies become available...
  39. ncbi request reprint Magnetic resonance imaging evaluation of hepatic cysts in early autosomal-dominant polycystic kidney disease: the Consortium for Radiologic Imaging Studies of Polycystic Kidney Disease cohort
    Kyongtae T Bae
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin J Am Soc Nephrol 1:64-9. 2006
    ..Hepatic cysts are more prevalent and larger in total cyst volume in women than in men. Hepatic cyst prevalence and aggregate total hepatic cyst volume increased with age...
  40. ncbi request reprint Volume progression in autosomal dominant polycystic kidney disease: the major factor determining clinical outcomes
    Jared J Grantham
    Kansas University Medical Center, Kansas City, Kansas, USA
    Clin J Am Soc Nephrol 1:148-57. 2006
    ....
  41. ncbi request reprint Screening for primary aldosteronism: implications of an increased plasma aldosterone/renin ratio
    Gary L Schwartz
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA
    Clin Chem 48:1919-23. 2002
    ..We determined the sensitivity, specificity, and predictive value of the ratio to identify combinations of renin and aldosterone compatible with primary aldosteronism...
  42. ncbi request reprint Interacting effects of gender and genotype on blood pressure response to hydrochlorothiazide
    Gary L Schwartz
    Division of Hypertension, Department of Internal Medicine, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Kidney Int 62:1718-23. 2002
    ..The insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene is associated with variation in serum ACE activity and may influence BP in a gender-specific manner...
  43. pmc Genomic association analysis suggests chromosome 12 locus influencing antihypertensive response to thiazide diuretic
    Stephen T Turner
    Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN 55905, USA
    Hypertension 52:359-65. 2008
    ..These results support the use of genome-wide association analyses to identify novel genes influencing antihypertensive drug responses...

Research Grants5

  1. Symposium for Molecular and Therapeutic Insights in PKD
    Arlene Chapman; Fiscal Year: 2002
    ..Day 5 will be devoted to autosomal recessive kidney diseases and the last half day will be devoted to potential therapeutic strategies in cystic disorders of the kidney. ..
  2. "The Early Collaborative Clinical Studies in PKD: The C*
    Arlene Chapman; Fiscal Year: 2007
    ....
  3. Polycystic Kidney Disease Clinical Trials Network
    Arlene Chapman; Fiscal Year: 2006
    ..Ultimately these studies should demonstrate slowing or halting progression of ADPKD. ..