L Capuron

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Neuropsychopharmacology 26:643-52. 2002
  2. ncbi request reprint Timing and specificity of the cognitive changes induced by interleukin-2 and interferon-alpha treatments in cancer patients
    L Capuron
    INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, Bordeaux, France
    Psychosom Med 63:376-86. 2001
  3. ncbi request reprint Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy
    L Capuron
    INSERM U 394, Neurobiologie Integrative, Institut Francois Magendie, 33077, Bordeaux Cedex, France
    Psychoneuroendocrinology 26:797-808. 2001
  4. ncbi request reprint Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy
    L Capuron
    INSERM INRA, Integrative Neurobiology, Institut Francois Magendie, 33077 Bordeaux, France
    Mol Psychiatry 7:468-73. 2002
  5. ncbi request reprint Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 18:205-13. 2004
  6. ncbi request reprint [Neuro-immune interactions in psychopathology with the example of interferon-alpha-induced depression]
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30033, USA
    J Soc Biol 197:151-6. 2003
  7. ncbi request reprint Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy
    L Capuron
    Institut National de la Santé et de la Recherche Médicale U 394, Neurobiologie Integrative, Institut Francois Magendie, and Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France
    J Clin Oncol 18:2143-51. 2000
  8. pmc Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:41-8. 2005
  9. pmc Neuropsychiatric adverse effects of interferon-alpha: recognition and management
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    CNS Drugs 19:105-23. 2005
  10. pmc Anterior cingulate activation and error processing during interferon-alpha treatment
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1001 Woodruff Circle, Atlanta, GA 30322, USA
    Biol Psychiatry 58:190-6. 2005

Detail Information

Publications24

  1. ncbi request reprint Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Neuropsychopharmacology 26:643-52. 2002
    ..quot;..
  2. ncbi request reprint Timing and specificity of the cognitive changes induced by interleukin-2 and interferon-alpha treatments in cancer patients
    L Capuron
    INSERM U394, Neurobiologie Integrative, Institut Francois Magendie, Bordeaux, France
    Psychosom Med 63:376-86. 2001
    ....
  3. ncbi request reprint Association between immune activation and early depressive symptoms in cancer patients treated with interleukin-2-based therapy
    L Capuron
    INSERM U 394, Neurobiologie Integrative, Institut Francois Magendie, 33077, Bordeaux Cedex, France
    Psychoneuroendocrinology 26:797-808. 2001
    ..These results support the hypothesis of close relationship between depressive symptoms and the activation of the cytokine network...
  4. ncbi request reprint Association between decreased serum tryptophan concentrations and depressive symptoms in cancer patients undergoing cytokine therapy
    L Capuron
    INSERM INRA, Integrative Neurobiology, Institut Francois Magendie, 33077 Bordeaux, France
    Mol Psychiatry 7:468-73. 2002
    ..These findings indicate that the development of depressive symptoms in patients undergoing cytokine therapy could be mediated by a reduced availability of the serotonin relevant amino acid precursor, tryptophan...
  5. ncbi request reprint Baseline mood and psychosocial characteristics of patients developing depressive symptoms during interleukin-2 and/or interferon-alpha cancer therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Behav Immun 18:205-13. 2004
    ....
  6. ncbi request reprint [Neuro-immune interactions in psychopathology with the example of interferon-alpha-induced depression]
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30033, USA
    J Soc Biol 197:151-6. 2003
    ..In addition, some behavioral and biological markers of the vulnerability for IFN-alpha-induced depression were identified. These findings provide important information concerning the relationship between cytokines and depression...
  7. ncbi request reprint Early depressive symptoms in cancer patients receiving interleukin 2 and/or interferon alfa-2b therapy
    L Capuron
    Institut National de la Santé et de la Recherche Médicale U 394, Neurobiologie Integrative, Institut Francois Magendie, and Institut Bergonié, Comprehensive Cancer Center, Bordeaux, France
    J Clin Oncol 18:2143-51. 2000
    ..The objective of the present study was to evaluate the depressive and anxiety symptoms induced by IL-2 and/or INFalpha-2b in cancer patients during the first days of cytokine immunotherapy...
  8. pmc Depression during pegylated interferon-alpha plus ribavirin therapy: prevalence and prediction
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Clin Psychiatry 66:41-8. 2005
    ..Newer, pegylated preparations of IFN-alpha have a longer half-life, require once-per-week dosing, and may be associated with reduced neuropsychiatric burden. Limited data exist on depression during pegylated IFN-alpha therapy...
  9. pmc Neuropsychiatric adverse effects of interferon-alpha: recognition and management
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    CNS Drugs 19:105-23. 2005
    ..When this occurs, IFN alpha and antidepressants should be stopped, an emergency psychiatric consultation should be obtained, and treatment with a mood stabilizer should be initiated...
  10. pmc Anterior cingulate activation and error processing during interferon-alpha treatment
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1001 Woodruff Circle, Atlanta, GA 30322, USA
    Biol Psychiatry 58:190-6. 2005
    ..Interferon (IFN)-alpha is notorious for causing behavioral symptoms, including depression, fatigue, and cognitive dysfunction, and has been used to investigate the effects of cytokines on the brain...
  11. pmc Cytokines sing the blues: inflammation and the pathogenesis of depression
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 101 Woodruff Circle, Suite 4000, Atlanta, GA 30322, USA
    Trends Immunol 27:24-31. 2006
    ..These findings suggest that targeting proinflammatory cytokines and their signaling pathways might represent a novel strategy to treat depression...
  12. pmc IFN-alpha-induced motor slowing is associated with increased depression and fatigue in patients with chronic hepatitis C
    Matthias Majer
    Department of Psychiatry and Behavioural Sciences, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Road, Atlanta, GA 30322, USA
    Brain Behav Immun 22:870-80. 2008
    ..Motor slowing and its correlation with psychiatric symptoms suggest that altered basal ganglia function may contribute to the pathogenesis of IFN-alpha-induced behavioural changes...
  13. pmc Neuroendocrine-immune mechanisms of behavioral comorbidities in patients with cancer
    Andrew H Miller
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Winship Cancer Institute, 1365 C Clifton Rd, 5th Floor, Atlanta, GA 30322, USA
    J Clin Oncol 26:971-82. 2008
    ....
  14. ncbi request reprint Depressive symptoms and viral clearance in patients receiving interferon-alpha and ribavirin for hepatitis C
    Charles L Raison
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Brain Behav Immun 19:23-7. 2005
    ....
  15. ncbi request reprint Cytokines and psychopathology: lessons from interferon-alpha
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Biol Psychiatry 56:819-24. 2004
    ....
  16. ncbi request reprint Treatment of cytokine-induced depression
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Suite 4000, Atlanta, GA 30322, USA
    Brain Behav Immun 16:575-80. 2002
    ....
  17. doi request reprint Dietary patterns derived by hybrid clustering method in older people: association with cognition, mood, and self-rated health
    Cecilia Samieri
    INSERM, U897, University Victor Segalen Bordeaux 2, Case 11, 146 rue Leo Saignat, F 33076 Bordeaux cedex, France
    J Am Diet Assoc 108:1461-71. 2008
    ..Dietary patterns that represent a combination of foods may better predict disease risk than single foods or nutrients...
  18. ncbi request reprint Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences and the Winship Cancer Institute, Department of Hematology and Oncology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Psychiatry 160:1342-5. 2003
    ..The authors assessed the relationship between the hypothalamic-pituitary-adrenal (HPA) axis response to interferon-alpha (IFN-alpha) and the development of major depression during IFN-alpha treatment...
  19. ncbi request reprint Interferon-alpha-induced changes in tryptophan metabolism. relationship to depression and paroxetine treatment
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Biol Psychiatry 54:906-14. 2003
    ..Tryptophan (TRP) degradation into kynurenine (KYN) by the enzyme, indoleamine-2,3-dioxygenase, during immune activation may contribute to development of depressive symptoms during interferon (IFN)-alpha therapy...
  20. ncbi request reprint Plasma homocysteine and immune activation in patients with malignant melanoma undergoing treatment with IFN-alpha
    Barbara Frick
    Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A 6020 Innsbruck, Austria
    J Interferon Cytokine Res 24:311-7. 2004
    ..These results indicate that IFN-alpha directly activates macrophages to release neopterin and to degrade tryptophan, but obviously treatment with INF-alpha did not affect homocysteine metabolism...
  21. ncbi request reprint Cytokines and depression: the need for a new paradigm
    Lucile Capuron
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA 30322, USA
    Brain Behav Immun 17:S119-24. 2003
    ..This paper discusses ways in which these emerging data may lead to advances in the recognition and management of non-specific neurobehavioral symptoms associated with the development and progression of cancer...
  22. ncbi request reprint Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropsychopharmacology 32:2384-92. 2007
    ..These data indicate that IFN-alpha as well as other cytokines of the innate immune response may target basal ganglia nuclei, thereby contributing to fatigue-related symptoms in medically ill patients...
  23. pmc Identification and treatment of symptoms associated with inflammation in medically ill patients
    Robert Dantzer
    Integrative Immunology and Behavior Program, 212 ERML, 1201 W Gregory Drive, University of Illinois at Urbana Champaign, Urbana, IL 61801, USA
    Psychoneuroendocrinology 33:18-29. 2008
    ..This resulted in a number of recommendations that should improve the recognition and management of inflammation-associated symptoms in medically ill patients...
  24. ncbi request reprint Cognitive dysfunction relates to subjective report of mental fatigue in patients with chronic fatigue syndrome
    Lucile Capuron
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Neuropsychopharmacology 31:1777-84. 2006
    ....