LOU ANN SCISM BROWN

Summary

Affiliation: Emory University
Country: USA

Publications

  1. doi request reprint Glutathione attenuates ethanol-induced alveolar macrophage oxidative stress and dysfunction by downregulating NADPH oxidases
    Samantha M Yeligar
    Dept of Pediatrics, Division of Neonatal Perinatal Medicine, Emory Univ, 2015 Uppergate Dr, Atlanta, GA 30322
    Am J Physiol Lung Cell Mol Physiol 306:L429-41. 2014
  2. pmc Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation
    Lou Ann S Brown
    Department of Pediatrics, Division of Neonatology, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Alcohol 41:317-24. 2007
  3. ncbi request reprint Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat
    Lou Ann S Brown
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 292:L824-32. 2007
  4. ncbi request reprint Acute and chronic alcohol abuse modulate immunity
    Lou Ann S Brown
    Department of Pediatrics, Emory University, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 30:1624-31. 2006
  5. ncbi request reprint Chronic ethanol ingestion potentiates TNF-alpha-mediated oxidative stress and apoptosis in rat type II cells
    L A Brown
    Department of Pediatrics, Emory University School of Medicine and Atlanta Veterans Affairs Medical Center, Atlanta, Georgia 30322, USA
    Am J Physiol Lung Cell Mol Physiol 281:L377-86. 2001
  6. ncbi request reprint Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability?
    Lou Ann S Brown
    Department of Pediatrics, Emory University, 2015 Uppergate Drive, NE, Atlanta, GA 30322, USA
    Alcohol 33:191-7. 2004
  7. ncbi request reprint Effect of chronic ethanol ingestion on alveolar type II cell: glutathione and inflammatory mediator-induced apoptosis
    L A Brown
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Alcohol Clin Exp Res 25:1078-85. 2001
  8. ncbi request reprint Granulocyte/macrophage colony-stimulating factor treatment improves alveolar epithelial barrier function in alcoholic rat lung
    Andres Pelaez
    Atlanta Veterans Affairs Medical Center Pulmonary Section, Decatur, and Division of Critical Care Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Am J Physiol Lung Cell Mol Physiol 286:L106-11. 2004
  9. ncbi request reprint Effects of chronic hepatic dysfunction on pulmonary glutathione homeostasis
    Marilyn G Foreman
    Department of Medicine, Division of Pulmonary and Critical Care, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Alcohol Clin Exp Res 26:1840-5. 2002
  10. ncbi request reprint Glutathione replacement preserves the functional surfactant phospholipid pool size and decreases sepsis-mediated lung dysfunction in ethanol-fed rats
    Alvaro Velasquez
    Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA
    Alcohol Clin Exp Res 26:1245-51. 2002

Collaborators

Detail Information

Publications28

  1. doi request reprint Glutathione attenuates ethanol-induced alveolar macrophage oxidative stress and dysfunction by downregulating NADPH oxidases
    Samantha M Yeligar
    Dept of Pediatrics, Division of Neonatal Perinatal Medicine, Emory Univ, 2015 Uppergate Dr, Atlanta, GA 30322
    Am J Physiol Lung Cell Mol Physiol 306:L429-41. 2014
    ..These studies provide GSH as a novel therapeutic approach for attenuating alcohol-induced derangements in AM Nox expression, oxidative stress, dysfunction, and risk for pneumonia. ..
  2. pmc Alveolar type II cells from ethanol-fed rats produce a fibronectin-enriched extracellular matrix that promotes monocyte activation
    Lou Ann S Brown
    Department of Pediatrics, Division of Neonatology, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Alcohol 41:317-24. 2007
    ..The newly deposited fibronectin-enriched matrices may stimulate the expression of pro-inflammatory cytokines in monocytic cells recruited to the lung after injury thereby explaining the priming effects of ethanol...
  3. ncbi request reprint Glutathione availability modulates alveolar macrophage function in the chronic ethanol-fed rat
    Lou Ann S Brown
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Physiol Lung Cell Mol Physiol 292:L824-32. 2007
    ..These results suggested that decreased glutathione availability in the alcoholic lung contribute to alveolar macrophage dysfunction via oxidative stress, resulting in not only decreased function but decreased viability...
  4. ncbi request reprint Acute and chronic alcohol abuse modulate immunity
    Lou Ann S Brown
    Department of Pediatrics, Emory University, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 30:1624-31. 2006
    ..Nagy, and (8) Hepatitis C Virus Infection and Alcohol Use by Gyongyi Szabo. Meeting coorganizers were Elizabeth J. Kovacs, Lou Ann S. Brown, Thomas R. Jerrells, and Robert T. Cook...
  5. ncbi request reprint Chronic ethanol ingestion potentiates TNF-alpha-mediated oxidative stress and apoptosis in rat type II cells
    L A Brown
    Department of Pediatrics, Emory University School of Medicine and Atlanta Veterans Affairs Medical Center, Atlanta, Georgia 30322, USA
    Am J Physiol Lung Cell Mol Physiol 281:L377-86. 2001
    ..This may be particularly relevant in ARDS when type II cell viability is critical to repair of the damaged alveolar epithelium and may have important ramifications for the treatment of ARDS patients with a history of alcohol abuse...
  6. ncbi request reprint Chronic ethanol ingestion and the risk of acute lung injury: a role for glutathione availability?
    Lou Ann S Brown
    Department of Pediatrics, Emory University, 2015 Uppergate Drive, NE, Atlanta, GA 30322, USA
    Alcohol 33:191-7. 2004
    ..Because chronic oxidative stress alters cellular functions and viability, the lung becomes more susceptible when a second hit such as sepsis occurs...
  7. ncbi request reprint Effect of chronic ethanol ingestion on alveolar type II cell: glutathione and inflammatory mediator-induced apoptosis
    L A Brown
    Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Alcohol Clin Exp Res 25:1078-85. 2001
    ..We hypothesized that this GSH depletion by ethanol, particularly mitochondrial GSH, predisposed type II cells to inflammatory mediator-induced apoptosis...
  8. ncbi request reprint Granulocyte/macrophage colony-stimulating factor treatment improves alveolar epithelial barrier function in alcoholic rat lung
    Andres Pelaez
    Atlanta Veterans Affairs Medical Center Pulmonary Section, Decatur, and Division of Critical Care Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Am J Physiol Lung Cell Mol Physiol 286:L106-11. 2004
    ....
  9. ncbi request reprint Effects of chronic hepatic dysfunction on pulmonary glutathione homeostasis
    Marilyn G Foreman
    Department of Medicine, Division of Pulmonary and Critical Care, Morehouse School of Medicine, Atlanta, Georgia 30310, USA
    Alcohol Clin Exp Res 26:1840-5. 2002
    ..During periods of oxidant stress, individuals may exhibit relative deficiencies of GSH. With cirrhosis, the end result of chronic alcohol ingestion, this deficiency is more profound...
  10. ncbi request reprint Glutathione replacement preserves the functional surfactant phospholipid pool size and decreases sepsis-mediated lung dysfunction in ethanol-fed rats
    Alvaro Velasquez
    Atlanta Veterans Affairs Medical Center, 1670 Clairmont Road, Decatur, GA 30033, USA
    Alcohol Clin Exp Res 26:1245-51. 2002
    ..Therefore, we hypothesized that ethanol ingestion, via glutathione depletion, could alter surfactant phospholipid distribution between LA and SA forms and thereby exacerbate sepsis-mediated lung dysfunction in vivo...
  11. ncbi request reprint In vivo dysfunction of the term alveolar macrophage after in utero ethanol exposure
    Xiao Du Ping
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Emory University, Atlanta, Georgia 30322, USA
    Alcohol Clin Exp Res 31:308-16. 2007
    ..We hypothesized that dysfunction of the neonatal alveolar macrophage exposed to ETOH in utero would persist at term gestation...
  12. pmc Chronic alcoholism alters systemic and pulmonary glutathione redox status
    Mary Y Yeh
    Division of Neonatology, Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Respir Crit Care Med 176:270-6. 2007
    ..In clinical studies, this association has been centered on depletion of pulmonary glutathione and subsequent chronic oxidant stress...
  13. pmc Oxidant-induced atrogin-1 and transforming growth factor-beta1 precede alcohol-related myopathy in rats
    Jeffrey S Otis
    Pulmonary, Allergy and Critical Care Medicine, Atlanta VA Medical Center, Emory University School of Medicine, Decatur, Georgia 30033, USA
    Muscle Nerve 36:842-8. 2007
    ..Therefore, targeted anti-oxidant treatments such as procysteine supplementation may benefit individuals with chronic alcohol abuse, particularly if given prior to the development of clinically significant myopathy...
  14. pmc Non-invasive evaluation of pulmonary glutathione in the exhaled breath condensate of otherwise healthy alcoholics
    Mary Y Yeh
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    Respir Med 102:248-55. 2008
    ..Non-invasive sampling in the exhaled breath condensate (EBC) to monitor alveolar GSH would facilitate research in pulmonary oxidative stress...
  15. pmc Lung lining fluid glutathione attenuates IL-13-induced asthma
    Matthew H Lowry
    The Pulmonary Center, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Am J Respir Cell Mol Biol 38:509-16. 2008
    ..Inhibiting GGT activity in lung lining fluid may represent a novel therapeutic approach for preventing and treating asthma...
  16. pmc Alveolar macrophage phagocytosis is impaired in children with poorly controlled asthma
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 121:1372-8, 1378.e1-3. 2008
    ..Lower respiratory tract infection is a differentiating feature of children with poorly controlled asthma...
  17. pmc Chronic ethanol ingestion increases superoxide production and NADPH oxidase expression in the lung
    John A Polikandriotis
    Department of Medicine, Atlanta VA and Emory University Medical Center, Atlanta VAMC 151 P, 1670 Clairmont Rd, Decatur, GA 30033, USA
    Am J Respir Cell Mol Biol 34:314-9. 2006
    ....
  18. ncbi request reprint Chronic ethanol ingestion in rats decreases granulocyte-macrophage colony-stimulating factor receptor expression and downstream signaling in the alveolar macrophage
    Pratibha C Joshi
    Atlanta Veterans Affairs Medical Center, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 175:6837-45. 2005
    ..1 nuclear binding and that these chronic defects can be reversed relatively quickly with rGM-CSF treatment in vivo...
  19. ncbi request reprint Elevated plasma and lung endothelial selectin levels in patients with acute respiratory distress syndrome and a history of chronic alcohol abuse
    Ellen L Burnham
    Department of Medicine, Division of Pulmonary and Critical Care, Emory University School of Medicine, Atlanta, GA, USA
    Crit Care Med 32:675-9. 2004
    ..Based on the effects of alcohol on endothelial cell and alveolar-capillary barrier function, we hypothesized that chronic alcohol exposure may be associated with increased sE-selectin in ARDS patients...
  20. ncbi request reprint Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung
    Rabih I Bechara
    Section of Pulmonary and Critical Care Medicine, Decatur, GA, USA
    Am J Respir Crit Care Med 170:188-94. 2004
    ..We speculate that this mechanism could contribute to the increased risk of acute respiratory distress syndrome in alcoholic patients...
  21. ncbi request reprint Is maternal alcohol use a risk factor for early-onset sepsis in premature newborns?
    Theresa W Gauthier
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, Emory University School of Medicine, 2015 Uppergate Drive, Atlanta, GA 30322, USA
    Alcohol 33:139-45. 2004
    ..The effects of maternal alcohol abuse during pregnancy on the risk of infection in the VLBW newborn require further analysis...
  22. ncbi request reprint Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability
    Theresa W Gauthier
    Department of Pediatrics, Emory University School of Medicine, 2040 Ridgewood Atlanta, GA 30322, USA
    Pediatr Res 57:76-81. 2005
    ..These results add a new dimension to the detrimental effects of fetal alcohol exposure on the developing alveolar macrophage, raising the possibility of GSH therapy to augment premature alveolar macrophage function...
  23. ncbi request reprint Effects of chronic alcohol abuse on alveolar epithelial barrier function and glutathione homeostasis
    Ellen L Burnham
    Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Alcohol Clin Exp Res 27:1167-72. 2003
    ..We postulated that humans who chronically abuse alcohol will have similar alterations in alveolar-capillary barrier function...
  24. ncbi request reprint Angiotensin II mediates glutathione depletion, transforming growth factor-beta1 expression, and epithelial barrier dysfunction in the alcoholic rat lung
    Rabih I Bechara
    Atlanta Veterans Affairs Medical Center Pulmonary Section, Decatur, GA 30033, USA
    Am J Physiol Lung Cell Mol Physiol 289:L363-70. 2005
    ..Together, these results suggest that angiotensin II mediates oxidative stress and the consequent TGF-beta1 expression and alveolar epithelial barrier dysfunction that characterize the alcoholic lung...
  25. ncbi request reprint Chronic ethanol ingestion increases expression of the angiotensin II type 2 (AT2) receptor and enhances tumor necrosis factor-alpha- and angiotensin II-induced cytotoxicity via AT2 signaling in rat alveolar epithelial cells
    Rabih I Bechara
    Atlanta VAMC, the Pulmonary and Critical Care Medicine Division, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Alcohol Clin Exp Res 27:1006-14. 2003
    ..Although angiotensin II mediates TNF-alpha-induced apoptosis of AECs in vitro, its role in ethanol-mediated susceptibility to AEC apoptosis is unknown...
  26. ncbi request reprint Mechanical ventilation exacerbates alveolar macrophage dysfunction in the lungs of ethanol-fed rats
    Pradip P Kamat
    Atlanta Veterans Administration Medical Center and the Department of Pediatrics, Emory University, Atlanta, Georgia, USA
    Alcohol Clin Exp Res 29:1457-65. 2005
    ....
  27. ncbi request reprint Maternal alcohol abuse and neonatal infection
    Theresa W Gauthier
    Department of Pediatrics, Division of Neonatology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Alcohol Clin Exp Res 29:1035-43. 2005
    ..Since chronic alcohol use suppresses the adult immune system, we tested the hypothesis that maternal alcohol ingestion increases the risk of infection in term newborns...
  28. ncbi request reprint Association of glutathione-S-transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia
    Martha H Manar
    Division of Neonatal Perinatal Medicine, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Perinatol 24:30-5. 2004
    ..We hypothesized that polymorphisms encoding for less efficient enzymes were associated with bronchopulmonary dysphasia (BPD)...

Research Grants15

  1. CHRONIC ETHANOL: MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS
    LOU ANN SCISM BROWN; Fiscal Year: 2010
    ..3) Determine if strategies to relieve ER stress will rescue the alcoholic AT2 cell from its pro-apoptotic phenotype. 4) Determine if relief of ER stress will rescue AT2 cell apoptosis in the alcoholic lung during endotoxemia. ..
  2. CHRONIC ETHANOL: MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS
    Lou Ann Brown; Fiscal Year: 2007
    ..3) Determine if strategies to relieve ER stress will rescue the alcoholic AT2 cell from its pro-apoptotic phenotype. 4) Determine if relief of ER stress will rescue AT2 cell apoptosis in the alcoholic lung during endotoxemia. ..
  3. Noninvasive breath condensate: ARDS risk in alcoholics
    Lou Ann Brown; Fiscal Year: 2006
    ..abstract_text> ..
  4. CHRONIC ETHANOL: MITOCHONDRIAL DYSFUNCTION AND APOPTOSIS
    Lou Ann Brown; Fiscal Year: 2003
    ..Inhibition of ETOH-induced ROS generation should then normalize mitochondrial function and desensitize the ETOH-exposed AT2 cells to cytotoxic agents. ..
  5. ALCOHOLISM:ALTERED ALVEOLAR MATRIX AND ACUTE LUNG INJURY
    Lou Ann Brown; Fiscal Year: 2003
    ....
  6. Polarity of Redox Control and Risk of Injury in the Alveolar Epithelium
    Dean P Jones; Fiscal Year: 2010
    ..The results of these proposed studies will provide an unprecedented knowledge concerning the subcellular compartmentalization of oxidative stress in the lung. ..