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Genomes and GenesSpecies | J Douglas BremnerSummaryAffiliation: Emory University Country: USA Publications
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Publications
Retinoic acid and affective disorders: the evidence for an associationJ Douglas Bremner
Departments of Psychiatry and Radiology, Emory University School of Medicine, Atlanta, GA, USA
J Clin Psychiatry 73:37-50. 2012..This article reviews the evidence for isotretinoin's relationships with depression and suicidality...
Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot studyJ Douglas Bremner
Department of Psychiatry, Radiology and Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
J Psychopharmacol 19:159-65. 2005..However, treatment associated improvements in memory and cognition did not achieve statistical significance. These findings suggest that phenytoin treatment may be associated with changes in brain structure in patients with PTSD...- Neuroanatomical changes associated with pharmacotherapy in posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA 30322, USA
Ann N Y Acad Sci 1032:154-7. 2004..Patients subjectively reported an improvement in cognition and work performance. These studies are consistent with the idea that antidepressants have a beneficial effect on hippocampal function in PTSD patients... - Effects of dexamethasone on declarative memory function in posttraumatic stress disorderJ Douglas Bremner
Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta 30306 GA, USA
Psychiatry Res 129:1-10. 2004.... - Psychometric properties of the Early Trauma Inventory-Self ReportJ Douglas Bremner
Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30306, USA
J Nerv Ment Dis 195:211-8. 2007..These findings suggest that the ETI-SR is a valid measure of early trauma, and suggest future directions for a shortened version of the ETI-SR that could be more easily incorporated into clinical research studies and practice settings... - Treatment of posttraumatic stress disorder with phenytoin: an open-label pilot studyJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
J Clin Psychiatry 65:1559-64. 2004..The purpose of this study was to assess the effects of phenytoin on symptoms of PTSD... - Cortisol, dehydroepiandrosterone, and estradiol measured over 24 hours in women with childhood sexual abuse-related posttraumatic stress disorderDouglas Bremner
Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
J Nerv Ment Dis 195:919-27. 2007..These findings suggest that a resting hypocortisolemia in the afternoon hours with increased cortisol pulsatility is associated with childhood abuse-related PTSD in women... - Cognitive processes in dissociation: comment on Giesbrecht et al. (2008)J Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia 30306, USA
Psychol Bull 136:1-6; discussion 7-11. 2010..The current comment offers a critical review and rebuttal of Giesbrecht et al.'s argument that there is no relationship between trauma and dissociation... - Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depressionJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, and Atlanta VA Medical Center, Decatur, GA, USA
Am J Psychiatry 161:637-45. 2004..The purpose of the present study was to assess hippocampal and prefrontal functioning during performance of a verbal declarative memory task in subjects with midlife major depression... - Functional brain imaging alterations in acne patients treated with isotretinoinJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
Am J Psychiatry 162:983-91. 2005..The purpose of this study was to assess the effects of isotretinoin on brain functioning in acne patients... - Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorderJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
Psychol Med 35:791-806. 2005..No studies have examined neural correlates of fear conditioning and extinction in patients with post-traumatic stress disorder (PTSD)... - Effects of traumatic stress on brain structure and function: relevance to early responses to traumaJ Douglas Bremner
Emory University School of Medicine, Atlanta, GA, USA
J Trauma Dissociation 6:51-68. 2005..Only a few treatment studies have been performed in the early trauma period, and more research in this area is needed... - Functional neuroimaging in post-traumatic stress disorderJ Douglas Bremner
Emory University, Atlanta, GA 30306, USA
Expert Rev Neurother 7:393-405. 2007..Future studies are required to assess the relationship between recovery from traumatic stress and changes in brain function... - The neurobiology of retinoic acid in affective disordersJ Douglas Bremner
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30306, USA
Prog Neuropsychopharmacol Biol Psychiatry 32:315-31. 2008..This report reviews the evidence in this area and describes several systems that may be targets of retinoic acid and which contribute to the pathophysiology of depression... - Neuroimaging in posttraumatic stress disorder and other stress-related disordersJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road, Room 308e, Mailstop 1256 001 AT, Atlanta GA 30306, USA
Neuroimaging Clin N Am 17:523-38, ix. 2007..Abnormalities in these brain areas are hypothesized to underlie symptoms of PTSD and other stress-related psychiatric disorders... - Effects of antidepressant treatment on neural correlates of emotional and neutral declarative verbal memory in depressionJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States
J Affect Disord 101:99-111. 2007..The purpose of this study was to examine the effects of treatment with antidepressants on verbal declarative memory in patients with depression... - Stress and brain atrophyJ Douglas Bremner
Departments of Psychiatry and Radiology, Emory University School of Medicine, Atlanta VAMC, Decatur GA 30306, USA
CNS Neurol Disord Drug Targets 5:503-12. 2006..Treatment with antidepressants and phenytoin reverse hippocampal volume reduction and memory deficits in PTSD patients, suggesting that these agents may promote neurogenesis in humans... - Surfing the net for medical information about psychological trauma: an empirical study of the quality and accuracy of trauma-related websitesJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
Med Inform Internet Med 31:227-36. 2006..These findings suggest that although abundant, websites providing information about psychological trauma are often not useful, and can sometimes provide inaccurate and potentially harmful information to consumers of medical information... - The relationship between cognitive and brain changes in posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, SS No 539 64 8946, Suite 306E, 1256 Briarcliff Rd, Atlanta, GA 30307, USA
Ann N Y Acad Sci 1071:80-6. 2006..These studies suggest that medications may counteract the effects of stress on the brain in patients with PTSD... - Structural and functional plasticity of the human brain in posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
Prog Brain Res 167:171-86. 2008..Antidepressant treatments and changes in environment can reverse the effects of stress on hippocampal neurogenesis, and humans with PTSD showed increased hippocampal volume with both paroxetine and phenytoin... - Brain imaging in anxiety disordersJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University, 1256 Briarcliff Rd, Atlanta, GA 30306, USA
Expert Rev Neurother 4:275-84. 2004..This article reviews animal models for anxiety disorders, current brain imaging findings and outlines future directions for research in this area... - Functional neuroanatomical correlates of traumatic stress revisited 7 years later, this time with dataJ Douglas Bremner
Emory Center for Positron Emission Tomography, Atlanta, Georgia, USA
Psychopharmacol Bull 37:6-25. 2003..This understanding, in turn, will promote the development of future treatment advances for stress-related psychiatric disorders such as posttraumatic stress disorder... - Regional brain metabolic correlates of alpha-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depressionJ Douglas Bremner
Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
JAMA 289:3125-34. 2003.... - MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory Clinical Neuroscience Research Unit, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306, USA
Am J Psychiatry 160:924-32. 2003..The purpose of this study was to measure both hippocampal structure and function in women with and without early childhood sexual abuse and the diagnosis of posttraumatic stress disorder (PTSD)... - Long-term effects of childhood abuse on brain and neurobiologyJ Douglas Bremner
Departments of Psychiatry and Radiology, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306, USA
Child Adolesc Psychiatr Clin N Am 12:271-92. 2003..Long-term alterations in these brain regions are hypothesized to play a role in the maintenance of PTSD, depression, and other psychiatric symptoms after childhood abuse... - Traumatic stress: effects on the brainJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
Dialogues Clin Neurosci 8:445-61. 2006..Treatments that are efficacious for PTSD show a promotion of neurogenesis in animal studies, as well as promotion of memory and increased hippocampal volume in PTSD... - Gender differences in cognitive and neural correlates of remembrance of emotional wordsJ D Bremner
Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
Psychopharmacol Bull 35:55-78. 2001..The findings suggest differences in cognitive appraisal and involvement of a broader network of brain regions mediating emotion during remembrance of emotional words in women compared with men... - Neuroimaging studies in post-traumatic stress disorderJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, 1364 Clifton Road, Atlanta, GA 30322, USA
Curr Psychiatry Rep 4:254-63. 2002..Several studies have now shown changes in structure (smaller volume) of the hippocampus in PTSD. These studies are beginning to map out a neural circuitry of PTSD that may have future implications for diagnosis and treatment... - Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuseJ D Bremner
Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, 1364 Briarcliff Road, Atlanta, GA 30322, USA
Psychoneuroendocrinology 28:733-50. 2003..Although cortisol has been found to be low at baseline, there does not appear to be an impairment in cortisol response to stressors in PTSD... - Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuseJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia 30306, USA
Biol Psychiatry 53:879-89. 2003.... - Common genetic contributions to depressive symptoms and inflammatory markers in middle-aged men: the Twins Heart StudyShaoyong Su
Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1256 Briarcliff Road NE, Suite 1 North, Atlanta, GA 30306, USA
Psychosom Med 71:152-8. 2009..Recent data suggested that MDD and inflammation share common genes... - Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin studyViola Vaccarino
Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30306, USA
Biol Psychiatry 64:476-83. 2008..We sought to examine whether MPO and other markers of inflammation are associated with MDD and whether the association is confounded by genetic or other shared familial factors... - Deficits in verbal declarative memory function in women with childhood sexual abuse-related posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
J Nerv Ment Dis 192:643-9. 2004..These findings suggest that early abuse with PTSD is associated with deficits in verbal declarative memory, and that these effects are not related to the nonspecific effects of childhood abuse... - Common genes contribute to depressive symptoms and heart rate variability: the Twins Heart StudyShaoyong Su
Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30306, USA
Twin Res Hum Genet 13:1-9. 2010..These results suggest that a common neurobiological dysfunction links depression and autonomic dysregulation... - Effects of smoking on coronary microcirculatory function: a twin studyCherie Rooks
Department of Epidemiology, Rollins School of Public Health, Emory University School of Medicine, Atlanta, GA 30322, USA
Atherosclerosis 215:500-6. 2011..Inflammation and oxidative stress may be the mechanisms through which smoking affects the microvasculature... - Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorderEric Vermetten
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
Biol Psychiatry 54:693-702. 2003..6% increase in mean hippocampal volume. CONCLUSIONS: These findings suggest that long-term treatment with paroxetine is associated with improvement of verbal declarative memory deficits and an increase in hippocampal volume in PTSD... - Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
Biol Psychiatry 55:612-20. 2004..CONCLUSIONS: These findings add further evidence for dysfunction of a network of brain regions, including anterior cingulate and visual and parietal cortex, in abuse-related PTSD... - Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorderJ Douglas Bremner
Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, USA
Biol Psychiatry 54:710-8. 2003.... - Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transportersNachwa Jarkas
Center for Positron Emission Tomography, Emory University, Atlanta, GA 30322, USA
Nucl Med Biol 32:211-24. 2005..Arterial plasma metabolites of HOMADAM were analyzed in a rhesus monkey by HPLC and displayed a single peak that corresponded to unmetabolized HOMADAM. CONCLUSION: HOMADAM is an excellent candidate for PET primate imaging of brain SERTs... - Effects of glucocorticoids on declarative memory function in major depressionJ Douglas Bremner
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 126 Briarcliff Road, Atlanta, GA 30306, USA
Biol Psychiatry 55:811-5. 2004.... - Early trauma and inflammation: role of familial factors in a study of twinsCherie Rooks
Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA
Psychosom Med 74:146-52. 2012.... - Major depression and coronary flow reserve detected by positron emission tomographyViola Vaccarino
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30306, USA
Arch Intern Med 169:1668-76. 2009..We sought to examine the relationship between MDD and coronary flow reserve (CFR), the ratio of maximum flow during stress to flow at rest measured in milliliters per minute per gram of tissue... 
Depressive symptoms and heart rate variability: evidence for a shared genetic substrate in a study of twinsViola Vaccarino
Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1256 Briarcliff Road NE, Suite 1 North, Atlanta, GA 30306, USA
Psychosom Med 70:628-36. 2008..Furthermore, little is known about whether depression and HRV share common genetic pathways...- Neuropsychological functioning in patients with posttraumatic stress disorder following short-term paroxetine treatmentNegar Fani
Department of Neuropsychology and Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA
Psychopharmacol Bull 42:53-68. 2009..The purpose of the present study was to replicate prior findings and to extend the previous study by comparing the effects of paroxetine versus placebo on cognition in patients with PTSD... - Increased neural response to trauma scripts in posttraumatic stress disorder following paroxetine treatment: A pilot studyNegar Fani
Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30306, United States
Neurosci Lett 491:196-201. 2011..These pilot data reveal putative mechanisms for SSRI treatment in PTSD and substantiate the need for large-scale placebo-controlled studies investigating these effects... - Serotonin transporter gene, depressive symptoms, and interleukin-6Shaoyong Su
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
Circ Cardiovasc Genet 2:614-20. 2009..We explored the relationship of genetic variants of the serotonin transporter gene SLC6A4, a key regulator of the serotonergic neurotransmission, with both depressive symptoms and plasma interleukin-6 (IL-6) levels... - Circuits and systems in stress. I. Preclinical studiesEric Vermetten
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
Depress Anxiety 15:126-47. 2002..Intensity and duration of the stressor, and timing of the stressor in life, have strong impact in this respect... - Adverse childhood experiences and chronic obstructive pulmonary disease in adultsRobert F Anda
CDC, National Center for Chronic Disease Prevention and Health Promotion, Division of Adult and Community Health, Atlanta, GA 30341 3717, USA
Am J Prev Med 34:396-403. 2008..Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality in the U.S. However, little is known about the influence of childhood stressors on its occurrence... - Posttraumatic stress disorder: a state-of-the-science reviewCharles B Nemeroff
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
J Psychiatr Res 40:1-21. 2006.... - Measurement of heritability of myocardial blood flow by positron emission tomography: the Twins Heart StudyShaoyong Su
Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences University, School of Medicine, Augusta, Georgia, USA
Heart 98:495-9. 2012..To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET)... - Habitual dietary sodium intake is inversely associated with coronary flow reserve in middle-aged male twinsSilvia C Eufinger
Nutrition and Health Sciences Program, Emory University, Atlanta, GA 30322, USA
Am J Clin Nutr 95:572-9. 2012..Evidence links dietary sodium to hypertension and cardiovascular disease (CVD), but investigation of its influence on cardiovascular function is limited... - Genetic and environmental influences on systemic markers of inflammation in middle-aged male twinsShaoyong Su
Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30306, USA
Atherosclerosis 200:213-20. 2008..The aims of this study were to determine the relative influence of genetic and environmental contributions to inflammatory biomarkers, and to what extent correlations among these markers are due to genetic or environmental factors... - Reduced volume of orbitofrontal cortex in major depressionJ Douglas Bremner
Atlanta VA Medical Center, Decatur, Georgia, USA
Biol Psychiatry 51:273-9. 2002..The findings were significant after statistically controlling for brain size. CONCLUSIONS: These findings are consistent with smaller orbitofrontal cortical volume in depression... - Depression and history of attempted suicide as risk factors for heart disease mortality in young individualsAmit J Shah
Division of Cardiology, Department of Medicine, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
Arch Gen Psychiatry 68:1135-42. 2011..Although depression is associated with increased cardiovascular morbidity and mortality, there is virtually no information on whether it also increases the risk in young populations... - Inflammation is related to coronary flow reserve detected by positron emission tomography in asymptomatic male twinsViola Vaccarino
Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA
J Am Coll Cardiol 57:1271-9. 2011..This study sought to examine the relationship between inflammation and coronary microvascular function in asymptomatic individuals using positron emission tomography (PET) and assessment of coronary flow reserve (CFR)... - Relationship of enhanced norepinephrine activity during memory consolidation to enhanced long-term memory in humansSteven M Southwick
Department of Psychiatry, Yale University School of Medicine, CT, USA
Am J Psychiatry 159:1420-2. 2002..The purpose of this study was to investigate the effect of enhanced noradrenergic activity on memory consolidation in humans... - Salivary cortisol among American Indians with and without posttraumatic stress disorder (PTSD): gender and alcohol influencesMark L Laudenslager
University of Colorado Denver School of Medicine, Department of Psychiatry, UCD and HSC Mail Code A011 09, Denver, CO 80220, USA
Brain Behav Immun 23:658-62. 2009..g., cardiac imaging, medical, dental exams, etc.), or concurrent depression... - Psychotic depression and mortalityMeena Vythilingam
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Am J Psychiatry 160:574-6. 2003..The authors hypothesized that patients with psychotic depression would have higher mortality rates than patients with nonpsychotic depression... - Adverse childhood experiences and prescribed psychotropic medications in adultsRobert F Anda
ACE Study Group, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3717, USA
Am J Prev Med 32:389-94. 2007..These ACEs included: abuse (emotional, physical, or sexual), witnessing domestic violence, growing up with substance abusing, mentally ill, or criminal household members, and parental separation/divorce... - Olfaction as a traumatic reminder in posttraumatic stress disorder: case reports and reviewEric Vermetten
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
J Clin Psychiatry 64:202-7. 2003..Though trauma-related smells have long been noted by clinicians to be precipitants of traumatic memories in patients with posttraumatic stress disorder (PTSD), very few reports have been published that document this... - Posttraumatic stress disorder and impaired autonomic modulation in male twinsAmit J Shah
Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia
Biol Psychiatry 73:1103-10. 2013..We aimed to assess whether PTSD and combat trauma exposure are associated with lower heart rate variability (HRV), a measure of autonomic function and a predictor of death... - Circuits and systems in stress. II. Applications to neurobiology and treatment in posttraumatic stress disorderEric Vermetten
Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30306, USA
Depress Anxiety 16:14-38. 2002..Current and new targets for systems that play a role in the neural circuitry of PTSD are discussed. This material provides a basis for understanding the psychopathology of stress-related disorders, in particular PTSD... - Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysisNoriyuki Kitayama
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
J Affect Disord 88:79-86. 2005..We therefore performed a meta-analytic study of all of these studies to clarify the role of hippocampal structural changes in subjects with PTSD... - A comparison of resting-state brain activity in humans and chimpanzeesJames K Rilling
Department of Anthropology, Center for Behavioral Neuroscience, Division of Psychobiology, Yerkes National Primate Research Center, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:17146-51. 2007..Our results raise the possibility that the resting state of chimpanzees involves emotionally laden episodic memory retrieval and some level of mental self-projection, albeit in the absence of language and conceptual processing... - Stress model for research into preterm delivery among black womenCarol J Rowland Hogue
Department of Epidemiology, Rollins School of Public Health, Emory University School of Medicine, Atlanta, GA 30322, USA
Am J Obstet Gynecol 192:S47-55. 2005..Future etiologic research must take into account the complexities of the measurement of stress age and past and current exposures to stress, which includes internalized racism and interpersonal racism... - Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNTMargaret R Davis
PET Center, Emory University, Atlanta, Georgia, USA
J Nucl Med 44:855-61. 2003..Having picked up presymptomatic changes in the hemisphere opposite the unaffected side of the body in our early-stage (unilateral) PD patients, it appears that, like other DAT radioligands, it may be able to identify presymptomatic PD... - The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiologyRobert F Anda
Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Adult and Community Health, Atlanta, Georgia 30341-3717, USA
Eur Arch Psychiatry Clin Neurosci 256:174-86. 2006.... - Marked lability in urinary cortisol levels in subgroups of combat veterans with posttraumatic stress disorder during an intensive exposure treatment programJohn W Mason
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Psychosom Med 64:238-46. 2002.... - Heritability of carotid intima-media thickness: a twin studyJinying Zhao
Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30306, United States
Atherosclerosis 197:814-20. 2008..To estimate the heritability of carotid intima-media thickness (IMT), a surrogate marker for atherosclerosis, independent of traditional coronary risk factors... - Adherence to the mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: a twin studyJun Dai
Nutrition and Health Sciences Program, Emory University School of Medicine, Atlanta, GA, USA
Circulation 117:169-75. 2008..It is unknown to what extent the association between the Mediterranean diet and inflammation is due to genetic or other familial factors... - Neuroimaging of childhood traumaJ Douglas Bremner
Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA 30322, USA
Semin Clin Neuropsychiatry 7:104-12. 2002..These initial results suggest that childhood abuse in the setting of PTSD is associated with long-term changes in brain structure and function... - Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorderMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, MAP, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
Psychiatry Res 139:89-99. 2005.... - Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorderEric Vermetten
University Medical Center, Utrecht, The Netherlands
Psychopharmacol Bull 40:8-30. 2007..Primitive brain systems involved in fear responsivity and survival also mediate smell, including the olfactory cortex and amygdala. The purpose of this study was to measure neural correlates of olfaction in PTSD... - Predictors of mood response to acute tryptophan depletion. A reanalysisLinda Booij
Department of Psychology, University, Leiden, The Netherlands
Neuropsychopharmacology 27:852-61. 2002..Whether the effects of ATD represent a reversal of the action of SSRI antidepressants or individual vulnerability probably depends upon the timing of the procedure in the course of remission of a depressive episode... - Childhood trauma associated with smaller hippocampal volume in women with major depressionMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
Am J Psychiatry 159:2072-80. 2002..In this study, the volumes of the hippocampus and of control brain regions were measured in depressed women with and without childhood abuse and in healthy nonabused comparison subjects... - Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorderEric Vermetten
Rudolf Magnus Institute of Neurosciences, Department Psychiatry, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Ann N Y Acad Sci 1071:184-202. 2006..These results suggest that successful treatment with SSRI in chronic PTSD is associated with a trend for a decrease in baseline diurnal cortisol and with reduced cortisol reactivity to stress... - Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSDBernet M Elzinga
Section of Clinical and Health Psychology, Leiden University, The Netherlands
Neuropsychopharmacology 28:1656-65. 2003..There was no association between memory performance and cortisol levels. These results are consistent with higher cortisol levels following exposure to traumatic stressors in PTSD... - Neural correlates of memories of abandonment in women with and without borderline personality disorderChristian G Schmahl
Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
Biol Psychiatry 54:142-51. 2003..These brain areas may mediate symptoms of BPD... - Hippocampal and amygdalar volumes in dissociative identity disorderEric Vermetten
Department of Psychiatry, Rudolf Magnus Institute of Neurosciences, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
Am J Psychiatry 163:630-6. 2006..The authors examined hippocampal and amygdalar volumes in patients with dissociative identity disorder, a disorder that has been associated with a history of severe childhood trauma... - A positron emission tomography study of memories of childhood abuse in borderline personality disorderChristian G Schmahl
Department of Psychosomatic Medicine, Central Institute of Mental Health, Mannheim, Germany
Biol Psychiatry 55:759-65. 2004..These brain areas might mediate trauma-related symptoms, such as dissociation or affective instability, in patients with BPD... - Psychophysiological reactivity to traumatic and abandonment scripts in borderline personality and posttraumatic stress disorders: a preliminary reportChristian G Schmahl
Department of Psychosomatic Medicine, Central Institute of Mental Health, J 5, D 68159 Mannheim, Germany
Psychiatry Res 126:33-42. 2004..A divergence in pathophysiology in these two disorders is suggested that may be linked to childhood trauma. However, this interpretation must be tested in a larger population... - Smaller volume of anterior cingulate cortex in abuse-related posttraumatic stress disorderNoriyuki Kitayama
Division of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira shi, Tokyo 187 8553, Japan
J Affect Disord 90:171-4. 2006..The anterior cingulate cortex (ACC) plays an important role in emotion, and studies in animals have shown changes in ACC structure with early life stress. The purpose of this study was to measure volume of the ACC in PTSD... - Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatmentMeena Vythilingam
Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892-2670, USA
Biol Psychiatry 56:101-12. 2004..Treatment with antidepressants significantly improved memory and depression but did not alter hippocampal volume, suggesting that antidepressants may improve hippocampal function in the absence of detectable structural changes... - Post-traumatic stress disorder and memory: prescient medicolegal testimony at the International War Crimes Tribunal?Landy F Sparr
Department of Psychiatry OP02, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
J Am Acad Psychiatry Law 33:71-8. 2005..With the expert witness discussion as background, this article reviews the most recent research about the nature of memory in the aftermath of trauma and the politics of psychological trauma and the law... - Morphologic alterations in the corpus callosum in abuse-related posttraumatic stress disorder: a preliminary studyNoriyuki Kitayama
Division of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
J Nerv Ment Dis 195:1027-9. 2007.... - Stress-induced cortisol elevations are associated with impaired delayed, but not immediate recallBernet M Elzinga
Section of Clinical and Health Psychology, University of Leiden, P O Box 9555, 2300 RB Leiden, The Netherlands
Psychiatry Res 134:211-23. 2005..These findings may have implications for understanding the effects of traumatic stress on memory functioning in patients with stress-related psychiatric disorders... - Decreased heart rate variability is associated with higher levels of inflammation in middle-aged menRachel Lampert
Department of Medicine Cardiology, Yale University School of Medicine, New Haven, CT 06520, USA
Am Heart J 156:759.e1-7. 2008..We examined the association between heart rate variability (HRV), a measure of autonomic function, and inflammation, measured by C-reactive protein (CRP) and interleukin-6 (IL-6)... - Neuroimaging in borderline personality disorderChristian Schmahl
Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
J Psychiatr Res 40:419-27. 2006..Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology...
Research Grants
- Biological Correlates of Traumatic StressJAMES BREMNER; Fiscal Year: 2007..The mentoring provided by the applicant will provide an important new crop of investigators to conduct the next generation of research in the field of biological correlates of traumatic stress. ..
- HIPPOCAMPUS IN WOMEN WITH CHILDHOOD ABUSE RELATED PTSDJAMES BREMNER; Fiscal Year: 2001..We hypothesize a relationship between a failure in hippocampal activation and hippocampal volume reduction in patients with PTSD. ..
- Neural Circuits in Women with Abuse and PTSDJAMES DOUGLAS BREMNER; Fiscal Year: 2010..We hypothesize that paroxetine will result in an improvement in memory function, increased hippocampal volume and NAA, and increased frontal and hippocampal function ..
- Mechanisms of Depression in CVDJAMES BREMNER; Fiscal Year: 2009..Understanding brain-based mechanisms by which depression increases mortality from CVD has the potential to lead to new treatments for this disorder. ..
- Neural Circuits in Women with Abuse and PTSDJAMES BREMNER; Fiscal Year: 2007..We hypothesize that paroxetine will result in an improvement in memory function, increased hippocampal volume and NAA, and increased frontal and hippocampal function ..
- Training Program in Neuroimaging SciencesJAMES BREMNER; Fiscal Year: 2007..Clinical research training is offered in imaging techniques (PET, MRI, fMRI, spectroscopy) with applications to mental health. ..
- Benzodiazepine Receptor in PTSDJAMES BREMNER; Fiscal Year: 2007....
- Neural Circuits in Women with Abuse and PTSDJAMES BREMNER; Fiscal Year: 2005..We hypothesize increased SC responses will correlate with increased amygdala/decreased prefrontal function in PTSD. Secondary exploratory analyses will compare brain activation patterns in early onset to adult onset PTSD. ..
- Mechanisms of Depression in CVDJAMES DOUGLAS BREMNER; Fiscal Year: 2010..Understanding brain-based mechanisms by which depression increases mortality from CVD has the potential to lead to new treatments for this disorder. ..