J Douglas Bremner

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Retinoic acid and affective disorders: the evidence for an association
    J Douglas Bremner
    Departments of Psychiatry and Radiology, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Psychiatry 73:37-50. 2012
  2. ncbi request reprint Functional brain imaging alterations in acne patients treated with isotretinoin
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    Am J Psychiatry 162:983-91. 2005
  3. ncbi request reprint Brain imaging in anxiety disorders
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University, 1256 Briarcliff Rd, Atlanta, GA 30306, USA
    Expert Rev Neurother 4:275-84. 2004
  4. ncbi request reprint Functional neuroimaging in post-traumatic stress disorder
    J Douglas Bremner
    Emory University, Atlanta, GA 30306, USA
    Expert Rev Neurother 7:393-405. 2007
  5. ncbi request reprint Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot study
    J Douglas Bremner
    Department of Psychiatry, Radiology and Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    J Psychopharmacol 19:159-65. 2005
  6. ncbi request reprint Neuroanatomical changes associated with pharmacotherapy in posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1032:154-7. 2004
  7. ncbi request reprint Effects of dexamethasone on declarative memory function in posttraumatic stress disorder
    J Douglas Bremner
    Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta 30306 GA, USA
    Psychiatry Res 129:1-10. 2004
  8. pmc Structural and functional plasticity of the human brain in posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Prog Brain Res 167:171-86. 2008
  9. ncbi request reprint Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, and Atlanta VA Medical Center, Decatur, GA, USA
    Am J Psychiatry 161:637-45. 2004
  10. ncbi request reprint Cortisol, dehydroepiandrosterone, and estradiol measured over 24 hours in women with childhood sexual abuse-related posttraumatic stress disorder
    Douglas Bremner
    Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    J Nerv Ment Dis 195:919-27. 2007

Research Grants

  1. Biological Correlates of Traumatic Stress
    JAMES BREMNER; Fiscal Year: 2007
  2. HIPPOCAMPUS IN WOMEN WITH CHILDHOOD ABUSE RELATED PTSD
    JAMES BREMNER; Fiscal Year: 2001
  3. Neural Circuits in Women with Abuse and PTSD
    JAMES DOUGLAS BREMNER; Fiscal Year: 2010
  4. Mechanisms of Depression in CVD
    JAMES BREMNER; Fiscal Year: 2009
  5. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2009
  6. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2007
  7. Training Program in Neuroimaging Sciences
    JAMES BREMNER; Fiscal Year: 2007
  8. Benzodiazepine Receptor in PTSD
    JAMES BREMNER; Fiscal Year: 2007
  9. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2005
  10. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2004

Detail Information

Publications91

  1. pmc Retinoic acid and affective disorders: the evidence for an association
    J Douglas Bremner
    Departments of Psychiatry and Radiology, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Psychiatry 73:37-50. 2012
    ..This article reviews the evidence for isotretinoin's relationships with depression and suicidality...
  2. ncbi request reprint Functional brain imaging alterations in acne patients treated with isotretinoin
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    Am J Psychiatry 162:983-91. 2005
    ..The purpose of this study was to assess the effects of isotretinoin on brain functioning in acne patients...
  3. ncbi request reprint Brain imaging in anxiety disorders
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University, 1256 Briarcliff Rd, Atlanta, GA 30306, USA
    Expert Rev Neurother 4:275-84. 2004
    ..This article reviews animal models for anxiety disorders, current brain imaging findings and outlines future directions for research in this area...
  4. ncbi request reprint Functional neuroimaging in post-traumatic stress disorder
    J Douglas Bremner
    Emory University, Atlanta, GA 30306, USA
    Expert Rev Neurother 7:393-405. 2007
    ..Future studies are required to assess the relationship between recovery from traumatic stress and changes in brain function...
  5. ncbi request reprint Effects of phenytoin on memory, cognition and brain structure in post-traumatic stress disorder: a pilot study
    J Douglas Bremner
    Department of Psychiatry, Radiology and Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    J Psychopharmacol 19:159-65. 2005
    ..However, treatment associated improvements in memory and cognition did not achieve statistical significance. These findings suggest that phenytoin treatment may be associated with changes in brain structure in patients with PTSD...
  6. ncbi request reprint Neuroanatomical changes associated with pharmacotherapy in posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1032:154-7. 2004
    ..Patients subjectively reported an improvement in cognition and work performance. These studies are consistent with the idea that antidepressants have a beneficial effect on hippocampal function in PTSD patients...
  7. ncbi request reprint Effects of dexamethasone on declarative memory function in posttraumatic stress disorder
    J Douglas Bremner
    Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta 30306 GA, USA
    Psychiatry Res 129:1-10. 2004
    ....
  8. pmc Structural and functional plasticity of the human brain in posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    Prog Brain Res 167:171-86. 2008
    ..Antidepressant treatments and changes in environment can reverse the effects of stress on hippocampal neurogenesis, and humans with PTSD showed increased hippocampal volume with both paroxetine and phenytoin...
  9. ncbi request reprint Deficits in hippocampal and anterior cingulate functioning during verbal declarative memory encoding in midlife major depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, and Atlanta VA Medical Center, Decatur, GA, USA
    Am J Psychiatry 161:637-45. 2004
    ..The purpose of the present study was to assess hippocampal and prefrontal functioning during performance of a verbal declarative memory task in subjects with midlife major depression...
  10. ncbi request reprint Cortisol, dehydroepiandrosterone, and estradiol measured over 24 hours in women with childhood sexual abuse-related posttraumatic stress disorder
    Douglas Bremner
    Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    J Nerv Ment Dis 195:919-27. 2007
    ..These findings suggest that a resting hypocortisolemia in the afternoon hours with increased cortisol pulsatility is associated with childhood abuse-related PTSD in women...
  11. pmc Neuroimaging in posttraumatic stress disorder and other stress-related disorders
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road, Room 308e, Mailstop 1256 001 AT, Atlanta GA 30306, USA
    Neuroimaging Clin N Am 17:523-38, ix. 2007
    ..Abnormalities in these brain areas are hypothesized to underlie symptoms of PTSD and other stress-related psychiatric disorders...
  12. pmc The relationship between cognitive and brain changes in posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, SS No 539 64 8946, Suite 306E, 1256 Briarcliff Rd, Atlanta, GA 30307, USA
    Ann N Y Acad Sci 1071:80-6. 2006
    ..These studies suggest that medications may counteract the effects of stress on the brain in patients with PTSD...
  13. pmc Surfing the net for medical information about psychological trauma: an empirical study of the quality and accuracy of trauma-related websites
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    Med Inform Internet Med 31:227-36. 2006
    ..These findings suggest that although abundant, websites providing information about psychological trauma are often not useful, and can sometimes provide inaccurate and potentially harmful information to consumers of medical information...
  14. pmc Stress and brain atrophy
    J Douglas Bremner
    Departments of Psychiatry and Radiology, Emory University School of Medicine, Atlanta VAMC, Decatur GA 30306, USA
    CNS Neurol Disord Drug Targets 5:503-12. 2006
    ..Treatment with antidepressants and phenytoin reverse hippocampal volume reduction and memory deficits in PTSD patients, suggesting that these agents may promote neurogenesis in humans...
  15. pmc Effects of antidepressant treatment on neural correlates of emotional and neutral declarative verbal memory in depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, United States
    J Affect Disord 101:99-111. 2007
    ..The purpose of this study was to examine the effects of treatment with antidepressants on verbal declarative memory in patients with depression...
  16. pmc Traumatic stress: effects on the brain
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    Dialogues Clin Neurosci 8:445-61. 2006
    ..Treatments that are efficacious for PTSD show a promotion of neurogenesis in animal studies, as well as promotion of memory and increased hippocampal volume in PTSD...
  17. ncbi request reprint Effects of traumatic stress on brain structure and function: relevance to early responses to trauma
    J Douglas Bremner
    Emory University School of Medicine, Atlanta, GA, USA
    J Trauma Dissociation 6:51-68. 2005
    ..Only a few treatment studies have been performed in the early trauma period, and more research in this area is needed...
  18. pmc Positron emission tomographic imaging of neural correlates of a fear acquisition and extinction paradigm in women with childhood sexual-abuse-related post-traumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    Psychol Med 35:791-806. 2005
    ..No studies have examined neural correlates of fear conditioning and extinction in patients with post-traumatic stress disorder (PTSD)...
  19. pmc The neurobiology of retinoic acid in affective disorders
    J Douglas Bremner
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30306, USA
    Prog Neuropsychopharmacol Biol Psychiatry 32:315-31. 2008
    ..This report reviews the evidence in this area and describes several systems that may be targets of retinoic acid and which contribute to the pathophysiology of depression...
  20. pmc Psychometric properties of the Early Trauma Inventory-Self Report
    J Douglas Bremner
    Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30306, USA
    J Nerv Ment Dis 195:211-8. 2007
    ..These findings suggest that the ETI-SR is a valid measure of early trauma, and suggest future directions for a shortened version of the ETI-SR that could be more easily incorporated into clinical research studies and practice settings...
  21. ncbi request reprint MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Clinical Neuroscience Research Unit, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306, USA
    Am J Psychiatry 160:924-32. 2003
    ..The purpose of this study was to measure both hippocampal structure and function in women with and without early childhood sexual abuse and the diagnosis of posttraumatic stress disorder (PTSD)...
  22. pmc Cognitive processes in dissociation: comment on Giesbrecht et al. (2008)
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia 30306, USA
    Psychol Bull 136:1-6; discussion 7-11. 2010
    ..The current comment offers a critical review and rebuttal of Giesbrecht et al.'s argument that there is no relationship between trauma and dissociation...
  23. ncbi request reprint Cortisol response to a cognitive stress challenge in posttraumatic stress disorder (PTSD) related to childhood abuse
    J D Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, 1364 Briarcliff Road, Atlanta, GA 30322, USA
    Psychoneuroendocrinology 28:733-50. 2003
    ..Although cortisol has been found to be low at baseline, there does not appear to be an impairment in cortisol response to stressors in PTSD...
  24. pmc Regional brain metabolic correlates of alpha-methylparatyrosine-induced depressive symptoms: implications for the neural circuitry of depression
    J Douglas Bremner
    Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    JAMA 289:3125-34. 2003
    ....
  25. ncbi request reprint Long-term effects of childhood abuse on brain and neurobiology
    J Douglas Bremner
    Departments of Psychiatry and Radiology, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306, USA
    Child Adolesc Psychiatr Clin N Am 12:271-92. 2003
    ..Long-term alterations in these brain regions are hypothesized to play a role in the maintenance of PTSD, depression, and other psychiatric symptoms after childhood abuse...
  26. ncbi request reprint Treatment of posttraumatic stress disorder with phenytoin: an open-label pilot study
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    J Clin Psychiatry 65:1559-64. 2004
    ..The purpose of this study was to assess the effects of phenytoin on symptoms of PTSD...
  27. ncbi request reprint Gender differences in cognitive and neural correlates of remembrance of emotional words
    J D Bremner
    Departments of Psychiatry and Behavioral Sciences and Radiology, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA, USA
    Psychopharmacol Bull 35:55-78. 2001
    ..The findings suggest differences in cognitive appraisal and involvement of a broader network of brain regions mediating emotion during remembrance of emotional words in women compared with men...
  28. ncbi request reprint Functional neuroanatomical correlates of traumatic stress revisited 7 years later, this time with data
    J Douglas Bremner
    Emory Center for Positron Emission Tomography, Atlanta, Georgia, USA
    Psychopharmacol Bull 37:6-25. 2003
    ..This understanding, in turn, will promote the development of future treatment advances for stress-related psychiatric disorders such as posttraumatic stress disorder...
  29. ncbi request reprint Neuroimaging studies in post-traumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, 1364 Clifton Road, Atlanta, GA 30322, USA
    Curr Psychiatry Rep 4:254-63. 2002
    ..Several studies have now shown changes in structure (smaller volume) of the hippocampus in PTSD. These studies are beginning to map out a neural circuitry of PTSD that may have future implications for diagnosis and treatment...
  30. ncbi request reprint Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia 30306, USA
    Biol Psychiatry 53:879-89. 2003
    ..The purpose of this study was to assess neural correlates of emotionally valenced declarative memory in women with early childhood sexual abuse and PTSD...
  31. pmc Common genetic contributions to depressive symptoms and inflammatory markers in middle-aged men: the Twins Heart Study
    Shaoyong Su
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1256 Briarcliff Road NE, Suite 1 North, Atlanta, GA 30306, USA
    Psychosom Med 71:152-8. 2009
    ..Recent data suggested that MDD and inflammation share common genes...
  32. pmc Association of major depressive disorder with serum myeloperoxidase and other markers of inflammation: a twin study
    Viola Vaccarino
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia 30306, USA
    Biol Psychiatry 64:476-83. 2008
    ..We sought to examine whether MPO and other markers of inflammation are associated with MDD and whether the association is confounded by genetic or other shared familial factors...
  33. ncbi request reprint Deficits in verbal declarative memory function in women with childhood sexual abuse-related posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    J Nerv Ment Dis 192:643-9. 2004
    ..These findings suggest that early abuse with PTSD is associated with deficits in verbal declarative memory, and that these effects are not related to the nonspecific effects of childhood abuse...
  34. pmc Common genes contribute to depressive symptoms and heart rate variability: the Twins Heart Study
    Shaoyong Su
    Department of Medicine, School of Medicine, Emory University, Atlanta, GA 30306, USA
    Twin Res Hum Genet 13:1-9. 2010
    ..These results suggest that a common neurobiological dysfunction links depression and autonomic dysregulation...
  35. pmc Effects of smoking on coronary microcirculatory function: a twin study
    Cherie Rooks
    Department of Epidemiology, Rollins School of Public Health, Emory University School of Medicine, Atlanta, GA 30322, USA
    Atherosclerosis 215:500-6. 2011
    ..Inflammation and oxidative stress may be the mechanisms through which smoking affects the microvasculature...
  36. ncbi request reprint Neural correlates of the classic color and emotional stroop in women with abuse-related posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 55:612-20. 2004
    ..Dysfunction of the anterior cingulate/medial prefrontal cortex has been implicated in posttraumatic stress disorder (PTSD). The purpose of this study was to use the Stroop task as a probe of anterior cingulate function in PTSD...
  37. pmc Long-term treatment with paroxetine increases verbal declarative memory and hippocampal volume in posttraumatic stress disorder
    Eric Vermetten
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 54:693-702. 2003
    ..This study assessed the effects of long-term treatment with paroxetine on hippocampal volume and declarative memory performance in PTSD...
  38. ncbi request reprint Assessment of the hypothalamic-pituitary-adrenal axis over a 24-hour diurnal period and in response to neuroendocrine challenges in women with and without childhood sexual abuse and posttraumatic stress disorder
    J Douglas Bremner
    Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia, USA
    Biol Psychiatry 54:710-8. 2003
    ..We performed a comprehensive assessment of the HPA axis in women with and without a history of early childhood sexual abuse and posttraumatic stress disorder (PTSD)...
  39. pmc Post-traumatic stress disorder and incidence of coronary heart disease: a twin study
    Viola Vaccarino
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    J Am Coll Cardiol 62:970-8. 2013
    ..The aim of this study was to determine whether post-traumatic stress disorder (PTSD) is associated with coronary heart disease (CHD) using a prospective twin study design and objective measures of CHD...
  40. ncbi request reprint Effects of glucocorticoids on declarative memory function in major depression
    J Douglas Bremner
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 126 Briarcliff Road, Atlanta, GA 30306, USA
    Biol Psychiatry 55:811-5. 2004
    ..The purpose of this study was to assess the effects of the glucocorticoid, dexamethasone, on verbal declarative memory function in patients with untreated unipolar major depressive disorder (MDD)...
  41. ncbi request reprint Carbon-11 HOMADAM: a novel PET radiotracer for imaging serotonin transporters
    Nachwa Jarkas
    Center for Positron Emission Tomography, Emory University, Atlanta, GA 30322, USA
    Nucl Med Biol 32:211-24. 2005
    ..Carbon-11-labeled N,N-dimethyl-2-(2'-amino-4'-hydroxymethylphenylthio)benzylamine (HOMADAM) was synthesized as a new serotonin transporter (SERT) imaging agent...
  42. pmc Early trauma and inflammation: role of familial factors in a study of twins
    Cherie Rooks
    Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Rd, Atlanta, GA 30322, USA
    Psychosom Med 74:146-52. 2012
    ....
  43. pmc Major depression and coronary flow reserve detected by positron emission tomography
    Viola Vaccarino
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30306, USA
    Arch Intern Med 169:1668-76. 2009
    ..We sought to examine the relationship between MDD and coronary flow reserve (CFR), the ratio of maximum flow during stress to flow at rest measured in milliliters per minute per gram of tissue...
  44. doi request reprint Depressive symptoms and heart rate variability: evidence for a shared genetic substrate in a study of twins
    Viola Vaccarino
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, 1256 Briarcliff Road NE, Suite 1 North, Atlanta, GA 30306, USA
    Psychosom Med 70:628-36. 2008
    ..Furthermore, little is known about whether depression and HRV share common genetic pathways...
  45. pmc Posttraumatic stress disorder and impaired autonomic modulation in male twins
    Amit J Shah
    Department of Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA
    Biol Psychiatry 73:1103-10. 2013
    ..We aimed to assess whether PTSD and combat trauma exposure are associated with lower heart rate variability (HRV), a measure of autonomic function and a predictor of death...
  46. pmc Neuropsychological functioning in patients with posttraumatic stress disorder following short-term paroxetine treatment
    Negar Fani
    Department of Neuropsychology and Behavioral Neuroscience, Georgia State University, Atlanta, GA, USA
    Psychopharmacol Bull 42:53-68. 2009
    ..The purpose of the present study was to replicate prior findings and to extend the previous study by comparing the effects of paroxetine versus placebo on cognition in patients with PTSD...
  47. pmc Increased neural response to trauma scripts in posttraumatic stress disorder following paroxetine treatment: A pilot study
    Negar Fani
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30306, United States
    Neurosci Lett 491:196-201. 2011
    ..These pilot data reveal putative mechanisms for SSRI treatment in PTSD and substantiate the need for large-scale placebo-controlled studies investigating these effects...
  48. pmc Serotonin transporter gene, depressive symptoms, and interleukin-6
    Shaoyong Su
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Circ Cardiovasc Genet 2:614-20. 2009
    ..We explored the relationship of genetic variants of the serotonin transporter gene SLC6A4, a key regulator of the serotonergic neurotransmission, with both depressive symptoms and plasma interleukin-6 (IL-6) levels...
  49. pmc Association between posttraumatic stress disorder and inflammation: a twin study
    Laura Plantinga
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, United States
    Brain Behav Immun 30:125-32. 2013
    ..There was no evidence of interaction by zygosity. Elevated hsCRP and ICAM-1 are associated with PTSD, and these associations may be confounded by shared non-genetic, antecedent familial and environmental factors...
  50. ncbi request reprint Circuits and systems in stress. I. Preclinical studies
    Eric Vermetten
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Depress Anxiety 15:126-47. 2002
    ..Intensity and duration of the stressor, and timing of the stressor in life, have strong impact in this respect...
  51. doi request reprint Adverse childhood experiences and chronic obstructive pulmonary disease in adults
    Robert F Anda
    CDC, National Center for Chronic Disease Prevention and Health Promotion, Division of Adult and Community Health, Atlanta, GA 30341 3717, USA
    Am J Prev Med 34:396-403. 2008
    ..Chronic obstructive pulmonary disease (COPD) is an important cause of morbidity and mortality in the U.S. However, little is known about the influence of childhood stressors on its occurrence...
  52. ncbi request reprint Posttraumatic stress disorder: a state-of-the-science review
    Charles B Nemeroff
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322 4990, USA
    J Psychiatr Res 40:1-21. 2006
    ....
  53. doi request reprint Measurement of heritability of myocardial blood flow by positron emission tomography: the Twins Heart Study
    Shaoyong Su
    Georgia Prevention Institute, Department of Pediatrics, Georgia Health Sciences University, School of Medicine, Augusta, Georgia, USA
    Heart 98:495-9. 2012
    ..To estimate the heritability of myocardial blood flow (MBF) and coronary flow reserve (CFR) measured with positron emission tomography (PET)...
  54. pmc Habitual dietary sodium intake is inversely associated with coronary flow reserve in middle-aged male twins
    Silvia C Eufinger
    Nutrition and Health Sciences Program, Emory University, Atlanta, GA 30322, USA
    Am J Clin Nutr 95:572-9. 2012
    ..Evidence links dietary sodium to hypertension and cardiovascular disease (CVD), but investigation of its influence on cardiovascular function is limited...
  55. ncbi request reprint Reduced volume of orbitofrontal cortex in major depression
    J Douglas Bremner
    Atlanta VA Medical Center, Decatur, Georgia, USA
    Biol Psychiatry 51:273-9. 2002
    ..The purpose of this study was to measure volume of orbitofrontal cortex and other frontal cortical subregions in patients with major depression...
  56. pmc Depression and history of attempted suicide as risk factors for heart disease mortality in young individuals
    Amit J Shah
    Division of Cardiology, Department of Medicine, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Arch Gen Psychiatry 68:1135-42. 2011
    ..Although depression is associated with increased cardiovascular morbidity and mortality, there is virtually no information on whether it also increases the risk in young populations...
  57. pmc Genetic and environmental influences on systemic markers of inflammation in middle-aged male twins
    Shaoyong Su
    Department of Medicine, Division of Cardiology, Emory University School of Medicine, Atlanta, GA 30306, USA
    Atherosclerosis 200:213-20. 2008
    ..The aims of this study were to determine the relative influence of genetic and environmental contributions to inflammatory biomarkers, and to what extent correlations among these markers are due to genetic or environmental factors...
  58. ncbi request reprint Psychotic depression and mortality
    Meena Vythilingam
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 160:574-6. 2003
    ..The authors hypothesized that patients with psychotic depression would have higher mortality rates than patients with nonpsychotic depression...
  59. ncbi request reprint Relationship of enhanced norepinephrine activity during memory consolidation to enhanced long-term memory in humans
    Steven M Southwick
    Department of Psychiatry, Yale University School of Medicine, CT, USA
    Am J Psychiatry 159:1420-2. 2002
    ..The purpose of this study was to investigate the effect of enhanced noradrenergic activity on memory consolidation in humans...
  60. pmc Inflammation is related to coronary flow reserve detected by positron emission tomography in asymptomatic male twins
    Viola Vaccarino
    Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA
    J Am Coll Cardiol 57:1271-9. 2011
    ..This study sought to examine the relationship between inflammation and coronary microvascular function in asymptomatic individuals using positron emission tomography (PET) and assessment of coronary flow reserve (CFR)...
  61. pmc Salivary cortisol among American Indians with and without posttraumatic stress disorder (PTSD): gender and alcohol influences
    Mark L Laudenslager
    University of Colorado Denver School of Medicine, Department of Psychiatry, UCD and HSC Mail Code A011 09, Denver, CO 80220, USA
    Brain Behav Immun 23:658-62. 2009
    ..g., cardiac imaging, medical, dental exams, etc.), or concurrent depression...
  62. ncbi request reprint Meta-analysis of mental stress-induced myocardial ischemia and subsequent cardiac events in patients with coronary artery disease
    Jingkai Wei
    Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia
    Am J Cardiol 114:187-92. 2014
    ..Whether this increased risk is generalizable to the CAD population at large and varies in patient subgroups warrant further investigation. ..
  63. pmc Adverse childhood experiences and prescribed psychotropic medications in adults
    Robert F Anda
    ACE Study Group, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341 3717, USA
    Am J Prev Med 32:389-94. 2007
    ..These ACEs included: abuse (emotional, physical, or sexual), witnessing domestic violence, growing up with substance abusing, mentally ill, or criminal household members, and parental separation/divorce...
  64. ncbi request reprint Olfaction as a traumatic reminder in posttraumatic stress disorder: case reports and review
    Eric Vermetten
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA
    J Clin Psychiatry 64:202-7. 2003
    ..Though trauma-related smells have long been noted by clinicians to be precipitants of traumatic memories in patients with posttraumatic stress disorder (PTSD), very few reports have been published that document this...
  65. ncbi request reprint Circuits and systems in stress. II. Applications to neurobiology and treatment in posttraumatic stress disorder
    Eric Vermetten
    Department of Psychiatry, Emory University School of Medicine, Atlanta, Georgia 30306, USA
    Depress Anxiety 16:14-38. 2002
    ..Current and new targets for systems that play a role in the neural circuitry of PTSD are discussed. This material provides a basis for understanding the psychopathology of stress-related disorders, in particular PTSD...
  66. ncbi request reprint Magnetic resonance imaging (MRI) measurement of hippocampal volume in posttraumatic stress disorder: a meta-analysis
    Noriyuki Kitayama
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30306, USA
    J Affect Disord 88:79-86. 2005
    ..We therefore performed a meta-analytic study of all of these studies to clarify the role of hippocampal structural changes in subjects with PTSD...
  67. pmc A comparison of resting-state brain activity in humans and chimpanzees
    James K Rilling
    Department of Anthropology, Center for Behavioral Neuroscience, Division of Psychobiology, Yerkes National Primate Research Center, Emory University School of Medicine, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:17146-51. 2007
    ..Our results raise the possibility that the resting state of chimpanzees involves emotionally laden episodic memory retrieval and some level of mental self-projection, albeit in the absence of language and conceptual processing...
  68. ncbi request reprint Stress model for research into preterm delivery among black women
    Carol J Rowland Hogue
    Department of Epidemiology, Rollins School of Public Health, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Obstet Gynecol 192:S47-55. 2005
    ..Future etiologic research must take into account the complexities of the measurement of stress age and past and current exposures to stress, which includes internalized racism and interpersonal racism...
  69. pmc The enduring effects of abuse and related adverse experiences in childhood. A convergence of evidence from neurobiology and epidemiology
    Robert F Anda
    Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Division of Adult and Community Health, Atlanta, Georgia 30341 3717, USA
    Eur Arch Psychiatry Clin Neurosci 256:174-86. 2006
    ..Epidemiological studies have documented the impact of childhood maltreatment on health and emotional well-being...
  70. ncbi request reprint Initial human PET imaging studies with the dopamine transporter ligand 18F-FECNT
    Margaret R Davis
    PET Center, Emory University, Atlanta, Georgia, USA
    J Nucl Med 44:855-61. 2003
    ....
  71. ncbi request reprint Marked lability in urinary cortisol levels in subgroups of combat veterans with posttraumatic stress disorder during an intensive exposure treatment program
    John W Mason
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychosom Med 64:238-46. 2002
    ....
  72. pmc Heritability of carotid intima-media thickness: a twin study
    Jinying Zhao
    Division of Cardiology, Department of Medicine, Emory University School of Medicine, Atlanta, GA 30306, United States
    Atherosclerosis 197:814-20. 2008
    ..To estimate the heritability of carotid intima-media thickness (IMT), a surrogate marker for atherosclerosis, independent of traditional coronary risk factors...
  73. pmc Adherence to the mediterranean diet is inversely associated with circulating interleukin-6 among middle-aged men: a twin study
    Jun Dai
    Nutrition and Health Sciences Program, Emory University School of Medicine, Atlanta, GA, USA
    Circulation 117:169-75. 2008
    ..It is unknown to what extent the association between the Mediterranean diet and inflammation is due to genetic or other familial factors...
  74. ncbi request reprint Neuroimaging of childhood trauma
    J Douglas Bremner
    Department of Psychiatry, Emory Center for Positron Emission Tomography, Emory University School of Medicine, Atlanta, GA 30322, USA
    Semin Clin Neuropsychiatry 7:104-12. 2002
    ..These initial results suggest that childhood abuse in the setting of PTSD is associated with long-term changes in brain structure and function...
  75. ncbi request reprint Post-traumatic stress disorder and memory: prescient medicolegal testimony at the International War Crimes Tribunal?
    Landy F Sparr
    Department of Psychiatry OP02, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97201, USA
    J Am Acad Psychiatry Law 33:71-8. 2005
    ..With the expert witness discussion as background, this article reviews the most recent research about the nature of memory in the aftermath of trauma and the politics of psychological trauma and the law...
  76. pmc Neuroimaging in borderline personality disorder
    Christian Schmahl
    Department of Psychosomatic Medicine and Psychotherapy, Central Institute of Mental Health, J5, D 68159 Mannheim, Germany
    J Psychiatr Res 40:419-27. 2006
    ..Dysfunction in a frontolimbic network is suggested to mediate much, if not all of the borderline symptomatology...
  77. pmc Positron tomographic emission study of olfactory induced emotional recall in veterans with and without combat-related posttraumatic stress disorder
    Eric Vermetten
    University Medical Center, Utrecht, The Netherlands
    Psychopharmacol Bull 40:8-30. 2007
    ..Primitive brain systems involved in fear responsivity and survival also mediate smell, including the olfactory cortex and amygdala. The purpose of this study was to measure neural correlates of olfaction in PTSD...
  78. pmc Smaller volume of anterior cingulate cortex in abuse-related posttraumatic stress disorder
    Noriyuki Kitayama
    Division of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, 4 1 1 Ogawa Higashi, Kodaira shi, Tokyo 187 8553, Japan
    J Affect Disord 90:171-4. 2006
    ..The anterior cingulate cortex (ACC) plays an important role in emotion, and studies in animals have shown changes in ACC structure with early life stress. The purpose of this study was to measure volume of the ACC in PTSD...
  79. pmc Alterations in stress reactivity after long-term treatment with paroxetine in women with posttraumatic stress disorder
    Eric Vermetten
    Rudolf Magnus Institute of Neurosciences, Department Psychiatry, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Ann N Y Acad Sci 1071:184-202. 2006
    ..These results suggest that successful treatment with SSRI in chronic PTSD is associated with a trend for a decrease in baseline diurnal cortisol and with reduced cortisol reactivity to stress...
  80. pmc Hippocampal and amygdalar volumes in dissociative identity disorder
    Eric Vermetten
    Department of Psychiatry, Rudolf Magnus Institute of Neurosciences, University Medical Center, Int mailbox B01206, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Am J Psychiatry 163:630-6. 2006
    ..The authors examined hippocampal and amygdalar volumes in patients with dissociative identity disorder, a disorder that has been associated with a history of severe childhood trauma...
  81. ncbi request reprint Smaller head of the hippocampus in Gulf War-related posttraumatic stress disorder
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, MAP, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
    Psychiatry Res 139:89-99. 2005
    ....
  82. pmc Decreased heart rate variability is associated with higher levels of inflammation in middle-aged men
    Rachel Lampert
    Department of Medicine Cardiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am Heart J 156:759.e1-7. 2008
    ..We examined the association between heart rate variability (HRV), a measure of autonomic function, and inflammation, measured by C-reactive protein (CRP) and interleukin-6 (IL-6)...
  83. ncbi request reprint Stress-induced cortisol elevations are associated with impaired delayed, but not immediate recall
    Bernet M Elzinga
    Section of Clinical and Health Psychology, University of Leiden, P O Box 9555, 2300 RB Leiden, The Netherlands
    Psychiatry Res 134:211-23. 2005
    ..These findings may have implications for understanding the effects of traumatic stress on memory functioning in patients with stress-related psychiatric disorders...
  84. ncbi request reprint Hippocampal volume, memory, and cortisol status in major depressive disorder: effects of treatment
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland 20892 2670, USA
    Biol Psychiatry 56:101-12. 2004
    ..However, the relationships between depression, hippocampal structure and function, and cortisol levels are unclear and the effects of antidepressant treatment on the measures are not well studied...
  85. pmc Childhood trauma associated with smaller hippocampal volume in women with major depression
    Meena Vythilingam
    Mood and Anxiety Disorders Program, National Institute of Mental Health, 15K North Drive, Room 111, MSC 2670, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 159:2072-80. 2002
    ..In this study, the volumes of the hippocampus and of control brain regions were measured in depressed women with and without childhood abuse and in healthy nonabused comparison subjects...
  86. pmc Morphologic alterations in the corpus callosum in abuse-related posttraumatic stress disorder: a preliminary study
    Noriyuki Kitayama
    Division of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
    J Nerv Ment Dis 195:1027-9. 2007
    ....
  87. ncbi request reprint Psychophysiological reactivity to traumatic and abandonment scripts in borderline personality and posttraumatic stress disorders: a preliminary report
    Christian G Schmahl
    Department of Psychosomatic Medicine, Central Institute of Mental Health, J 5, D 68159 Mannheim, Germany
    Psychiatry Res 126:33-42. 2004
    ..A divergence in pathophysiology in these two disorders is suggested that may be linked to childhood trauma. However, this interpretation must be tested in a larger population...
  88. ncbi request reprint Higher cortisol levels following exposure to traumatic reminders in abuse-related PTSD
    Bernet M Elzinga
    Section of Clinical and Health Psychology, Leiden University, The Netherlands
    Neuropsychopharmacology 28:1656-65. 2003
    ..There was no association between memory performance and cortisol levels. These results are consistent with higher cortisol levels following exposure to traumatic stressors in PTSD...
  89. ncbi request reprint A positron emission tomography study of memories of childhood abuse in borderline personality disorder
    Christian G Schmahl
    Department of Psychosomatic Medicine, Central Institute of Mental Health, Mannheim, Germany
    Biol Psychiatry 55:759-65. 2004
    ..This pilot study was conducted to measure the neural correlates of recall of traumatic memories in women with and without BPD...
  90. ncbi request reprint Neural correlates of memories of abandonment in women with and without borderline personality disorder
    Christian G Schmahl
    Department of Psychiatry and Psychotherapy, University of Freiburg Medical School, Freiburg, Germany
    Biol Psychiatry 54:142-51. 2003
    ..One particularly salient feature of the disorder is fear of abandonment. This pilot study was conducted to measure neural correlates of memories of abandonment in women with and without BPD...
  91. ncbi request reprint Predictors of mood response to acute tryptophan depletion. A reanalysis
    Linda Booij
    Department of Psychology, University, Leiden, The Netherlands
    Neuropsychopharmacology 27:852-61. 2002
    ..Whether the effects of ATD represent a reversal of the action of SSRI antidepressants or individual vulnerability probably depends upon the timing of the procedure in the course of remission of a depressive episode...

Research Grants19

  1. Biological Correlates of Traumatic Stress
    JAMES BREMNER; Fiscal Year: 2007
    ..The mentoring provided by the applicant will provide an important new crop of investigators to conduct the next generation of research in the field of biological correlates of traumatic stress. ..
  2. HIPPOCAMPUS IN WOMEN WITH CHILDHOOD ABUSE RELATED PTSD
    JAMES BREMNER; Fiscal Year: 2001
    ..We hypothesize a relationship between a failure in hippocampal activation and hippocampal volume reduction in patients with PTSD. ..
  3. Neural Circuits in Women with Abuse and PTSD
    JAMES DOUGLAS BREMNER; Fiscal Year: 2010
    ..We hypothesize that paroxetine will result in an improvement in memory function, increased hippocampal volume and NAA, and increased frontal and hippocampal function ..
  4. Mechanisms of Depression in CVD
    JAMES BREMNER; Fiscal Year: 2009
    ..Understanding brain-based mechanisms by which depression increases mortality from CVD has the potential to lead to new treatments for this disorder. ..
  5. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2009
    ..We hypothesize that paroxetine will result in an improvement in memory function, increased hippocampal volume and NAA, and increased frontal and hippocampal function ..
  6. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2007
    ..We hypothesize that paroxetine will result in an improvement in memory function, increased hippocampal volume and NAA, and increased frontal and hippocampal function ..
  7. Training Program in Neuroimaging Sciences
    JAMES BREMNER; Fiscal Year: 2007
    ..Clinical research training is offered in imaging techniques (PET, MRI, fMRI, spectroscopy) with applications to mental health. ..
  8. Benzodiazepine Receptor in PTSD
    JAMES BREMNER; Fiscal Year: 2007
    ....
  9. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2005
    ..We hypothesize increased SC responses will correlate with increased amygdala/decreased prefrontal function in PTSD. Secondary exploratory analyses will compare brain activation patterns in early onset to adult onset PTSD. ..
  10. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2004
    ..We hypothesize increased SC responses will correlate with increased amygdala/decreased prefrontal function in PTSD. Secondary exploratory analyses will compare brain activation patterns in early onset to adult onset PTSD. ..
  11. Neural Circuits in Women with Abuse and PTSD
    JAMES BREMNER; Fiscal Year: 2003
    ..We hypothesize increased SC responses will correlate with increased amygdala/decreased prefrontal function in PTSD. Secondary exploratory analyses will compare brain activation patterns in early onset to adult onset PTSD. ..
  12. HIPPOCAMPUS IN WOMEN WITH CHILDHOOD ABUSE RELATED PTSD
    JAMES BREMNER; Fiscal Year: 2000
    ..We hypothesize a relationship between a failure in hippocampal activation and hippocampal volume reduction in patients with PTSD. ..
  13. Mechanisms of Depression in CVD
    JAMES DOUGLAS BREMNER; Fiscal Year: 2010
    ..Understanding brain-based mechanisms by which depression increases mortality from CVD has the potential to lead to new treatments for this disorder. ..