Daniel Brat

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint The role of neuropathology in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    J Neurooncol 118:461-78. 2014
  2. ncbi request reprint Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population
    Daniel J Brat
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 64:920-7. 2004
  3. doi request reprint Diagnosis of malignant glioma: role of neuropathology
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University Hospital, G 169, 1364 Clifton Rd NE, Atlanta, GA 30322, USA
    J Neurooncol 89:287-311. 2008
  4. ncbi request reprint Congenital glioblastoma: a clinicopathologic and genetic analysis
    Daniel J Brat
    Departments of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Brain Pathol 17:276-81. 2007
  5. ncbi request reprint Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression
    Daniel J Brat
    Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Intern Med 138:659-68. 2003
  6. ncbi request reprint Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine H 176, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Lab Invest 84:397-405. 2004
  7. ncbi request reprint Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors
    Daniel J Brat
    Department of Pathology and Laboratory Medicine and Laboratory of Molecular Neuro Oncology, Emory University School of Medicine, Atlanta, GA, USA
    Front Biosci 8:d100-16. 2003
  8. ncbi request reprint Surgical neuropathology update: a review of changes introduced by the WHO classification of tumours of the central nervous system, 4th edition
    Daniel J Brat
    Department of Pathology, EmoryUniversity, Atlanta, GA, USA
    Arch Pathol Lab Med 132:993-1007. 2008
  9. ncbi request reprint Infiltrative astrocytomas with granular cell features (granular cell astrocytomas): a study of histopathologic features, grading, and outcome
    Daniel J Brat
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 26:750-7. 2002
  10. pmc Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from Radiation Therapy Oncology Group trials
    Daniel J Brat
    Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuro Oncol 6:96-103. 2004

Detail Information

Publications76

  1. ncbi request reprint The role of neuropathology in the management of progressive glioblastoma : a systematic review and evidence-based clinical practice guideline
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    J Neurooncol 118:461-78. 2014
    ..1. What are the most important diagnostic considerations in reporting progressive glioblastoma?..
  2. ncbi request reprint Pseudopalisades in glioblastoma are hypoxic, express extracellular matrix proteases, and are formed by an actively migrating cell population
    Daniel J Brat
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 64:920-7. 2004
    ....
  3. doi request reprint Diagnosis of malignant glioma: role of neuropathology
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University Hospital, G 169, 1364 Clifton Rd NE, Atlanta, GA 30322, USA
    J Neurooncol 89:287-311. 2008
  4. ncbi request reprint Congenital glioblastoma: a clinicopathologic and genetic analysis
    Daniel J Brat
    Departments of Pathology and Laboratory Medicine and Winship Cancer Institute, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Brain Pathol 17:276-81. 2007
    ..Nonetheless, the strong nuclear expression of p53 in these and other pediatric GBMs could indicate that p53 dysregulation is important to tumorigenesis...
  5. ncbi request reprint Malignant glioma physiology: cellular response to hypoxia and its role in tumor progression
    Daniel J Brat
    Emory University School of Medicine, Atlanta, Georgia, USA
    Ann Intern Med 138:659-68. 2003
  6. ncbi request reprint Vaso-occlusive and prothrombotic mechanisms associated with tumor hypoxia, necrosis, and accelerated growth in glioblastoma
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine H 176, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Lab Invest 84:397-405. 2004
    ..Since the hypoxic induction of angiogenesis appears to support further neoplastic growth, therapeutic targeting of the underlying vascular pathology and thrombosis could provide a new means to prolong time to progression...
  7. ncbi request reprint Genetic modulation of hypoxia induced gene expression and angiogenesis: relevance to brain tumors
    Daniel J Brat
    Department of Pathology and Laboratory Medicine and Laboratory of Molecular Neuro Oncology, Emory University School of Medicine, Atlanta, GA, USA
    Front Biosci 8:d100-16. 2003
    ..Thus, genetic events that occur during the progression of infiltrating astrocytomas promote angiogenesis, both by modulating hypoxia induced gene expression and by regulating of pro- and anti- angiogenic factors...
  8. ncbi request reprint Surgical neuropathology update: a review of changes introduced by the WHO classification of tumours of the central nervous system, 4th edition
    Daniel J Brat
    Department of Pathology, EmoryUniversity, Atlanta, GA, USA
    Arch Pathol Lab Med 132:993-1007. 2008
    ..A number of established brain tumors are reorganized, including medulloblastomas and primitive neuroectodermal tumors, in an attempt to more closely align classification with current understanding of central nervous system neoplasia...
  9. ncbi request reprint Infiltrative astrocytomas with granular cell features (granular cell astrocytomas): a study of histopathologic features, grading, and outcome
    Daniel J Brat
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 26:750-7. 2002
    ..6 months). Two patients died postoperatively, and one was alive at 51 months. Granular cell astrocytoma is an uncommon morphologic variant that appears to be rapidly progressive and usually fatal...
  10. pmc Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from Radiation Therapy Oncology Group trials
    Daniel J Brat
    Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuro Oncol 6:96-103. 2004
    ..Long-term and short-term survival groups of high-grade astrocytomas appear to have dissimilar frequencies of 19q, 9p, and 10q deletions. TMA-FISH is a rapid and efficient way of evaluating genetic alterations in such tumors...
  11. ncbi request reprint Newly codified glial neoplasms of the 2007 WHO Classification of Tumours of the Central Nervous System: angiocentric glioma, pilomyxoid astrocytoma and pituicytoma
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
    Brain Pathol 17:319-24. 2007
    ..It is solid in architecture, composed of spindle cells and presumably derived from pituicytes. Pituicytomas are indolent tumours, and are designated WHO grade I...
  12. ncbi request reprint Genetic and biologic progression in astrocytomas and their relation to angiogenic dysregulation
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Adv Anat Pathol 9:24-36. 2002
    ..Understanding genetic events and their relation to angiogenic regulation in astrocytic neoplasms may eventually lead to therapies that are specifically directed at molecularly defined subsets of these diseases...
  13. ncbi request reprint Extraventricular neurocytomas: pathologic features and clinical outcome
    D J Brat
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Surg Pathol 25:1252-60. 2001
    ..Thus, the majority of EVNs are well differentiated and appear unlikely to recur after gross total resection. Subtotal resection, atypical histologic features, and high cell proliferation rates correlate with recurrence...
  14. ncbi request reprint Tau-associated neuropathology in ganglion cell tumours increases with patient age but appears unrelated to ApoE genotype
    D J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuropathol Appl Neurobiol 27:197-205. 2001
    ..GVD, tau-positive NFT and NPT, and argentophilic bodies occur more often in ganglion cell tumours from patients over 30-yrs-old, but do not appear to be associated with a specific ApoE genotype...
  15. ncbi request reprint Astroblastoma: clinicopathologic features and chromosomal abnormalities defined by comparative genomic hybridization
    D J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Brain Pathol 10:342-52. 2000
    ....
  16. pmc Towards building computerized image analysis framework for nucleus discrimination in microscopy images of diffuse glioma
    Jun Kong
    Emory University, Center for Comprehensive Informatics, Atlanta, GA 30322, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:6605-8. 2011
    ..We compare the performance of the proposed analysis algorithm with that of CellProfiler, a classical analysis software for cell image process, and present the superiority of our method to CellProfiler...
  17. ncbi request reprint Clarifying the diffuse gliomas: an update on the morphologic features and markers that discriminate oligodendroglioma from astrocytoma
    Meenakshi Gupta
    Department of Pathology and Laboratory Medicine and the Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Am J Clin Pathol 124:755-68. 2005
    ..The Olig family of transcription factors has not demonstrated their diagnostic usefulness. Diffuse gliomas remain a diagnostic challenge, and new markers are needed for proper classification and directed therapies...
  18. ncbi request reprint Cancer therapy with a replicating oncolytic adenovirus targeting the hypoxic microenvironment of tumors
    Dawn E Post
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Emory University, Atlanta, Georgia 30322, USA
    Clin Cancer Res 10:8603-12. 2004
    ....
  19. ncbi request reprint Notch1 and notch2 have opposite effects on embryonal brain tumor growth
    Xing Fan
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 64:7787-93. 2004
    ..Our data indicate that Notch1 and Notch2 can have opposite effects on the growth of a single tumor type, and show that Notch2 can be overexpressed after gene amplification in human tumors...
  20. pmc Hypoxia and the hypoxia-inducible-factor pathway in glioma growth and angiogenesis
    Balveen Kaur
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery and Hematology Oncology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuro Oncol 7:134-53. 2005
    ..While HIF activation strongly promotes angiogenesis, the emerging vasculature is often abnormal, leading to a vicious cycle that causes further hypoxia and HIF upregulation...
  21. ncbi request reprint Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 9:3469-75. 2003
    ....
  22. pmc Aberrant methylation and down-regulation of TMS1/ASC in human glioblastoma
    Annalisa R Stone
    Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, 1365 C Clifton Rd, NE, Atlanta, GA 30322, USA
    Am J Pathol 165:1151-61. 2004
    ..The data suggest a role for the epigenetic silencing of TMS1 in the pathogenesis of human GBM. Methylation of TMS1 may prove to be a useful prognostic marker and/or predictor of patient survival and tumor malignancy...
  23. ncbi request reprint 'Pseudopalisading' necrosis in glioblastoma: a familiar morphologic feature that links vascular pathology, hypoxia, and angiogenesis
    Yuan Rong
    Department of Pathology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neuropathol Exp Neurol 65:529-39. 2006
    ....
  24. ncbi request reprint PTEN and hypoxia regulate tissue factor expression and plasma coagulation by glioblastoma
    Yuan Rong
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 65:1406-13. 2005
    ....
  25. pmc Early growth response gene-1 regulates hypoxia-induced expression of tissue factor in glioblastoma multiforme through hypoxia-inducible factor-1-independent mechanisms
    Yuan Rong
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:7067-74. 2006
    ..We conclude that hypoxic up-regulation of tissue factor in glioblastoma multiforme cells depends largely on Egr-1 and is independent of HIF-1...
  26. ncbi request reprint Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor
    Balveen Kaur
    Laboratory of Molecular Neuro Oncology, Departments of Neurosurgery, Hematology Oncology, Winship Cancer Institute, Emory University, Atlanta, GA 30322, USA
    Oncogene 24:3632-42. 2005
    ..Modulation of this cleavage or delivery of Vasculostatin may constitute novel treatment modalities for cancer and other diseases of aberrant angiogenesis, especially in the brain...
  27. ncbi request reprint Antitumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model
    Seung Hee Kang
    Department of Hematology Oncology, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 66:11991-7. 2006
    ....
  28. ncbi request reprint Proliferation (MIB-1 expression) in oligodendrogliomas: assessment of quantitative methods and prognostic significance
    Kathleen E Coleman
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Appl Immunohistochem Mol Morphol 14:109-14. 2006
    ..The objectivity and speed of the image analysis systems make them an attractive alternative to visual estimation, and larger series should be analyzed for prognostic value...
  29. pmc Intravascular thrombosis in central nervous system malignancies: a potential role in astrocytoma progression to glioblastoma
    Mahtab Tehrani
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Pathol 18:164-71. 2008
    ..Thus, intravascular thrombosis is more frequent in GBM than other CNS malignancies. When present in AAs, it appears to indicate aggressive clinical behavior...
  30. ncbi request reprint Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration
    Fatima W Khwaja
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 12:6331-6. 2006
    ..The goal of our study was to find reliable markers that could be used for disease monitoring as well as to identify new targets for the therapeutic intervention for malignant astrocytoma (WHO grades 3 and 4)...
  31. pmc Epidermal growth factor receptor and PTEN modulate tissue factor expression in glioblastoma through JunD/activator protein-1 transcriptional activity
    Yuan Rong
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer Res 69:2540-9. 2009
    ..These mechanisms are likely at work in vivo, as EGFR expression was highly correlated with TF expression in human high-grade astrocytoma specimens...
  32. pmc An integrative approach for in silico glioma research
    Lee A D Cooper
    Center for Comprehensive Informatics, Atlanta, GA 30322, USA
    IEEE Trans Biomed Eng 57:2617-21. 2010
    ..The preliminary results demonstrate the potential of combining morphometric and molecular characterizations for in silico research...
  33. ncbi request reprint Granular cell astrocytomas show a high frequency of allelic loss but are not a genetically defined subset
    Amilcar A Castellano-Sanchez
    Department of Pathology, Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Brain Pathol 13:185-94. 2003
    ..Instead, it appears that granular cell change occurs across genetic subsets. The high frequency of allelic loss, especially on 9p and 10q, may confer aggressive growth potential and be related to their rapid clinical progression...
  34. ncbi request reprint Protease-activated receptor-1 in human brain: localization and functional expression in astrocytes
    Candice E Junge
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 188:94-103. 2004
    ....
  35. pmc Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma
    Robert C Castellino
    Department of Pediatrics, Aflac Cancer Center and Blood Disorders Service, Children s Healthcare of Atlanta, Emory University School of Medicine, Atlanta, Georgia, USA
    PLoS ONE 5:e10849. 2010
    ..Recent publications have described an important role for cross talk between PI-3 kinase and sonic hedgehog signaling pathways in the pathogenesis of medulloblastoma...
  36. ncbi request reprint 9p21 and 13q14 dosages in ependymomas. A clinicopathologic study of 101 cases
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Mod Pathol 17:9-14. 2004
    ....
  37. pmc Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism
    Balveen Kaur
    Department of Neurosurgery, Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 69:1212-20. 2009
    ..These results advance the understanding of brain-specific angiogenic regulation, and suggest that Vstat120 has therapeutic potential in the treatment of brain tumors and other intracerebral vasculopathies...
  38. ncbi request reprint De novo germline TP53 mutation presenting with synchronous malignancies of the central nervous system
    Matthew J Schniederjan
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Pediatr Blood Cancer 53:1352-4. 2009
    ..This case identifies a rare, de novo, germline TP53 mutation presenting with synchronous CNS malignancies and exhibiting a more fulminant course than typical cases of Li-Fraumeni syndrome...
  39. pmc In silico analysis of nuclei in glioblastoma using large-scale microscopy images improves prediction of treatment response
    Jun Kong
    Emory University, Center for Comprehensive Informatics, Atlanta, GA 30322, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:87-90. 2011
    ..As a result, this analysis method shows potential to facilitate a better understanding of disease progression and patients' response to therapy for glioblastoma...
  40. ncbi request reprint Tuberous sclerosis-associated lesions of the kidney, brain, and skin are angiogenic neoplasms
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, WMB 5309, 1639 Pierce Street, Atlanta, GA 30322, USA
    J Am Acad Dermatol 46:376-80. 2002
    ..Progressive growth and malignant transformation of brain and kidney lesions constitute the major cause of morbidity and mortality in adults with tuberous sclerosis. In addition, growth of skin lesions may be disfiguring to patients...
  41. doi request reprint Phase I analysis of BCNU-impregnated biodegradable polymer wafers followed by systemic interferon alfa-2b in adults with recurrent glioblastoma multiforme
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, 1365B Clifton Road, NE Ste 6200, Atlanta, GA 30332, USA
    J Neurooncol 90:293-9. 2008
    ..This is a report of a phase I dose-finding study for IFNalpha(2b) in combination with surgery and BCNU wafers in patients with recurrent glioblastoma...
  42. ncbi request reprint Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion
    Anita C Bellail
    Laboratory of Molecular Neuro Oncology, Department of Neurosurgery, Hematology Oncology, Winship Cancer Institute and Brain Tumor Program, Emory University, Atlanta, GA 30322, USA
    Int J Biochem Cell Biol 36:1046-69. 2004
    ..This review will focus on the impact of microregional heterogeneity of the ECM on glioma invasion in the normal adult brain and its modifications in tumoral brain...
  43. ncbi request reprint Genetic and hypoxic regulation of angiogenesis in gliomas
    Balveen Kaur
    Laboratory of Molecular Neuro Oncology, Department of Neuro surgery and Hematology Oncology, and Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurooncol 70:229-43. 2004
    ..This review will summarize the properties of angiogenic dysregulation that lead to the highly vascularized nature of these tumors...
  44. pmc Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression
    Balveen Kaur
    Laboratory of Molecular Neuro Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
    Am J Pathol 162:19-27. 2003
    ..The finding that expression of BAI proteins may be lost during tumor formation is of special interest as restoration of their function in tumors may be of therapeutic benefit...
  45. doi request reprint Distinguishing chordoid meningiomas from their histologic mimics: an immunohistochemical evaluation
    Ankur R Sangoi
    Department of Pathology, Stanford University, Stanford, CA, USA
    Am J Surg Pathol 33:669-81. 2009
    ..Of note, this study is the first to characterize the D2-40 immunoprofile in extraskeletal myxoid chondrosarcoma, results that could be of utility in differential diagnostic assessment...
  46. ncbi request reprint Chordoid glioma: a case report and molecular characterization of five cases
    Craig Horbinski
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain Pathol 19:439-48. 2009
    ..These are the fifth through ninth reported cases of chordoid gliomas with molecular characterization suggesting a distinct genetic origin from other gliomas...
  47. ncbi request reprint Alterations in molecular pathways of diffusely infiltrating glial neoplasms: application to tumor classification and anti-tumor therapy (Review)
    Stephen B Hunter
    Department of Pathology and Laboratory Medicine, Emory University Hospital, H 173, NE, Atlanta, GA 30322, USA
    Int J Oncol 23:857-69. 2003
    ..Although at the present no molecular system for the classification of brain tumors has been generally accepted, microarray technologies offer the exciting prospect of practical molecular classification in the future...
  48. ncbi request reprint Differential expression between pilocytic and anaplastic astrocytomas: identification of apolipoprotein D as a marker for low-grade, non-infiltrating primary CNS neoplasms
    Stephen Hunter
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neuropathol Exp Neurol 61:275-81. 2002
    ..ApoD might play a role in either decreased proliferation or cyst formation in pilocytic astrocytomas, gangliogliomas, SEGAs, and PXAs...
  49. ncbi request reprint Special lecture: glial reactivity after damage: implications for scar formation and neuronal recovery
    Cecily E Hamill
    Department of Pharmacology, Emory University, Rollins Research Center, Atlanta, Georgia, USA
    Clin Neurosurg 52:29-44. 2005
  50. ncbi request reprint Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hum Pathol 35:1413-8. 2004
    ..3) The characteristic FXIIIa staining pattern reported for HPC also is encountered frequently in anaplastic meningiomas and therefore is nonspecific in this diagnostic setting...
  51. pmc The role of interleukin-8 and its receptors in gliomagenesis and tumoral angiogenesis
    Daniel J Brat
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuro Oncol 7:122-33. 2005
    ..A precise definition of the mechanisms by which IL-8 exerts its proangiogenic functions requires further study for the development of effective IL-8-targeted therapies...
  52. ncbi request reprint Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Biol Chem 280:5870-4. 2005
    ..Our data are the first to demonstrate that specific signaling abnormalities underlie specific hamartomas in a model of a human genetic disorder...
  53. ncbi request reprint Genetic markers in glioblastoma: prognostic significance and future therapeutic implications
    Charles Hill
    Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
    Adv Anat Pathol 10:212-7. 2003
    ..It remains to be seen if GBMs with 1p and 19q losses are chemosensitive in the same manner as oligodendrogliomas...
  54. ncbi request reprint Akt phosphorylation regulates the tumour-suppressor merlin through ubiquitination and degradation
    Xiaoling Tang
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    Nat Cell Biol 9:1199-207. 2007
    ..Furthermore, Akt-mediated phosphorylation leads to merlin degradation by ubiquitination. These studies demonstrate that Akt-mediated merlin phosphorylation regulates the function of merlin in the absence of an inactivating mutation...
  55. pmc Targeted cancer gene therapy using a hypoxia inducible factor dependent oncolytic adenovirus armed with interleukin-4
    Dawn E Post
    Department of Neurosurgery, Winship Cancer Institute, Emory University School of Medicine, 1365C Clifton Road, Atlanta, GA 30322, USA
    Cancer Res 67:6872-81. 2007
    ....
  56. ncbi request reprint Upregulation of hypoxia inducible factor is associated with attenuation of neuronal injury in neonatal piglets undergoing deep hypothermic circulatory arrest
    Faraz Kerendi
    Division of Cardiothoracic Surgery, Emory University School of Medicine, Atlanta, GA, USA
    J Thorac Cardiovasc Surg 130:1079. 2005
    ....
  57. ncbi request reprint Best cases from the AFIP: glioblastoma multiforme
    David A Altman
    Department of Radiology, Emory University School of Medicine, 1364 Clifton Rd NE, Atlanta, GA 30322, USA
    Radiographics 27:883-8. 2007
  58. pmc The contribution of protease-activated receptor 1 to neuronal damage caused by transient focal cerebral ischemia
    Candice E Junge
    Department of Pharmacology, Emory University, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 100:13019-24. 2003
    ....
  59. ncbi request reprint Differential expression of folate receptor in pituitary adenomas
    Chheng Orn Evans
    Department of Neurosurgery, Division of Cancer Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Cancer Res 63:4218-24. 2003
    ..These results demonstrate that overexpression of FRalpha mRNA by NF pituitary adenomas results in production of properly folded FRalpha protein, may mediate vitamin transport, and could potentially facilitate the growth of these tumors...
  60. doi request reprint Management of newly diagnosed glioblastoma: guidelines development, value and application
    Jeffrey J Olson
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Neurooncol 93:1-23. 2009
    ....
  61. ncbi request reprint Delivery systems and molecular targets of mechanism-based therapies for GBM
    Surasak Phuphanich
    Department of Hematology Oncology, Winship Cancer Institute, Suite C 5002, 1365 C Clifton Road NE, Atlanta, GA 30322, USA
    Expert Rev Neurother 4:649-63. 2004
    ..Future goals are to tailor therapies to a tumor's molecular, proteomic or genomic status ,and manage glioblastoma multiformes as in chronic diseases in a multidisciplinary clinical setting...
  62. pmc Human BRE1 is an E3 ubiquitin ligase for Ebp1 tumor suppressor
    Zhixue Liu
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 20:757-68. 2009
    ..It is robustly phosphorylated and localized in the nucleus of primary gliomas, correlating with hBre1 subcellular residency. Thus, hBre1 inhibits Ebp1's tumor suppressive activity through mediating its polyubiquitination and degradation...
  63. ncbi request reprint Fatal West Nile virus encephalitis in a renal transplant recipient
    Melissa M Cushing
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Am J Clin Pathol 121:26-31. 2004
    ..Immunosuppression of the transplant recipient might have been responsible for the fulminant viral effects. The pathologic diagnosis helped guide subsequent epidemiologic and laboratory studies...
  64. ncbi request reprint Primary central nervous system posttransplant lymphoproliferative disorders
    Amilcar A Castellano-Sanchez
    Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
    Am J Clin Pathol 121:246-53. 2004
    ..Extremely short survival periods were noted for each CNS PTLD that followed peripheral blood stem cell transplantation. Survival of others with CNS PTLD varied; some lived more than 2 years...
  65. ncbi request reprint Proteomic analysis of cerebrospinal fluid discriminates malignant and nonmalignant disease of the central nervous system and identifies specific protein markers
    Fatima W Khwaja
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proteomics 6:6277-87. 2006
    ..3-13.7 kDa peak range in non-neoplastic CSF and was most prominent in inflammatory conditions. Our approach provides a rational basis for identifying biomarkers that could be used for detection, diagnosis, and monitoring of CNS diseases...
  66. ncbi request reprint An astroblastoma mimicking a cavernous malformation: case report
    Luis M Tumialan
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Neurosurgery 60:E569-70; discussion E570. 2007
    ..Hemorrhage, which suggested the presence of a vascular lesion in this patient, has not been previously described as a feature of this neoplasm...
  67. pmc Silencing of TMS1/ASC promotes resistance to anoikis in breast epithelial cells
    MELISSA J PARSONS
    Graduate Program in Genetics and Molecular Biology, Emory University, Atlanta, Georgia, USA
    Cancer Res 69:1706-11. 2009
    ..This conclusion is supported by in vivo data showing that TMS1 is selectively down-regulated in the aberrant epithelial cells filling the lumen of the breast duct in a subset of primary DCIS lesions...
  68. ncbi request reprint Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Front Biosci 8:a1-9. 2003
    ....
  69. ncbi request reprint Pituicytoma: report of two cases and clues regarding histogenesis
    Arthur J Ulm
    Department of Neurological Surgery, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    Neurosurgery 54:753-7; discussion 757-8. 2004
    ..We present a report of two patients with pituicytomas and review the literature regarding treatment and prognosis for this unusual lesion. Possible histogenetic relationships of this tumor with other pituitary neoplasms are presented...
  70. ncbi request reprint The elusive origin of chordoid glioma
    Daniel J Brat
    Arch Pathol Lab Med 130:437-8. 2006
  71. ncbi request reprint Galectin-3 expression is ubiquitous in tumors of the sellar region, nervous system, and mimics: an immunohistochemical and RT-PCR study
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 32:1344-52. 2008
    ..Diagnostic uses of this marker may be limited to specific settings, including some meningioma subtypes and nerve sheath tumors...
  72. pmc Depletion of peripheral macrophages and brain microglia increases brain tumor titers of oncolytic viruses
    Giulia Fulci
    Molecular Neuro oncology Laboratories, Neurosurgery Service, and Center for Molecular Imaging, Massachusetts General Hospital, Charlestown, Massachusetts, USA
    Cancer Res 67:9398-406. 2007
    ..In support of this new therapeutic paradigm, we observed intratumoral up-regulation of CD68+ and CD163+ cells following treatment with OV in a patient with glioblastoma...
  73. pmc The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice
    Andrew A Pieper
    Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 102:14052-7. 2005
    ..We propose that a deficiency in adult neurogenesis may cause the behavioral and neuroanatomical abnormalities seen in Npas3-/- mice, and we speculate that impaired neurogenesis may be involved in the pathophysiology of schizophrenia...
  74. ncbi request reprint Astroblastoma: radiologic-pathologic correlation and distinction from ependymoma
    John D Port
    Neuroradiology Division, Johns Hopkins Hospital, Baltimore, MD, USA
    AJNR Am J Neuroradiol 23:243-7. 2002
    ..The solid component of the mass has a bubbly appearance and a T2 signal that is isointense to gray matter. Punctate calcifications are often present. Neuroradiologists should be familiar with the characteristic appearance of this tumor...
  75. doi request reprint Protocol for the examination of specimens from patients with tumors of the brain/spinal cord
    Joseph E Parisi
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Arch Pathol Lab Med 132:907-12. 2008

Research Grants7

  1. Intravascular Thrombosis in Glioblastoma
    Daniel Brat; Fiscal Year: 2005
    ..Our emerging model represents a paradigm shift in the understanding of GBM and should lead directly to more effective therapies. ..
  2. Comparative DNA Microarray Analysis of Brain Tumors
    Daniel Brat; Fiscal Year: 2006
    ....
  3. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel Brat; Fiscal Year: 2006
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. [unreadable] [unreadable]..
  4. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel Brat; Fiscal Year: 2007
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. [unreadable] [unreadable]..
  5. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel Brat; Fiscal Year: 2008
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
  6. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel Brat; Fiscal Year: 2009
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..
  7. Vaso-occlusive Mechanisms that Induce Hypoxia and Cause Glioma Progression.
    Daniel J Brat; Fiscal Year: 2010
    ..This proposal introduces entirely novel concepts that may explain the highly aggressive properties of GBM and suggests therapeutic approaches that could potentially stabilize its progression. ..