S D Boden

Summary

Affiliation: Emory University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, USA
    Spine (Phila Pa 1976) 24:1179-85. 1999
  2. ncbi request reprint The use of coralline hydroxyapatite with bone marrow, autogenous bone graft, or osteoinductive bone protein extract for posterolateral lumbar spine fusion
    S D Boden
    Emory Spine Center, Department of Orthopaedic Surgery, Emory University School of Medicine, Georgia, USA
    Spine (Phila Pa 1976) 24:320-7. 1999
  3. ncbi request reprint Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Tissue Eng 6:383-99. 2000
  4. ncbi request reprint The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 25:376-81. 2000
  5. ncbi request reprint Reversing the inhibitory effect of nicotine on spinal fusion using an osteoinductive protein extract
    D H Silcox
    Emory Spine Center, Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 23:291-6; discussion 297. 1998
  6. ncbi request reprint Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1)
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 23:2486-92. 1998
  7. ncbi request reprint 1995 Volvo Award in basic sciences. The use of an osteoinductive growth factor for lumbar spinal fusion. Part II: Study of dose, carrier, and species
    S D Boden
    Department of Orthopaedics, Emory University School of Medicine, Decatur, Georgia, USA
    Spine (Phila Pa 1976) 20:2633-44. 1995
  8. ncbi request reprint Experimental spinal fusion with recombinant human bone morphogenetic protein-2
    J H Schimandle
    Emory Spine Center, Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:1326-37. 1995
  9. ncbi request reprint LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation
    S D Boden
    Emory University School of Medicine, Department of Orthopaedic Surgery, and Atlanta Veterans Affairs Medical Center, Decatur, Georgia 30033, USA
    Endocrinology 139:5125-34. 1998
  10. ncbi request reprint New formulations of demineralized bone matrix as a more effective graft alternative in experimental posterolateral lumbar spine arthrodesis
    G J Martin
    Department of Orthopaedic Surgery and Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 24:637-45. 1999

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Posterolateral lumbar intertransverse process spine arthrodesis with recombinant human bone morphogenetic protein 2/hydroxyapatite-tricalcium phosphate after laminectomy in the nonhuman primate
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, USA
    Spine (Phila Pa 1976) 24:1179-85. 1999
    ..Even in the presence of a laminectomy defect, there was no evidence of bone induction outside the confines of the ceramic carrier...
  2. ncbi request reprint The use of coralline hydroxyapatite with bone marrow, autogenous bone graft, or osteoinductive bone protein extract for posterolateral lumbar spine fusion
    S D Boden
    Emory Spine Center, Department of Orthopaedic Surgery, Emory University School of Medicine, Georgia, USA
    Spine (Phila Pa 1976) 24:320-7. 1999
    ..A posterolateral lumbar arthrodesis animal model using coralline hydroxyapatite as a bone graft substitute...
  3. ncbi request reprint Biology of lumbar spine fusion and use of bone graft substitutes: present, future, and next generation
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia 30033, USA
    Tissue Eng 6:383-99. 2000
    ..This strategy of local gene therapy may provide a basis for the next generation of bone graft substitutes...
  4. ncbi request reprint The use of rhBMP-2 in interbody fusion cages. Definitive evidence of osteoinduction in humans: a preliminary report
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 25:376-81. 2000
    ..A prospective randomized controlled human clinical pilot trial...
  5. ncbi request reprint Reversing the inhibitory effect of nicotine on spinal fusion using an osteoinductive protein extract
    D H Silcox
    Emory Spine Center, Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 23:291-6; discussion 297. 1998
    ..This study shows that the inhibitory effect of nicotine can be overcome with an osteoinductive bone growth factor in an animal model...
  6. ncbi request reprint Lumbar spine fusion by local gene therapy with a cDNA encoding a novel osteoinductive protein (LMP-1)
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 23:2486-92. 1998
    ..Furthermore, these results demonstrate that posterior thoracic or lumbar spine fusion can be achieved in rats by local delivery of the LMP-1 cDNA...
  7. ncbi request reprint 1995 Volvo Award in basic sciences. The use of an osteoinductive growth factor for lumbar spinal fusion. Part II: Study of dose, carrier, and species
    S D Boden
    Department of Orthopaedics, Emory University School of Medicine, Decatur, Georgia, USA
    Spine (Phila Pa 1976) 20:2633-44. 1995
    ..The achievement of posterolateral spinal fusion in the rhesus monkey using an osteoinductive growth factor is a significant step toward the biologic enhancement of spinal fusion in humans...
  8. ncbi request reprint Experimental spinal fusion with recombinant human bone morphogenetic protein-2
    J H Schimandle
    Emory Spine Center, Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:1326-37. 1995
    ..Fusions achieved with recombinant human bone morphogenetic protein-2 were biomechanically stronger and stiffer than autograft fusions...
  9. ncbi request reprint LMP-1, a LIM-domain protein, mediates BMP-6 effects on bone formation
    S D Boden
    Emory University School of Medicine, Department of Orthopaedic Surgery, and Atlanta Veterans Affairs Medical Center, Decatur, Georgia 30033, USA
    Endocrinology 139:5125-34. 1998
    ..These data demonstrate that LMP-1 is an essential positive regulator of the osteoblast differentiation program as well as an important intermediate step in the BMP-6 signaling pathway...
  10. ncbi request reprint New formulations of demineralized bone matrix as a more effective graft alternative in experimental posterolateral lumbar spine arthrodesis
    G J Martin
    Department of Orthopaedic Surgery and Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 24:637-45. 1999
    ..These newer formulations of Grafton appear to have a greater capacity to form bone than the gel form or autogenous bone graft alone in this model...
  11. ncbi request reprint Do the intervertebral disc cells respond to different levels of hydrostatic pressure?
    W C Hutton
    Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Clin Biomech (Bristol, Avon) 16:728-34. 2001
    ..To test the hypothesis that hydrostatic pressure directly affects the synthesis of collagen and proteoglycan by intervertebral disc cells...
  12. ncbi request reprint Recombinant human bone morphogenetic protein-2 overcomes the inhibitory effect of ketorolac, a nonsteroidal anti-inflammatory drug (NSAID), on posterolateral lumbar intertransverse process spine fusion
    G J Martin
    Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 24:2188-93; discussion 2193-4. 1999
    ..On the basis of these data, caution is urged in the routine use of nonsteroidal anti-inflammatory drugs for postoperation analgesia in patients undergoing spine arthrodesis...
  13. ncbi request reprint Adenoviral delivery of LIM mineralization protein-1 induces new-bone formation in vitro and in vivo
    M Viggeswarapu
    Department of Orthopaedic Surgery, Emory Spine Center, Emory University School of Medicine, Decatur, GA 30033, USA
    J Bone Joint Surg Am 83:364-76. 2001
    ..CONCLUSIONS: Adenoviral delivery of LMP-1 cDNA promotes spinal fusion in immune-competent rabbits...
  14. ncbi request reprint The effect of nicotine on spinal fusion
    D H Silcox
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:1549-53. 1995
    ..The results suggested that bone formed in the face of systemic nicotine may have inferior biomechanic properties...
  15. ncbi request reprint 1995 Volvo Award in basic sciences. The use of an osteoinductive growth factor for lumbar spinal fusion. Part I: Biology of spinal fusion
    S D Boden
    Department of Orthopaedics, Emory University School of Medicine, Decatur, Georgia, USA
    Spine (Phila Pa 1976) 20:2626-32. 1995
    ..This enhanced understanding of the biology of spinal fusion with autogenous bone graft will provide a foundation for optimizing the use of osteoinductive bone growth factors in this healing process...
  16. ncbi request reprint Video-assisted lateral intertransverse process arthrodesis. Validation of a new minimally invasive lumbar spinal fusion technique in the rabbit and nonhuman primate (rhesus) models
    S D Boden
    Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 21:2689-97. 1996
    ....
  17. ncbi request reprint Spine fusion by gene therapy
    S T Yoon
    Department of Orthopaedic Surgery, The Emory Spine Center, Atlanta, GA 30033, USA
    Gene Ther 11:360-7. 2004
    ..Finally, a strategy for in vitro and in vivo testing must be developed to maximize the chances of success in human trials...
  18. ncbi request reprint Experimental posterolateral lumbar spinal fusion with a demineralized bone matrix gel
    M A Morone
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 23:159-67. 1998
    ..However, demineralized bone matrix did not increase the frequency of successful fusion when added to the standard amount of autograft...
  19. ncbi request reprint A rabbit model for nonunion of lumbar intertransverse process spine arthrodesis
    M A Feiertag
    The Emory Spine Center, Department of Orthopaedics, Emory University, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 21:27-31. 1996
    ..With respect to excessive motion as a promoter of nonunion in spine arthrodeses, the early postoperative time period appears critical...
  20. ncbi request reprint The effect of nicotine on incorporation of cancellous bone graft in an animal model
    G D Riebel
    Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:2198-202. 1995
    ..3) The vascular effects are reversible within 2 weeks of elimination of nicotine, although late bony resorption continues beyond the time of high serum nicotine levels...
  21. ncbi request reprint An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics
    S D Boden
    Emory Spine Center, Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:412-20. 1995
    ..This model provides an opportunity to explore questions relevant to the biology of intertransverse process fusion and to investigate the coupling of the membranous and endochondral mechanisms of bone formation during spinal fusion...
  22. ncbi request reprint The effect of hydrostatic pressure on intervertebral disc metabolism
    W C Hutton
    Department of Orthopaedics, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 24:1507-15. 1999
    ..CONCLUSIONS: Hydrostatic pressure directly affects the synthesis of collagen and proteoglycan by the intervertebral disc cells...
  23. ncbi request reprint Spine update. The use of animal models to study spinal fusion
    J H Schimandle
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia
    Spine (Phila Pa 1976) 19:1998-2006. 1994
    ..A valid animal model will prove essential in studying the use of growth factors for spinal fusion. The ultimate goal is that fusion nonunions will no longer be of clinical concern...
  24. ncbi request reprint Biologic enhancement of spinal fusion
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:113S-123S. 1995
    ..The feasibility of biologic enhancement of spinal fusion with osteoinductive growth factors has been shown in animals. CONCLUSION: The efficacy of bone growth factors for lumbar fusion remains to be definitively established in humans...
  25. ncbi request reprint Molecular biology and spinal disorders. A survey for the clinician
    D A Altman
    Emory Spine Center, Department of Orthopaedic Surgery, Emory University School of Medicine, USA
    Spine (Phila Pa 1976) 24:723-30. 1999
    ..The intent of this update is to provide the spine clinician with a basic understanding of molecular biology, the type of information that may be learned from its application, and the potential for gene therapy in spine disorders...
  26. ncbi request reprint Rheumatoid arthritis of the cervical spine. Surgical decision making based on predictors of paralysis and recovery
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Emory Spine Center, Atlanta, Georgia
    Spine (Phila Pa 1976) 19:2275-80. 1994
    ..An improved understanding of the natural history, physical findings, and radiographic parameters will allow the construction of a management strategy for timely intervention in rheumatoid patients with progressive cervical disease...
  27. ncbi request reprint Spine update. Animal use in spinal research
    J H Schimandle
    Emory Spine Center, Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia
    Spine (Phila Pa 1976) 19:2474-7. 1994
    ..Animal data are only as applicable as the model from which it is derived. Thus, future animal models must be carefully chosen using rational guidelines and should overcome the deficiencies and limitations of previous models...
  28. ncbi request reprint Biologic factors affecting spinal fusion and bone regeneration
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 20:102S-112S. 1995
    ..CONCLUSIONS: Future research should focus on expanding our existing knowledge pertaining to the basic biology of bone regeneration specific to spinal fusion...
  29. ncbi request reprint Glucocorticoid-induced differentiation of fetal rat calvarial osteoblasts is mediated by bone morphogenetic protein-6
    S D Boden
    Department of Orthopaedic Surgery, Emory University School of Medicine and Veterans Affairs Medical Center, Atlanta, Georgia 30033, USA
    Endocrinology 138:2820-8. 1997
    ..We conclude that GC-induced differentiation of osteoblasts from the pluripotent precursors is mediated, in part, by BMP-6. These results suggest that BMP-6 has an important and unique role during early osteoblast differentiation...
  30. ncbi request reprint The outcome of posterolateral fusion in highly selected patients with discogenic low back pain
    L M Parker
    Department of Orthopaedic Surgery, Emory Spine Center, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 21:1909-16; discussion 1916-7. 1996
    ..Prospective and randomized study with objective pain criteria, independent review, and patient-oriented outcome is recommended...
  31. ncbi request reprint Inflammatory disorders of the cervical spine
    M F Reiter
    Department of Orthopaedic Surgery, Emory Spine Center, Emory University School of Medicine, Atlanta, Georgia, USA
    Spine (Phila Pa 1976) 23:2755-66. 1998
    ..The current surgical procedures available to treat these conditions are discussed with emphasis on distinguishing those cases in which stabilization alone is required from those in which a decompression procedure is also necessary...