Research Topics
Genomes and Genes
| Elisabeth B BinderSummaryAffiliation: Emory University Country: USA Publications
Research Grants
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Detail Information
Publications
Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatmentElisabeth B Binder
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
Nat Genet 36:1319-25. 2004..These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs...
Gender-specific association of galanin polymorphisms with HPA-axis dysregulation, symptom severity, and antidepressant treatment responsePaul G Unschuld
Max Planck Institute of Psychiatry, Munchen, Germany
Neuropsychopharmacology 35:1583-92. 2010..The reported associations in independent samples of AD and MDD support an estrogen-dependent function of GAL in pathophysiology of anxiety and depression, affecting response to antidepressant treatment...
Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment responseElisabeth B Binder
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
Arch Gen Psychiatry 67:369-79. 2010..The corticotropin-releasing factor (CRF, or corticotropin-releasing hormone) and arginine vasopressin systems have been implicated in the pathophysiology of anxiety and depressive disorders and response to antidepressant treatment...- Association of polymorphisms in P2RX7 and CaMKKb with anxiety disordersAngelika Erhardt
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, D 80804 München, Germany
J Affect Disord 101:159-68. 2007..This region contains two candidate genes for purinergic ligand-gated ion channels, P2RX7 and P2RX4, and one gene coding for calmodulin-dependent protein kinase kinase b (CaMKKb)... - A genomewide association study points to multiple loci that predict antidepressant drug treatment outcome in depressionMarcus Ising
Max Planck Institute of Psychiatry, Munich 80804, Germany
Arch Gen Psychiatry 66:966-75. 2009..Genetic factors and clinical characteristics contribute to the failure of a favorable treatment outcome... - Polymorphisms in the galanin gene are associated with symptom-severity in female patients suffering from panic disorderPaul G Unschuld
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 München, Germany
J Affect Disord 105:177-84. 2008..Furthermore, GAL is involved in hypothalamic-hypophysiotropic signalling and cosecreted with luteinizing hormone-releasing hormone (LHRH), possibly acting as a mediator of estrogen action... - Polymorphisms within the metabotropic glutamate receptor 1 gene are associated with depression phenotypesAndreas Menke
Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
Psychoneuroendocrinology 37:565-75. 2012.... - Dexamethasone stimulated gene expression in peripheral blood is a sensitive marker for glucocorticoid receptor resistance in depressed patientsAndreas Menke
Moleculargenetics of Affective Disorders, Max Planck Institute of Psychiatry, Kraepelinstr, Munich, Germany
Neuropsychopharmacology 37:1455-64. 2012.... - Association of genetic variants in the neurotrophic receptor-encoding gene NTRK2 and a lifetime history of suicide attempts in depressed patientsMartin A Kohli
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D 80804 Munich, Germany
Arch Gen Psychiatry 67:348-59. 2010..Especially in suicide victims, lower postmortem brain messenger RNA and protein levels of neurotrophins and their receptors have been reported... - Polymorphisms in GRIK4, HTR2A, and FKBP5 show interactive effects in predicting remission to antidepressant treatmentSonja Horstmann
Max Planck Institute of Psychiatry, Munich, Germany
Neuropsychopharmacology 35:727-40. 2010.... - Using polymorphisms in FKBP5 to define biologically distinct subtypes of posttraumatic stress disorder: evidence from endocrine and gene expression studiesDivya Mehta
Max Planck Institute of Psychiatry, Kraepelinstrasse, Munich, Germany
Arch Gen Psychiatry 68:901-10. 2011..Polymorphisms in the gene encoding the glucocorticoid receptor (GR) regulating co-chaperone FKBP5 have been shown to alter GR sensitivity and are associated with an increased risk to develop posttraumatic stress disorder (PTSD)... - Combined effects of exonic polymorphisms in CRHR1 and AVPR1B genes in a case/control study for panic disorderMartin E Keck
Max Planck Institute of Psychiatry, Munich, Germany
Am J Med Genet B Neuropsychiatr Genet 147:1196-204. 2008..These data suggest that polymorphisms in the AVPR1B and the CRHR1 genes alter the susceptibility to panic disorder... - Polymorphisms in the serotonin receptor gene HTR2A are associated with quantitative traits in panic disorderPaul G Unschuld
Max Planck Institute of Psychiatry, Munchen, Germany
Am J Med Genet B Neuropsychiatr Genet 144:424-9. 2007..These results further underline a possible important role of genetic variations within the system controlling serotonergic neurotransmission for the development and course of disease in PD... - Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depressionManfred Uhr
Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
Neuron 57:203-9. 2008..This finding can be viewed as a further step into personalized antidepressant treatment... - Clinical characteristics and treatment outcome in a representative sample of depressed inpatients - findings from the Munich Antidepressant Response Signature (MARS) projectJohannes M Hennings
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
J Psychiatr Res 43:215-29. 2009..We demonstrated that this subgroup can be characterized by a set of demographic, clinical and neuroendocrine variables allowing to predict unfavorable outcome at an early stage of treatment... - Combined dexamethasone/corticotropin releasing hormone test predicts treatment response in major depression - a potential biomarker?Marcus Ising
Max Planck Institute of Psychiatry, Munich, Germany
Biol Psychiatry 62:47-54. 2007..In the present study, we examined whether change in HPA system function during the first weeks of hospitalization predicts response to antidepressant treatment in major depression and thus constitutes a potential biomarker... - The neuronal transporter gene SLC6A15 confers risk to major depressionMartin A Kohli
Max Planck Institute of Psychiatry, D 80804 Munich, Germany
Neuron 70:252-65. 2011..Our convergent data from human genetics, expression studies, brain imaging, and animal models suggest a pathophysiological mechanism for MD that may be accessible to drug targeting... - Regulation of the hypothalamic-pituitary-adrenocortical system in patients with panic disorderAngelika Erhardt
Max Planck Institute of Psychiatry, Munich, Germany
Neuropsychopharmacology 31:2515-22. 2006..However, differences in the suppression effects and psychopathological correlation patterns between depressed and panic patients suggest different biological mechanisms of HPA system dysregulation in both disorders... - Successful antidepressant therapy restores the disturbed interplay between TNF-alpha system and HPA axisHubertus Himmerich
Max Planck Institute of Psychiatry, Munich, Germany
Biol Psychiatry 60:882-8. 2006.... - Genome-wide association study of antidepressant treatment-emergent suicidal ideationAndreas Menke
Max Planck Institute of Psychiatry, Munich, Germany
Neuropsychopharmacology 37:797-807. 2012..Although our data need to be interpreted carefully owing to the small numbers in both cohorts, they suggest that a combination of genetic markers might indeed be used to identify patients at risk for TESI... - Polymorphisms in the GAD2 gene-region are associated with susceptibility for unipolar depression and with a risk factor for anxiety disordersPaul G Unschuld
Max Planck Institute of Psychiatry, Munchen, Germany
Am J Med Genet B Neuropsychiatr Genet 150:1100-9. 2009..However, data from expression studies imply that these polymorphisms could tag functional effects on the neighboring gene MYO3A, which is also expressed in the brain, including the cingulate cortex and the amygdala... - Rare variants in TMEM132D in a case-control sample for panic disorderCarina Quast
Max Planck Institute of Psychiatry, Munich, Germany
Am J Med Genet B Neuropsychiatr Genet 159:896-907. 2012..Our data suggest that not only common but also putatively functional and/or rare variants within TMEM132D might contribute to the risk to develop anxiety disorders. © 2012 Wiley Periodicals, Inc... - Association of a Met88Val diazepam binding inhibitor (DBI) gene polymorphism and anxiety disorders with panic attacksChristoph K Thoeringer
Max Planck Institute of Psychiatry, Munich 80804, Germany
J Psychiatr Res 41:579-84. 2007..43; 95% CI: 0.19-0.95). In conclusion, these results suggest a central role of DBI genetic variants in the susceptibility for the development of anxiety disorders that are characterized by the occurrence of panic attacks... - Interaction of FKBP5 gene variants and adverse life events in predicting depression onset: results from a 10-year prospective community studyPetra Zimmermann
Max Planck Institute of Psychiatry, Munich, Germany
Am J Psychiatry 168:1107-16. 2011..The authors explored gene-environment interactions between FKBP5 gene variants and adverse life events in predicting the first occurrence of a major depressive episode... - Expression and regulation of the Fkbp5 gene in the adult mouse brainSebastian H Scharf
Research Group Molecular Stress Physiology, Max Planck Institute of Psychiatry, Munich, Germany
PLoS ONE 6:e16883. 2011.... - The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disordersElisabeth B Binder
Max Planck Institute of Psychiatry, Munich, Germany
Psychoneuroendocrinology 34:S186-95. 2009..In addition, they are also associated with faster response to antidepressant treatment. FKBP5 might thus be an interesting therapeutic target for the prevention and treatment of stress-related psychiatric disorders... - The combined dexamethasone/CRH test as a potential surrogate marker in depressionMarcus Ising
Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
Prog Neuropsychopharmacol Biol Psychiatry 29:1085-93. 2005..Further systematic research is required and already ongoing to confirm the suitability of the combined dex/CRH test as a surrogate marker in depression... - Hypothalamus-pituitary-adrenal system regulation and suicidal behavior in depressionAndrea Pfennig
Max Planck Institute of Psychiatry, Munich, Germany
Biol Psychiatry 57:336-42. 2005..So far data on the involvement of the HPA axis in the pathophysiology of suicidal behavior in depressed patients are controversial... - P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorderSusanne Lucae
The Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Hum Mol Genet 15:2438-45. 2006..This polymorphism results in an amino acid exchange in the C-terminal cytosolic domain of the P2RX7 channel protein, suggesting that the observed P2RX7 polymorphism might play a causal role in the development of depression... - Pharmacogenomics of antidepressant drugsSonja Horstmann
Max Planck Institute of Psychiatry, Munich, Germany
Pharmacol Ther 124:57-73. 2009..Illustrated by examples from current candidate gene- and whole genome association studies, this manuscript critically discusses aspects of pharmacogenetic studies in antidepressant response related to study design and clinical relevance... - Toward a reliable distinction between patients with mild cognitive impairment and Alzheimer-type dementia versus major depressionAnke Post
Max Planck Institute of Psychiatry, Munich, Germany
Biol Psychiatry 59:858-62. 2006..CONCLUSIONS: Soluble amyloid precursor protein/APLP2 and alpha-sAPP concentrations in CSF can differentiate between DAT and MCI versus MDE, facilitating early ameliorative interventions and appropriate treatment regimens... - The 5-HTTLPR polymorphism modulates the influence on environmental stressors on peripartum depression symptomsDivya Mehta
Max Planck Institute of Psychiatry, Munich, Germany
J Affect Disord 136:1192-7. 2012..The aim of this study was to evaluate the influence of stressful life events in combination with the serotonin transporter gene 5-HTTLPR polymorphism on peripartum depressive symptoms... - Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactionsTorsten Klengel
Max Planck Institute of Psychiatry, Munich, Germany
Nat Neurosci 16:33-41. 2013..This identification of molecular mechanisms of genotype-directed long-term environmental reactivity will be useful for designing more effective treatment strategies for stress-related disorders... - A beginners guide to SNP calling from high-throughput DNA-sequencing dataAndre Altmann
Statistical Genetics, Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Hum Genet 131:1541-54. 2012..To this end, we employ several alignment programs and SNP calling routines for highlighting the fact that the choice of the tools significantly affects the final results... - Peripheral blood gene expression: it all boils down to the RNA collection tubesAndreas Menke
Max Planck Institute of Psychiatry, Kraepelinstr, 10, D 80804 Munich, Germany
BMC Res Notes 5:1. 2012..abstract:.. - vipR: variant identification in pooled DNA using RAndre Altmann
Department of Statistical Genetics, Max Planck Institute of Psychiatry, Munich, Germany
Bioinformatics 27:i77-84. 2011..The resulting sequence data, however, poses a bioinformatics challenge: the discrimination of sequencing errors from real sequence variants present at a low frequency in the DNA pool... - Polymorphisms in CRHR1 and the serotonin transporter loci: gene x gene x environment interactions on depressive symptomsKerry J Ressler
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 954 Gatewood Drive, Atlanta, GA 30329, USA
Am J Med Genet B Neuropsychiatr Genet 153:812-24. 2010.... - Post-traumatic stress disorder is associated with PACAP and the PAC1 receptorKerry J Ressler
Howard Hughes Medical Institute, Chevy Chase, Maryland 20815, USA
Nature 470:492-7. 2011..These sex-specific effects may occur via oestrogen regulation of ADCYAP1R1. PACAP levels and ADCYAP1R1 SNPs may serve as useful biomarkers to further our mechanistic understanding of PTSD... - Gene × environment vulnerability factors for PTSD: the HPA-axisDivya Mehta
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Neuropharmacology 62:654-62. 2012..This article is part of a Special Issue entitled 'Post-Traumatic Stress Disorder'... - Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919)Anke Post
Max Planck Institute of Psychiatry, Kraepelinstrasse 10, 80804 Munich, Germany
Psychopharmacology (Berl) 180:150-8. 2005.... - Individual stress vulnerability is predicted by short-term memory and AMPA receptor subunit ratio in the hippocampusMathias V Schmidt
Research Group Neurobiology of Stress, Max Planck Institute of Psychiatry, 80804 Munich, Germany
J Neurosci 30:16949-58. 2010..Those individual differences can be predicted by the assessment of short-term memory, thereby opening up the possibility for a specific treatment by enhancing AMPA receptor function... - Gene expression studies in major depressionDivya Mehta
Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
Curr Psychiatry Rep 12:135-44. 2010..Finally, we discuss possible new strategies for the gene expression studies in MD that circumvent some of the addressed issues... - Epigenetics, depression and antidepressant treatmentAndreas Menke
Max Planck Institute of Psychiatry, Kraepelinstr 10, D 80804 Munich, Germany
Curr Pharm Des 18:5879-89. 2012..Most notably, epigenetic alterations are potentially reversible and accessibe for drug treatment, which lead to the development of novel classes of antidepressant drugs... - ABCB1 (MDR1)-type P-glycoproteins at the blood-brain barrier modulate the activity of the hypothalamic-pituitary-adrenocortical system: implications for affective disorderMarianne B Muller
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Neuropsychopharmacology 28:1991-9. 2003.... - Effects of neurotensin receptor antagonism on latent inhibition in Sprague-Dawley ratsElisabeth B Binder
Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
Psychopharmacology (Berl) 161:288-95. 2002..A critical test of this hypothesis would be to determine if NT is involved in the expression of latent inhibition (LI), a psychophysiological and pharmacological model of schizophrenia... - Polymorphisms of the glucocorticoid receptor gene and major depressionElisabeth F C van Rossum
Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
Biol Psychiatry 59:681-8. 2006..The N363S and BclI polymorphisms have been associated with hypersensitivity to glucocorticoids, whereas the ER22/23EK polymorphism is related to glucocorticoid resistance... - Pharmacogenomics and antidepressant drugsElisabeth B Binder
Max-Planck Institute of Psychiatry, Munich, Germany
Ann Med 38:82-94. 2006..These studies mark the beginning of an emerging standard SNP profiling system that ultimately allows identifying the right drug for the right patient at the right time... - Changes in the hypothalamic-pituitary-adrenal axis and leptin levels during antidepressant treatmentHubertus Himmerich
Max Planck Institut fur Psychiatrie, Munchen, Deutschland
Neuropsychobiology 55:28-35. 2007..Glucocorticoids themselves are reported to increase leptin synthesis and secretion in humans... - Influence of child abuse on adult depression: moderation by the corticotropin-releasing hormone receptor geneRebekah G Bradley
Atlanta VA Medical Center, Georgia, USA
Arch Gen Psychiatry 65:190-200. 2008..Child abuse and trauma alter the endogenous stress response, principally corticotropin-releasing hormone and its downstream effectors, suggesting that a gene x environment interaction at this locus may be important in depression... - Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adultsElisabeth B Binder
Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia 30329, USA
JAMA 299:1291-305. 2008..Both genetic and environmental factors are contributory, with child abuse providing significant risk liability... - Evidence for a relationship between genetic variants at the brain-derived neurotrophic factor (BDNF) locus and major depressionJohannes Schumacher
Institute of Human Genetics, University of Bonn, Bonn
Biol Psychiatry 58:307-14. 2005.... - Neurotensin receptor antagonist SR 142948A alters Fos expression and extrapyramidal side effect profile of typical and atypical antipsychotic drugsElisabeth B Binder
Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuropsychopharmacology 29:2200-7. 2004..The effects of the NT receptor antagonist were paralleled by its effects on catalepsy in olanzapine--but not haloperidol--treated animals... - Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideationAndreas Menke
Am J Psychiatry 165:917-8. 2008
Research Grants
- Peri-Partum Depression and Genetics of Glucocorticoid Receptor Regulating GenesElisabeth Binder; Fiscal Year: 2007..Such 'a priori' identification of women at risk will directly contribute to treatment planning and enhancement of perinatal health, obstetrical outcome, and infant well-being. ..