E B Binder

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA
    Trials 13:106. 2012
  2. pmc The genetic basis of mood and anxiety disorders - changing paradigms
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Munich Germany and Dept, of Psychiatry and Behavioral Sciences Emory University School of Medicine, Atlanta, GA, USA
    Biol Mood Anxiety Disord 2:17. 2012
  3. pmc The CRF system, stress, depression and anxiety-insights from human genetic studies
    E B Binder
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:574-88. 2010
  4. doi request reprint Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Arch Gen Psychiatry 67:369-79. 2010
  5. doi request reprint HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients
    E B Binder
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D80804 Munich, Germany
    Psychoneuroendocrinology 34:99-109. 2009
  6. doi request reprint Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
    S Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:736-47. 2010
  7. doi request reprint TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
    A Erhardt
    Max Planck Institute of Psychiatry, Munchen, Germany
    Mol Psychiatry 16:647-63. 2011
  8. ncbi request reprint Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating
    E B Binder
    Max Planck Institute for Psychiatry, 80804 Munich, Germany
    J Neurosci 21:601-8. 2001
  9. doi request reprint Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression
    A Menke
    Department of Molecular Genetics of Affective Disorders, Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Genes Brain Behav 12:289-96. 2013
  10. pmc The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders
    C K Thoeringer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Neural Transm 116:649-57. 2009

Collaborators

Detail Information

Publications18

  1. pmc Predictors of remission in depression to individual and combined treatments (PReDICT): study protocol for a randomized controlled trial
    Boadie W Dunlop
    Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1256 Briarcliff Road, Building A, 3rd Floor, Atlanta, GA 30306, USA
    Trials 13:106. 2012
    ..Consequently, we initiated a randomized clinical trial designed to identify factors that moderate response to three treatments for MDD among patients never treated previously for the condition...
  2. pmc The genetic basis of mood and anxiety disorders - changing paradigms
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Munich Germany and Dept, of Psychiatry and Behavioral Sciences Emory University School of Medicine, Atlanta, GA, USA
    Biol Mood Anxiety Disord 2:17. 2012
    ....
  3. pmc The CRF system, stress, depression and anxiety-insights from human genetic studies
    E B Binder
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:574-88. 2010
    ..In-depth characterization of these variants will likely be important in furthering our understanding of the long-term consequences of adverse experience...
  4. doi request reprint Association of polymorphisms in genes regulating the corticotropin-releasing factor system with antidepressant treatment response
    Elisabeth B Binder
    Max Planck Institute of Psychiatry, Kraepelinstr 2 10, 80804 Munich, Germany
    Arch Gen Psychiatry 67:369-79. 2010
    ..The corticotropin-releasing factor (CRF, or corticotropin-releasing hormone) and arginine vasopressin systems have been implicated in the pathophysiology of anxiety and depressive disorders and response to antidepressant treatment...
  5. doi request reprint HPA-axis regulation at in-patient admission is associated with antidepressant therapy outcome in male but not in female depressed patients
    E B Binder
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, D80804 Munich, Germany
    Psychoneuroendocrinology 34:99-109. 2009
    ..In male patients, a single measure of HPA-axis dysregulation at admission may serve as a predictor of response to antidepressant treatment in addition to the previously reported repeated measure of the Dex-CRH test...
  6. doi request reprint Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression
    S Kloiber
    Max Planck Institute of Psychiatry, Munich, Germany
    Mol Psychiatry 15:736-47. 2010
    ..Identifying depressed patients at high risk for MetS using genetic variants could have direct clinical impact on individualized disease management and prevention strategies...
  7. doi request reprint TMEM132D, a new candidate for anxiety phenotypes: evidence from human and mouse studies
    A Erhardt
    Max Planck Institute of Psychiatry, Munchen, Germany
    Mol Psychiatry 16:647-63. 2011
    ..TMEM132D may thus be an important new candidate gene for PD as well as more generally for anxiety-related behavior...
  8. ncbi request reprint Enhanced neurotensin neurotransmission is involved in the clinically relevant behavioral effects of antipsychotic drugs: evidence from animal models of sensorimotor gating
    E B Binder
    Max Planck Institute for Psychiatry, 80804 Munich, Germany
    J Neurosci 21:601-8. 2001
    ..These novel findings, together with previous observations, suggest that neurotensin receptor agonists may represent a novel class of antipsychotic drugs...
  9. doi request reprint Genetic variation in FKBP5 associated with the extent of stress hormone dysregulation in major depression
    A Menke
    Department of Molecular Genetics of Affective Disorders, Max Planck Institute of Psychiatry, D 80804 Munich, Germany
    Genes Brain Behav 12:289-96. 2013
    ..This finding suggests that endocrine alterations in depressed patients are determined by genetic variants and may allow identification of specific subgroups...
  10. pmc The GABA transporter 1 (SLC6A1): a novel candidate gene for anxiety disorders
    C K Thoeringer
    Max Planck Institute of Psychiatry, Kraepelinstrasse 2 10, 80804 Munich, Germany
    J Neural Transm 116:649-57. 2009
    ..These data indicate a high load of genetic variance within SLC6A1 on pathological anxiety and highlight GAT-1 as a promising target for treatment of anxiety disorders with panic symptoms...
  11. ncbi request reprint Polymorphisms in the angiotensin-converting enzyme gene are associated with unipolar depression, ACE activity and hypercortisolism
    T C Baghai
    Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Munich, Germany
    Mol Psychiatry 11:1003-15. 2006
    ..We could show that SNP rs4291 influences ACE activity and HPA-axis hyperactivity and might therefore represent a common pathophysiologic link for unipolar depression and cardiovascular disease...
  12. pmc Convergent animal and human evidence suggests the activin/inhibin pathway to be involved in antidepressant response
    K Ganea
    Max Planck Institute of Psychiatry, Munich, Germany
    Transl Psychiatry 2:e177. 2012
    ..Further, our data suggest this pathway to be a target for more rapid-acting antidepressants in the future...
  13. ncbi request reprint Neurotensin and dopamine interactions
    E B Binder
    Laboratory of Neuropsychopharmacology, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Pharmacol Rev 53:453-86. 2001
    ..Last, because of the extensive literature on NT/DA interactions available in the rat, our discussion will be based primarily on studies using this species...
  14. ncbi request reprint Impaired divided attention predicts delayed response and risk to relapse in subjects with depressive disorders
    M Majer
    Max Planck Institute of Psychiatry, Munich, Germany
    Psychol Med 34:1453-63. 2004
    ..This study addresses the complex relationship between cognitive function and the course of depression...
  15. pmc Replication and meta-analysis of TMEM132D gene variants in panic disorder
    A Erhardt
    Max Planck Institute of Psychiatry, Munich, Germany
    Transl Psychiatry 2:e156. 2012
    ..Our results also indicate that patient ascertainment and genetic background could be important sources of heterogeneity modifying this association signal in different populations...
  16. doi request reprint Regulation of mRNA expression encoding chaperone and co-chaperone proteins of the glucocorticoid receptor in peripheral blood: association with depressive symptoms during pregnancy
    E R Katz
    Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta, GA, USA
    Psychol Med 42:943-56. 2012
    ..Major depressive disorder during pregnancy associates with potentially detrimental consequences for mother and child. The current study examined peripheral blood gene expression as a potential biomarker for prenatal depressive symptoms...
  17. ncbi request reprint Pharmacological and nonpharmacological factors influencing hypothalamic-pituitary-adrenocortical axis reactivity in acutely depressed psychiatric in-patients, measured by the Dex-CRH test
    H E Künzel
    Department of Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany
    Neuropsychopharmacology 28:2169-78. 2003
    ..Finally, more severe vegetative symptoms are associated with an enhanced HPA-axis activity...
  18. ncbi request reprint The role of neurotensin in the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs
    E B Binder
    Max Planck Institute for Psychiatry, Munich, Germany
    Biol Psychiatry 50:856-72. 2001
    ..This review summarizes the evidence in support of a role for the NT system in both the pathophysiology of schizophrenia and the mechanism of action of antipsychotic drugs...