RANJITA S BETARBET

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Animal models of Parkinson's disease
    Ranjita Betarbet
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Bioessays 24:308-18. 2002
  2. pmc Fas-associated factor 1 and Parkinson's disease
    Ranjita Betarbet
    Center for Neurodegenerative Disease, Emory University, Whitehead Biomedical Research Building, Room 505G, 615 Michael Street, Atlanta, Georgia 30322, USA
    Neurobiol Dis 31:309-15. 2008
  3. ncbi request reprint Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system
    Ranjita Betarbet
    Center for Neurodegenerative Disease, Center for Neurodegenerative Diseases, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    Neurobiol Dis 22:404-20. 2006
  4. ncbi request reprint Ubiquitin-proteasome system and Parkinson's diseases
    Ranjita Betarbet
    Center for Neurodegenerative Disease, Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 191:S17-27. 2005
  5. ncbi request reprint Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP
    Ranjita Betarbet
    Department of Neurology and Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 189:393-403. 2004
  6. ncbi request reprint Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson's disease
    Ranjita Betarbet
    Department of Neurology and the Center for Neurodegenerative Disease, Emory University, Atlanta GA 30322, USA
    Exp Neurol 187:76-85. 2004
  7. ncbi request reprint Mechanistic approaches to Parkinson's disease pathogenesis
    Ranjita Betarbet
    Center for Neurodegenerative Disease and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Brain Pathol 12:499-510. 2002
  8. pmc RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells
    Elaine L Pranski
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 54:264-79. 2013
  9. ncbi request reprint Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    Todd B Sherer
    Center for Neurodegenerative Disease, Department of Neurology, Emory University, Atlanta, GA 30032, USA
    Exp Neurol 179:9-16. 2003
  10. ncbi request reprint An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    Todd B Sherer
    Center for Neurodegenerative Disease and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 22:7006-15. 2002

Detail Information

Publications20

  1. ncbi request reprint Animal models of Parkinson's disease
    Ranjita Betarbet
    Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Bioessays 24:308-18. 2002
    ..This review critically discusses animal models of PD and compares them with characteristics of the human disease...
  2. pmc Fas-associated factor 1 and Parkinson's disease
    Ranjita Betarbet
    Center for Neurodegenerative Disease, Emory University, Whitehead Biomedical Research Building, Room 505G, 615 Michael Street, Atlanta, Georgia 30322, USA
    Neurobiol Dis 31:309-15. 2008
    ..These studies, together with previous genetic linkage studies, highlight the potential significance of FAF1 in pathogenesis of idiopathic PD...
  3. ncbi request reprint Intersecting pathways to neurodegeneration in Parkinson's disease: effects of the pesticide rotenone on DJ-1, alpha-synuclein, and the ubiquitin-proteasome system
    Ranjita Betarbet
    Center for Neurodegenerative Disease, Center for Neurodegenerative Diseases, Whitehead Biomedical Research Building, 615 Michael Street, Atlanta, GA 30322, USA
    Neurobiol Dis 22:404-20. 2006
    ....
  4. ncbi request reprint Ubiquitin-proteasome system and Parkinson's diseases
    Ranjita Betarbet
    Center for Neurodegenerative Disease, Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 191:S17-27. 2005
    ..In vivo and in vitro studies have linked parkin, alpha-synuclein, and oxidative stress to a compromised UPS and PD pathogenesis suggesting novel therapeutic targets...
  5. ncbi request reprint Regulation of dopamine receptor and neuropeptide expression in the basal ganglia of monkeys treated with MPTP
    Ranjita Betarbet
    Department of Neurology and Center for Neurodegenerative Disease, Emory University, Atlanta, GA 30322, USA
    Exp Neurol 189:393-403. 2004
    ..Simultaneous study of the alterations in these various components of the 'direct' and 'indirect' pathways in the same animals will enable better understanding of the pathophysiology of PD and its therapeutic targets...
  6. ncbi request reprint Differential expression and ser897 phosphorylation of striatal N-methyl-d-aspartate receptor subunit NR1 in animal models of Parkinson's disease
    Ranjita Betarbet
    Department of Neurology and the Center for Neurodegenerative Disease, Emory University, Atlanta GA 30322, USA
    Exp Neurol 187:76-85. 2004
    ..Furthermore, the alterations observed in protein kinase A-dependent phosphorylation of NR1 are suggestive of receptor internalization and subcellular trafficking of NR1 in response to increased striatal glutamatergic activity...
  7. ncbi request reprint Mechanistic approaches to Parkinson's disease pathogenesis
    Ranjita Betarbet
    Center for Neurodegenerative Disease and Department of Neurology, Emory University, Atlanta, GA 30322, USA
    Brain Pathol 12:499-510. 2002
    ..A better understanding of the mechanisms underlying PD should reveal novel therapeutic targets...
  8. pmc RING finger protein 11 (RNF11) modulates susceptibility to 6-OHDA-induced nigral degeneration and behavioral deficits through NF-κB signaling in dopaminergic cells
    Elaine L Pranski
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neurobiol Dis 54:264-79. 2013
    ..This neuron-specific role of RNF11 in the brain has important implications for targeted therapeutics aimed at preventing neurodegeneration...
  9. ncbi request reprint Subcutaneous rotenone exposure causes highly selective dopaminergic degeneration and alpha-synuclein aggregation
    Todd B Sherer
    Center for Neurodegenerative Disease, Department of Neurology, Emory University, Atlanta, GA 30032, USA
    Exp Neurol 179:9-16. 2003
    ..Subcutaneous rotenone exposure caused alpha-synuclein-positive cytoplasmic aggregates in nigral neurons. This new protocol for chronic rotenone administration is a substantial improvement in terms of simplicity and throughput...
  10. ncbi request reprint An in vitro model of Parkinson's disease: linking mitochondrial impairment to altered alpha-synuclein metabolism and oxidative damage
    Todd B Sherer
    Center for Neurodegenerative Disease and Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 22:7006-15. 2002
    ....
  11. pmc Neuronal RING finger protein 11 (RNF11) regulates canonical NF-κB signaling
    Elaine L Pranski
    Center for Neurodegenerative Disease, Department of Neurology, Emory University School of Medicine, 615 Michael St, Suite 500, Atlanta, GA 30322, USA
    J Neuroinflammation 9:67. 2012
    ....
  12. pmc A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease
    Pier Giorgio Mastroberardino
    Department of Neurology, University of Pittsburgh, 3501 Fifth Avenue, Pittsburgh, PA 15260, USA
    Neurobiol Dis 34:417-31. 2009
    ..Thus, we have discovered a novel mitochondrial iron transport system that goes awry in PD, and which may provide a new target for therapeutic intervention...
  13. pmc RNF11 modulates microglia activation through NF-κB signalling cascade
    Nirjari V Dalal
    Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, United States
    Neurosci Lett 528:174-9. 2012
    ..Thus our investigations clearly demonstrated that microglial RNF11 is a negative regulator of NF-κB signalling pathway and could be a strong potential target for modulating inflammatory responses in neurodegenerative diseases...
  14. ncbi request reprint Selective microglial activation in the rat rotenone model of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Emory University, 30322, Atlanta, GA, USA
    Neurosci Lett 341:87-90. 2003
    ..Reactive astrocytosis was minimal and limited to a thin rim around the lesion. Marked microglial activation with minimal astrocytosis is another pathological feature of PD reproduced by rotenone treatment...
  15. ncbi request reprint Environment, mitochondria, and Parkinson's disease
    Todd B Sherer
    Department of Neurology, Emory University, Atlanta, Georgia 30322, USA
    Neuroscientist 8:192-7. 2002
    ..Complex I defects may result in oxidative stress and increase the susceptibility of neurons to excitotoxic death. In this way, environmental exposures and mitochondrial dysfunction may interact and result in neurodegeneration...
  16. ncbi request reprint The rotenone model of Parkinson's disease: genes, environment and mitochondria
    J Timothy Greenamyre
    Center for Neurodegenerative Disease, Emory University, 615 Michael Street, Room 505M, Atlanta, GA 30322, USA
    Parkinsonism Relat Disord 9:S59-64. 2003
    ..If so, protective strategies devised for one type of PD may be broadly useful for other forms of the disease...
  17. ncbi request reprint Mechanism of toxicity in rotenone models of Parkinson's disease
    Todd B Sherer
    Center for Neurodegenerative Disease, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 23:10756-64. 2003
    ..These results, using three models of increasing complexity, demonstrate the involvement of oxidative damage in rotenone toxicity and support the evaluation of antioxidant therapies for Parkinson's disease...
  18. pmc Comparative distribution of protein components of the A20 ubiquitin-editing complex in normal human brain
    Elaine L Pranski
    Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, United States
    Neurosci Lett 520:104-9. 2012
    ..This study provides useful information about region specific expression of the A20 complex components that will be invaluable while determining the role of NF-κB signaling pathway in neuronal development and degeneration...
  19. ncbi request reprint Role of external pallidal segment in primate parkinsonism: comparison of the effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism and lesions of the external pallidal segment
    Jesus Soares
    Department of Neurology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 24:6417-26. 2004
    ..The results indicate that a mere reduction of GPe activity does not produce parkinsonism. Other changes, such as altered discharge patterns in STN and GPi, may play an important role in the generation of parkinsonism...
  20. ncbi request reprint PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain
    Leah R Anderson
    Center for Neurodegenerative Disease, Graduate Program in Neuroscience, Emory University, Atlanta, Georgia 30322, USA
    J Neuropathol Exp Neurol 66:955-64. 2007
    ..Collectively, these findings identify RNF11 as a strong candidate gene at the PARK10 locus and highlight its potential significance in the development of the common form of PD...

Research Grants4

  1. RNF11, a novel E3 ubiquitin ligase associated with PD pathogenesis
    Ranjita Betarbet; Fiscal Year: 2007
    ..rotenone model in rats and a-synuclein transgenic mice and (b) in autopsy brain tissue from PD patients. This study will determine a role for RNF11 and how it confers protection against dopamine cell death seen in Parkinson's disease. ..
  2. RNF11, a novel E3 ubiquitin ligase associated with PD pathogenesis
    RANJITA S BETARBET; Fiscal Year: 2010
    ..This study will determine a role for RNF11 and how it confers protection against dopamine cell death seen in Parkinson's disease. ..