Affiliation: Emory University
- Pearls: myastheniaMichael Benatar
Emory University School of Medicine and School of Public Health, Atlanta, Georgia, USA
Semin Neurol 30:35-7. 2010....
- Lost in translation: treatment trials in the SOD1 mouse and in human ALSMichael Benatar
Department of Neurology, Emory University School of Medicine, Woodruff Memorial Building, 1639 Pierce Drive, Atlanta, GA 30322, USA
Neurobiol Dis 26:1-13. 2007..These conclusions should be tempered by the methodological limitations of the relevant literature...
- Preparing for a U.S. National ALS Registry: Lessons from a pilot project in the State of GeorgiaMichael Benatar
Department of Neurology, School of Medicine, Emory University, Atlanta, Georgia 30322, USA
Amyotroph Lateral Scler 12:130-5. 2011..Predictive algorithms may permit correct classification of a large proportion of cases without the need for verification based on medical record review...
- Preventing familial amyotrophic lateral sclerosis: is a clinical trial feasible?Michael Benatar
Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
J Neurol Sci 251:3-9. 2006..To evaluate the feasibility of a clinical trial designed to delay or prevent the onset of disease amongst subjects at risk for familial amyotrophic lateral sclerosis (fALS)...
- A systematic review of diagnostic studies in myasthenia gravisMichael Benatar
Department of Neurology, Emory University, 1365A Clifton Road NE, Atlanta, GA 30322, USA
Neuromuscul Disord 16:459-67. 2006..We suggest that caution should be exercised in the interpretation of the diagnostic performance of these tests given the methodological limitations of the studies upon which test performance is based...
- Reference data for commonly used sensory and motor nerve conduction studiesMichael Benatar
Department of Neurology, Emory University School of Medicine, Woodruff Memorial Building, Suite 6000, 101 Woodruff Circle, Atlanta, Georgia 30322, USA
Muscle Nerve 40:772-94. 2009..The goal of this study was to generate reference data for a wide range of sensory and motor nerve conduction studies (NCSs) that are commonly used in routine electrodiagnostic practice...
- Concentric-needle single-fiber electromyography for the diagnosis of myasthenia gravisMichael Benatar
Department of Neurology, Emory University School of Medicine, 1365A Clifton Road NE, Atlanta, Georgia 30322, USA
Muscle Nerve 34:163-8. 2006..93 and 0.76, respectively. These results indicate that CN-SFEMG showing abnormal jiggle is extremely useful for confirming the diagnosis of MG, but that CN-SFEMG showing normal jiggle has limited utility in excluding the diagnosis...
- Accuracy of repetitive nerve stimulation for diagnosis of the cramp-fasciculation syndromeTaylor B Harrison
Department of Neurology, Emory University, 101 Woodruff Circle, Suite 6000, Room 6103, Atlanta, Georgia 30322, USA
Muscle Nerve 35:776-80. 2007..These results suggest that CFS represents a form of peripheral nerve hyperexcitability and, furthermore, that RNS is a clinically useful test for CFS...
- Diagnostic accuracy of thoracic paraspinal electromyography in amyotrophic lateral sclerosisAchraf A Makki
Department of Neurology, Emory University, Atlanta, GA 30322, USA
J Clin Neurophysiol 24:298-300. 2007..Because T-PSP EMG is used clinically in an effort to confirm the diagnosis (and not as a screening test), these results suggest that T-PSP EMG is an extremely useful adjunct for the diagnosis of ALS...
- Developing reference data for nerve conduction studies: an application of quantile regressionLimin Peng
Department of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Georgia, USA
Muscle Nerve 40:763-71. 2009..The goal of this article is to introduce a statistical method known as quantile regression, which we contend is better suited than existing methods to generate reference data, especially when there is a need to adjust for covariates...
- Utility of axial and radial diffusivity from diffusion tensor MRI as markers of neurodegeneration in amyotrophic lateral sclerosisNader S Metwalli
The Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology Emory University, Atlanta, GA, USA
Brain Res 1348:156-64. 2010..Conclusion: In ALS, axial diffusivity and radial diffusivity may be useful diffusion tensor imaging-derived indices to consider in addition to fractional anisotropy and mean diffusivity to aid in demonstrating neurodegenerative changes...
- Treatment of ocular symptoms in myasthenia gravisMinal J Bhanushali
Emory University, Department of Neurology, Atlanta, GA 30322, USA
Neurology 71:1335-41. 2008..The choice between acetyl-cholinesterase inhibitors (AChE-Is) and steroids as symptomatic therapy for ocular symptoms in myasthenia is controversial...
- Design of the Efficacy of Prednisone in the Treatment of Ocular Myasthenia (EPITOME) trialMichael Benatar
Department of Neurology, University of Miami, Miller School of Medicine, Miami, Florida, USA
Ann N Y Acad Sci 1275:17-22. 2012....
- Medical and surgical treatment for ocular myastheniaMichael Benatar
Department of Neurology, University of Miami, Miami, Florida, USA
Cochrane Database Syst Rev 12:CD005081. 2012..Of these between 50% to 60% develop generalized disease, most within two years. Their management is controversial. This is an update of a review first published in 2006 and previously updated in 2008 and 2010...
- Recommendations for myasthenia gravis clinical trialsMichael Benatar
Department of Neurology, University of Miami School of Medicine, Miami, Florida, USA
Muscle Nerve 45:909-17. 2012..The hope is that these updated task force recommendations will expedite the development and acceptance of more effective and less noxious therapies for MG...
- Levetiracetam versus carbamazepine monotherapy for partial epilepsy in children less than 16 years of ageScott Perry
Department of Pediatrics, Division of Child Neurology, Emory University, Atlanta, GA 30322, USA
J Child Neurol 23:515-9. 2008..07). Levetiracetam and carbamazepine monotherapy demonstrate similar efficacy for treatment of partial epilepsy and are well tolerated in children...
- Repetitive nerve stimulation for the evaluation of peripheral nerve hyperexcitabilityMichael Benatar
Department of Neurology, Emory University, 1365A Clifton Road N E, Atlanta, GA 30322, USA
J Neurol Sci 221:47-52. 2004..To examine the utility of repetitive nerve stimulation (RNS) in the evaluation of peripheral nerve hyperexcitability (PNH)...
- The spectrum of cranial neuropathy in patients with Bell's palsyMichael Benatar
Department of Neurology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass, USA
Arch Intern Med 164:2383-5. 2004..We sought to determine prospectively the presence of signs indicating an associated cranial neuropathy in patients with Bell's palsy...
- Motor neuron involvement in multisystem proteinopathy: implications for ALSMichael Benatar
Department of Neurology, University of Miami, Miami, FL, USA
Neurology 80:1874-80. 2013..To explore the putative connection between inclusion body myopathy, Paget disease, frontotemporal dementia (IBMPFD) and motor neuron disease (MND)...
- What zebras and mice can teach us about familial ALSMichael Benatar
Department of Neurology, Emory University, Woodruff Memorial Building, 101 Woodruff Circle, Atlanta, GA 30322, USA
Neuromuscul Disord 17:671-2. 2007
- Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trialsMaria Philip
Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
Stroke 40:577-81. 2009..We analyzed the quality and adequacy of animal studies supporting the efficacy of NXY-059 and other neuroprotective agents that are currently being investigated in phase II/III trials...
- The electromyographic diagnosis of amyotrophic lateral sclerosis: does the evidence support the El Escorial criteria?Achraf A Makki
Department of Neurology, Emory University School of Medicine, Woodruff Memorial Building, 101 Woodruff Circle, Suite 6000, Atlanta, Georgia 30322, USA
Muscle Nerve 35:614-9. 2007..These findings lend support to the EMG criteria proposed at El Escorial...
- Electrical impedance myography as a biomarker to assess ALS progressionSeward B Rutkove
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Amyotroph Lateral Scler 13:439-45. 2012..In conclusion, EIM can serve as a useful ALS biomarker that offers the prospect of greatly accelerating phase 2 clinical trials...
- Diffusion tensor imaging reveals regional differences in the cervical spinal cord in amyotrophic lateral sclerosisGovind Nair
Biomedical Imaging Technology Center, Department of Biomedical Engineering, Emory University and Georgia Institute of Technology, Atlanta, GA, USA
Neuroimage 53:576-83. 2010....
- Efficacy and tolerability of levetiracetam in children younger than 4 years: a retrospective reviewM Scott Perry
Department of Pediatrics, Emory University, Atlanta, Georgia 30322, USA
Epilepsia 48:1123-7. 2007..To review our experience of the efficacy and tolerability of levetiracetam (LEV) in children younger than 4 years...
- Evidence report: the medical treatment of ocular myasthenia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of NeurologyMichael Benatar
Department of Neurology, Emory University School of Medicine, OH, USA
Neurology 68:2144-9. 2007..To perform a systematic review of the relevant literature and to provide evidence-based guidelines for the medical treatment of ocular myasthenia...
- Treatment of pyridostigmine-induced AV block with hyoscyamine in a patient with myasthenia gravisAnil Gehi
Section of Cardiac Electrophysiology, Division of Cardiology, Emory University School of Medicine, Atlanta, Georgia, USA
J Cardiovasc Electrophysiol 19:214-6. 2008..Treatment with hyoscyamine resulted in complete resolution of AV block, thereby avoiding pacemaker implantation...
- Sural and radial sensory responses in healthy adults: diagnostic implications for polyneuropathyGregory J Esper
Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, TCC 810, Boston, Massachusetts 02215, USA
Muscle Nerve 31:628-32. 2005..21. Sural and radial SNAP amplitudes but not SRAR were strongly and inversely correlated with age and BMI. These age-adjusted normal values and revised SRAR will aid in the electrodiagnosis of polyneuropathy...
- Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choicesSean I Savitz
Department of Neurology, University of Texas Houston Medical School, Houston, TX 77030, USA
Cerebrovasc Dis 26:156-62. 2008..Recent studies have introduced more sensitive outcome measures such as the shift analysis to detect a treatment effect in AIS trials and are also including imaging as a surrogate of injury...
- The muddle of mycophenolate mofetil in myastheniaMichael Benatar
Neurology 71:390-1. 2008
- Selecting promising ALS therapies in clinical trialsJonathan D Glass
Neurology 68:1545-6; author reply 1546. 2007
- Distal symmetric polyneuropathy: limitations of the proposed case definitionMichael Benatar
Muscle Nerve 34:131-4. 2006
- Electrodiagnostic criteria for carpal tunnel syndrome in axonal polyneuropathyEroboghene E Ubogu
Neurology Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
Muscle Nerve 33:747-52. 2006..These novel MUCS electrodiagnostic criteria should facilitate more accurate electrodiagnostic confirmation of CTS in this population...
- Interferon beta-1a and beta-1b for treatment of multiple sclerosisMichael Benatar
Lancet 360:1428; author reply 1428-9. 2002