GARY BASSELLSummaryAffiliation: Emory University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and functionClaudia Fallini
Department of Cell Biology, Emory University School of Medicine, Atlanta 30322, USA
Mol Neurodegener 5:17. 2010..This technique allows for the study of the effects of gene expression and silencing on the development and survival of motor neurons...- RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control on neuronal functionGary J Bassell
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
EMBO Rep 7:31-5. 2006 
Fragile X syndrome: loss of local mRNA regulation alters synaptic development and functionGary J Bassell
Department of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
Neuron 60:201-14. 2008..The understanding of FMRP function at synapses has led to rationale therapeutic approaches...- Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexesWilfried Rossoll
Departments of Cell Biology and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
Results Probl Cell Differ 48:289-326. 2009..Further work to elucidate SMN mechanisms within motor neurons and other cell types involved in neuromuscular circuitry hold promise for the potential treatment of SMA... - S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascadeUsha Narayanan
Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
J Biol Chem 283:18478-82. 2008..Together these data reveal a S6K1-PP2A signaling module regulating FMRP function and place FMRP phosphorylation in the mGluR-triggered signaling cascade required for protein-synthesis-dependent synaptic plasticity... - Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptorsMika Nakamoto
Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Whitehead Biomedical Research Building, Atlanta, GA 30322, USA
Proc Natl Acad Sci U S A 104:15537-42. 2007.... - Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndromeChristina Gross
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 30:10624-38. 2010..Targeting excessive PI3K activity might thus be a potent therapeutic strategy for FXS... - Single molecule-sensitive probes for imaging RNA in live cellsPhilip J Santangelo
Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
Nat Methods 6:347-9. 2009.... - Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turningYukio Sasaki
Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 30:9349-58. 2010..Our findings provide new insight into how the regulated phosphorylation of mRNA-binding proteins influences local translation underlying growth cone motility and axon guidance... 
FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2AUsha Narayanan
Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
J Neurosci 27:14349-57. 2007..Collectively, these data reveal an immediate-early signaling pathway linking group I mGluR activity to rapid FMRP phosphorylation dynamics mediated by mTOR and PP2A...- Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomesHouping Wang
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
Mol Biol Cell 19:105-14. 2008.... - Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndromeRavi S Muddashetty
Department of Cell Biology, Emory University, Atlanta, Georgia 30322, USA
J Neurosci 27:5338-48. 2007.... - Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAsDianna E Willis
Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
J Cell Biol 178:965-80. 2007..Thus, extracellular ligands can regulate protein generation within subcellular regions by specifically altering the localized levels of particular mRNAs... - Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neuronsDhanrajan M Tiruchinapalli
Department of Neuroscience, Rose F Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 23:3251-61. 2003..The activity-dependent trafficking of ZBP1 and its dynamic movements within dendritic spines provide new evidence to implicate RNA binding proteins as regulators of mRNA transport to activated synapses in response to synaptic activity... - Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localizationHonglai L Zhang
Department of Neuroscience, Rose F Kennedy Center for Mental Retardation, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 23:6627-37. 2003..Such observations provide motivation to investigate possible transport defects or inefficiency of SMN associated RNPs in motor neuron axons in SMA... - Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapsesTaesun Eom
Department of Neuroscience, Rose F Kennedy Center for Mental Retardation, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 23:10433-44. 2003..These results reveal a novel function for an mRNA localization element and its binding protein in the regulation of dendritic morphology and synaptic growth via dendritic filopodia... - Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1Stefan Huttelmaier
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
Nature 438:512-5. 2005..These sequential events provide both temporal and spatial control over beta-actin mRNA translation, which is important for cell migration and neurite outgrowth... - Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neuronsSonja Y Grooms
Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 26:8339-51. 2006..Bidirectional regulation of dendritic mRNA abundance represents a potentially powerful means to effect long-lasting changes in synaptic strength... - Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neuronsHonglai Zhang
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
J Neurosci 26:8622-32. 2006..These findings provide new insight into the molecular composition of distinct SMN multiprotein complexes in neurons and motivation to investigate deficiencies of localized RNPs in SMA... - An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidanceJiaqi Yao
Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
Nat Neurosci 9:1265-73. 2006.... - Neuronal RNA granules: movers and makersMichael A Kiebler
Center for Brain Research, Medical University of Vienna, A 1090 Vienna, Austria
Neuron 51:685-90. 2006..We focus on three classes of RNA granules that include transport RNPs, stress granules, and P bodies and discuss their potential functions in RNA localization, microRNA-mediated translational regulation, and mRNA degradation... - QNQKE targeting motif for the SMN-Gemin multiprotein complexin neuronsHonglai Zhang
Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, USA
J Neurosci Res 85:2657-67. 2007..These findings provide further evidence in support of a neuronal function for SMN and motivation to investigate for impaired assembly and/or localization of mRNP complexes as an underlying cause of SMA... - A predominantly nuclear protein affecting cytoplasmic localization of beta-actin mRNA in fibroblasts and neuronsWei Gu
Department of Anatomy, Albert Einstein College of Medicine, Bronx, NY 10461, USA
J Cell Biol 156:41-51. 2002..These data suggest that ZBP2, although predominantly a nuclear protein, has a role in the cytoplasmic localization of beta-actin mRNA...
Research Grants
- Imaging FMRP Regulation and FunctionGARY BASSELL; Fiscal Year: 2007..These studies will provide new insight into the molecular and cellular basis for altered synaptic plasticity in Fragile X Syndrome. ..
- Beta-Acting mRNA Localization in NeuronsGARY BASSELL; Fiscal Year: 2007..The elucidation of molecular mechanisms involved in mRNA transport and their perturbation will provide new insight into protein sorting mechanisms that regulate growth cone motility and process outgrowth during neuronal development. ..
- mRNA translation for nerve regenerationGARY BASSELL; Fiscal Year: 2007..We anticipate that the proposed basic research will provide new insight into molecular mechanisms underlying optimal axon regeneration and has important implications for future developments of therapies and treatments for nerve injury. ..
- Imaging FMRP Regulation and FunctionGary J Bassell; Fiscal Year: 2010..This research is expected to provide new insight into mechanisms of synaptic plasticity underlying learning and memory, and may lead to the development of new therapeutic strategies for fragile x and other forms of mental illness. ..
- Spinal Muscular Atrophy: SMNs role in MRNA localization and local translationGary J Bassell; Fiscal Year: 2010..This research will provide new insight into neuronal functions for SMN, whereby possible defects in the assembly, localization and/or translation of mRNP complexes may contribute to the disease process in SMA. ..
- Spinal Muscular Atrophy: SMNs role in MRNA localization and local translationGARY BASSELL; Fiscal Year: 2009..This research will provide new insight into neuronal functions for SMN, whereby possible defects in the assembly, localization and/or translation of mRNP complexes may contribute to the disease process in SMA. ..
- BETA-ACTIN MRNA LOCALIZATIONGARY BASSELL; Fiscal Year: 2002..The elucidation of a mechanism to regulate mRNA localization to growth cones will provide insight into the regulation of growth cone structure and mechanisms that may underlie process outgrowth. ..
- HIGH RESOLUTION VISUALIZATION OF GENE EXPRESSION IN SITUGARY BASSELL; Fiscal Year: 2003..abstract_text> ..
- Imaging FMRP Regulation and FunctionGary J Bassell; Fiscal Year: 2011..This research is expected to provide new insight into mechanisms of synaptic plasticity underlying learning and memory, and may lead to the development of new therapeutic strategies for fragile x and other forms of mental illness. ..