GARY BASSELL

Summary

Affiliation: Emory University
Country: USA

Publications

  1. pmc High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function
    Claudia Fallini
    Department of Cell Biology, Emory University School of Medicine, Atlanta 30322, USA
    Mol Neurodegener 5:17. 2010
  2. pmc Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function
    Gary J Bassell
    Department of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuron 60:201-14. 2008
  3. pmc RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control on neuronal function
    Gary J Bassell
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    EMBO Rep 7:31-5. 2006
  4. pmc Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes
    Wilfried Rossoll
    Departments of Cell Biology and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Results Probl Cell Differ 48:289-326. 2009
  5. pmc S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade
    Usha Narayanan
    Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 283:18478-82. 2008
  6. pmc Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors
    Mika Nakamoto
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Whitehead Biomedical Research Building, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:15537-42. 2007
  7. pmc Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 30:10624-38. 2010
  8. doi request reprint Single molecule-sensitive probes for imaging RNA in live cells
    Philip J Santangelo
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
    Nat Methods 6:347-9. 2009
  9. pmc Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning
    Yukio Sasaki
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 30:9349-58. 2010
  10. ncbi request reprint FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A
    Usha Narayanan
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 27:14349-57. 2007

Research Grants

  1. Imaging FMRP Regulation and Function
    GARY BASSELL; Fiscal Year: 2007
  2. Beta-Acting mRNA Localization in Neurons
    GARY BASSELL; Fiscal Year: 2007
  3. mRNA translation for nerve regeneration
    GARY BASSELL; Fiscal Year: 2007
  4. Imaging FMRP Regulation and Function
    Gary J Bassell; Fiscal Year: 2010
  5. Spinal Muscular Atrophy: SMNs role in MRNA localization and local translation
    Gary J Bassell; Fiscal Year: 2010
  6. Spinal Muscular Atrophy: SMNs role in MRNA localization and local translation
    GARY BASSELL; Fiscal Year: 2009
  7. BETA-ACTIN MRNA LOCALIZATION
    GARY BASSELL; Fiscal Year: 2002
  8. HIGH RESOLUTION VISUALIZATION OF GENE EXPRESSION IN SITU
    GARY BASSELL; Fiscal Year: 2003
  9. Imaging FMRP Regulation and Function
    Gary J Bassell; Fiscal Year: 2011

Collaborators

Detail Information

Publications24

  1. pmc High-efficiency transfection of cultured primary motor neurons to study protein localization, trafficking, and function
    Claudia Fallini
    Department of Cell Biology, Emory University School of Medicine, Atlanta 30322, USA
    Mol Neurodegener 5:17. 2010
    ..This technique allows for the study of the effects of gene expression and silencing on the development and survival of motor neurons...
  2. pmc Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function
    Gary J Bassell
    Department of Cell Biology and Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuron 60:201-14. 2008
    ..The understanding of FMRP function at synapses has led to rationale therapeutic approaches...
  3. pmc RNA exodus to Israel: RNA controlling function in the far reaches of the neuron. Workshop on RNA control on neuronal function
    Gary J Bassell
    Department of Cell Biology, Emory University School of Medicine, Atlanta, GA 30322, USA
    EMBO Rep 7:31-5. 2006
  4. pmc Spinal muscular atrophy and a model for survival of motor neuron protein function in axonal ribonucleoprotein complexes
    Wilfried Rossoll
    Departments of Cell Biology and Neurology, Center for Neurodegenerative Disease, Emory University School of Medicine, Atlanta, GA 30322, USA
    Results Probl Cell Differ 48:289-326. 2009
    ..Further work to elucidate SMN mechanisms within motor neurons and other cell types involved in neuromuscular circuitry hold promise for the potential treatment of SMA...
  5. pmc S6K1 phosphorylates and regulates fragile X mental retardation protein (FMRP) with the neuronal protein synthesis-dependent mammalian target of rapamycin (mTOR) signaling cascade
    Usha Narayanan
    Department of Human Genetics, Emory University, Atlanta, Georgia 30322, USA
    J Biol Chem 283:18478-82. 2008
    ..Together these data reveal a S6K1-PP2A signaling module regulating FMRP function and place FMRP phosphorylation in the mGluR-triggered signaling cascade required for protein-synthesis-dependent synaptic plasticity...
  6. pmc Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors
    Mika Nakamoto
    Department of Human Genetics, Emory University School of Medicine, 615 Michael Street, Whitehead Biomedical Research Building, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 104:15537-42. 2007
    ....
  7. pmc Excess phosphoinositide 3-kinase subunit synthesis and activity as a novel therapeutic target in fragile X syndrome
    Christina Gross
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 30:10624-38. 2010
    ..Targeting excessive PI3K activity might thus be a potent therapeutic strategy for FXS...
  8. doi request reprint Single molecule-sensitive probes for imaging RNA in live cells
    Philip J Santangelo
    Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA
    Nat Methods 6:347-9. 2009
    ....
  9. pmc Phosphorylation of zipcode binding protein 1 is required for brain-derived neurotrophic factor signaling of local beta-actin synthesis and growth cone turning
    Yukio Sasaki
    Department of Cell Biology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 30:9349-58. 2010
    ..Our findings provide new insight into how the regulated phosphorylation of mRNA-binding proteins influences local translation underlying growth cone motility and axon guidance...
  10. ncbi request reprint FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A
    Usha Narayanan
    Department of Human Genetics, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Neurosci 27:14349-57. 2007
    ..Collectively, these data reveal an immediate-early signaling pathway linking group I mGluR activity to rapid FMRP phosphorylation dynamics mediated by mTOR and PP2A...
  11. pmc Dynamic association of the fragile X mental retardation protein as a messenger ribonucleoprotein between microtubules and polyribosomes
    Houping Wang
    Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Mol Biol Cell 19:105-14. 2008
    ....
  12. ncbi request reprint Dysregulated metabotropic glutamate receptor-dependent translation of AMPA receptor and postsynaptic density-95 mRNAs at synapses in a mouse model of fragile X syndrome
    Ravi S Muddashetty
    Department of Cell Biology, Emory University, Atlanta, Georgia 30322, USA
    J Neurosci 27:5338-48. 2007
    ....
  13. pmc Extracellular stimuli specifically regulate localized levels of individual neuronal mRNAs
    Dianna E Willis
    Nemours Biomedical Research, Alfred I duPont Hospital for Children, Wilmington, DE 19803, USA
    J Cell Biol 178:965-80. 2007
    ..Thus, extracellular ligands can regulate protein generation within subcellular regions by specifically altering the localized levels of particular mRNAs...
  14. ncbi request reprint Activity-dependent trafficking and dynamic localization of zipcode binding protein 1 and beta-actin mRNA in dendrites and spines of hippocampal neurons
    Dhanrajan M Tiruchinapalli
    Department of Neuroscience, Rose F Kennedy Center for Research in Mental Retardation and Human Development, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:3251-61. 2003
    ..The activity-dependent trafficking of ZBP1 and its dynamic movements within dendritic spines provide new evidence to implicate RNA binding proteins as regulators of mRNA transport to activated synapses in response to synaptic activity...
  15. ncbi request reprint Active transport of the survival motor neuron protein and the role of exon-7 in cytoplasmic localization
    Honglai L Zhang
    Department of Neuroscience, Rose F Kennedy Center for Mental Retardation, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:6627-37. 2003
    ..Such observations provide motivation to investigate possible transport defects or inefficiency of SMN associated RNPs in motor neuron axons in SMA...
  16. ncbi request reprint Localization of a beta-actin messenger ribonucleoprotein complex with zipcode-binding protein modulates the density of dendritic filopodia and filopodial synapses
    Taesun Eom
    Department of Neuroscience, Rose F Kennedy Center for Mental Retardation, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 23:10433-44. 2003
    ..These results reveal a novel function for an mRNA localization element and its binding protein in the regulation of dendritic morphology and synaptic growth via dendritic filopodia...
  17. ncbi request reprint Spatial regulation of beta-actin translation by Src-dependent phosphorylation of ZBP1
    Stefan Huttelmaier
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Nature 438:512-5. 2005
    ..These sequential events provide both temporal and spatial control over beta-actin mRNA translation, which is important for cell migration and neurite outgrowth...
  18. ncbi request reprint Activity bidirectionally regulates AMPA receptor mRNA abundance in dendrites of hippocampal neurons
    Sonja Y Grooms
    Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:8339-51. 2006
    ..Bidirectional regulation of dendritic mRNA abundance represents a potentially powerful means to effect long-lasting changes in synaptic strength...
  19. ncbi request reprint Multiprotein complexes of the survival of motor neuron protein SMN with Gemins traffic to neuronal processes and growth cones of motor neurons
    Honglai Zhang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Neurosci 26:8622-32. 2006
    ..These findings provide new insight into the molecular composition of distinct SMN multiprotein complexes in neurons and motivation to investigate deficiencies of localized RNPs in SMA...
  20. ncbi request reprint An essential role for beta-actin mRNA localization and translation in Ca2+-dependent growth cone guidance
    Jiaqi Yao
    Department of Neuroscience and Cell Biology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, 675 Hoes Lane, Piscataway, New Jersey 08854, USA
    Nat Neurosci 9:1265-73. 2006
    ....
  21. ncbi request reprint Neuronal RNA granules: movers and makers
    Michael A Kiebler
    Center for Brain Research, Medical University of Vienna, A 1090 Vienna, Austria
    Neuron 51:685-90. 2006
    ..We focus on three classes of RNA granules that include transport RNPs, stress granules, and P bodies and discuss their potential functions in RNA localization, microRNA-mediated translational regulation, and mRNA degradation...
  22. ncbi request reprint QNQKE targeting motif for the SMN-Gemin multiprotein complexin neurons
    Honglai Zhang
    Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York, USA
    J Neurosci Res 85:2657-67. 2007
    ..These findings provide further evidence in support of a neuronal function for SMN and motivation to investigate for impaired assembly and/or localization of mRNP complexes as an underlying cause of SMA...
  23. pmc A predominantly nuclear protein affecting cytoplasmic localization of beta-actin mRNA in fibroblasts and neurons
    Wei Gu
    Department of Anatomy, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 156:41-51. 2002
    ..These data suggest that ZBP2, although predominantly a nuclear protein, has a role in the cytoplasmic localization of beta-actin mRNA...

Research Grants30

  1. Imaging FMRP Regulation and Function
    GARY BASSELL; Fiscal Year: 2007
    ..These studies will provide new insight into the molecular and cellular basis for altered synaptic plasticity in Fragile X Syndrome. ..
  2. Beta-Acting mRNA Localization in Neurons
    GARY BASSELL; Fiscal Year: 2007
    ..The elucidation of molecular mechanisms involved in mRNA transport and their perturbation will provide new insight into protein sorting mechanisms that regulate growth cone motility and process outgrowth during neuronal development. ..
  3. mRNA translation for nerve regeneration
    GARY BASSELL; Fiscal Year: 2007
    ..We anticipate that the proposed basic research will provide new insight into molecular mechanisms underlying optimal axon regeneration and has important implications for future developments of therapies and treatments for nerve injury. ..
  4. Imaging FMRP Regulation and Function
    Gary J Bassell; Fiscal Year: 2010
    ..This research is expected to provide new insight into mechanisms of synaptic plasticity underlying learning and memory, and may lead to the development of new therapeutic strategies for fragile x and other forms of mental illness. ..
  5. Spinal Muscular Atrophy: SMNs role in MRNA localization and local translation
    Gary J Bassell; Fiscal Year: 2010
    ..This research will provide new insight into neuronal functions for SMN, whereby possible defects in the assembly, localization and/or translation of mRNP complexes may contribute to the disease process in SMA. ..
  6. Spinal Muscular Atrophy: SMNs role in MRNA localization and local translation
    GARY BASSELL; Fiscal Year: 2009
    ..This research will provide new insight into neuronal functions for SMN, whereby possible defects in the assembly, localization and/or translation of mRNP complexes may contribute to the disease process in SMA. ..
  7. BETA-ACTIN MRNA LOCALIZATION
    GARY BASSELL; Fiscal Year: 2002
    ..The elucidation of a mechanism to regulate mRNA localization to growth cones will provide insight into the regulation of growth cone structure and mechanisms that may underlie process outgrowth. ..
  8. HIGH RESOLUTION VISUALIZATION OF GENE EXPRESSION IN SITU
    GARY BASSELL; Fiscal Year: 2003
    ..abstract_text> ..
  9. Imaging FMRP Regulation and Function
    Gary J Bassell; Fiscal Year: 2011
    ..This research is expected to provide new insight into mechanisms of synaptic plasticity underlying learning and memory, and may lead to the development of new therapeutic strategies for fragile x and other forms of mental illness. ..