J L Arbiser

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi request reprint Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway
    Kwang Seok Ahn
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Res 4:621-33. 2006
  2. ncbi request reprint Presence of p16 hypermethylation and Epstein-Barr virus infection in transplant-associated hematolymphoid neoplasm of the skin
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Acad Dermatol 55:794-8. 2006
  3. pmc The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis
    Shruti M Raja
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Cancer Ther 7:2212-23. 2008
  4. pmc Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis
    Arumugam Nagalingam
    Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD 21231, USA
    Breast Cancer Res 14:R35. 2012
  5. pmc Cooperative benefit for the combination of rapamycin and imatinib in tuberous sclerosis complex neoplasia
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine Winship Cancer Institute and Atlanta Veterans Administration Hospital, WMB 5309, 1639 Pierce Drive, Atlanta, GA, 30322, USA
    Vasc Cell 4:11. 2012
  6. pmc Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Pathol 161:781-6. 2002
  7. pmc SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, and Veterans Administration Medical Center, Atlanta, GA 30322, USA
    Mol Med 8:551-8. 2002
  8. doi request reprint Fumarate esters as angiogenesis inhibitors: key to action in psoriasis?
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Invest Dermatol 131:1189-91. 2011
  9. pmc Translating cyclooxygenase signaling in patch heterozygote mice into a randomized clinical trial in basal cell carcinoma
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta Veterans Administration Medical Center, GA 30322, USA
    Cancer Prev Res (Phila) 3:4-7. 2010
  10. ncbi request reprint Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Mol Med 9:929-34. 2009

Research Grants

  1. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2001
  2. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2009
  3. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
  4. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2007
  5. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2006
  6. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2005
  7. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2005
  8. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2004
  9. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2003
  10. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2002

Detail Information

Publications91

  1. ncbi request reprint Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-kappaB activation pathway
    Kwang Seok Ahn
    Cytokine Research Laboratory, Department of Experimental Therapeutics, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    Mol Cancer Res 4:621-33. 2006
    ..Thus, overall, our results indicate that NF-kappaB and NF-kappaB-regulated gene expression inhibited by honokiol enhances apoptosis and suppresses osteoclastogenesis and invasion...
  2. ncbi request reprint Presence of p16 hypermethylation and Epstein-Barr virus infection in transplant-associated hematolymphoid neoplasm of the skin
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Acad Dermatol 55:794-8. 2006
    ..Epstein-Barr virus (EBV) is associated with the malignant transformation of B, T, and NK lymphocytes in humans, especially in immunosuppressed individuals...
  3. pmc The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis
    Shruti M Raja
    Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Mol Cancer Ther 7:2212-23. 2008
    ..Collectively, we conclude that c-FLIP down-regulation is a key event for honokiol to modulate the death receptor-induced apoptosis...
  4. pmc Honokiol activates AMP-activated protein kinase in breast cancer cells via an LKB1-dependent pathway and inhibits breast carcinogenesis
    Arumugam Nagalingam
    Department of Oncology, Johns Hopkins University School of Medicine and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore MD 21231, USA
    Breast Cancer Res 14:R35. 2012
    ..In the present study, we sought to examine the effectiveness of honokiol in inhibiting migration and invasion of breast cancer cells and to elucidate the underlying molecular mechanisms...
  5. pmc Cooperative benefit for the combination of rapamycin and imatinib in tuberous sclerosis complex neoplasia
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine Winship Cancer Institute and Atlanta Veterans Administration Hospital, WMB 5309, 1639 Pierce Drive, Atlanta, GA, 30322, USA
    Vasc Cell 4:11. 2012
    ..Our findings provide a rationale for the combined use of rapamycin and imatinib, both FDA approved drugs, for the treatment of TS...
  6. pmc Functional tyrosine kinase inhibitor profiling: a generally applicable method points to a novel role of platelet-derived growth factor receptor-beta in tuberous sclerosis
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Pathol 161:781-6. 2002
    ..Thus, we describe a novel but simple method of determining the functional tyrosine kinase profile of a neoplastic cell and our results suggest that STI571 might be useful in the treatment of neoplasms commonly seen in patients with TS...
  7. pmc SVR angiosarcomas can be rejected by CD4 costimulation dependent and CD8 costimulation independent pathways
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, and Veterans Administration Medical Center, Atlanta, GA 30322, USA
    Mol Med 8:551-8. 2002
    ..We wished to determine whether virally- induced endothelial tumors are rejected by CD4 and CD8 lymphocytes, and whether there are differences in requirements for costimulation in the rejection of these tumors by lymphocyte subsets...
  8. doi request reprint Fumarate esters as angiogenesis inhibitors: key to action in psoriasis?
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Invest Dermatol 131:1189-91. 2011
    ..Fumarate, a natural product that is generated internally in humans during the Krebs cycle, is an attractive alternative to these therapies. However, the mechanism for fumarate's activity in psoriasis remains unknown...
  9. pmc Translating cyclooxygenase signaling in patch heterozygote mice into a randomized clinical trial in basal cell carcinoma
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta Veterans Administration Medical Center, GA 30322, USA
    Cancer Prev Res (Phila) 3:4-7. 2010
    ..They then studied pharmacologic COX inhibition in mice and humans with loss of patch, finding a trend in humans toward decreased BCC burden. This finding has implications for public health...
  10. ncbi request reprint Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Curr Mol Med 9:929-34. 2009
    ..I hypothesize that hemangiomas, angiosarcomas, and vascular malformations represent the extremes of signaling abnormalities seen in pathogenic angiogenesis...
  11. ncbi request reprint Molecular regulation of angiogenesis and tumorigenesis by signal transduction pathways: evidence of predictable and reproducible patterns of synergy in diverse neoplasms
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, WMB 5309, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Semin Cancer Biol 14:81-91. 2004
    ..These strategies may be useful in the design of prevention and treatment strategies for cancer...
  12. ncbi request reprint Naturally occurring proteasome inhibitors from mate tea (Ilex paraguayensis) serve as models for topical proteasome inhibitors
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Invest Dermatol 125:207-12. 2005
    ..Based upon these findings, preclinical and clinical trials of topical cinnamate esters as proteasome inhibitors are warranted for psoriasis and other inflammatory disorders...
  13. ncbi request reprint Involvement of p53 and p16 tumor suppressor genes in recessive dystrophic epidermolysis bullosa-associated squamous cell carcinoma
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine and Atlanta VA Medical Center, Atlanta, Georgia 30322, USA
    J Invest Dermatol 123:788-90. 2004
    ..This is the first description of specific abnormalities in tumor suppressor genes in RDEB associated SCC, and demonstrates that alterations in both p53 and p16ink4a can contribute to RDEB associated SCC...
  14. pmc Solenopsin, the alkaloidal component of the fire ant (Solenopsis invicta), is a naturally occurring inhibitor of phosphatidylinositol-3-kinase signaling and angiogenesis
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, WMB 5309, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Blood 109:560-5. 2007
    ..Interestingly, solenopsin also inhibited Akt-1 activity in an ATP-competitive manner in vitro without affecting 27 of 28 other protein kinases tested...
  15. doi request reprint Unexpected autocrine role of vascular endothelial growth factor in squamous cell carcinoma
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Invest Dermatol 129:538-40. 2009
    ..This knowledge is important because inhibitors of VEGF, including bevacizumab (anti-VEGF antibodies) and sorafenib (Braf/VEGFR2 kinase inhibitor), have already entered the clinic. These agents may "remodel" tumor signaling...
  16. ncbi request reprint Carbazole is a naturally occurring inhibitor of angiogenesis and inflammation isolated from antipsoriatic coal tar
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Invest Dermatol 126:1396-402. 2006
    ..Given its antiangiogenic and anti-inflammatory activities, carbazole is likely a major component of the antipsoriatic activity of coal tar. Carbazole and derivatives may be useful in the therapy of human psoriasis...
  17. ncbi request reprint Tuberous sclerosis-associated lesions of the kidney, brain, and skin are angiogenic neoplasms
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, WMB 5309, 1639 Pierce Street, Atlanta, GA 30322, USA
    J Am Acad Dermatol 46:376-80. 2002
    ..Progressive growth and malignant transformation of brain and kidney lesions constitute the major cause of morbidity and mortality in adults with tuberous sclerosis. In addition, growth of skin lesions may be disfiguring to patients...
  18. pmc Reactive oxygen generated by Nox1 triggers the angiogenic switch
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 99:715-20. 2002
    ..Nox1 induction of VEGF is eliminated by coexpression of catalase, indicating that hydrogen peroxide signals part of the switch to the angiogenic phenotype...
  19. pmc Clioquinol-zinc chelate: a candidate causative agent of subacute myelo-optic neuropathy
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
    Mol Med 4:665-70. 1998
    ..Discontinuation of oral clioquinol use led to elimination of SMON, however, the mechanism of how clioquinol induces neurotoxicity is unclear...
  20. ncbi request reprint The antiangiogenic agents TNP-470 and 2-methoxyestradiol inhibit the growth of angiosarcoma in mice
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Acad Dermatol 40:925-9. 1999
    ..Endothelial malignancies, such as angiosarcoma and hemangioendothelioma, are often resistant to chemotherapy and surgery, and may result in death. Improved means of therapy are needed for these disorders...
  21. pmc Isolation of mouse stromal cells associated with a human tumor using differential diphtheria toxin sensitivity
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
    Am J Pathol 155:723-9. 1999
    ..This method allows rapid isolation of stromal cells and should facilitate biochemical and genetic analysis of tumor-stromal interactions...
  22. ncbi request reprint Corticotropin-releasing hormone stimulates angiogenesis and epithelial tumor growth in the skin
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Invest Dermatol 113:838-42. 1999
    ..3-fold over control) and tumor growth (5-fold over control). Peripheral corticotropin-releasing hormone may thus enhance local angiogenesis, which may provide clues to its function outside of the nervous system...
  23. pmc Overexpression of VEGF 121 in immortalized endothelial cells causes conversion to slowly growing angiosarcoma and high level expression of the VEGF receptors VEGFR-1 and VEGFR-2 in vivo
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Am J Pathol 156:1469-76. 2000
    ..These results suggest that high level expression of VEGF in endothelial cells may result in malignant transformation. This transformation process likely involves both autocrine and paracrine pathways...
  24. pmc Why targeted therapy hasn't worked in advanced cancer
    Jack L Arbiser
    Department of Dermatology and Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    J Clin Invest 117:2762-5. 2007
    ..Currently, a major focus of pharmaceutical companies is to develop ever more potent and specific tyrosine kinases. The results presented here suggest that this approach may not be successful...
  25. ncbi request reprint Differential expression of active mitogen-activated protein kinase in cutaneous endothelial neoplasms: implications for biologic behavior and response to therapy
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
    J Am Acad Dermatol 44:193-7. 2001
    ..Activation of mitogen-activated protein kinase (MAPK) is an important signal transduction mechanism that may predict response of a tumor to chemotherapy...
  26. pmc The generation and characterization of a cell line derived from a sporadic renal angiomyolipoma: use of telomerase to obtain stable populations of cells from benign neoplasms
    J L Arbiser
    Department of Dermatology, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Am J Pathol 159:483-91. 2001
    ..These cells should serve as a valuable tool to elucidate signal transduction pathways underlying renal angiomyolipomas...
  27. ncbi request reprint High-level expression of vascular endothelial growth factor and its receptors in an aphthous ulcer
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine and Emory Skin Disease Research Center, Atlanta, Georgia 30322, USA
    J Cutan Med Surg 7:225-8. 2003
    ..These ulcers cause significant morbidity through pain and interference with eating. Thalidomide, an angiogenesis inhibitor, is efficacious for the treatment of aphthous ulcers...
  28. pmc Curcumin is an in vivo inhibitor of angiogenesis
    J L Arbiser
    Department of Dermatology, Harvard Medical School, Boston, Massachusetts, USA
    Mol Med 4:376-83. 1998
    ..The genetic changes in carcinogenesis in these organs involve different genes, but curcumin is effective in preventing carcinogenesis in both organs. A possible explanation for this finding is that curcumin may inhibit angiogenesis...
  29. ncbi request reprint Malignant transformation of human cells by constitutive expression of platelet-derived growth factor-BB
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine and Veterans Affairs Hospital, Atlanta, Georgia 30322, USA
    J Biol Chem 280:13936-43. 2005
    ..Our model allows the assessment of epigenetic changes that occur during human carcinogenesis. In addition, these studies provide insight into the clinical failure of tyrosine kinase inhibitors as monotherapy for advanced malignancy...
  30. ncbi request reprint Malignant transformation of melanocytes to melanoma by constitutive activation of mitogen-activated protein kinase kinase (MAPKK) signaling
    Baskaran Govindarajan
    Department of Dermatology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:9790-5. 2003
    ..Activation of MAP kinase signaling may be an important pathway involved in melanoma transformation. Inhibition of MAP kinase signaling may be useful in the prevention and treatment of melanoma...
  31. ncbi request reprint Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Biol Chem 280:5870-4. 2005
    ..Our data are the first to demonstrate that specific signaling abnormalities underlie specific hamartomas in a model of a human genetic disorder...
  32. ncbi request reprint Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo
    Xianhe Bai
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Biol Chem 278:35501-7. 2003
    ..Our preclinical data suggests that honokiol is a systemically available and non-toxic inhibitor of angiogenesis and should be further evaluated as a potential chemotherapeutic agent...
  33. ncbi request reprint Tuberous sclerosis-associated neoplasms express activated p42/44 mitogen-activated protein (MAP) kinase, and inhibition of MAP kinase signaling results in decreased in vivo tumor growth
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 9:3469-75. 2003
    ....
  34. ncbi request reprint Altered basic fibroblast growth factor expression in common epidermal neoplasms: examination with in situ hybridization and immunohistochemistry
    J L Arbiser
    Department of Dermatology, Emory Skin Disease Research Core Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Acad Dermatol 42:973-7. 2000
    ..The distribution of these growth factors in skin disease has not been determined...
  35. pmc Infectious angiogenesis: Bartonella bacilliformis infection results in endothelial production of angiopoetin-2 and epidermal production of vascular endothelial growth factor
    Francesca Cerimele
    Emory Skin Disease Research Core Center, Department of Dermatology, Emory University School of Medicine, Boston, Massachusetts, USA
    Am J Pathol 163:1321-7. 2003
    ..Infection of cultured endothelium with B. bacilliformis also resulted in induction of angiopoetin-2 in vitro. These findings imply a collaboration between infected endothelium and overlying epidermis to induce angiogenesis...
  36. pmc Reactive oxygen-induced carcinogenesis causes hypermethylation of p16(Ink4a) and activation of MAP kinase
    Baskaran Govindarajan
    Department of Medicine, Dermatology, Emory University School of Medicine, Atlanta, GQ 30322, USA
    Mol Med 8:1-8. 2002
    ..In addition, occupational exposure to nickel has been shown to result in an increased risk of carcinogenesis. The molecular mechanisms of foreign body-induced carcinogenesis are not fully understood...
  37. pmc Honokiol, a multifunctional antiangiogenic and antitumor agent
    Levi E Fried
    Department of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta VA Medical Center, Atlanta, Georgia 30322, USA
    Antioxid Redox Signal 11:1139-48. 2009
    ..Knowledge of the dual activities of honokiol can assist with the development of honokiol derivatives and the design of clinical trials that will maximize the potential benefit of honokiol in the patient setting...
  38. ncbi request reprint Diffuse dermal angiomatosis of the breast: response to isotretinoin
    E R McLaughlin
    Department of Dermatology, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    J Am Acad Dermatol 45:462-5. 2001
    ..We report a case of a young woman whose disorder responded to isotretinoin. Our findings have potential relevance to the treatment of skin disorders in which ulceration is a prominent feature...
  39. ncbi request reprint Microphthalmia transcription factor immunohistochemistry: a useful diagnostic marker in the diagnosis and detection of cutaneous melanoma, sentinel lymph node metastases, and extracutaneous melanocytic neoplasms
    D J Brat
    Department of Dermatology, Emory University School of Medicine, 5309 Woodruff Memorial Bldg, Atlanta, GA 30322, USA
    J Am Acad Dermatol 45:414-9. 2001
    ..Use of this stain may facilitate detection of micrometastases in sentinel lymph nodes...
  40. ncbi request reprint Curcumin as an inhibitor of angiogenesis
    Sulochana S Bhandarkar
    Department of Dermatology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, GA 30322, USA
    Adv Exp Med Biol 595:185-95. 2007
    ..Curcumin's effect on the overall process of angiogenesis compounds its enormous potential as an antiangiogenic drug...
  41. pmc Facile purification of honokiol and its antiviral and cytotoxic properties
    Franck Amblard
    Department of Pediatrics and Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Med Chem 49:3426-7. 2006
    ..A separation of honokiol 1 from the closely structurally related magnolol 2 was developed. Honokiol demonstrated weak activity against HIV-1 in human lymphocytes...
  42. pmc Honokiol is a potent scavenger of superoxide and peroxyl radicals
    Sergey Dikalov
    Division of Cardiology, Emory University School of Medicine, 1639 Pierce Drive, Suite 319 WMB, Atlanta, GA 30322, United States
    Biochem Pharmacol 76:589-96. 2008
    ..5x10(6)M(-1)s(-1)). Therefore, honokiol is an effective scavenger of both superoxide and peroxyl radicals, which may be important for physiological activity of honokiol...
  43. ncbi request reprint Ulcerative granulomatous mycosis fungoides
    Sareeta R S Parker
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
    Skinmed 8:188-90. 2010
    ..Several of the plaques, including one on his right flank, had overlying deep ulcerations (Figure 1A and 1B). Bilateral inguinal lymphadenopathy was present...
  44. ncbi request reprint The duality of angiogenesis: implications for therapy of human disease
    Betsy N Perry
    Department of Dermatology, Emory University School of Medicine and Veterans Administration Hospital, Atlanta, Georgia 30322, USA
    J Invest Dermatol 126:2160-6. 2006
    ....
  45. ncbi request reprint Honokiol, a natural plant product, inhibits the bone metastatic growth of human prostate cancer cells
    Katsumi Shigemura
    Molecular Urology and Therapeutics Program, Department of Urology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, USA
    Cancer 109:1279-89. 2007
    ..has been shown to induce apoptosis in malignant cells. The effect of honokiol and the combined therapy with docetaxel on prostate cancer (PCa) growth and bone metastasis was investigated in experimental models...
  46. pmc Overexpression of Akt converts radial growth melanoma to vertical growth melanoma
    Baskaran Govindarajan
    Department of Dermatology, Emory University School of Medicine, and Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA
    J Clin Invest 117:719-29. 2007
    ..Akt thus serves as a molecular switch that increases angiogenesis and the generation of superoxide, fostering more aggressive tumor behavior. Targeting Akt and ROS may be of therapeutic importance in treatment of advanced melanoma...
  47. ncbi request reprint Cutaneous lesions of secondary syphilis are highly angiogenic
    Nada C Macaron
    Departments of Pathology and Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Acad Dermatol 48:878-81. 2003
    ..The role of angiogenesis in infectious processes is poorly studied. Some viruses have been linked to angiogenesis, but the role of bacteria and protozoa in inducing angiogenesis in chronic infections is poorly understood...
  48. doi request reprint Effectiveness of gentian violet and similar products commonly used to treat pyodermas
    Ricardo L Berrios
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Dermatol Clin 29:69-73. 2011
    ..Given their low cost, ease of application, and favorable side effect profile, triphenylmethanes must be considered legitimate treatment options for pyodermas, particularly in the face of continued and emerging bacterial resistance...
  49. pmc Novel antiangiogenic agents in dermatology
    Ricardo L Berrios
    Emory University School of Medicine, Department of Dermatology, 101 Woodruff Cr, Suite 5001, Atlanta, GA 30322, USA
    Arch Biochem Biophys 508:222-6. 2011
    ..In this review, we highlight our experience with a group of existing and novel, small molecules that combine several modes of action against angiogenesis in addition to other properties--triarylmethane dyes and fulvene derivatives...
  50. ncbi request reprint Neuroendocrine lung tumors: grade correlates with proliferation but not angiogenesis
    Z K Arbiser
    Department of Pathology, Southern Regional Medical Center (ZKA, Riverdale, Georgia, USA
    Mod Pathol 14:1195-9. 2001
    ..The association of increased proliferation and tumor type may prove to be clinically useful and shed light on the role of sequential oncogenic alterations in NLT...
  51. pmc Synthesis, cytotoxicity, and antiviral activities of new neolignans related to honokiol and magnolol
    Franck Amblard
    Department of Pediatrics and Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Bioorg Med Chem Lett 17:4428-31. 2007
    ..Certain compounds exhibited specific anti-proliferation activity against SVR cells and moderate anti-HIV-1 activity in primary human lymphocytes. Compound 5h was the most potent compound and its anti-tumor activity was evaluated in vivo...
  52. ncbi request reprint The role of angiogenesis in the pathogenesis of psoriasis
    Ramon Alvin Chua
    Department of Dermatology, Emory University School of Medicine, Atlanta Veterans Administration Hospital, Atlanta, GA 30322, USA
    Autoimmunity 42:574-9. 2009
    ..Mediators such as VEGF and angiopoietin-2 play significant roles in the pathophysiology and may even account for the maintenance of the chronic inflammatory state. Targets in this shared pathway may offer alternative avenues for therapy...
  53. ncbi request reprint Mitogen-actived protein kinase activation is an early event in melanoma progression
    Cynthia Cohen
    Department of Pathology, Public Health, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 8:3728-33. 2002
    ..Because of these findings, we wanted to assess the role of MAPK signaling in melanoma progression and angiogenesis...
  54. ncbi request reprint Are keloids really "gli-loids"?: High-level expression of gli-1 oncogene in keloids
    A Kim
    Department of Dermatology, Emory University School of Medicine, 1639 Pierce Dr, Atlanta, GA 30322, USA
    J Am Acad Dermatol 45:707-11. 2001
    ..Currently, no entirely satisfactory method of treatment exists for these lesions. Recently, a patient who was enrolled in a clinical trial of topical tacrolimus for atopic dermatitis applied this drug to a keloid and noted clearing...
  55. ncbi request reprint Molecular patterns in melanoma and therapeutic targets
    R A Chua
    Departments of Dermatology, Emory University School of Medicine, Atlanta Veterans Administration Hospital, Atlanta, GA, USA
    G Ital Dermatol Venereol 145:597-602. 2010
    ..While a cure is not yet within grasp, the picture on the horizon is less hazy and the next decade promises to yield exciting new therapeutic discoveries...
  56. pmc Expression of the neural stem cell markers NG2 and L1 in human angiomyolipoma: are angiomyolipomas neoplasms of stem cells?
    So Dug Lim
    Department of Urology, Emory University School of Medicine, and Atlanta VA Medical Center, Georgia 30322, USA
    Mol Med 13:160-5. 2007
    ..These results support a novel histogenesis of angiomyolipoma as a defect in differentiation of stem cell precursors...
  57. doi request reprint Tris (dibenzylideneacetone) dipalladium, a N-myristoyltransferase-1 inhibitor, is effective against melanoma growth in vitro and in vivo
    Sulochana S Bhandarkar
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin Cancer Res 14:5743-8. 2008
    ..Studies were carried out to determine the mechanism of action of Tris DBA...
  58. pmc Fulvene-5 potently inhibits NADPH oxidase 4 and blocks the growth of endothelial tumors in mice
    Sulochana S Bhandarkar
    Department of Dermatology and Atlanta Veterans Administration Medical Center, Emory University, Atlanta, Georgia 30322, USA
    J Clin Invest 119:2359-65. 2009
    ..In conclusion, the present study establishes Nox4 as a critical regulator of hemangioma growth and identifies fulvenes as a potential class of candidate inhibitor to therapeutically interfere with Nox function...
  59. ncbi request reprint The antidepressant sertraline downregulates Akt and has activity against melanoma cells
    Kalpana K Reddy
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
    Pigment Cell Melanoma Res 21:451-6. 2008
    ..Use of antidepressants that decrease Akt may improve the efficacy of interferon and other therapies against melanoma. Further studies are needed to elucidate whether sertraline acts as an Akt inhibitor in melanoma...
  60. pmc Reactive oxygen signaling and MAPK activation distinguish Epstein-Barr Virus (EBV)-positive versus EBV-negative Burkitt's lymphoma
    Francesca Cerimele
    Department of Dermatology, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Proc Natl Acad Sci U S A 102:175-9. 2005
    ..Our findings imply that inhibition of ROS may be useful in the treatment of EBV-induced neoplasia...
  61. ncbi request reprint Molecular pathogenesis of vascular anomalies: classification into three categories based upon clinical and biochemical characteristics
    Katarina G Chiller
    Emory University, Department of Dermatology, Atlanta, Georgia 30322, USA
    Lymphat Res Biol 1:267-81. 2003
    ..The occurrences of arteriovenous malformations in territories susceptible to increased remodeling also point towards epigenetic events in the development of vascular malformations...
  62. ncbi request reprint Implications of Epstein-Barr Virus (EBV)-induced carcinogenesis on cutaneous inflammation and carcinogenesis: evidence of recurring patterns of angiogenesis and signal transduction
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia, USA
    J Invest Dermatol 124:xi-xii. 2005
  63. ncbi request reprint Keloids demonstrate high-level epidermal expression of vascular endothelial growth factor
    Amy Kim Gira
    Department of Dermatology, Emory University School of Medicine and Atlanta Veterans Administration Medical Center, Atlanta, Georgia 30322, USA
    J Am Acad Dermatol 50:850-3. 2004
    ..Angiogenesis inhibition has been shown to be effective in treatment of malignancy in both animal models and human beings...
  64. doi request reprint Transgrediens pachyonychia congenita (PC): case series of a nonclassical PC presentation
    K Harris
    Department of Dermatology, University of Utah, Huntsman Cancer Institute, 2000 Circle of Hope, Rm 5242, Salt Lake City, UT 84112, USA
    Br J Dermatol 166:124-8. 2012
    ..Pachyonychia congenita (PC) is a rare keratin disorder that typically presents with nail dystrophy and focal plantar keratoderma. We present seven cases of PC with transgrediens involvement of the dorsal feet...
  65. doi request reprint Maspin expression, angiogenesis, prognostic parameters, and outcome in malignant melanoma
    Ramon Chua
    Department of Dermatology, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Am Acad Dermatol 60:758-66. 2009
    ..However, it has been correlated with malignant behavior in pancreatic and ovarian cancer. The role of maspin in malignant melanoma (MM) has not yet been systematically examined...
  66. ncbi request reprint Apolipoprotein D is down-regulated during malignant transformation of neurofibromas
    Stephen Hunter
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Hum Pathol 36:987-93. 2005
    ..This expression pattern may serve as a marker for cell cycle inhibition during peripheral nerve tumorigenesis...
  67. doi request reprint The reactive oxygen-driven tumor: relevance to melanoma
    Levi Fried
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
    Pigment Cell Melanoma Res 21:117-22. 2008
    ..The phenotype of the reactive oxygen driven tumor can be monitored using available markers already in use in most hospital laboratories...
  68. ncbi request reprint Angiogenesis in cutaneous lesions of leprosy: implications for treatment
    Sulochana S Bhandarkar
    Department of Dermatology, Emory University School of Medicine, WMB 5309, 1639 Pierce Dr, Atlanta, GA 30322, USA
    Arch Dermatol 143:1527-9. 2007
    ..To examine the potential role of angiogenesis in leprosy...
  69. ncbi request reprint AKT1 overexpression in endothelial cells leads to the development of cutaneous vascular malformations in vivo
    Betsy Perry
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arch Dermatol 143:504-6. 2007
    ..Akt1 is a serine-threonine protein kinase, which is a key mediator of resistance to programmed cell death. Our objective was to determine whether sustained activation of Akt1 could lead to vascular malformation in mice...
  70. ncbi request reprint Wilms tumor 1 expression present in most melanomas but nearly absent in nevi
    Betsy N Perry
    School of Medicine, Department of Dermatology, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA
    Arch Dermatol 142:1031-4. 2006
    ..These mutations suggest not only that nevi and melanomas share a common origin but also that additional events are required for transformation to malignant melanoma...
  71. ncbi request reprint Mammalian target of rapamycin (mTOR) is activated in cutaneous vascular malformations in vivo
    Farheen Shirazi
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Lymphat Res Biol 5:233-6. 2007
    ..Since there are no Akt inhibitors approved for clinical use, we examined phosphorylated S6 expression, a downstream target of Akt. Phosphorylated S6 indicates potential sensitivity to rapamycin...
  72. ncbi request reprint Weight loss-induced calciphylaxis: potential role of matrix metalloproteinases
    Girish Munavalli
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA, U S A
    J Dermatol 30:915-9. 2003
    ..Inhibitors of matrix metalloproteinases may be useful in the prevention and treatment of calciphylaxis...
  73. ncbi request reprint gli-1 Oncogene is highly expressed in granulomatous skin disorders, including sarcoidosis, granuloma annulare, and necrobiosis lipoidica diabeticorum
    Nada C Macaron
    Department of Pathology, and Emory Center for Outcomes Research, Emory University School of Medicine, Atlanta, GA 30322, USA
    Arch Dermatol 141:259-62. 2005
    ..In a previous immunohistochemistry study of keloids, a scar granuloma stained highly positive for glioma-associated oncogene homologue (gli)-1...
  74. ncbi request reprint Activation of B-raf in non-malignant nevi predicts a novel tumor suppressor gene in melanoma (MAP kinase phosphatase)
    Jack L Arbiser
    Department of Dermatology and Emory Skin Disease Research Core Center, Emory University School of Medicine, Atlana, Georgia, USA
    J Invest Dermatol 121:xiv. 2003
  75. ncbi request reprint Reversing the angiogenic switch with photodynamic therapy
    Jack L Arbiser
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA, USA
    J Invest Dermatol 121:xi-xii. 2003
  76. pmc Efficacy of rapamycin in scleroderma: a case study
    Levi Fried
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Lymphat Res Biol 6:217-9. 2008
    ..We observed rapid improvement in skin stiffness and mobility. Our results provide the rationale for larger clinical trials of rapamycin in scleroderma and other fibrotic disorders...
  77. ncbi request reprint Regulation of endothelial cell differentiation and transformation by H-Ras
    Emma Rennel
    Department of Genetics and Pathology, Vascular Biology Unit, The Rudbeck Laboratory, Uppsala University, S 751 85 Uppsala, Sweden
    Exp Cell Res 291:189-200. 2003
    ..However, this activity must be tightly regulated as aberrant activity can disturb the ability of endothelial cells to undergo differentiation...
  78. ncbi request reprint PSK and Trx80 inhibit B-cell growth in EBV-infected cord blood mononuclear cells through T cells activated by the monocyte products IL-15 and IL-12
    Anquan Liu
    Microbiology and Tumor Biology Center, Karolinska Institute, Box 280, 171 77 Stockholm, Sweden
    Blood 105:1606-13. 2005
    ..Phosphatidylinositol 3-(PI 3)-kinase and reactive oxygen species (ROSs) were involved in the PSK-induced activation of monocytes. Restimulation of the cultures with EBV-transformed B cells generated specific cytotoxic activity...
  79. ncbi request reprint Phosphorylation by mitogen-activated protein kinase mediates the hypoxia-induced turnover of the TAL1/SCL transcription factor in endothelial cells
    Tong Tang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA
    J Biol Chem 277:18365-72. 2002
    ....
  80. ncbi request reprint Design, synthesis, and biological evaluation of angiogenesis inhibitors: aromatic enone and dienone analogues of curcumin
    Thomas Philip Robinson
    Computational Center for Molecular Structure and Design, Department of Chemistry, University of Georgia, Athens 30602 2556, USA
    Bioorg Med Chem Lett 13:115-7. 2003
    ..These compounds were screened for antiangiogenic properties via an in vitro SVR assay and were found to inhibit cell proliferation...
  81. pmc Tumor necrosis factor-related apoptosis-inducing ligand can induce apoptosis in subsets of premalignant cells
    Xiaojun Lu
    Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO, USA
    Am J Pathol 165:1613-20. 2004
    ..These results suggest that TRAIL can induce apoptosis in premalignant cells and suggests a novel therapy for the treatment of premalignant lesions in vivo...
  82. ncbi request reprint Honokiol, a natural biphenyl, inhibits in vitro and in vivo growth of breast cancer through induction of apoptosis and cell cycle arrest
    Ido Wolf
    Division of Hematology Oncology, UCLA School of Medicine, Los Angeles, CA, USA
    Int J Oncol 30:1529-37. 2007
    ..Our data suggest that HNK is a systemically available, non-toxic inhibitor of breast cancer growth and should be examined for clinical applications...
  83. ncbi request reprint Honokiol, a natural plant product, inhibits inflammatory signals and alleviates inflammatory arthritis
    Melissa E Munroe
    Department of Microbiology, University of Iowa, IA 52242, USA
    J Immunol 179:753-63. 2007
    ..These promising findings suggest that the nontoxic anti-inflammatory properties of HNK could be valuable for blocking the autoimmune response...
  84. ncbi request reprint Shb gene knockdown increases the susceptibility of SVR endothelial tumor cells to apoptotic stimuli in vitro and in vivo
    Nina S Funa
    Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden
    J Invest Dermatol 128:710-6. 2008
    ..It is concluded that Shb regulates apoptosis and cell shape in tumor endothelial cells via FAK, and that Shb is a potential target for inhibition of angiogenesis...
  85. pmc Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells
    Avalon Garcia
    Department of Biological Sciences, Hunter College of the City University of New York, New York 10021, USA
    Clin Cancer Res 14:4267-74. 2008
    ..Honokiol is a compound that suppresses tumor growth in mouse models. The purpose of this study was to investigate the effect of honokiol on PLD survival signals and the Ras dependence of these signals...
  86. pmc A modified cysteinyl-labeling assay reveals reversible oxidation of protein tyrosine phosphatases in angiomyolipoma cells
    Benoit Boivin
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724 2208, USA
    Proc Natl Acad Sci U S A 105:9959-64. 2008
    ..We anticipate that this cysteinyl-labeling enrichment strategy can be applied broadly to study reversible oxidation as a mechanism of harnessing PTP catalytic activity in a variety of signaling pathways...
  87. ncbi request reprint Synthesis and biological evaluation of aromatic enones related to curcumin
    Thomas Philip Robinson
    Center for Biomolecular Structure and Dynamics, Department of Chemistry, University of Georgia, Athens, GA 30602, USA
    Bioorg Med Chem 13:4007-13. 2005
    ..Due to both their commercial availability and their fairly straightforward synthetic preparation, these low molecular weight compounds are attractive leads for developing future angiogenic inhibitors...
  88. ncbi request reprint Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors
    Benjamin Lefkove
    Department of Dermatology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Expert Rev Anti Infect Ther 5:573-9. 2007
    ....
  89. ncbi request reprint Angiomotin expression promotes hemangioendothelioma invasion
    Tetyana Levchenko
    Department of Oncology Pathology, Cancer Centre Karolinska Institute, S 17176, Stockholm, Sweden
    Oncogene 23:1469-73. 2004
    ..However, time-lapse photography showed a significant increase in random motility in MAE-Amot cells. We conclude that angiomotin may promote angiogenesis by both stimulating invasion as well as stabilizing established tubes...
  90. doi request reprint Solenopsin A, a venom alkaloid from the fire ant Solenopsis invicta, inhibits quorum-sensing signaling in Pseudomonas aeruginosa
    Junguk Park
    Department of Chemistry and Immunology, Scripps Research Institute, La Jolla, CA 92037, USA
    J Infect Dis 198:1198-201. 2008
    ..Interestingly, exogenously added C(4)-homoserine lactone (HSL), but not 3-oxo-C(12)-HSL, restored P. aeruginosa QS signaling, suggesting that solenopsin A targets the C(4)-HSL-dependent rhl QS system...
  91. ncbi request reprint Role of manganese superoxide dismutase in cancer
    Jack L Arbiser
    Nat Med 9:1103; author reply 1103. 2003

Research Grants13

  1. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2001
    ....
  2. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2009
    ....
  3. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2009
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  4. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2007
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  5. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2006
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  6. Skin Manifestations of Tuberous Sclerosis
    Jack Arbiser; Fiscal Year: 2005
    ..Specific Aim 3. To determine whether dysregulation of p16ink4a and PTCH (patched) acts as a modifier of theTS phenotype in transgenic mice expressing dominant negative tuberin. ..
  7. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2005
    ....
  8. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2004
    ....
  9. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2003
    ....
  10. Cutaneous Hemangiomas and Signal Transduction
    Jack Arbiser; Fiscal Year: 2002
    ....
  11. Cutaneous Hemangiomas and Signal Transduction
    Jack L Arbiser; Fiscal Year: 2010
    ....