Aftab Ansari

Summary

Affiliation: Emory University
Country: USA

Publications

  1. ncbi Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses
    Tetsuya Adachi
    Department of Immunology, University of the Ryukyus, Okinawa, Japan
    Retrovirology 8:84. 2011
  2. ncbi Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts
    Susan T Stephenson
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Retrovirology 7:107. 2010
  3. ncbi Drugs of abuse and HIV--a perspective
    Aftab Ahmed Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Woodruff Memorial Building, Atlanta, GA 30322, USA
    J Neuroimmunol 147:9-12. 2004
  4. ncbi Autoimmunity, anergy, lentiviral immunity and disease
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Room 2309 WMB, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Autoimmun Rev 3:530-40. 2004
  5. ncbi Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Immunol Res 29:1-18. 2004
  6. ncbi The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Autoimmun 28:152-9. 2007
  7. ncbi A case for innate immune effector mechanisms as contributors to disease resistance in SIV-infected sooty mangabeys
    Lara E Pereira
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Curr HIV Res 7:12-22. 2009
  8. ncbi Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 186:1044-59. 2011
  9. ncbi Incorporation of innate immune effector mechanisms in the formulation of a vaccine against HIV-1
    Aftab A Ansari
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Adv Exp Med Biol 780:143-59. 2011
  10. ncbi Lessons learnt from studies of the immune characterization of naturally SIV infected sooty mangabeys
    Aftab A Ansari
    Department of Pathology Laboratory Medicine, Emory University School of Medicine, Atlanta 30322, GA
    Front Biosci 8:s1030-50. 2003

Research Grants

  1. CD4 T Cell Activation in SIV+Disease Resistant Mangabeys
    Aftab Ansari; Fiscal Year: 2004
  2. HIV INFECTION/COCAINE EFFECT ON CARDIOVASCULAR PATHOLOGY
    Aftab Ansari; Fiscal Year: 2003
  3. Role of T Cell Immunity in Primate AIDS
    Aftab Ansari; Fiscal Year: 2006
  4. MOLECULAR MECHANISMS OF CD4+ T CELL DYSFUNCTION IN SIV
    Aftab Ansari; Fiscal Year: 2009
  5. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2010
  6. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2011
  7. ROLE OF VIRUS SPECIFIC T CELL IMMUNITY IN PRIMATE AIDS
    Aftab Ansari; Fiscal Year: 1992
  8. VIRUS SPECIFIC T CELL IMMUNITY AND PRIMATE AIDS
    Aftab Ansari; Fiscal Year: 2000

Collaborators

Detail Information

Publications44

  1. ncbi Identification of an unique CXCR4 epitope whose ligation inhibits infection by both CXCR4 and CCR5 tropic human immunodeficiency type-I viruses
    Tetsuya Adachi
    Department of Immunology, University of the Ryukyus, Okinawa, Japan
    Retrovirology 8:84. 2011
    ....
  2. ncbi Distinct host cell proteins incorporated by SIV replicating in CD4+ T cells from natural disease resistant versus non-natural disease susceptible hosts
    Susan T Stephenson
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Retrovirology 7:107. 2010
    ....
  3. ncbi Drugs of abuse and HIV--a perspective
    Aftab Ahmed Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Woodruff Memorial Building, Atlanta, GA 30322, USA
    J Neuroimmunol 147:9-12. 2004
    ..The scope of the studies that are needed to address this issue and the limitations inherent in such studies are summarized below...
  4. ncbi Autoimmunity, anergy, lentiviral immunity and disease
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Room 2309 WMB, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Autoimmun Rev 3:530-40. 2004
    ..We believe that such findings have important implications for the design of vaccines against human HIV infection...
  5. ncbi Use of recombinant cytokines for optimized induction of antiviral immunity against SIV in the nonhuman primate model of human AIDS
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Immunol Res 29:1-18. 2004
    ..This article provides a summary of our work with such cytokines, which includes attempts to define optimum dosing schedules that lead to optimal primary and lasting memory antigen-specific immune responses...
  6. ncbi The role of disease stage, plasma viral load and regulatory T cells (Tregs) on autoantibody production in SIV-infected non-human primates
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Autoimmun 28:152-9. 2007
    ....
  7. ncbi A case for innate immune effector mechanisms as contributors to disease resistance in SIV-infected sooty mangabeys
    Lara E Pereira
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, USA
    Curr HIV Res 7:12-22. 2009
    ....
  8. ncbi Blocking of α4β7 gut-homing integrin during acute infection leads to decreased plasma and gastrointestinal tissue viral loads in simian immunodeficiency virus-infected rhesus macaques
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 186:1044-59. 2011
    ....
  9. ncbi Incorporation of innate immune effector mechanisms in the formulation of a vaccine against HIV-1
    Aftab A Ansari
    Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
    Adv Exp Med Biol 780:143-59. 2011
    ..Finally, the major points from this report and the data presented on similar subjects by other investigators is utilized to provide a summary of the potential future directions that we need to take in efforts to move this field forward...
  10. ncbi Lessons learnt from studies of the immune characterization of naturally SIV infected sooty mangabeys
    Aftab A Ansari
    Department of Pathology Laboratory Medicine, Emory University School of Medicine, Atlanta 30322, GA
    Front Biosci 8:s1030-50. 2003
    ..leprae infection (see Dr. B. Gormus's chapter). Some of our working hypotheses that are aimed to provide explanations for some of these paradoxes are provided herein...
  11. ncbi Administration of recombinant rhesus interleukin-12 during acute simian immunodeficiency virus (SIV) infection leads to decreased viral loads associated with prolonged survival in SIVmac251-infected rhesus macaques
    A A Ansari
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 76:1731-43. 2002
    ..This is the first study to demonstrate the capacity of IL-12 to significantly protect macaques from SIV-induced disease, and it provides a useful model to more precisely identify correlates of virus-specific disease-protective responses...
  12. ncbi Autoimmune mechanisms as the basis for human peripartum cardiomyopathy
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Room 4107B Winship Cancer Institute, Emory University School of Medicine, 1365 B Clifton Rd, Atlanta, GA 30322, USA
    Clin Rev Allergy Immunol 23:301-24. 2002
    ..A working model for the pathogenesis of this disease is also described herein...
  13. ncbi Plasmacytoid dendritic cells are recruited to the colorectum and contribute to immune activation during pathogenic SIV infection in rhesus macaques
    Suefen Kwa
    Emory Vaccine Center, Department of Microbiology and Immunology, Yerkes National Primate Research Center, Emory University, Atlanta, GA 30329, USA
    Blood 118:2763-73. 2011
    ..Our results uncover a new mechanism by which pDCs influence immune activation in colorectal tissue after pathogenic immunodeficiency virus infections...
  14. ncbi Optimization of in vitro expansion of macaque CD4 T cells using anti-CD3 and co-stimulation for autotransfusion therapy
    Nattawat Onlamoon
    Department of Pathology and Lab Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Med Primatol 35:178-93. 2006
    ..Finally, anti-CD3/28-expanded CD4(+) T cells uniformly exhibited a central memory phenotype, absence of CCR5 expression, marked CXCR4 expression in vitro, low levels of caspase 3 but also of Bcl-2 expression...
  15. ncbi Fetal cord blood mononuclear cells that are collected at term from HIV-1 infected women harbor transcriptionally active integrated proviral DNA
    Jane E Ellis
    Department of Gynecology and Obstetrics, Emory University School of Medicine, Atlanta, GA, USA
    Am J Obstet Gynecol 197:371.e1-6. 2007
    ....
  16. ncbi Differences in the constitutive and SIV infection induced expression of Siglecs by hematopoietic cells from non-human primates
    Jiraporn Jaroenpool
    Department of Pathology and Lab Medicine, Emory University School of Medicine, Winship Cancer Center, Room, 2309 WMB, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Cell Immunol 250:91-104. 2007
    ..The reasons for the failure to detect these molecules at the protein level and the mechanisms for such distinct effects of SIV infection on Siglec expression are discussed...
  17. ncbi Soluble PD-1 rescues the proliferative response of simian immunodeficiency virus-specific CD4 and CD8 T cells during chronic infection
    Nattawat Onlamoon
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Immunology 124:277-93. 2008
    ..The results of these studies serve as a foundation for future in vivo trials of the use of rMamu-PD-1 to potentially enhance and/or restore antiviral immune responses in vivo...
  18. ncbi Anti-CD3/28 mediated expansion of macaque CD4+ T cells is polyclonal and provides extended survival after adoptive transfer
    Nattawat Onlamoon
    Department of Pathology and Lab Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Med Primatol 36:206-18. 2007
    ....
  19. ncbi Human and nonhuman primate lentiviral infection and autoimmunity
    Nattawat Onlamoon
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Ann N Y Acad Sci 1050:397-409. 2005
    ....
  20. ncbi CD4+ T cells from simian immunodeficiency virus disease-resistant sooty mangabeys produce more IL-2 than cells from disease-susceptible species: involvement of p300 and CREB at the proximal IL-2 promoter in IL-2 up-regulation
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University, 101 Woodruff Circle, Atlanta, GA 30322, USA
    J Immunol 178:7720-9. 2007
    ..These unique characteristics of the proximal IL-2 promoter in SM therefore can represent one of the mechanisms contributing to the resistance of these cells to undergo anergy...
  21. ncbi Maintenance of CD4+ T cell TCR Vbeta repertoire heterogeneity is characteristic of apathogenic SIV infection in non-human primate model of AIDS
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University, WMB rm 2337A, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Virology 369:324-8. 2007
    ....
  22. ncbi Multiple KIR gene polymorphisms are associated with plasma viral loads in SIV-infected rhesus macaques
    Porntip Chaichompoo
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Cell Immunol 263:176-87. 2010
    ..In addition, we herein document the existence of additional new alleles for the KIR1D, KIR2DL4, and the KIR3DH loci...
  23. ncbi Decreased NK cell frequency and function is associated with increased risk of KIR3DL allele polymorphism in simian immunodeficiency virus-infected rhesus macaques with high viral loads
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    J Immunol 182:3638-49. 2009
    ..This data for the first time defines multiple alleles of KIR3DL in RM and shows an association between virus control, NK cell function and genetic polymorphisms of KIR receptors...
  24. ncbi Availability of activated CD4+ T cells dictates the level of viremia in naturally SIV-infected sooty mangabeys
    Nichole R Klatt
    Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 118:2039-49. 2008
    ..Our results suggest that the availability of activated CD4+ T cells, rather than immune control of SIV replication, is the main determinant of set-point viral load during natural SIV infection of SMs...
  25. ncbi Human tissue mast cells are an inducible reservoir of persistent HIV infection
    J Bruce Sundstrom
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 109:5293-300. 2007
    ..These data provide the first in vivo evidence that tissue MCs, developed from infected circulating prMCs, comprise a long-lived inducible reservoir of persistent HIV in infected persons during HAART...
  26. ncbi CD4+ T cell signaling in the natural SIV host--implications for disease pathogenesis
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
    Front Biosci 8:s904-12. 2003
    ..This review summarizes currently available data on CD4+ T cell function in the naturally SIV infected sooty mangabey with potential implications of these characteristics for our understanding of the pathogenesis of SIV infection...
  27. ncbi Dysregulation of the polo-like kinase pathway in CD4+ T cells is characteristic of pathogenic simian immunodeficiency virus infection
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 78:1464-72. 2004
    ..Altogether this study presents a novel mechanism underlying M-phase defects observed in CD4(+) T cells from HIV or SIV-infected disease-susceptible humans and RM which may contribute to aberrant T-cell responses and disease pathogenesis...
  28. ncbi Adoptive transfer of simian immunodeficiency virus (SIV) naïve autologous CD4(+) cells to macaques chronically infected with SIV is sufficient to induce long-term nonprogressor status
    Francois Villinger
    Department of Pathology and Laboratory Medicine, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA 30322, USA
    Blood 99:590-9. 2002
    ....
  29. ncbi Is peripartum cardiomyopathy an organ-specific autoimmune disease?
    J Bruce Sundstrom
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Autoimmun Rev 1:73-7. 2002
    ..g. expression of PD-L1 on cardiac tissues and the role of regulatory T cells, may help to elucidate the autoimmune mechanisms of PPCM...
  30. ncbi Signaling through Toll-like receptors triggers HIV-1 replication in latently infected mast cells
    J Bruce Sundstrom
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 172:4391-401. 2004
    ..Taken together, these results indicate that mast cells may serve both as a viral reservoir and as a model for studying mechanisms of postintegration latency in HIV infection...
  31. ncbi Genetic analysis of cytokine promoters in nonhuman primates: implications for Th1/Th2 profile characteristics and SIV disease pathogenesis
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University, 1639 Pierce Drive, Atlanta, GA 30322, USA
    Clin Dev Immunol 11:35-44. 2004
    ....
  32. ncbi Central memory CD4 T cells are the predominant cell subset resistant to anergy in SIV disease resistant sooty mangabeys
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    AIDS 20:181-8. 2006
    ....
  33. ncbi Evidence for antibody-mediated enhancement of simian immunodeficiency virus (SIV) Gag antigen processing and cross presentation in SIV-infected rhesus macaques
    Francois Villinger
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    J Virol 77:10-24. 2003
    ....
  34. ncbi Pathogenic and apathogenic courses of SIV infection are associated with distinct and characteristic regulatory patterns of G1/S and G2/M cell cycle checkpoints in CD4+ T cells
    Pavel Bostik
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    AIDS Res Hum Retroviruses 22:1122-30. 2006
    ..resistance in these two species, respectively...
  35. ncbi Magnetic resonance imaging of activated proliferating rhesus macaque T cells labeled with superparamagnetic monocrystalline iron oxide nanoparticles
    J Bruce Sundstrom
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Woodruff Memorial Building, Room 2335A, 1639 Pierce Drive, Atlanta, GA, USA
    J Acquir Immune Defic Syndr 35:9-21. 2004
    ..These results indicate that intracellular labeling with MION can be a useful technique for noninvasively monitoring trafficking patterns of adoptively transferred leukocyte subsets in real-time by MRI in nonhuman primate models of AIDS...
  36. ncbi Cytokine analysis by intracellular staining
    Aftab A Ansari
    Department of Pathology and Laboratory Medicine, Robert W. Woodruff Health Sciences Center, Emory University School of Medicine, Atlanta, GA, USA
    Methods Mol Med 72:423-35. 2002
  37. ncbi IgE-FcepsilonRI interactions determine HIV coreceptor usage and susceptibility to infection during ontogeny of mast cells
    J Bruce Sundstrom
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    J Immunol 182:6401-9. 2009
    ....
  38. ncbi Characterization and role of lentivirus-associated host proteins
    Keli Kolegraff
    Department of Pathology and Laboratory Medicine, Emory University, WMB Room 2309, 101 Woodruff Circle, Atlanta, GA 30322, USA
    Exp Biol Med (Maywood) 231:252-63. 2006
    ....
  39. ncbi Dengue virus-induced hemorrhage in a nonhuman primate model
    Nattawat Onlamoon
    Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA
    Blood 115:1823-34. 2010
    ....
  40. ncbi A re-evaluation of the mechanisms leading to dengue hemorrhagic fever
    Sansanee Noisakran
    Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Ann N Y Acad Sci 1171:E24-35. 2009
    ..The observation may partially explain the dysfunction of platelets observed in dengue affected patients...
  41. ncbi Navigating the passage between Charybdis and Scylla: recognizing the achievements of Noel Rose
    Aftab A Ansari
    Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
    J Autoimmun 33:165-9. 2009
    ..Hence, this volume has been coined "Navigating the Passage Between Charybdis and Scylla: Recognizing the Achievements of Noel Rose."..
  42. ncbi Combined pathological effects of cocaine abuse and HIV infection on the cardiovascular system: an autopsy study of 187 cases from the Fulton County Medical Examiner's office
    Mario I Mosunjac
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia 30303, USA
    Am J Forensic Med Pathol 29:9-13. 2008
    ..5%, 17.4%, and 17.4% vs. 6.5%, 3.3%, and 0% in CONT group) may indicate possible combined and/or cumulative effects of HIV and cocaine on cardiovascular pathology...
  43. ncbi Magnitude of alloresponses to MHC class I/II expressing human cardiac myocytes is limited by their intrinsic ability to process and present antigenic peptides
    J Bruce Sundstrom
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Clin Dev Immunol 10:213-26. 2003
    ..These results suggest that weak allogenicity of cardiac myocytes may be governed by their limited expression of MHC genes and gene products critical for antigen processing and presentation...
  44. ncbi The development of mouse APECED models provides new insight into the role of AIRE in immune regulation
    Lara E Pereira
    Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA
    Clin Dev Immunol 12:211-6. 2005
    ..The findings thus far are compelling and prompt additional areas of study which are discussed...

Research Grants32

  1. CD4 T Cell Activation in SIV+Disease Resistant Mangabeys
    Aftab Ansari; Fiscal Year: 2004
    ..abstract_text> ..
  2. HIV INFECTION/COCAINE EFFECT ON CARDIOVASCULAR PATHOLOGY
    Aftab Ansari; Fiscal Year: 2003
    ..We reason that such studies may provide unique insights on the relationship between the effects of cocaine and HIV infection in the pathogenesis of cardiovascular disease. ..
  3. Role of T Cell Immunity in Primate AIDS
    Aftab Ansari; Fiscal Year: 2006
    ....
  4. MOLECULAR MECHANISMS OF CD4+ T CELL DYSFUNCTION IN SIV
    Aftab Ansari; Fiscal Year: 2009
    ..abstract_text> ..
  5. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2010
    ..Studies are therefore focused on defining these early events in SIV infected monkeys. ..
  6. Innate Immunity and SIV Infection
    Aftab A Ansari; Fiscal Year: 2011
    ..Studies are therefore focused on defining these early events in SIV infected monkeys. ..
  7. ROLE OF VIRUS SPECIFIC T CELL IMMUNITY IN PRIMATE AIDS
    Aftab Ansari; Fiscal Year: 1992
  8. VIRUS SPECIFIC T CELL IMMUNITY AND PRIMATE AIDS
    Aftab Ansari; Fiscal Year: 2000
    ....