Research Topics
| N Volkan AdsaySummaryAffiliation: Emory University Country: USA Publications
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Publications
Cystic neoplasia of the pancreas: pathology and biologyN Volkan Adsay
Department of Pathology, Emory University, Atlanta, GA 30322, USA
J Gastrointest Surg 12:401-4. 2008....
Tumor budding as a strong prognostic indicator in invasive ampullary adenocarcinomasNobuyuki Ohike
Departments of Pathology, Emory University Hospital, Atlanta, GA, USA
Am J Surg Pathol 34:1417-24. 2010..Therefore, budding should be incorporated into surgical pathology reports for AAC...
Intraductal and papillary variants of acinar cell carcinomas: a new addition to the challenging differential diagnosis of intraductal neoplasmsOlca Basturk
Department of Pathology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48201, USA
Am J Surg Pathol 31:363-70. 2007..The clinical significance of this variant is difficult to determine; however, it appears that the tumors are relatively small and metastasis at presentation is less common than typically seen in ACCs (1/7 vs. 50%)...
Differences in presentation and perioperative outcome after pancreaticoduodenectomy for cancer and benign pancreatitisCarrie K Chu
Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am Surg 76:606-13. 2010..Infectious complication risk is higher in patients with adenocarcinoma. Increased age and jaundice should raise suspicion of cancer in patients with chronic pancreatitis undergoing evaluation for surgical treatment...
DeltaNp63 expression in pancreas and pancreatic neoplasiaOlca Basturk
Department of Pathology, Harper University Hospital, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
Mod Pathol 18:1193-8. 2005..IV) No p63-expressing 'stem' cells are present in the pancreas...
Intra-ampullary papillary-tubular neoplasm (IAPN): characterization of tumoral intraepithelial neoplasia occurring within the ampulla: a clinicopathologic analysis of 82 casesNobuyuki Ohike
Department of Pathology, Emory University Hospital, Atlanta, GA, USA
Am J Surg Pathol 34:1731-48. 2010..Here, we provide a detailed analysis of these neoplasms, which we propose to refer to as intra-ampullary papillary-tubular neoplasm (IAPN)...
Pathogenesis of colloid (pure mucinous) carcinoma of exocrine organs: Coupling of gel-forming mucin (MUC2) production with altered cell polarity and abnormal cell-stroma interaction may be the key factor in the morphogenesis and indolent behavior of colloN Volkan Adsay
Department of Pathology, Karamanos Cancer Institute and Wayne State University, Detroit, Michigan 48201, USA
Am J Surg Pathol 27:571-8. 2003..This distinctive mucin, accumulated in the stroma surrounding the CC cells, may act as a containing factor, slackening the spread of the cells...
Pathologic staging of pancreatic, ampullary, biliary, and gallbladder cancers: pitfalls and practical limitations of the current AJCC/UICC TNM staging system and opportunities for improvementN Volkan Adsay
Department of Pathology, Emory University, School of Medicine, Atlanta, Georgia, USA
Semin Diagn Pathol 29:127-41. 2012..Proper grossing and appreciation of histo-anatomic subtleties of this region are crucial in addressing these issues and achieving more applicable and clinically relevant staging systems in the future...
The number of lymph nodes identified in a simple pancreatoduodenectomy specimen: comparison of conventional vs orange-peeling approach in pathologic assessmentN Volkan Adsay
Department of Pathology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, GA, USA
Mod Pathol 22:107-12. 2009..Therefore, lymph node harvest by the orange-peeling method should be performed routinely before specimen sectioning in assessment of pancreatoduodenectomy for ductal adenocarcinoma...
Impact of diabetes mellitus on perioperative outcomes after resection for pancreatic adenocarcinomaCarrie K Chu
Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA
J Am Coll Surg 210:463-73. 2010..Associations between diabetes mellitus (DM) and pancreatic ductal adenocarcinoma (PDAC) are well established; however, the impact of DM on perioperative morbidity and mortality after PDAC resection is unclear...
Excision repair cross-complementing gene-1, ribonucleotide reductase subunit M1, ribonucleotide reductase subunit M2, and human equilibrative nucleoside transporter-1 expression and prognostic value in biliary tract malignancySarah B Fisher
Department of Surgery, Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
Cancer 119:454-62. 2013..The differential expression and prognostic value of these biomarkers in biliary tract malignancy (BTM) is unknown...
Preoperative diabetes mellitus and long-term survival after resection of pancreatic adenocarcinomaCarrie K Chu
Department of Surgery, Emory University School of Medicine, Atlanta, GA, USA
Ann Surg Oncol 17:502-13. 2010..To assess clinicopathologic features and postresection survival of diabetes mellitus (DM)-associated pancreatic ductal adenocarcinoma (PDAC)...
Histopathological diagnosis of pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms: interobserver agreementDaniel S Longnecker
Department of Pathology, Dartmouth Hitchcock Medical Center, Lebanon, NH 03756, USA
Pancreas 31:344-9. 2005....
Multicomponent analysis of the pancreatic adenocarcinoma progression model using a pancreatic intraepithelial neoplasia tissue microarrayAnirban Maitra
Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Mod Pathol 16:902-12. 2003....
Positive immunohistochemical staining of KIT in solid-pseudopapillary neoplasms of the pancreas is not associated with KIT/PDGFRA mutationsDengfeng Cao
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD, USA
Mod Pathol 19:1157-63. 2006....
Chronic pancreatitis or pancreatic ductal adenocarcinoma?N Volkan Adsay
Department of Pathology, The Karmanos Cancer Institute and Wayne State University School of Medicine, Detroit, Michigan, USA
Semin Diagn Pathol 21:268-76. 2004..Combinations of these criteria should aid in the differential diagnosis of invasive ductal adenocarcinoma from benign/reactive ducts in the pancreas...
Lipomatous pseudohypertrophy of the pancreas: a clinicopathologically distinct entityDeniz Altinel
Department of Pathology, Emory University, Atlanta, GA 30322, USA
Pancreas 39:392-7. 2010..As a result, benign lesions are sometimes surgically removed. One such condition, which is poorly defined in the literature, is referred to as lipomatous pseudohypertrophy (LPH) of the pancreas...
Lipid-rich variant of pancreatic endocrine neoplasmsRajendra Singh
Department of Pathology, Harper Hospital and Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA
Am J Surg Pathol 30:194-200. 2006..EM supports the name lipid-rich for this variant. The findings suggest that the pathogenesis of lipid-rich tumors may be different from the VHL-associated clear-cell variants of PENs...
GLUT-1 expression in pancreatic neoplasia: implications in pathogenesis, diagnosis, and prognosisOlca Basturk
Department of Pathology, New York University, New York, NY, USA
Pancreas 40:187-92. 2011..However, literature regarding the significance of GLUT-1 expression in pancreatic neoplasia has been limited and controversial...
Is serous cystadenoma of the pancreas a model of clear-cell-associated angiogenesis and tumorigenesis?Duangpen Thirabanjasak
Department of Pathology, Wayne State University and Karmanos Cancer Institute, Detroit, MI, USA
Pancreatology 9:182-8. 2009..Over the years, we have also noticed that the tumor epithelium shows a prominent capillary network...
TNM staging of colorectal carcinoma: issues and caveatsJinru Shia
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Semin Diagn Pathol 29:142-53. 2012..The article also provides a brief discussion about some of the major adjunct histopathologic prognostic factors, such as medullary-type histology and tumor differentiation...
Tumor characteristics and survival analysis of incidental versus suspected gallbladder carcinomaLaura M Mazer
Department of Surgery, Emory University, 1364 Clifton Road, NE, Suite H 124 C, Atlanta, GA 30322, USA
J Gastrointest Surg 16:1311-7. 2012..There are scant data comparing presentation and outcome for patients with incidental versus suspected GBC. The goal of this study is to determine the clinical differences between these two entities...
Tumoral and angiogenesis factors in hepatocellular carcinoma after locoregional therapyAlton B Farris
Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA 30322, USA
Pathol Res Pract 208:15-21. 2012....
Squamoid cyst of pancreatic ducts: A distinct type of cystic lesion in the pancreasMohammad Othman
Department of Pathology, Wayne State University and Karmanos Cancer Institute, Detroit, MI 48021, USA
Am J Surg Pathol 31:291-7. 2007..It seems to be a metaplastic cystic transformation beginning in the intercalated ducts. Although obstructive etiology is suspected, a specific factor or surrogate evidence of obstruction such as chronic pancreatitis is typically lacking...
Urothelial carcinoma with villoglandular differentiation: a study of 14 casesMatthew Lim
Department of Pathology, Emory University School of Medicine, 1364 Clifton Road NE, Atlanta, GA 30322, USA
Mod Pathol 22:1280-6. 2009..These relatively rare tumors should be recognized as a variant of urothelial carcinoma...
Is nonsmall cell type high-grade neuroendocrine carcinoma of the tubular gastrointestinal tract a distinct disease entity?Jinru Shia
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
Am J Surg Pathol 32:719-31. 2008..These tumors are clinically aggressive. Prospective studies using defined diagnostic criteria are needed to determine their biologic characteristics and optimal management...
Intraductal papillary-mucinous neoplasms of the pancreas: an analysis of in situ and invasive carcinomas in 28 patientsN Volkan Adsay
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 1002, USA
Cancer 94:62-77. 2002....
The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesisN Volkan Adsay
Department of Pathology, Karmanos Cancer Institute, Detroit, Michigan, USA
Mod Pathol 15:1087-95. 2002....
Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathwaysDengfeng Cao
Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, MD 21231-2410, USA
Mod Pathol 18:752-61. 2005....
A proposal for a new and more practical grading scheme for pancreatic ductal adenocarcinomaN Volkan Adsay
Department of Pathology, Karmanos Cancer Institute and Harper University Hospital, Wayne State University, 3990 John R Street, Detroit, MI 48201, USA
Am J Surg Pathol 29:724-33. 2005..Most importantly, it is clinically relevant with good prognostic value. Lastly, it is also applicable for use in research, by utilizing "patterns," even in small specimens like microarrays or biopsies...
Pathology of genetically engineered mouse models of pancreatic exocrine cancer: consensus report and recommendationsRalph H Hruban
Department of Pathology, The Sol Goldman Center for Pancreatic Cancer Research, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA
Cancer Res 66:95-106. 2006....
Pathology reporting of neuroendocrine tumors: application of the Delphic consensus process to the development of a minimum pathology data setDavid S Klimstra
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Am J Surg Pathol 34:300-13. 2010..Examination of the areas of disagreement reveals significant opportunities for collaborative study to resolve unanswered questions...
Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signalingZhiwei Wang
Department of Pathology, Karmanos Cancer Institute, Wayne State University, 9374 Scott Hall, 540 East Canfield, Detroit, MI 48201, USA
Cancer Res 67:11377-85. 2007..e., MMP-9 and VEGF), resulting in the inhibition of invasion and angiogenesis...
An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasmsRalph H Hruban
Department of Pathology, The Johns Hopkins Medical Institutions, 401 N Broadway, Weinberg 2242, Baltimore, MD 21231 2410, USA
Am J Surg Pathol 28:977-87. 2004..We present a consensus classification of the precursor lesions in the pancreatic ducts, PanINs and IPMNs...
Giant and complicated variants of cystic bile duct hamartomas of the liver: MRI findings and pathological correlationsDiego R Martin
Emory University School of Medicine, Department of Radiology, Atlanta, Georgia 30322, USA
J Magn Reson Imaging 31:903-11. 2010..To describe a new category of liver cyst we propose calling "giant bile duct hamartoma (giant-BDH)" and to provide a more complete record of the magnetic resonance imaging (MRI) features of BDHs with potential for clinical impact...
Important prognostic factors in adenocarcinoma of the ampulla of VaterMichael C Lowe
Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322, USA
Am Surg 75:754-60; discussion 761. 2009..N1 disease and presence of PNI demonstrated independent associations with worse survival. Given high percentage of mixed histology, PNI may be more informative than the subtype in predicting outcome for patients with AmpCA...
Diagnostic features and differential diagnosis of autoimmune pancreatitisN Volkan Adsay
Department of Pathology, The Karmanos Cancer Institute and Wayne State University School of Medicine, Detroit, Michigan, USA
Semin Diagn Pathol 22:309-17. 2005..It is important to recognize the distinctive clinicopathologic features of this entity, so that it can be diagnosed accurately and managed appropriately...
MR imaging of cystic lesions of the pancreasBobby Kalb
Department of Radiology, Emory University School of Medicine, 1365 Clifton Rd NE, Building A, AT622, Atlanta, GA 30322, USA
Radiographics 29:1749-65. 2009..Primary cystic lesions are more common than solid neoplasms with cystic changes. Knowledge of the varied MR imaging appearances of pancreatic cystic lesions may help radiologists achieve greater specificity in diagnostic reporting...
Molecular classification of neoplasms of the pancreasRalph H Hruban
Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA
Hum Pathol 40:612-23. 2009..This classification does not ignore previous histology-based classification systems but instead embraces them, creating an integrated histological-molecular classification...
The "new kid on the block": Intraductal papillary mucinous neoplasms of the pancreas: current concepts and controversiesN Volkan Adsay
Department of Pathology, Harper University Hospital and Wayne State University School of Medicine, Detroit, MI 48201, USA
Surgery 133:459-63. 2003
Pancreatic cysts: pathologic classification, differential diagnosis, and clinical implicationsOlca Basturk
Department of Pathology, New York University, New York, New York, USA
Arch Pathol Lab Med 133:423-38. 2009..Consequently, in the past 2 decades, the nature of many cystic tumors in this organ has been better characterized, and significant developments have taken place in the classification and in our understanding of pancreatic cystic lesions...
MUC2 expression in primary mucinous and nonmucinous adenocarcinoma of the prostate: an analysis of 50 cases on radical prostatectomyAdeboye O Osunkoya
Department of Pathology, Emory University School of Medicine, Atlanta, GA 30322, USA
Mod Pathol 21:789-94. 2008....
Intraductal papillary mucinous neoplasms of the pancreas: pathology and molecular geneticsN Volkan Adsay
Department of Pathology, Harper University Hospital and Karmanos Cancer Institute, Wayne State University, Detroit, Michigan, USA
J Gastrointest Surg 6:656-9. 2002
Secondary tumors of the pancreas: an analysis of a surgical and autopsy database and review of the literatureN Volkan Adsay
Department of Pathology, The Karmanos Cancer Institute and Wayne State University, Harper Hospital, 3990 John R Street, Detroit, MI 48201, USA
Virchows Arch 444:527-35. 2004..These are predominantly hematopoietic malignancies or carcinomas of renal or gastric origin. Secondary tumors should be entertained in both the clinical and pathological differential diagnosis of pancreatic neoplasia...
Pathologic staging of tumors: pitfalls and opportunities for improvementsN Volkan Adsay
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA
Semin Diagn Pathol 29:103-8. 2012....
An analysis of human equilibrative nucleoside transporter-1, ribonucleoside reductase subunit M1, ribonucleoside reductase subunit M2, and excision repair cross-complementing gene-1 expression in patients with resected pancreas adenocarcinoma: implicationSarah B Fisher
Division of Surgical Oncology, Department of Surgery, Winship Cancer Institute, Emory University, Atlanta, Georgia 30322, USA
Cancer 119:445-53. 2013..To the authors's knowledge, their role in PAC is not defined...
Hepatocellular carcinoma lesion characterization: single-institution clinical performance review of multiphase gadolinium-enhanced MR imaging--comparison to prior same-center results after MR systems improvementsDavid J S Becker-Weidman
Department of Radiology, Emory University School of Medicine, Atlanta, GA, USA
Radiology 261:824-33. 2011....
Clinicopathologic analysis of pancreatic adenocarcinoma in African Americans and CaucasiansNat L Pernick
Department of Pathology, Barbara Ann Karmanos Cancer Institute and Wayne State University School of Medicine, Detroit, USA
Pancreas 26:28-32. 2003..At the molecular level, African Americans had more frequent K- mutations to valine than did Caucasians...
E-cadherin expression in plasmacytoid, signet ring cell and micropapillary variants of urothelial carcinoma: comparison with usual-type high-grade urothelial carcinomaMatthew G Lim
Department of Pathology, Emory University School of Medicine, Atlanta, GA, USA
Mod Pathol 24:241-7. 2011..Loss of E-cadherin expression may be a marker of plasmacytoid and signet ring cell differentiation in urothelial carcinoma...
Desmoplastic small cell tumor in the pancreasTarek A Bismar
Department of Pathology, Harper University Hospital, Wayne State University, Detroit, MI 48201, USA
Am J Surg Pathol 28:808-12. 2004..This case is also another demonstrative example of how DSCT may form a dominant mass in intraabdominal organs...
Neoplastic precursors of the gallbladder and extrahepatic biliary systemN Volkan Adsay
Department of Pathology, Emory University School of Medicine, 1364 Clifton Road, H 180 B, Atlanta, GA 30322, USA
Gastroenterol Clin North Am 36:889-900, vii. 2007....
Almost all infiltrating colloid carcinomas of the pancreas and periampullary region arise from in situ papillary neoplasms: a study of 39 casesGregory Seidel
Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland, USA
Am J Surg Pathol 26:56-63. 2002..Instead, other factors such as tumor location, perineural invasion, vascular invasion, and margin status after resection are far more important...
Primary versus radiation-associated craniofacial osteosarcoma: Biologic and clinicopathologic comparisonsJonathan B McHugh
Department of Pathology, University of Michigan, Ann Arbor, Michigan 48109-0054, USA
Cancer 107:554-62. 2006..In addition, they demonstrate higher expression rates of adverse prognostic indicators, further highlighting the distinction...
Histopathologic assessment of pancreatic cancer: does one size fit all?Michelle D Reid
Department of Pathology, Emory University School of Medicine, Atlanta, Georgia, USA
J Surg Oncol 107:67-77. 2013..Because these tumors are often combined with PDAC in research databases, it causes misleading variability in the analysis of pancreatic cancers. We examine the histopathology of a variety of pancreatic cancers...
Lymphoplasmacytic sclerosing (autoimmune) pancreatitisDavid S Klimstra
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
Semin Diagn Pathol 21:237-46. 2004..This review presents the defining clinical and pathologic features of LPSP and discusses the ongoing efforts to understand the pathogenesis of this disease...
Lymphoepithelial cysts of the pancreas: a report of 12 cases and a review of the literatureN Volkan Adsay
Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA
Mod Pathol 15:492-501. 2002..LECs are not associated with the clinical syndromes that are seen with their analogues in the salivary glands...
Inactivation of Smad4 accelerates Kras(G12D)-mediated pancreatic neoplasiaKyoko Kojima
Department of Microbiology, The University of Alabama at Birmingham, Birmingham, AL 35294, USA
Cancer Res 67:8121-30. 2007..This indicates that Smad4 is dispensable for normal pancreatic development but is critical for at least partial suppression of multiple Kras(G12D)-dependent disease-associated phenotypes...
Pancreatic endocrine tumors with ductulesRunjan Chetty
Am J Surg Pathol 29:136-7; author reply 137-8. 2005
Pathologically and biologically distinct types of epithelium in intraductal papillary mucinous neoplasms: delineation of an "intestinal" pathway of carcinogenesis in the pancreasN Volkan Adsay
Departments of Pathology, Karmanos Cancer Institute and Wayne State University, Detroit, MI 48201, USA
Am J Surg Pathol 28:839-48. 2004....
Solid-pseudopapillary tumors of the pancreas: case report and literature reviewWesley P Francis
Department of Surgery, Wayne State University, Detroit, Michigan 48201, USA
Curr Surg 63:469-72. 2006..The patient underwent complete excision of the tumor and had an open Roux-en-Y gastric bypass performed concurrently. The patient had an uneventful postoperative course. A review of the literature is presented...
Not all "mucinous carcinomas" are equal: time to redefine and reinvestigate the biologic significance of mucin types and patterns in the GI tractN Volkan Adsay
Virchows Arch 447:111-2. 2005
Biliary intraepithelial neoplasia: an international interobserver agreement study and proposal for diagnostic criteriaYoh Zen
Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
Mod Pathol 20:701-9. 2007..This classification should help to advance clinical and research applications...
Fas and Fas ligand expression in pancreatic adenocarcinomaNat L Pernick
LLC, PathologyOutlines com
Pancreas 25:e36-41. 2002..Both proteins are expressed in most if not all pancreatic carcinoma cell lines, but their study in primary human tumors has been limited...
Pancreatic pseudotumors: non-neoplastic solid lesions of the pancreas that clinically mimic pancreas cancerN Volkan Adsay
Karmanos Cancer Institute Wayne State University, Detroit, Michigan, USA
Semin Diagn Pathol 21:260-7. 2004..Nonspecific terms such as "inflammatory pseudotumor" ought to be avoided, and every attempt should be made to classify a "pseudotumor" into a more specific diagnostic category discussed above...
Multicystic adenomatoid hamartoma of the pancreas: a hitherto undescribed pancreatic tumor occurring in a 3-year-old boyMichael Thrall
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, USA
Pediatr Dev Pathol 11:314-20. 2008..quot; As a result of its superficial resemblance to Stocker type 2 cystic adenomatoid malformation of the lung, we are proposing the name "multicystic adenomatoid hamartoma" for this lesion...
Role of MUC genes and mucins in pancreatic neoplasiaN Volkan Adsay
Am J Gastroenterol 101:2330-2. 2006
Oncocytic papillary neoplasms of the biliary tract: a clinicopathological, mucin core and Wnt pathway protein analysis of four casesMarjan Rouzbahman
Department of Pathology, University Health Network University of Toronto, Toronto, Canada
Pathology 39:413-8. 2007....
Kras(G12D) and Smad4/Dpc4 haploinsufficiency cooperate to induce mucinous cystic neoplasms and invasive adenocarcinoma of the pancreasKamel Izeradjene
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
Cancer Cell 11:229-43. 2007..Our findings suggest that the sequence, as well as the context, in which these critical mutations are acquired helps determine the ensuing pathology...
Highly expressed genes in pancreatic ductal adenocarcinomas: a comprehensive characterization and comparison of the transcription profiles obtained from three major technologiesChristine A Iacobuzio-Donahue
Departments of Pathology, Surgery, Oncology, and Medicine, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA
Cancer Res 63:8614-22. 2003....
