Guoxin Zhu

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors
    Guoxin Zhu
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 13:1231-5. 2003
  2. ncbi request reprint Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors
    Guoxin Zhu
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Med Chem 46:2027-30. 2003
  3. pmc Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening
    Andrea Sussman
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Eukaryot Cell 3:932-43. 2004
  4. ncbi request reprint Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors
    Guoxin Zhu
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 14:3057-61. 2004
  5. ncbi request reprint Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles
    Thomas A Engler
    Lilly Research Laboratories, Eli Lilly and Company, 46285, Indianapolis, IN, USA
    Bioorg Med Chem Lett 13:2261-7. 2003
  6. pmc Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells
    Robert D Van Horn
    Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 285:21849-57. 2010
  7. ncbi request reprint Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors
    Concha Sanchez-Martinez
    DCR and T, Lilly Spain S A, Avda de la Industria 30, 28108 Alcobendas, Madrid, Spain
    Bioorg Med Chem Lett 13:3835-9. 2003
  8. ncbi request reprint Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides
    Concha Sanchez-Martinez
    DCR and T, Lilly Spain S A, Avda de la Industria 30, 28108 Alcobendas, Madrid, Spain
    Bioorg Med Chem Lett 13:3841-6. 2003

Collaborators

Detail Information

Publications8

  1. ncbi request reprint Synthesis of quinolinyl/isoquinolinyl[a]pyrrolo [3,4-c] carbazoles as cyclin D1/CDK4 inhibitors
    Guoxin Zhu
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 13:1231-5. 2003
    ..Compound 1d also inhibited tumor cell growth, arrested tumor cells in G1 phase and inhibited pRb phosphorylation...
  2. ncbi request reprint Synthesis, structure-activity relationship, and biological studies of indolocarbazoles as potent cyclin D1-CDK4 inhibitors
    Guoxin Zhu
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Med Chem 46:2027-30. 2003
    ..Both compounds had high selectivity against the other kinases. These D1/CDK4 inhibitors inhibited tumor cell growth, arrested tumor cells at the G1 phase, and inhibited pRb phosphorylation...
  3. pmc Discovery of cercosporamide, a known antifungal natural product, as a selective Pkc1 kinase inhibitor through high-throughput screening
    Andrea Sussman
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Eukaryot Cell 3:932-43. 2004
    ..The synergistic antifungal activity between Pkc1 kinase and beta-1,3-glucan synthase inhibitors points to a potential highly effective combination therapy to treat fungal infections...
  4. ncbi request reprint Synthesis of 1,7-annulated indoles and their applications in the studies of cyclin dependent kinase inhibitors
    Guoxin Zhu
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 14:3057-61. 2004
    ..These inhibitors also arrested tumor cells at the G1 phase and inhibited pRb phosphorylation...
  5. ncbi request reprint Novel, potent and selective cyclin D1/CDK4 inhibitors: indolo[6,7-a]pyrrolo[3,4-c]carbazoles
    Thomas A Engler
    Lilly Research Laboratories, Eli Lilly and Company, 46285, Indianapolis, IN, USA
    Bioorg Med Chem Lett 13:2261-7. 2003
    ..These inhibitors also effect strong G1 arrest in these cell lines and inhibit Rb phosphorylation at Ser780 consistent with inhibition of cyclin D1/CDK4...
  6. pmc Cdk1 activity is required for mitotic activation of aurora A during G2/M transition of human cells
    Robert D Van Horn
    Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 285:21849-57. 2010
    ....
  7. ncbi request reprint Aryl[a]pyrrolo[3,4-c]carbazoles as selective cyclin D1-CDK4 inhibitors
    Concha Sanchez-Martinez
    DCR and T, Lilly Spain S A, Avda de la Industria 30, 28108 Alcobendas, Madrid, Spain
    Bioorg Med Chem Lett 13:3835-9. 2003
    ..A potent and selective D1-CDK4 inhibitor, 7a (D1-CDK4 IC(50)=45 nM), has been identified. The potency, selectivity profile against other kinases, and structure-activity relationship (SAR) trends of this class of compounds are discussed...
  8. ncbi request reprint Studies on cyclin-dependent kinase inhibitors: indolo-[2,3-a]pyrrolo[3,4-c]carbazoles versus bis-indolylmaleimides
    Concha Sanchez-Martinez
    DCR and T, Lilly Spain S A, Avda de la Industria 30, 28108 Alcobendas, Madrid, Spain
    Bioorg Med Chem Lett 13:3841-6. 2003
    ..Cell-cycle analysis using flow cytometry have also shown that the indolocarbazoles are selective G1 blockers while the bis-indolylmaleimides arrest cells in the G2/M phase...