Yan Zhou

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho
    Yan Zhou
    Neuroscience Discovery Research and Bioresearch Technologies and Proteins, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Science 302:1215-7. 2003
  2. pmc Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma
    Yan Zhou
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    FASEB J 22:47-54. 2008
  3. ncbi request reprint Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing
    Yuan Su
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Biochemistry 43:6899-908. 2004
  4. ncbi request reprint FRAT1 peptide decreases Abeta production in swAPP(751) cells
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, IN 46285, USA
    FEBS Lett 553:347-50. 2003
  5. ncbi request reprint Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, Indiana 46285, USA
    Transgenic Res 13:385-96. 2004
  6. ncbi request reprint Divergent roles of GSK3 and CDK5 in APP processing
    John Ryder
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Biochem Biophys Res Commun 312:922-9. 2003
  7. ncbi request reprint Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5
    Feng Liu
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    FEBS Lett 547:193-6. 2003
  8. doi request reprint H-loop histidine catalyzes ATP hydrolysis in the E. coli ABC-transporter HlyB
    Yan Zhou
    Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N Blackford St, Indianapolis, IN 46202, USA
    Phys Chem Chem Phys 15:15811-5. 2013
  9. ncbi request reprint A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis
    Kumar Sambamurti
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29425, USA
    Curr Alzheimer Res 3:81-90. 2006
  10. ncbi request reprint A recombinant E1-deleted porcine adenovirus-3 as an expression vector
    Alexander Zakhartchouk
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada
    Virology 313:377-86. 2003

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho
    Yan Zhou
    Neuroscience Discovery Research and Bioresearch Technologies and Proteins, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Science 302:1215-7. 2003
    ..Thus, the Rho-Rock pathway may regulate amyloid precursor protein processing, and a subset of NSAIDs can reduce Abeta42 through inhibition of Rho activity...
  2. pmc Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma
    Yan Zhou
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    FASEB J 22:47-54. 2008
    ..Our results indicate that geranylgeranyl isoprenoids may be an important physiological facilitator of gamma-secretase activity that can foster production of the pathologically important Abeta42...
  3. ncbi request reprint Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing
    Yuan Su
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Biochemistry 43:6899-908. 2004
    ..Moreover, lithium treatment abolished GSK3beta-mediated Abeta increase in the brains of GSK3beta transgenics and reduced plaque burden in the brains of the PDAPP (APP(V717F)) transgenic mice...
  4. ncbi request reprint FRAT1 peptide decreases Abeta production in swAPP(751) cells
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, IN 46285, USA
    FEBS Lett 553:347-50. 2003
    ..Thus, we provide evidence that direct regulation of GSK3alpha/beta by FRAT1 peptide significantly decreases Abeta production in swAPP(751) cells...
  5. ncbi request reprint Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, Indiana 46285, USA
    Transgenic Res 13:385-96. 2004
    ....
  6. ncbi request reprint Divergent roles of GSK3 and CDK5 in APP processing
    John Ryder
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Biochem Biophys Res Commun 312:922-9. 2003
    ..Our data support a function for both GSK3 and CDK5 in APP processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease...
  7. ncbi request reprint Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5
    Feng Liu
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    FEBS Lett 547:193-6. 2003
    ..These results confirm the involvement of Cdk5 in APP processing, and suggest that p35- and p25-mediated Cdk5 activities lead to discrete APP phosphorylation...
  8. doi request reprint H-loop histidine catalyzes ATP hydrolysis in the E. coli ABC-transporter HlyB
    Yan Zhou
    Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N Blackford St, Indianapolis, IN 46202, USA
    Phys Chem Chem Phys 15:15811-5. 2013
    ..Our findings suggest that the essential function of the H-loop residue H662 is to provide a "chemical linchpin" that shuttles protons between reactants through a relay mechanism, thereby catalyzing ATP hydrolysis in HlyB. ..
  9. ncbi request reprint A partial failure of membrane protein turnover may cause Alzheimer's disease: a new hypothesis
    Kumar Sambamurti
    Department of Neurosciences, Medical University of South Carolina, 173 Ashley Avenue, BSB 403, Charleston, SC 29425, USA
    Curr Alzheimer Res 3:81-90. 2006
    ....
  10. ncbi request reprint A recombinant E1-deleted porcine adenovirus-3 as an expression vector
    Alexander Zakhartchouk
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada
    Virology 313:377-86. 2003
    ..We demonstrated that PAV219 was able to transduce and direct expression of GFP in some human cell lines...
  11. ncbi request reprint Effect of the phosphatidylinositol 3-kinase/Akt pathway on influenza A virus propagation
    Yeun Kyung Shin
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada
    J Gen Virol 88:942-50. 2007
    ..These data suggest that the PI3K/Akt signalling pathway plays a role in influenza virus propagation...
  12. ncbi request reprint [Effects of antisense oligonucleotide to nuclear factor-kappaB on the development of bleomycin-induced pulmonary fibrosis and IL-4 expression therein: experiment with mice]
    Xiao Ye Zhang
    Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China
    Zhonghua Yi Xue Za Zhi 87:195-9. 2007
    ....
  13. pmc Region-specific changes in the subcellular distribution of AMPA receptor GluR1 subunit in the rat ventral tegmental area after acute or chronic morphine administration
    Diane A Lane
    Department of Neurology and Neuroscience, Division of Neurobiology, Weill Medical College of Cornell University, New York, New York 10021, USA
    J Neurosci 28:9670-81. 2008
    ....
  14. ncbi request reprint [Blood leptin, orexins and NPY levels and their relations in obese children]
    Xiao min Lou
    Department of Envirommental Health, West China School of Public Health, Sichan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:621-4. 2006
    ..To investigate the concentration levels of leptin, orexins and neuropeptide Y (NPY) in the blood of obese children, and to analysed the relationship between these substances...
  15. pmc Lineage specification and plasticity in CD19- early B cell precursors
    Lynn L Rumfelt
    Division of Basic Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    J Exp Med 203:675-87. 2006
    ..A) stage, and B/T lymphoid plasticity persists until the CD19+ pro-B stage. Thus, MLP, CLP, and Fr. A represent progressively B lineage-specified stages in development, before the CD19+ B lineage-committed pro-B stage...
  16. ncbi request reprint Immunologic analysis induced by DNA vaccine encoding E protein of Beijing-1 strain derived from Japanese encephalitis virus
    Guo he Feng
    Department of Infectious Diseases, Second Affiliated Hospital of China Medical University, Shenyang, China
    Intervirology 50:93-8. 2007
    ..This study aimed to construct a recombinant encoding E protein of the Beijing-1 strain derived from Japanese encephalitis virus and analyze the humoral, cellular and protective immunity induced by the above recombinant...
  17. ncbi request reprint OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action
    Yan Zhou
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    J Natl Cancer Inst 97:1781-5. 2005
    ..The promising anticancer activity of OSW-1 and its unique mechanism of action make this compound worthy of further investigation for its potential to overcome drug resistance...
  18. ncbi request reprint Differential effects of cocaine on firing rate and pattern of dopamine neurons: role of alpha1 receptors and comparison with L-dopa and apomorphine
    Yan Zhou
    Neuropsychopharmacological Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 0651, USA
    J Pharmacol Exp Ther 317:196-201. 2006
    ..The maintained SO after cocaine injection may reflect continued modulation of DA neurons by forebrain inputs, regulate the pattern of DA release, and provide a temporal structure for selection of synaptic inputs to DA neurons...
  19. ncbi request reprint Combination of porphyrins and DNA-alkylation agents: synthesis and tumor cell apoptosis induction
    Hanping He
    College of Chemistry and Molecular Sciences, Wuhan University, Hubei, PR China
    Bioorg Med Chem 14:1068-77. 2006
    ....
  20. ncbi request reprint Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress
    Yumin Hu
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Biol Chem 280:39485-92. 2005
    ....
  21. ncbi request reprint Mu opioid receptor and orexin/hypocretin mRNA levels in the lateral hypothalamus and striatum are enhanced by morphine withdrawal
    Yan Zhou
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, 1230 York Avenue, New York, New York 10021, USA
    J Endocrinol 191:137-45. 2006
    ..hyp orexin activity plays a role in morphine-withdrawal-related behaviors...
  22. ncbi request reprint Mechanism of influenza A virus NS1 protein interaction with the p85beta, but not the p85alpha, subunit of phosphatidylinositol 3-kinase (PI3K) and up-regulation of PI3K activity
    Yang Li
    Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E3, Canada
    J Biol Chem 283:23397-409. 2008
    ..Finally, the mechanism by which binding of NS1 to p85beta regulates PI3K activity was discussed based on a predicted structural model of NS1-p85-p110 complex...
  23. ncbi request reprint Effects of acute "binge" cocaine on mRNA levels of mu opioid receptor and neuropeptides in dopamine D1 or D3 receptor knockout mice
    Yan Zhou
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, New York 10021, USA
    Synapse 61:50-9. 2007
    ....
  24. ncbi request reprint The mammalian Golgi regulates numb signaling in asymmetric cell division by releasing ACBD3 during mitosis
    Yan Zhou
    Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Cell 129:163-78. 2007
    ....
  25. ncbi request reprint A SPG3A mutation with a novel foot phenotype of hereditary spastic paraplegia in a Chinese Han family
    Xun Hua Li
    Department of Neurology, First Affiliated Hospital, Sun Yat Sen University, Guangzhou, 510089, China
    Chin Med J (Engl) 120:834-7. 2007
  26. ncbi request reprint Alternative splicing and expression profile analysis of expressed sequence tags in domestic pig
    Liang Zhang
    James D Watson Institute of Genome Sciences, Zhejiang University, Hangzhou 310008, China
    Genomics Proteomics Bioinformatics 5:25-34. 2007
    ..Finally, a total of 1,223 genes with average 2.8 splicing variants were detected among 16,540 unique genes. The overview of expression profiles would change when we take alternative splicing into account...
  27. ncbi request reprint The phosphothreonine lyase activity of a bacterial type III effector family
    Hongtao Li
    National Institute of Biological Sciences, Beijing, 102206, China
    Science 315:1000-3. 2007
    ..This unexpected enzymatic activity, termed phosphothreonine lyase, appeared specific for MAPKs and was shared by other OspF family members...
  28. ncbi request reprint ent-Abietane diterpenoids from Isodon rubescens var. rubescens
    Sheng Xiong Huang
    State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People s Republic of China
    Phytochemistry 68:616-22. 2007
    ..The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC(50) value of 0.91 microM against A549 cells...
  29. ncbi request reprint Utilization of RNA polymerase I promoter and terminator sequences to develop a DNA transfection system for the study of hepatitis C virus internal ribosomal entry site-dependent translation
    Jae Ku Oem
    Vaccine and Infectious Disease Organization VIDO, University of Saskatchewan, 120 Veterinary Road, Saskatoon, Sask, Canada S7N 5E3
    J Clin Virol 40:55-9. 2007
    ..HCV protein translation is controlled by an internal ribosomal entry site (IRES) within the 5'-untranslated region (UTR). HCV IRES-dependent translation is critical for HCV-associated pathogenesis...
  30. ncbi request reprint TGFB1 and TGFBR2 functional polymorphisms and risk of esophageal squamous cell carcinoma: a case-control analysis in a Chinese population
    Guangfu Jin
    Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, 140 Hanzhong Road, 210029 Nanjing, China
    J Cancer Res Clin Oncol 134:345-51. 2008
    ..This population-based case-control study was to evaluate the contribution of functional polymorphisms in TGFB1 C-509T, Leu10Pro and TGFBR2 G-875A to the risk of esophageal squamous cell carcinoma (ESCC)...
  31. pmc Chronic administration of morphine is associated with a decrease in surface AMPA GluR1 receptor subunit in dopamine D1 receptor expressing neurons in the shell and non-D1 receptor expressing neurons in the core of the rat nucleus accumbens
    Michael J Glass
    Department of Neurology and Neuroscience, 411 East 69th Street, Well Medical College of Cornell University, NY, NY 10021, USA
    Exp Neurol 210:750-61. 2008
    ....
  32. ncbi request reprint Type IVB piliated Salmonella typhi enhance IL-6 and NF-kappaB production in human monocytic THP-1 cells through activation of protein kinase C
    Fubin Wang
    Department of Immunology, School of Medicine, Wuhan University, Wuhan 430071, PR China
    Immunobiology 210:283-93. 2005
    ..typhi play important roles in the production of NF-kappaB and the proinflammatory cytokine IL-6, and in the stimulation of PKC activity and therefore, may have effects on the development of fever and other inflammatory responses...
  33. ncbi request reprint Functional characterization of evolutionarily conserved DNA regions in forkhead box f1 gene locus
    Il Man Kim
    Department of Medicine, The University of Chicago, Illinois 60637, USA
    J Biol Chem 280:37908-16. 2005
    ..3-kb Foxf1 promoter in cotransfection assays. These studies demonstrated that the conserved Foxf1 3'RE region is essential for proper tissue-specific regulation of the Foxf1 promoter region during mouse embryogenesis...
  34. ncbi request reprint Differential gene expression in the rat caudate putamen after "binge" cocaine administration: advantage of triplicate microarray analysis
    Vadim Yuferov
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Synapse 48:157-69. 2003
    ..These results demonstrate the potential of microarrays in profiling gene expression with > or =40% increase or > or =14% decrease in mRNA levels for discovery of novel cocaine-responsive genes...
  35. ncbi request reprint Two genes encoding protein phosphatase 2A catalytic subunits are differentially expressed in rice
    Richard Man Kit Yu
    Department of Biology and Chemistry, City University of Hong Kong, 83 Tat Chee Avenue, Kowloon, Hong Kong Special Administrative Region, People s Republic of China
    Plant Mol Biol 51:295-311. 2003
    ..In situ hybridization results show that both transcripts exhibit nearly identical cellular distribution, except in leaves, and are abundant in meristematic tissues including the young leaf blade of stems and the root tip...
  36. ncbi request reprint Alternate stoichiometries of alpha4beta2 nicotinic acetylcholine receptors
    Mark E Nelson
    Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104, USA
    Mol Pharmacol 63:332-41. 2003
    ..Alternate alpha4beta2 nAChR stoichiometries with distinct functional properties raise the possibility for an interesting mode of synaptic regulation for nicotinic signaling in the mammalian brain...
  37. ncbi request reprint [Differentiation of rat bone marrow stromal cells into neuron induced by baicalin]
    Yanjie Jia
    Department of Pediatrics, Xiangya Hospital, Central South University, Changsha 410008, China
    Zhonghua Yi Xue Za Zhi 82:1337-41. 2002
    ..To study the possibility that induced marrow stromal cells (MSCs) to neuron in vitro by baicalin, a kind of flavonoid isolated from an important medicinal plant Scutellariae Radix...
  38. ncbi request reprint [The research the relationship between N-acetyltransferase 1 gene polymorphisms and genetic susceptibility to sporadic colorectal adenocarcinoma]
    Youcai Zhang
    Department of Gasteroenterology, Zhongnan Hospital, Wuhan University, Wuhan Hospital, Wuhan, China
    Zhonghua Nei Ke Za Zhi 41:746-9. 2002
    ..In this study, we analyzed the association genetic polymorphisms of N-acetyltransferase 1 (NAT1) with genetic susceptibility to sporadic colorectal adenocarcinoma (SCRAC)...
  39. ncbi request reprint CXCR4 is a major chemokine receptor on glioma cells and mediates their survival
    Yan Zhou
    Departments of Oncology and Clinical Neurosciences, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada
    J Biol Chem 277:49481-7. 2002
    ..We conclude that glioma cells express a predominant chemokine receptor, CXCR4, and that this functions to regulate survival in part through activating pathways such as Akt...
  40. pmc Variant-type PML-RAR(alpha) fusion transcript in acute promyelocytic leukemia: use of a cryptic coding sequence from intron 2 of the RAR(alpha) gene and identification of a new clinical subtype resistant to retinoic acid therapy
    Bai Wei Gu
    State Key Lab for Medical Genomics and Samuel Waxman Cancer Research Foundation Lab, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China
    Proc Natl Acad Sci U S A 99:7640-5. 2002
    ....
  41. ncbi request reprint [Cloning and expression of human calcyclin binding protein (hCacyBP) gene]
    Wei Xia Liu
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 10005, China
    Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 34:181-6. 2002
    ..The results of immunohistochemistrial staining showed that the location of CacyBP in BT325 cell line before and after differentiation changed from cytoplasm into nucleus and perinucleus cytoplasm...
  42. pmc Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome
    Yan Zhou
    Department of Stomatology, University of California San Francisco, San Francisco, California 94143 0512, USA
    Am J Pathol 160:1405-23. 2002
    ..Together, the results of this study showed that VEGF family members regulate cytotrophoblast survival and that expression of a subset of family members is dysregulated in severe forms of preeclampsia...
  43. ncbi request reprint Presenilin-1 protects against neuronal apoptosis caused by its interacting protein PAG
    Yan Zhou
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurobiol Dis 9:126-38. 2002
    ....
  44. ncbi request reprint [Cloning, expression and purification of neural specific HuD cDNA]
    Jian Hua Chen
    Department of Neurology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China
    Zhongguo Yi Xue Ke Xue Yuan Xue Bao 24:250-3. 2002
    ..To prokaryoticly express and purify HuD protein and its RNA recognition motifs...
  45. ncbi request reprint Haploinsufficiency of the mouse Forkhead Box f1 gene causes defects in gall bladder development
    Vladimir V Kalinichenko
    Department of Molecular Genetics, University of Illinois at Chicago, College of Medicine, Chicago, Illinois 60607 7170, USA
    J Biol Chem 277:12369-74. 2002
    ....
  46. ncbi request reprint Human alpha4beta2 acetylcholine receptors formed from linked subunits
    Yan Zhou
    Department of Neuroscience, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104 6074, USA
    J Neurosci 23:9004-15. 2003
    ..These protein-engineering studies provide insight into the structure and function of alpha4beta2 AChRs, emphasizing the functional differences between alpha4beta2 AChRs of different stoichiometries...
  47. ncbi request reprint Steady-dose and escalating-dose "binge" administration of cocaine alter expression of behavioral stereotypy and striatal preprodynorphin mRNA levels in rats
    Stefan D Schlussman
    The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Bull 67:169-75. 2005
    ..These data suggest that the ppDyn response to cocaine in the CPu is not dose-dependent or that it has reached a maximal level at the 45 mg/kg daily dose...
  48. ncbi request reprint Immediate withdrawal from chronic "binge" cocaine administration increases mu-opioid receptor mRNA levels in rat frontal cortex
    Alexis Bailey
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10021, USA
    Brain Res Mol Brain Res 137:258-62. 2005
    ..Naloxone had no effect on the increase of MOP or ppdyn mRNA levels. The results indicate that the opioid system is altered during early withdrawal from chronic cocaine administration...
  49. ncbi request reprint Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane
    Yan Zhou
    National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, National Human Genome Center, Beijing 100005, China
    Biochim Biophys Acta 1669:142-54. 2005
    ..We propose that the NECL1 and protein 4.1N complex is involved in the morphological development, stability, and dynamic plasticity of the nervous system...
  50. pmc Intranasal vaccination induces protective immunity against intranasal infection with virulent Francisella tularensis biovar A
    Terry H Wu
    Department of Internal Medicine, University of New Mexico, 1 University of New Mexico, MSC10 5550, Albuquerque, NM 87131, USA
    Infect Immun 73:2644-54. 2005
    ..These results show that intranasal vaccination induces immunity that protects BALB/c mice from intranasal infection by F. tularensis biovar A...
  51. ncbi request reprint Double-stranded RNA-dependent protein kinase (PKR) is downregulated by phorbol ester
    Yan Zhou
    Department of Chemistry, Cleveland State University, OH 44115, USA
    FEBS J 272:1568-76. 2005
    ..Furthermore, we also found that proteasome inhibitors prevented PMA-induced down regulation of PKR, indicating that an active proteasome is required. Our results identify a novel mechanism for the post-translational regulation of PKR...
  52. ncbi request reprint Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    Rui Hua Xu
    Department of Molecular Pathology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Cancer Res 65:613-21. 2005
    ..Because the Warburg effect and hypoxia are frequently seen in human cancers, these findings may have broad clinical implications...
  53. pmc The analysis of large-scale gene expression correlated to the phase changes of the migratory locust
    Le Kang
    National Laboratory of Integrated Management of Insect Pests and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China
    Proc Natl Acad Sci U S A 101:17611-5. 2004
    ..This study provides ample molecular markers and genomic information on hemimetabolous insects and insights into the genetic and molecular mechanisms of phase changes in locusts...
  54. ncbi request reprint Psychostimulants induce low-frequency oscillations in the firing activity of dopamine neurons
    Wei Xing Shi
    Neuropsychopharmacological Research Unit, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 29:2160-7. 2004
    ..Further understanding of this novel effect may provide important insights into both the mechanism of action of psychostimulants and the neuronal circuitry that controls the activity of DA neurons in the brain...
  55. pmc Novel single-cell-level phenotypic assay for residual drug susceptibility and reduced replication capacity of drug-resistant human immunodeficiency virus type 1
    Haili Zhang
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Virol 78:1718-29. 2004
    ..Thus, the ability to simultaneously analyze residual susceptibility and reduced replication capacity of drug-resistant viruses may provide a basis for rational therapeutic decisions in the setting of treatment failure...
  56. ncbi request reprint Rapid hepatocyte nuclear translocation of the Forkhead Box M1B (FoxM1B) transcription factor caused a transient increase in size of regenerating transgenic hepatocytes
    Xinhe Wang
    Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine, 900 South Ashland Ave, Chicago, IL 60607 7170, USA
    Gene Expr 11:149-62. 2003
    ....
  57. ncbi request reprint cDNA cloning, chromosomal localization and expression pattern analysis of human LIM-homeobox gene LHX4
    Yaobo Liu
    Department of Neurobiology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China
    Brain Res 928:147-55. 2002
    ..Our results suggest that LHX4 may play a role in the CNS, especially the neocortex and the spinal cord, and provide a basis to investigate potential involvement of the LHX4 gene in human diseases...