Edward R Zartler

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi Application of residual dipolar couplings in organic compounds
    Jiangli Yan
    Triad Therapeutics, Inc, San Diego, CA 92121, USA
    Magn Reson Chem 43:53-64. 2005
  2. ncbi Fragonomics: fragment-based drug discovery
    Edward R Zartler
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Curr Opin Chem Biol 9:366-70. 2005
  3. ncbi Practical aspects of NMR-based fragment discovery
    Edward R Zartler
    Tessera Drug Discovery Consulting, Indianapolis, Indiana 46236, USA
    Curr Top Med Chem 7:1592-9. 2007
  4. ncbi RAMPED-UP NMR: multiplexed NMR-based screening for drug discovery
    Edward R Zartler
    Discovery Chemistry Research and Technologies, Biology Research Technologies and Proteins, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Am Chem Soc 125:10941-6. 2003
  5. ncbi Complete relative stereochemistry of multiple stereocenters using only residual dipolar couplings
    Jiangli Yan
    Discovery Chemistry Research and Technologies, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Am Chem Soc 126:5008-17. 2004
  6. ncbi A novel method for the determination of stereochemistry in six-membered chairlike rings using residual dipolar couplings
    Jiangli Yan
    Discovery Chemistry Research and Technologies, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Org Chem 68:1786-95. 2003
  7. ncbi The effect of relaxation on the epitope mapping by saturation transfer difference NMR
    Jiangli Yan
    Discovery Chemistry Research and Technologies, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Co, Indianapolis, IN 46285, USA
    J Magn Reson 163:270-6. 2003
  8. ncbi ID NMR Methods in ligand-receptor interactions
    Edward R Zartler
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Curr Top Med Chem 3:25-37. 2003

Detail Information

Publications8

  1. ncbi Application of residual dipolar couplings in organic compounds
    Jiangli Yan
    Triad Therapeutics, Inc, San Diego, CA 92121, USA
    Magn Reson Chem 43:53-64. 2005
    ..By simple inspection or order matrix calculations, RDCs provide unambiguous information about the relative configurations or complete stereochemistry of organic compounds...
  2. ncbi Fragonomics: fragment-based drug discovery
    Edward R Zartler
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Curr Opin Chem Biol 9:366-70. 2005
    ..This process is a highly integrated process, starting from library design to screening and medicinal chemistry. An overview of this process is presented with particular emphasis placed on the NMR aspect of screening...
  3. ncbi Practical aspects of NMR-based fragment discovery
    Edward R Zartler
    Tessera Drug Discovery Consulting, Indianapolis, Indiana 46236, USA
    Curr Top Med Chem 7:1592-9. 2007
    ..The choice of which method to use will be different for every need. We discuss the different methods, the data they produce, and how they are best utilized in a FBDD setting...
  4. ncbi RAMPED-UP NMR: multiplexed NMR-based screening for drug discovery
    Edward R Zartler
    Discovery Chemistry Research and Technologies, Biology Research Technologies and Proteins, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    J Am Chem Soc 125:10941-6. 2003
    ..To the best of our knowledge, this is the first time in any format that multiple proteins can be screened in one tube...
  5. ncbi Complete relative stereochemistry of multiple stereocenters using only residual dipolar couplings
    Jiangli Yan
    Discovery Chemistry Research and Technologies, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Am Chem Soc 126:5008-17. 2004
    ..The direct RDC of a stereocenter is important to the configuration determination, but the configuration of stereocenters devoid of protons can also be obtained from analysis of nearby RDCs...
  6. ncbi A novel method for the determination of stereochemistry in six-membered chairlike rings using residual dipolar couplings
    Jiangli Yan
    Discovery Chemistry Research and Technologies, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Org Chem 68:1786-95. 2003
    ..It was demonstrated that direct measurement of HMQC was quick and accurate for small molecules at natural abundance...
  7. ncbi The effect of relaxation on the epitope mapping by saturation transfer difference NMR
    Jiangli Yan
    Discovery Chemistry Research and Technologies, Lilly Research Labs, Lilly Corporate Center, Eli Lilly and Co, Indianapolis, IN 46285, USA
    J Magn Reson 163:270-6. 2003
    ..A saturation time shorter than T1s is suggested for improving the potential epitope map. Reduction in temperature was seen to enhance the saturation efficiency in small to medium size targets...
  8. ncbi ID NMR Methods in ligand-receptor interactions
    Edward R Zartler
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Curr Top Med Chem 3:25-37. 2003
    ..These one dimensional NMR methods increase both the throughput of screening and yield crucial data on the mode of binding. The practical utility of these techniques will be described...