David E Watson

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. pmc Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress
    Robert W Sobol
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 99:6860-5. 2002
  2. ncbi request reprint Genotyping with TaqMAMA
    Baohui Li
    Department of Lead Optimization Toxicology, A Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Genomics 83:311-20. 2004
  3. ncbi request reprint Comparison of gene expression changes induced in mouse and human cells treated with direct-acting mutagens
    Mohammed Islaih
    Eli Lilly and Company, Lilly Research Laboratories, Greenfield, Indiana 46140, USA
    Environ Mol Mutagen 44:401-19. 2004
  4. ncbi request reprint TaqMan applications in genetic and molecular toxicology
    David E Watson
    Investigative Toxicology, Toxicology and Drug Disposition, A Division ofEli Lilly and Company, Greenfield, Indiana 46140, USA
    Int J Toxicol 24:139-45. 2005
  5. ncbi request reprint Relationships between genomic, cell cycle, and mutagenic responses of TK6 cells exposed to DNA damaging chemicals
    Mohammed Islaih
    Investigative Toxicology, Toxicology and Drug Disposition, A Division of Eli Lilly and Company, P O Box 708, Greenfield, IN 46140, USA
    Mutat Res 578:100-16. 2005
  6. doi request reprint Quantification of heart fatty acid binding protein as a biomarker for drug-induced cardiac and musculoskeletal necroses
    Eugene Y Zhen
    Integrative Biology, Lilly Research Laboratories, Eli Lilly and Company, Greenfield, IN, USA
    Proteomics Clin Appl 1:661-71. 2007
  7. doi request reprint Qualification of cardiac troponin I concentration in mouse serum using isoproterenol and implementation in pharmacology studies to accelerate drug development
    Steven K Engle
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Toxicol Pathol 37:617-28. 2009
  8. ncbi request reprint Strategic use of immunoprecipitation and LC/MS/MS for trace-level protein quantification: myosin light chain 1, a biomarker of cardiac necrosis
    Michael J Berna
    Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana 46140, USA
    Anal Chem 79:4199-205. 2007
  9. doi request reprint Electrochemiluminescent immunoassay for rat skeletal troponin I (Tnni2) in serum
    Deqin Sun
    Investigative Toxicology, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Pharmacol Toxicol Methods 61:52-8. 2010
  10. doi request reprint Fabp3 as a biomarker of skeletal muscle toxicity in the rat: comparison with conventional biomarkers
    Michael L Pritt
    Investigative Toxicology, Lilly Research Laboratories, Greenfield, Indiana 46140, USA
    Toxicol Sci 103:382-96. 2008

Collaborators

Detail Information

Publications10

  1. pmc Mutations associated with base excision repair deficiency and methylation-induced genotoxic stress
    Robert W Sobol
    Laboratory of Structural Biology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 99:6860-5. 2002
    ..These results illustrate that BER plays a role in protecting mouse embryonic fibroblast cells against methylation-induced mutations and characterize the effect of a particular combination of BER gene defect and environmental exposure...
  2. ncbi request reprint Genotyping with TaqMAMA
    Baohui Li
    Department of Lead Optimization Toxicology, A Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Genomics 83:311-20. 2004
    ..TaqMAMA genotyping assays require minimal development time, have a high probability of success, produce reliable data that are straightforward to analyze, and are very cost-competitive...
  3. ncbi request reprint Comparison of gene expression changes induced in mouse and human cells treated with direct-acting mutagens
    Mohammed Islaih
    Eli Lilly and Company, Lilly Research Laboratories, Greenfield, Indiana 46140, USA
    Environ Mol Mutagen 44:401-19. 2004
    ..Bleomycin exerted comparable cytotoxic effects in the two cell lines. Overall, these studies were unable to identify distinctive gene expression changes that differentiated bleomycin from MMS in either TK6 cells or mouse lymphoma cells...
  4. ncbi request reprint TaqMan applications in genetic and molecular toxicology
    David E Watson
    Investigative Toxicology, Toxicology and Drug Disposition, A Division ofEli Lilly and Company, Greenfield, Indiana 46140, USA
    Int J Toxicol 24:139-45. 2005
    ..In addition to presenting these applications, the authors discuss some of the challenges of integrating TaqMan and other new technologies into the drug development process...
  5. ncbi request reprint Relationships between genomic, cell cycle, and mutagenic responses of TK6 cells exposed to DNA damaging chemicals
    Mohammed Islaih
    Investigative Toxicology, Toxicology and Drug Disposition, A Division of Eli Lilly and Company, P O Box 708, Greenfield, IN 46140, USA
    Mutat Res 578:100-16. 2005
    ..In contrast, the most mutagenic compounds caused fewer and less robust changes in global gene expression. There was therefore an inverse relationship between global gene expression and mutagenic potency...
  6. doi request reprint Quantification of heart fatty acid binding protein as a biomarker for drug-induced cardiac and musculoskeletal necroses
    Eugene Y Zhen
    Integrative Biology, Lilly Research Laboratories, Eli Lilly and Company, Greenfield, IN, USA
    Proteomics Clin Appl 1:661-71. 2007
    ..Fabp3 can be used as a biomarker for both cardiac and skeletal necroses. The cross-validation of the LC-SRM method with an existing ELISA method is described...
  7. doi request reprint Qualification of cardiac troponin I concentration in mouse serum using isoproterenol and implementation in pharmacology studies to accelerate drug development
    Steven K Engle
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Toxicol Pathol 37:617-28. 2009
    ....
  8. ncbi request reprint Strategic use of immunoprecipitation and LC/MS/MS for trace-level protein quantification: myosin light chain 1, a biomarker of cardiac necrosis
    Michael J Berna
    Lilly Research Laboratories, Eli Lilly and Company, Greenfield, Indiana 46140, USA
    Anal Chem 79:4199-205. 2007
    ....
  9. doi request reprint Electrochemiluminescent immunoassay for rat skeletal troponin I (Tnni2) in serum
    Deqin Sun
    Investigative Toxicology, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Pharmacol Toxicol Methods 61:52-8. 2010
    ..Skeletal muscle troponin I (sTnI) has been identified as a potential marker of skeletal muscle injury in humans and animals. When skeletal muscle tissue is injured, sTnI is released into circulation...
  10. doi request reprint Fabp3 as a biomarker of skeletal muscle toxicity in the rat: comparison with conventional biomarkers
    Michael L Pritt
    Investigative Toxicology, Lilly Research Laboratories, Greenfield, Indiana 46140, USA
    Toxicol Sci 103:382-96. 2008
    ..In addition, the combination of Fabp3 and aspartate aminotransferase (AST) had greater diagnostic value than the conventional combination of creatine kinase-MM isoenzyme (CK) and AST...