Yuan Su

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing
    Yuan Su
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Biochemistry 43:6899-908. 2004
  2. ncbi request reprint Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, Indiana 46285, USA
    Transgenic Res 13:385-96. 2004
  3. ncbi request reprint FRAT1 peptide decreases Abeta production in swAPP(751) cells
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, IN 46285, USA
    FEBS Lett 553:347-50. 2003
  4. ncbi request reprint Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations
    John Ryder
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Cell Signal 16:187-200. 2004
  5. ncbi request reprint Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho
    Yan Zhou
    Neuroscience Discovery Research and Bioresearch Technologies and Proteins, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Science 302:1215-7. 2003
  6. ncbi request reprint Divergent roles of GSK3 and CDK5 in APP processing
    John Ryder
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Biochem Biophys Res Commun 312:922-9. 2003
  7. ncbi request reprint Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5
    Feng Liu
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    FEBS Lett 547:193-6. 2003
  8. ncbi request reprint RIFLE: a novel ring zinc finger-leucine-rich repeat containing protein, regulates select cell adhesion molecules in PC12 cells
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Cell Biochem 90:1224-41. 2003
  9. ncbi request reprint Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751
    Feng Liu
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Exp Cell Res 287:387-96. 2003
  10. ncbi request reprint Inhibition of Abeta production and APP maturation by a specific PKA inhibitor
    Yuan Su
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    FEBS Lett 546:407-10. 2003

Collaborators

Detail Information

Publications16

  1. ncbi request reprint Lithium, a common drug for bipolar disorder treatment, regulates amyloid-beta precursor protein processing
    Yuan Su
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Biochemistry 43:6899-908. 2004
    ..Moreover, lithium treatment abolished GSK3beta-mediated Abeta increase in the brains of GSK3beta transgenics and reduced plaque burden in the brains of the PDAPP (APP(V717F)) transgenic mice...
  2. ncbi request reprint Overexpression of GSK3betaS9A resulted in tau hyperphosphorylation and morphology reminiscent of pretangle-like neurons in the brain of PDGSK3beta transgenic mice
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, Indiana 46285, USA
    Transgenic Res 13:385-96. 2004
    ....
  3. ncbi request reprint FRAT1 peptide decreases Abeta production in swAPP(751) cells
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Drop Code 0510, Indianapolis, IN 46285, USA
    FEBS Lett 553:347-50. 2003
    ..Thus, we provide evidence that direct regulation of GSK3alpha/beta by FRAT1 peptide significantly decreases Abeta production in swAPP(751) cells...
  4. ncbi request reprint Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations
    John Ryder
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Cell Signal 16:187-200. 2004
    ....
  5. ncbi request reprint Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho
    Yan Zhou
    Neuroscience Discovery Research and Bioresearch Technologies and Proteins, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Science 302:1215-7. 2003
    ..Thus, the Rho-Rock pathway may regulate amyloid precursor protein processing, and a subset of NSAIDs can reduce Abeta42 through inhibition of Rho activity...
  6. ncbi request reprint Divergent roles of GSK3 and CDK5 in APP processing
    John Ryder
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Biochem Biophys Res Commun 312:922-9. 2003
    ..Our data support a function for both GSK3 and CDK5 in APP processing, further implicating these two kinases in the pathogenesis of Alzheimer's disease...
  7. ncbi request reprint Regulation of amyloid precursor protein (APP) phosphorylation and processing by p35/Cdk5 and p25/Cdk5
    Feng Liu
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    FEBS Lett 547:193-6. 2003
    ..These results confirm the involvement of Cdk5 in APP processing, and suggest that p35- and p25-mediated Cdk5 activities lead to discrete APP phosphorylation...
  8. ncbi request reprint RIFLE: a novel ring zinc finger-leucine-rich repeat containing protein, regulates select cell adhesion molecules in PC12 cells
    Baolin Li
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Cell Biochem 90:1224-41. 2003
    ..Our results suggest that RIFLE represents a novel signaling protein that mediates components of the Wnt/wingless signaling pathway and cell adhesion in PC12 cells...
  9. ncbi request reprint Regulation of amyloid precursor protein expression and secretion via activation of ERK1/2 by hepatocyte growth factor in HEK293 cells transfected with APP751
    Feng Liu
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Exp Cell Res 287:387-96. 2003
    ....
  10. ncbi request reprint Inhibition of Abeta production and APP maturation by a specific PKA inhibitor
    Yuan Su
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    FEBS Lett 546:407-10. 2003
    ..Our data suggests that PKA plays an important role in the maturation of APP associated with APP processing...
  11. ncbi request reprint Effect of antisense RNA targeting polo-like kinase 1 on cell cycle and proliferation in A549 cells
    Qiong Zhou
    Department of Respiratory Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Chin Med J (Engl) 117:1642-9. 2004
    ..In addition, Plk1 has several functions in mitotic progression. In this study, the authors investigated the effect of Plk1 depletion on cell cycle progression and proliferation in A549 cells, a lung cancer cell line...
  12. ncbi request reprint [Effect of antisense RNA targeting Polo-like kinase 1 on cell cycle of lung cancer cell line A549]
    Qiong Zhou
    Department of Respiratory Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Health Ministry of China, Wuhan, Hubei, 430022, P R China
    Ai Zheng 24:149-54. 2005
    ..This study was to investigate the effect of down-regulation of Plk1 on cell cycle of A549 cells using the technique of antisense RNA...
  13. ncbi request reprint The cholesterol transporter ABCG1 modulates the subcellular distribution and proteolytic processing of beta-amyloid precursor protein
    Gavin H Tansley
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Lipid Res 48:1022-34. 2007
    ..These findings suggest that altered cholesterol metabolism and APP trafficking mediated by ABCG1 may contribute to the accelerated onset of AD neuropathology in DS...
  14. pmc Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma
    Yan Zhou
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    FASEB J 22:47-54. 2008
    ..Our results indicate that geranylgeranyl isoprenoids may be an important physiological facilitator of gamma-secretase activity that can foster production of the pathologically important Abeta42...
  15. ncbi request reprint [Pirh2 shRNA mediated by psiRNA-hH1 vector plasmid effectively inhibits the proliferation of lung carcinoma cells: in vitro and in vivo experiments]
    Yuan Su
    Department of Respiratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    Zhonghua Yi Xue Za Zhi 87:1199-203. 2007
    ..To investigate the role of P53 induced RING-H2 protein (pirh2) for proliferation of lung cancer cell in vitro and vivo...
  16. doi request reprint Effect of antisense RNA targeting Polo-like kinase 1 on cell growth in A549 lung cancer cells
    Qiong Zhou
    Department of Respiratory Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
    J Huazhong Univ Sci Technolog Med Sci 28:22-6. 2008
    ..Moreover, it sensitized lung cancer cells to chemotherapy...