M A Statnick

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC/MS/MS and the administration of three tracers simultaneously
    Anne B Need
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Life Sci 81:1389-96. 2007
  2. ncbi request reprint Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2
    Kumiko Takeuchi
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 17:6841-6. 2007
  3. pmc Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes
    M A Statnick
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0424, USA
    Int J Exp Diabetes Res 1:81-8. 2000
  4. ncbi request reprint Peptides that regulate food intake: antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization
    Michael A Statnick
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285 0545, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1399-408. 2003
  5. ncbi request reprint Na+-dependent high affinity binding of [3H]LY515300, a 3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid receptor inverse agonist
    Michael A Statnick
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0403, USA
    Eur J Pharmacol 482:139-50. 2003
  6. ncbi request reprint Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): effects on body weight homeostasis in lean and high-fat-fed obese rats
    F Rohner-Jeanrenaud
    Endocrine Research and Clinical Investigation, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
    Int J Obes Relat Metab Disord 26:143-9. 2002
  7. ncbi request reprint Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: comparison with the distribution of mu, delta and kappa binding sites
    S L Gackenheimer
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuropeptides 39:559-67. 2005
  8. ncbi request reprint Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats
    Harlan E Shannon
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 53:930-41. 2007
  9. ncbi request reprint Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1
    Kumiko Takeuchi
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 17:5349-52. 2007
  10. ncbi request reprint Na+ modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists
    Paul J Emmerson
    Endocrine Research, Lilly Research Laboratories, Lilly Corporate Center DC0403, Indianapolis, IN 46285, USA
    Eur J Pharmacol 494:121-30. 2004

Collaborators

Detail Information

Publications13

  1. ncbi request reprint In vivo rat brain opioid receptor binding of LY255582 assessed with a novel method using LC/MS/MS and the administration of three tracers simultaneously
    Anne B Need
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Life Sci 81:1389-96. 2007
    ..Examination of LY255582 in dose-occupancy experiments demonstrated a relative order of potency of mu>kappa>delta, reproducing the previously reported order determined with in vitro binding...
  2. ncbi request reprint Structure activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 2
    Kumiko Takeuchi
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 17:6841-6. 2007
    ..Compounds in the 6-(2,3,4,5-tetrahydro-1H-benzo[c]azepin-7-yloxy)nicotinamide scaffold exhibited potent in vitro functional antagonism at all three receptors...
  3. pmc Decreased expression of apM1 in omental and subcutaneous adipose tissue of humans with type 2 diabetes
    M A Statnick
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0424, USA
    Int J Exp Diabetes Res 1:81-8. 2000
    ....
  4. ncbi request reprint Peptides that regulate food intake: antagonism of opioid receptors reduces body fat in obese rats by decreasing food intake and stimulating lipid utilization
    Michael A Statnick
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285 0545, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1399-408. 2003
    ..Therefore, chronic treatment with LY255582 reduces adipose tissue mass by reducing energy intake and stimulating lipid use...
  5. ncbi request reprint Na+-dependent high affinity binding of [3H]LY515300, a 3,4-dimethyl-4-(3-hydroxyphenyl)piperidine opioid receptor inverse agonist
    Michael A Statnick
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0403, USA
    Eur J Pharmacol 482:139-50. 2003
    ..Thus, [3H]LY515300 is the first radiolabeled opioid receptor inverse agonist useful for the study of opioid receptors in cell lines and native tissues...
  6. ncbi request reprint Chronic central infusion of cocaine- and amphetamine-regulated transcript (CART 55-102): effects on body weight homeostasis in lean and high-fat-fed obese rats
    F Rohner-Jeanrenaud
    Endocrine Research and Clinical Investigation, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
    Int J Obes Relat Metab Disord 26:143-9. 2002
    ..Cocaine- and amphetamine-regulated transcript (CART) is expressed within hypothalamic nuclei implicated in the regulation of feeding behaviour. It is up-regulated by leptin, and CART-derived peptides acutely inhibit food intake...
  7. ncbi request reprint Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: comparison with the distribution of mu, delta and kappa binding sites
    S L Gackenheimer
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuropeptides 39:559-67. 2005
    ..Therefore, it is likely that LY255582 produces its effects on feeding and body weight gain through a combination of mu-, delta- and kappa-receptor activity...
  8. ncbi request reprint Effects of kappa opioid receptor agonists on attention as assessed by a 5-choice serial reaction time task in rats
    Harlan E Shannon
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 53:930-41. 2007
    ....
  9. ncbi request reprint Structure-activity relationship studies of carboxamido-biaryl ethers as opioid receptor antagonists (OpRAs). Part 1
    Kumiko Takeuchi
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 17:5349-52. 2007
    ....
  10. ncbi request reprint Na+ modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists
    Paul J Emmerson
    Endocrine Research, Lilly Research Laboratories, Lilly Corporate Center DC0403, Indianapolis, IN 46285, USA
    Eur J Pharmacol 494:121-30. 2004
    ..These data suggest that 4PP antagonists differ from morphinan antagonists in their inverse agonist activity and suggest a relationship between inverse agonism and anorectic activity...
  11. ncbi request reprint Galanin-like peptide functions more like leptin than like galanin
    Mark L Heiman
    Division of Endovcrinology, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, DC 0545, Indianapolis, Indiana 46285, USA
    Endocrinology 144:4707-8. 2003
  12. ncbi request reprint GH-releasing peptide-2 increases fat mass in mice lacking NPY: indication for a crucial mediating role of hypothalamic agouti-related protein
    Matthias Tschop
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Endocrinology 143:558-68. 2002
    ..To date, there are few therapeutics that can produce a positive energy balance. Ghrelin receptor agonists offer a treatment option for syndromes like anorexia nervosa, cancer cachexia, or AIDS wasting...
  13. doi request reprint Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582
    Allison E Sahr
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0403, USA
    Am J Physiol Regul Integr Comp Physiol 295:R463-71. 2008
    ..LY255582 may be a useful tool in understanding the neural mechanisms involved in the reinforcement mechanisms regulating food intake...