P Skolnick

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Antidepressants for the new millennium
    P Skolnick
    Neuroscience Discovery, Eli Lilly, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Eur J Pharmacol 375:31-40. 1999
  2. ncbi request reprint Polyamine-like actions of aminoglycosides at recombinant N-methyl-D-aspartate receptors
    S C Harvey
    Lilly Research Laboratories, Neuroscience Discovery, Eli Lilly and Company, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 291:285-91. 1999
  3. ncbi request reprint Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
    X Li
    Eli Lilly and Co, Lilly Research Laboratories, Indianapolis, IN 46285 0510, USA
    Neuropharmacology 40:1028-33. 2001
  4. ncbi request reprint The antibacterial and NMDA receptor activating properties of aminoglycosides are dissociable
    S C Harvey
    Lilly Research Laboratories, Neuroscience Discovery, Eli Lilly and Company Corporate Center, Bldg 48, Drop Code 0510, Indianapolis, IN, USA
    Eur J Pharmacol 387:1-7. 2000
  5. ncbi request reprint Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator
    B Legutko
    Eli Lilly and Co, Lilly Research Laboratories, Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 40:1019-27. 2001
  6. ncbi request reprint Spermine-induced toxicity in cerebellar granule neurons is independent of its actions at NMDA receptors
    J A Segal
    Lilly Research Laboratories, Neuroscience Discovery, Indianapolis, Indiana 46285 0510, USA
    J Neurochem 74:60-9. 2000
  7. ncbi request reprint A single amino acid residue on the alpha(5) subunit (Ile215) is essential for ligand selectivity at alpha(5)beta(3)gamma(2) gamma-aminobutyric acid(A) receptors
    M I Strakhova
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Mol Pharmacol 58:1434-40. 2000
  8. ncbi request reprint Current perspectives on the development of non-biogenic amine-based antidepressants
    P Skolnick
    Neuroscience Discovery, Eli Lilly and Co, Lilly Corporate Center, DC 0510, Indianapolis, IN 46285 0510, USA
    Pharmacol Res 43:411-23. 2001

Detail Information

Publications8

  1. ncbi request reprint Antidepressants for the new millennium
    P Skolnick
    Neuroscience Discovery, Eli Lilly, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Eur J Pharmacol 375:31-40. 1999
    ..The pathways leading to this convergence provide a rudimentary framework for discovering novel antidepressants...
  2. ncbi request reprint Polyamine-like actions of aminoglycosides at recombinant N-methyl-D-aspartate receptors
    S C Harvey
    Lilly Research Laboratories, Neuroscience Discovery, Eli Lilly and Company, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 291:285-91. 1999
    ..No direct relationships emerged between the effect of an aminoglycoside at a specific NMDA receptor subtype and the ototoxicity of these antibiotics...
  3. ncbi request reprint Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
    X Li
    Eli Lilly and Co, Lilly Research Laboratories, Indianapolis, IN 46285 0510, USA
    Neuropharmacology 40:1028-33. 2001
    ..These findings indicate that biarylpropylsulfonamides, exemplified by LY392098, may represent a novel class of antidepressants...
  4. ncbi request reprint The antibacterial and NMDA receptor activating properties of aminoglycosides are dissociable
    S C Harvey
    Lilly Research Laboratories, Neuroscience Discovery, Eli Lilly and Company Corporate Center, Bldg 48, Drop Code 0510, Indianapolis, IN, USA
    Eur J Pharmacol 387:1-7. 2000
    ..These findings indicate that it may be possible to develop an aminoglycoside antibiotic with reduced potential for ototoxicity...
  5. ncbi request reprint Regulation of BDNF expression in primary neuron culture by LY392098, a novel AMPA receptor potentiator
    B Legutko
    Eli Lilly and Co, Lilly Research Laboratories, Corporate Center, Indianapolis, IN 46285, USA
    Neuropharmacology 40:1019-27. 2001
    ..The ability of LY392098 to increase the expression of BDNF in primary neuron culture indicates this and related biarylpropylsulfonamides may be useful in the treatment of neuropsychiatric disorders...
  6. ncbi request reprint Spermine-induced toxicity in cerebellar granule neurons is independent of its actions at NMDA receptors
    J A Segal
    Lilly Research Laboratories, Neuroscience Discovery, Indianapolis, Indiana 46285 0510, USA
    J Neurochem 74:60-9. 2000
    ..Thus, in CGNs, spermine-induced toxicity does not occur by its modulation of NMDA receptors, although, under some circumstances, NMDA receptor activation can modulate spermine-induced toxicity...
  7. ncbi request reprint A single amino acid residue on the alpha(5) subunit (Ile215) is essential for ligand selectivity at alpha(5)beta(3)gamma(2) gamma-aminobutyric acid(A) receptors
    M I Strakhova
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Mol Pharmacol 58:1434-40. 2000
    ..The data demonstrate that amino acid residue alpha(5)215 is a determinant of both ligand affinity and efficacy at GABA(A) receptors containing an alpha(5) subunit...
  8. ncbi request reprint Current perspectives on the development of non-biogenic amine-based antidepressants
    P Skolnick
    Neuroscience Discovery, Eli Lilly and Co, Lilly Corporate Center, DC 0510, Indianapolis, IN 46285 0510, USA
    Pharmacol Res 43:411-23. 2001
    ..Drugs emerging from these strategies may offer significant advantages over currently used antidepressants...