Research Topics
Genomes and Genes
| Yuguang ShiSummaryAffiliation: Eli Lilly and Company Country: USA Publications
| Collaborators
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Detail Information
Publications
Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational controlY Shi
Diabetes Research, Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Mol Cell Biol 18:7499-509. 1998..We also identified PEK homologs from both Caenorhabditis elegans and the puffer fish Fugu rubripes, suggesting that this eIF-2alpha kinase plays an important role in translational control from nematodes to mammals...
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cellsY Shi
Diabetes Research, DC 0545, Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 274:5723-30. 1999..Thus PEK is believed to play an important role in regulating protein synthesis in the pancreatic islet, especially in islet delta cells...- Beyond skin color: emerging roles of melanin-concentrating hormone in energy homeostasis and other physiological functionsYuguang Shi
Endocrine Research, Lilly Research Laboratories, DC 0545, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Peptides 25:1605-11. 2004..This review focuses on emerging roles of MCH in regulating central and peripheral mechanisms... - When translation meets metabolism: multiple links to diabetesYuguang Shi
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Endocr Rev 24:91-101. 2003.... - Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferaseYanzhu Yang
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
J Biol Chem 279:55866-74. 2004..Northern blot analysis indicated that the human LPGAT1 was widely distributed, suggesting a dynamic functional role of the enzyme in different tissues... - A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouseJingsong Cao
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 279:31727-34. 2004..ALCAT1 represents the first identified cardiolipin-remodeling enzyme from any living organism; its identification implies a novel role for the endoplasmic reticulum in cardiolipin metabolism... - A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat dietJingsong Cao
Division of Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 279:18878-86. 2004..Taken together, our data suggest a predominant role of MGAT2 in dietary fat absorption... - Properties of the mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2Jingsong Cao
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 278:25657-63. 2003..The elucidation of properties of MGAT2 will facilitate future development of compounds that inhibit dietary fat absorption as a means to treat obesity... - Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activityJohn F Lockwood
Endocrine Research, DC 0545, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA
Am J Physiol Endocrinol Metab 285:E927-37. 2003.... - Catalytic properties of MGAT3, a putative triacylgycerol synthaseJingsong Cao
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Lipid Res 48:583-91. 2007..Our data suggest that MGAT3 functions as a novel triacylglycerol (TAG) synthase that catalyzes efficiently the two consecutive acylation steps in TAG synthesis... - Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cellsShaobo Zhang
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Biochem J 388:135-42. 2005.... - Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesityYanyun Chen
Division of Endocrinology, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
Endocrinology 143:2469-77. 2002..Our data firmly establish MCHR1 as a mediator of MCH effects on energy homeostasis and suggest that inactivation of MCHR1 alone is capable to counterbalance obesity induced by a high-fat diet... - Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2Xiaoying Gao
Endocrine Discovery Research, Lilly Research Laboratories, Eli Lilly and Co, DC 0545, Indianapolis, IN 46285, USA
Anal Biochem 328:187-95. 2004..These studies further extend the utility of Eu3+ chelate time-resolved fluorescence for the development of high-sensitivity, nonradioactive receptor binding assays and demonstrate the need to select the optimal ligand for labeling... - Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2Jingsong Cao
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 278:13860-6. 2003..Northern blot analysis indicates that the mouse MGAT2 is most abundantly expressed in the small intestine, suggesting that MGAT2 may play an important role in dietary fat absorption... - Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondriaDaohong Chen
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Biochem J 398:169-76. 2006..High levels of hCLS1 expression were also detected in liver, pancreas, kidney and small intestine, implying a functional role of hCLS1 in these tissues... - Lipid metabolic enzymes: emerging drug targets for the treatment of obesityYuguang Shi
Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Nat Rev Drug Discov 3:695-710. 2004 - Hepatitis C therapeutics: current status and emerging strategiesSeng-Lai Tan
Infectious Diseases Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Nat Rev Drug Discov 1:867-81. 2002..Successful therapeutic intervention of HCV will probably require combination approaches and new approaches, including host drug discovery targets... - Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulumShiyong Wu
Department of Radiation Oncology and Biological Chemistry, The Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
J Biol Chem 277:18077-83. 2002..These results support a novel mechanism by which UV irradiation regulates translation via an endoplasmic reticulum-stress signaling pathway... - Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cellsQuyen Van
Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada, R3E 0T6
Biochem J 401:103-9. 2007..The results identify PLS3 as a novel regulator of CL de novo biosynthesis and its resynthesis...