Yuguang Shi

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. pmc Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
    Y Shi
    Diabetes Research, Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Mol Cell Biol 18:7499-509. 1998
  2. ncbi request reprint Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells
    Y Shi
    Diabetes Research, DC 0545, Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 274:5723-30. 1999
  3. ncbi request reprint Beyond skin color: emerging roles of melanin-concentrating hormone in energy homeostasis and other physiological functions
    Yuguang Shi
    Endocrine Research, Lilly Research Laboratories, DC 0545, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Peptides 25:1605-11. 2004
  4. ncbi request reprint When translation meets metabolism: multiple links to diabetes
    Yuguang Shi
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Endocr Rev 24:91-101. 2003
  5. ncbi request reprint Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase
    Yanzhu Yang
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    J Biol Chem 279:55866-74. 2004
  6. ncbi request reprint A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse
    Jingsong Cao
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 279:31727-34. 2004
  7. ncbi request reprint A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet
    Jingsong Cao
    Division of Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 279:18878-86. 2004
  8. ncbi request reprint Properties of the mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2
    Jingsong Cao
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 278:25657-63. 2003
  9. ncbi request reprint Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity
    John F Lockwood
    Endocrine Research, DC 0545, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Am J Physiol Endocrinol Metab 285:E927-37. 2003
  10. ncbi request reprint Catalytic properties of MGAT3, a putative triacylgycerol synthase
    Jingsong Cao
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Lipid Res 48:583-91. 2007

Collaborators

Detail Information

Publications19

  1. pmc Identification and characterization of pancreatic eukaryotic initiation factor 2 alpha-subunit kinase, PEK, involved in translational control
    Y Shi
    Diabetes Research, Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Mol Cell Biol 18:7499-509. 1998
    ..We also identified PEK homologs from both Caenorhabditis elegans and the puffer fish Fugu rubripes, suggesting that this eIF-2alpha kinase plays an important role in translational control from nematodes to mammals...
  2. ncbi request reprint Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells
    Y Shi
    Diabetes Research, DC 0545, Endocrine Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 274:5723-30. 1999
    ..Thus PEK is believed to play an important role in regulating protein synthesis in the pancreatic islet, especially in islet delta cells...
  3. ncbi request reprint Beyond skin color: emerging roles of melanin-concentrating hormone in energy homeostasis and other physiological functions
    Yuguang Shi
    Endocrine Research, Lilly Research Laboratories, DC 0545, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Peptides 25:1605-11. 2004
    ..This review focuses on emerging roles of MCH in regulating central and peripheral mechanisms...
  4. ncbi request reprint When translation meets metabolism: multiple links to diabetes
    Yuguang Shi
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Endocr Rev 24:91-101. 2003
    ....
  5. ncbi request reprint Identification and characterization of a gene encoding human LPGAT1, an endoplasmic reticulum-associated lysophosphatidylglycerol acyltransferase
    Yanzhu Yang
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    J Biol Chem 279:55866-74. 2004
    ..Northern blot analysis indicated that the human LPGAT1 was widely distributed, suggesting a dynamic functional role of the enzyme in different tissues...
  6. ncbi request reprint A novel cardiolipin-remodeling pathway revealed by a gene encoding an endoplasmic reticulum-associated acyl-CoA:lysocardiolipin acyltransferase (ALCAT1) in mouse
    Jingsong Cao
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 279:31727-34. 2004
    ..ALCAT1 represents the first identified cardiolipin-remodeling enzyme from any living organism; its identification implies a novel role for the endoplasmic reticulum in cardiolipin metabolism...
  7. ncbi request reprint A predominant role of acyl-CoA:monoacylglycerol acyltransferase-2 in dietary fat absorption implicated by tissue distribution, subcellular localization, and up-regulation by high fat diet
    Jingsong Cao
    Division of Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 279:18878-86. 2004
    ..Taken together, our data suggest a predominant role of MGAT2 in dietary fat absorption...
  8. ncbi request reprint Properties of the mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2
    Jingsong Cao
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 278:25657-63. 2003
    ..The elucidation of properties of MGAT2 will facilitate future development of compounds that inhibit dietary fat absorption as a means to treat obesity...
  9. ncbi request reprint Human intestinal monoacylglycerol acyltransferase: differential features in tissue expression and activity
    John F Lockwood
    Endocrine Research, DC 0545, Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Am J Physiol Endocrinol Metab 285:E927-37. 2003
    ....
  10. ncbi request reprint Catalytic properties of MGAT3, a putative triacylgycerol synthase
    Jingsong Cao
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    J Lipid Res 48:583-91. 2007
    ..Our data suggest that MGAT3 functions as a novel triacylglycerol (TAG) synthase that catalyzes efficiently the two consecutive acylation steps in TAG synthesis...
  11. pmc Characterization of human SCD2, an oligomeric desaturase with improved stability and enzyme activity by cross-linking in intact cells
    Shaobo Zhang
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Biochem J 388:135-42. 2005
    ....
  12. ncbi request reprint Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity
    Yanyun Chen
    Division of Endocrinology, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
    Endocrinology 143:2469-77. 2002
    ..Our data firmly establish MCHR1 as a mediator of MCH effects on energy homeostasis and suggest that inactivation of MCHR1 alone is capable to counterbalance obesity induced by a high-fat diet...
  13. ncbi request reprint Europium-labeled melanin-concentrating hormone analogues: ligands for measuring binding to melanin-concentrating hormone receptors 1 and 2
    Xiaoying Gao
    Endocrine Discovery Research, Lilly Research Laboratories, Eli Lilly and Co, DC 0545, Indianapolis, IN 46285, USA
    Anal Biochem 328:187-95. 2004
    ..These studies further extend the utility of Eu3+ chelate time-resolved fluorescence for the development of high-sensitivity, nonradioactive receptor binding assays and demonstrate the need to select the optimal ligand for labeling...
  14. ncbi request reprint Cloning and functional characterization of a mouse intestinal acyl-CoA:monoacylglycerol acyltransferase, MGAT2
    Jingsong Cao
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biol Chem 278:13860-6. 2003
    ..Northern blot analysis indicates that the mouse MGAT2 is most abundantly expressed in the small intestine, suggesting that MGAT2 may play an important role in dietary fat absorption...
  15. pmc Identification and functional characterization of hCLS1, a human cardiolipin synthase localized in mitochondria
    Daohong Chen
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Biochem J 398:169-76. 2006
    ..High levels of hCLS1 expression were also detected in liver, pancreas, kidney and small intestine, implying a functional role of hCLS1 in these tissues...
  16. ncbi request reprint Lipid metabolic enzymes: emerging drug targets for the treatment of obesity
    Yuguang Shi
    Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Nat Rev Drug Discov 3:695-710. 2004
  17. ncbi request reprint Hepatitis C therapeutics: current status and emerging strategies
    Seng Lai Tan
    Infectious Diseases Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Nat Rev Drug Discov 1:867-81. 2002
    ..Successful therapeutic intervention of HCV will probably require combination approaches and new approaches, including host drug discovery targets...
  18. ncbi request reprint Ultraviolet light inhibits translation through activation of the unfolded protein response kinase PERK in the lumen of the endoplasmic reticulum
    Shiyong Wu
    Department of Radiation Oncology and Biological Chemistry, The Howard Hughes Medical Institute, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    J Biol Chem 277:18077-83. 2002
    ..These results support a novel mechanism by which UV irradiation regulates translation via an endoplasmic reticulum-stress signaling pathway...
  19. pmc Phospholipid scramblase-3 regulates cardiolipin de novo biosynthesis and its resynthesis in growing HeLa cells
    Quyen Van
    Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada, R3E 0T6
    Biochem J 401:103-9. 2007
    ..The results identify PLS3 as a novel regulator of CL de novo biosynthesis and its resynthesis...