Steven M Paul

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. doi request reprint Commentary on "a roadmap for the prevention of dementia: the inaugural Leon Thal Symposium"
    Eric R Siemers
    Eli Lilly and Company, Indianapolis, IN, USA
    Alzheimers Dement 4:171-3. 2008
  2. pmc Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease
    Jean Cosme Dodart
    Neuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Proc Natl Acad Sci U S A 102:1211-6. 2005
  3. pmc Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice
    Robert P Brendza
    Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:428-33. 2005
  4. ncbi request reprint The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice
    John D Fryer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:25754-9. 2005
  5. ncbi request reprint Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease
    Richard E Hartman
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:6213-20. 2005
  6. pmc Alcohol-sensitive GABA receptors and alcohol antagonists
    Steven M Paul
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Proc Natl Acad Sci U S A 103:8307-8. 2006
  7. doi request reprint Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice
    Kelly R Bales
    Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 29:6771-9. 2009
  8. ncbi request reprint A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes
    Yu Liang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurochem 88:623-34. 2004
  9. ncbi request reprint Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
    Jean Cosme Dodart
    Neuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Nat Neurosci 5:452-7. 2002
  10. doi request reprint Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism
    Lingzhi Zhao
    Neuroscience Discovery Research and Integrative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 29:3603-12. 2009

Collaborators

Detail Information

Publications49

  1. doi request reprint Commentary on "a roadmap for the prevention of dementia: the inaugural Leon Thal Symposium"
    Eric R Siemers
    Eli Lilly and Company, Indianapolis, IN, USA
    Alzheimers Dement 4:171-3. 2008
  2. pmc Gene delivery of human apolipoprotein E alters brain Abeta burden in a mouse model of Alzheimer's disease
    Jean Cosme Dodart
    Neuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Proc Natl Acad Sci U S A 102:1211-6. 2005
    ..Our data demonstrate rapid apoE isoform-dependent effects on brain Abeta burden in a mouse model of AD. Gene delivery of apoE2 may prevent or reduce brain Abeta burden and the subsequent development of neuritic plaques...
  3. pmc Anti-Abeta antibody treatment promotes the rapid recovery of amyloid-associated neuritic dystrophy in PDAPP transgenic mice
    Robert P Brendza
    Department of Neurology and Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:428-33. 2005
    ..This analysis suggests that ongoing axonal and dendritic damage is secondary to Abeta and is, in part, rapidly reversible...
  4. ncbi request reprint The low density lipoprotein receptor regulates the level of central nervous system human and murine apolipoprotein E but does not modify amyloid plaque pathology in PDAPP mice
    John D Fryer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:25754-9. 2005
    ....
  5. ncbi request reprint Treatment with an amyloid-beta antibody ameliorates plaque load, learning deficits, and hippocampal long-term potentiation in a mouse model of Alzheimer's disease
    Richard E Hartman
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:6213-20. 2005
    ....
  6. pmc Alcohol-sensitive GABA receptors and alcohol antagonists
    Steven M Paul
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Proc Natl Acad Sci U S A 103:8307-8. 2006
  7. doi request reprint Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice
    Kelly R Bales
    Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 29:6771-9. 2009
    ..Therapeutic strategies aimed at increasing the soluble levels of apoE protein, regardless of isoform, may effectively prevent and (or) treat Alzheimer's disease...
  8. ncbi request reprint A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytes
    Yu Liang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurochem 88:623-34. 2004
    ..LXR/RXR agonists may have significant impact on the pathogenesis of multiple neurological diseases, including AD...
  9. ncbi request reprint Immunization reverses memory deficits without reducing brain Abeta burden in Alzheimer's disease model
    Jean Cosme Dodart
    Neuroscience Discovery Research, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Nat Neurosci 5:452-7. 2002
    ....
  10. doi request reprint Macrophage-mediated degradation of beta-amyloid via an apolipoprotein E isoform-dependent mechanism
    Lingzhi Zhao
    Neuroscience Discovery Research and Integrative Biology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 29:3603-12. 2009
    ....
  11. ncbi request reprint Apolipoprotein E alters the processing of the beta-amyloid precursor protein in APP(V717F) transgenic mice
    Jean Cosme Dodart
    Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Brain Res 955:191-9. 2002
    ..Taken together, these data support a role for apoE in APP processing in vivo...
  12. pmc Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody
    Kelly R Bales
    Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Clin Invest 116:825-32. 2006
    ..Treatment with certain anti-A beta antibodies may therefore rapidly reverse this cholinergic dysfunction and relieve memory deficits associated with early AD...
  13. doi request reprint Safety and changes in plasma and cerebrospinal fluid amyloid beta after a single administration of an amyloid beta monoclonal antibody in subjects with Alzheimer disease
    Eric R Siemers
    Eli Lilly and Company, Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    Clin Neuropharmacol 33:67-73. 2010
    ..LY2062430 (solanezumab) is a humanized monoclonal antibody being studied as a putative disease-modifying treatment of AD...
  14. ncbi request reprint Nonsteroidal anti-inflammatory drugs can lower amyloidogenic Abeta42 by inhibiting Rho
    Yan Zhou
    Neuroscience Discovery Research and Bioresearch Technologies and Proteins, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Science 302:1215-7. 2003
    ..Thus, the Rho-Rock pathway may regulate amyloid precursor protein processing, and a subset of NSAIDs can reduce Abeta42 through inhibition of Rho activity...
  15. ncbi request reprint Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeutics
    Guoqing Cao
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Curr Alzheimer Res 4:179-84. 2007
    ..Taken together, these findings suggest that brain-penetrable LXR agonists or modulators may be useful therapeutic agents for the treatment and (or) prevention of Alzheimer's disease...
  16. ncbi request reprint Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-beta peptides
    Milla Koistinaho
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Nat Med 10:719-26. 2004
    ..Thus, Apoe seems to be important in the degradation and clearance of deposited Abeta species by astrocytes, a process that may be impaired in Alzheimer disease...
  17. ncbi request reprint ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo
    Ronald B DeMattos
    Neuroscience Discovery Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Neuron 41:193-202. 2004
    ..These findings demonstrate additive effects of apoE and clusterin on influencing Abeta deposition and that apoE plays an important role in regulating extracellular CNS Abeta metabolism independent of Abeta synthesis...
  18. ncbi request reprint NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells
    Yansheng Du
    Department of Neurology, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Brain Res Mol Brain Res 136:177-88. 2005
    ..Our data provide evidence that upregulation of APOE by A(beta) in astroglial cells is mediated by an NF-(kappa)B-element present in the 5'-flanking region of the APOE gene...
  19. ncbi request reprint Exacerbation of cerebral amyloid angiopathy-associated microhemorrhage in amyloid precursor protein transgenic mice by immunotherapy is dependent on antibody recognition of deposited forms of amyloid beta
    Margaret M Racke
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 25:629-36. 2005
    ..These results may have important implications for future immune-based therapeutic strategies for Alzheimer's disease...
  20. ncbi request reprint Immunotherapy for Alzheimer's disease: will vaccination work?
    Jean Cosme Dodart
    Lilly Research Laboratories, Eli Lilly and Company, Neuroscience Discovery Research, Indianapolis, IN 46285, USA
    Trends Mol Med 9:85-7. 2003
    ..However, given the potential efficacy of this approach, we believe that immunotherapy for AD should not be prematurely abandoned...
  21. ncbi request reprint p38 MAP kinase mediates bilirubin-induced neuronal death of cultured rat cerebellar granule neurons
    Suizhen Lin
    Department of Neurology, School of Medicine, Indiana University, Indianapolis, IN 46202, USA
    Neurosci Lett 353:209-12. 2003
    ..Our data suggest that hyperphosphorylation of p38 MAP kinase plays an important role in bilirubin-induced neuronal death and provides a novel approach to discovering drugs to treat bilirubin-induced encephalopathy...
  22. ncbi request reprint Minocycline blocks bilirubin neurotoxicity and prevents hyperbilirubinemia-induced cerebellar hypoplasia in the Gunn rat
    Suizhen Lin
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
    Eur J Neurosci 22:21-7. 2005
    ..Our findings may lead to novel approaches for treating bilirubin-induced encephalopathy...
  23. ncbi request reprint NF-kappaB mediates IL-1beta-induced synthesis/release of alpha2-macroglobulin in a human glial cell line
    Feng Gao
    Department of Neurology, Indiana University School of Medicine, Indianapolis, IN 46285, USA
    Brain Res Mol Brain Res 105:108-14. 2002
    ..Our data suggest that attenuation of IL-1beta-induced alpha(2)M synthesis/release by blocking NF-kappaB activation may potentially be 'protective' against the development of late-onset AD...
  24. ncbi request reprint Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide
    Josep Saura
    Department of Pharmacology, Toxicology and Psychiatry, Indiana School of Medicine, Indianapolis, Indiana, USA
    J Neurochem 85:1455-67. 2003
    ..The transcription factor NF-kappa B appears to be a critical mediator of LPS-stimulated apoJ expression from astroglia...
  25. pmc Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease
    Suzanne E Wahrle
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 118:671-82. 2008
    ..These data support the conclusions that increased ABCA1-mediated lipidation of apoE in the CNS can reduce amyloid burden and that increasing ABCA1 function may have a therapeutic effect on AD...
  26. pmc Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein
    Olav M Andersen
    Max Delbrueck Center for Molecular Medicine, D 13125 Berlin, Germany
    Proc Natl Acad Sci U S A 102:13461-6. 2005
    ..Consequently, reduced receptor expression in the human brain may increase Abeta production and plaque formation and promote spontaneous AD...
  27. ncbi request reprint Synaptic activity regulates interstitial fluid amyloid-beta levels in vivo
    John R Cirrito
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 48:913-22. 2005
    ..The findings also have important implications for treatment development...
  28. ncbi request reprint Deletion of Abca1 increases Abeta deposition in the PDAPP transgenic mouse model of Alzheimer disease
    Suzanne E Wahrle
    Program in Neurosciences, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:43236-42. 2005
    ..Together, these data suggest that despite substantially lower apoE levels, poorly lipidated apoE produced in the absence of ABCA1 is strongly amyloidogenic in vivo...
  29. pmc P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    John R Cirrito
    Department of Neurology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Clin Invest 115:3285-90. 2005
    ..These data establish a direct link between Pgp and Abeta metabolism in vivo and suggest that Pgp activity at the BBB could affect risk for developing AD as well as provide a novel diagnostic and therapeutic target...
  30. ncbi request reprint Apolipoprotein E and low density lipoprotein receptor-related protein facilitate intraneuronal Abeta42 accumulation in amyloid model mice
    Celina V Zerbinatti
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:36180-6. 2006
    ..Our results support the hypothesis that LRP binds and endocytoses Abeta42 both directly and via apoE but that endocytosed Abeta42 is not completely degraded and accumulates in intraneuronal lysosomes...
  31. ncbi request reprint Enrichment improves cognition in AD mice by amyloid-related and unrelated mechanisms
    David A Costa
    Johnnie B Byrd Sr Alzheimer s Center and Research Institute, Tampa, FL 33647, USA
    Neurobiol Aging 28:831-44. 2007
    ..These results indicate that EE protects against cognitive impairment in AD transgenic mice through a dual mechanism, including both amyloid dependent and independent mechanisms...
  32. pmc Geranylgeranyl pyrophosphate stimulates gamma-secretase to increase the generation of Abeta and APP-CTFgamma
    Yan Zhou
    Department of Neurosciences, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    FASEB J 22:47-54. 2008
    ..Our results indicate that geranylgeranyl isoprenoids may be an important physiological facilitator of gamma-secretase activity that can foster production of the pathologically important Abeta42...
  33. ncbi request reprint Human and murine ApoE markedly alters A beta metabolism before and after plaque formation in a mouse model of Alzheimer's disease
    Anne M Fagan
    Center for the Study of Nervous System Injury, Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurobiol Dis 9:305-18. 2002
    ....
  34. ncbi request reprint Plaque-associated disruption of CSF and plasma amyloid-beta (Abeta) equilibrium in a mouse model of Alzheimer's disease
    Ronald B DeMattos
    Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 81:229-36. 2002
    ..These findings suggest that there is a dynamic equilibrium between CNS and plasma Abeta, and that plaques create a new equilibrium because soluble CNS Abeta not only enters the plasma but also deposits onto amyloid plaques in the CNS...
  35. pmc Clusterin promotes amyloid plaque formation and is critical for neuritic toxicity in a mouse model of Alzheimer's disease
    Ronald B DeMattos
    Center for the Study of Nervous System Injury, Alzheimer s Disease Research Center, and Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:10843-8. 2002
    ..These findings demonstrate that clusterin markedly influences Abeta structure and neuritic toxicity in vivo and is likely to play an important role in Alzheimer's disease pathogenesis...
  36. ncbi request reprint Brain to plasma amyloid-beta efflux: a measure of brain amyloid burden in a mouse model of Alzheimer's disease
    Ronald B DeMattos
    Center for the Study of Nervous System Injury, Alzheimer s Disease Research Center, Department of Neurology, Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
    Science 295:2264-7. 2002
    ..This method may be useful for quantifying brain amyloid burden in patients at risk for or those who have been diagnosed with AD...
  37. ncbi request reprint Apolipoprotein E4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer's disease
    Richard E Hartman
    Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 22:10083-7. 2002
    ..These data support the hypothesis that APOE4 influences the neurodegenerative cascade after TBI via an effect on Abeta...
  38. ncbi request reprint Abeta immunization and anti-Abeta antibodies: potential therapies for the prevention and treatment of Alzheimer's disease
    David M Holtzman
    Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, MO 63110, USA
    Adv Drug Deliv Rev 54:1603-13. 2002
    ..Abeta-related immune therapies in humans are an exciting new area of AD research. Understanding their detailed mechanism(s) of action and their potential usefulness awaits the results of future animal and human studies...
  39. ncbi request reprint PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures
    Robert P Brendza
    Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 456:375-83. 2003
    ....
  40. ncbi request reprint Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice
    John D Fryer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:7889-96. 2003
    ..These findings demonstrate that murine apoE markedly promotes the formation of CAA and associated vessel damage and that the effect of apoE combined with the level of Abeta40 or the ratio of Abeta 40:42 facilitates this process...
  41. ncbi request reprint In vivo assessment of brain interstitial fluid with microdialysis reveals plaque-associated changes in amyloid-beta metabolism and half-life
    John R Cirrito
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:8844-53. 2003
    ..This now measurable in vivo pool is a likely target for new diagnostic and therapeutic strategies...
  42. ncbi request reprint Use of YFP to study amyloid-beta associated neurite alterations in live brain slices
    Robert P Brendza
    Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Aging 24:1071-7. 2003
    ..This acute slice preparation model should prove to be a useful tool to explore the pathophysiology of Abeta-related axonal, dendritic, and synaptic dysfunction...
  43. ncbi request reprint Use of multimetric statistical analysis to characterize and discriminate between the performance of four Alzheimer's transgenic mouse lines differing in Abeta deposition
    Ralph E Leighty
    Memory and Aging Research Laboratory, SCA 110, University of South Florida, Tampa, FL 33620, USA
    Behav Brain Res 153:107-21. 2004
    ..Analyses such as these will be very beneficial for the functional evaluation of therapeutic interventions against AD and for finding behavioral measures that can serve as predictors of pathology...
  44. ncbi request reprint Cognitive impairment in PDAPP mice depends on ApoE and ACT-catalyzed amyloid formation
    Lars N G Nilsson
    Department of Biochemistry and Molecular Biology, Suncoast Gerontology Center, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL 33612, USA
    Neurobiol Aging 25:1153-67. 2004
    ....
  45. pmc ApoAI deficiency results in marked reductions in plasma cholesterol but no alterations in amyloid-beta pathology in a mouse model of Alzheimer's disease-like cerebral amyloidosis
    Anne M Fagan
    Department of Neurology and Center for the Study of Nervous System Injury, Alzheimer s Disease Research Center, Washington University School of Medicine, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Am J Pathol 165:1413-22. 2004
    ..These and other data suggest that it is perhaps the level of brain apolipoprotein E, not cholesterol per se, that plays a primary role in brain Abeta metabolism...
  46. ncbi request reprint Apolipoprotein is required for the formation of filamentous amyloid, but not for amorphous Abeta deposition, in an AbetaPP/PS double transgenic mouse model of Alzheimer's disease
    David A Costa
    Department of Biochemistry and Molecular Biology and Suncoast Gerontology Center, University of South Florida, Tampa, FL 33620, USA
    J Alzheimers Dis 6:509-14. 2004
    ..Thus, preventing apoE from binding to Abeta may prove to be an effective means of therapeutic intervention...
  47. ncbi request reprint Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model
    John D Fryer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:2803-10. 2005
    ....
  48. doi request reprint Sortilin-related receptor with A-type repeats (SORLA) affects the amyloid precursor protein-dependent stimulation of ERK signaling and adult neurogenesis
    Michael Rohe
    Max Delbrueck Center for Molecular Medicine, Berlin, Germany
    J Biol Chem 283:14826-34. 2008
    ..Our data document a role for SORLA not only in control of plaque burden but also in APP-dependent neuronal signaling and suggest a molecular explanation for increased neurogenesis observed in some AD patients...
  49. pmc Increased soluble amyloid-beta peptide and memory deficits in amyloid model mice overexpressing the low-density lipoprotein receptor-related protein
    Celina V Zerbinatti
    Departments of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:1075-80. 2004
    ..These results provide in vivo evidence that LRP may contribute to memory deficits typical of Alzheimer's disease by modulating the pool of small soluble forms of Abeta...