P L Ornstein

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution
    P L Ornstein
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Med Chem 41:346-57. 1998
  2. ncbi request reprint 2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability
    P L Ornstein
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Med Chem 41:358-78. 1998
  3. ncbi request reprint Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution
    P L Ornstein
    Lilly Research Laboratories, Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA Ornstein
    J Med Chem 39:2219-31. 1996
  4. ncbi request reprint [3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain
    R A Wright
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 298:453-60. 2001
  5. ncbi request reprint Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist
    R W Fuller
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285
    Neuropharmacology 31:1027-32. 1992
  6. ncbi request reprint Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons
    D Bleakman
    Eli Lilly and Company, Lilly Neuroscience, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Eur J Pharmacol 378:331-7. 1999
  7. ncbi request reprint Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists
    H Zarrinmayeh
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Med Chem 41:2709-19. 1998

Collaborators

  • D D Schoepp
  • D R Gehlert
  • S L Gackenheimer
  • R A Wright
  • M B Arnold
  • D Bleakman
  • H Zarrinmayeh
  • W J Wheeler
  • K Hoo
  • A M Ogden
  • A M Nunes
  • D A Schober
  • B E Cantrell
  • P A Hipskind
  • D M Zimmerman
  • R F Bruns
  • T C Britton
  • R W Fuller
  • S K Hemrick-Luecke

Detail Information

Publications7

  1. ncbi request reprint 2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution
    P L Ornstein
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Med Chem 41:346-57. 1998
    ..Amino acid 113, with an IC50 of 0.010 microM in the [3H]Glu binding assay, was 52-fold more potent than 2, whose IC50 was 0.47 microM...
  2. ncbi request reprint 2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability
    P L Ornstein
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Med Chem 41:358-78. 1998
    ..p., 60 min preinjection). Thus, 168 represents a valuable tool to study the role of group II mGluRs in disease...
  3. ncbi request reprint Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution
    P L Ornstein
    Lilly Research Laboratories, Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA Ornstein
    J Med Chem 39:2219-31. 1996
    ....
  4. ncbi request reprint [3H]LY341495 binding to group II metabotropic glutamate receptors in rat brain
    R A Wright
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 298:453-60. 2001
    ..These studies indicate that [3H]LY341495 selectively labels group II (mGlu2/3) receptors, but under the conditions used, [3H]LY341495 may bind predominately to mGlu3 receptor populations in the rat forebrain...
  5. ncbi request reprint Protection against amphetamine-induced neurotoxicity toward striatal dopamine neurons in rodents by LY274614, an excitatory amino acid antagonist
    R W Fuller
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285
    Neuropharmacology 31:1027-32. 1992
    ....
  6. ncbi request reprint Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons
    D Bleakman
    Eli Lilly and Company, Lilly Neuroscience, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Eur J Pharmacol 378:331-7. 1999
    ..These results provide pharmacological evidence that ion channels comprised of GluR6 kainate receptor subunits mediate kainate receptor responses in hippocampal neurons cultured 6-8 DIV...
  7. ncbi request reprint Synthesis and evaluation of a series of novel 2-[(4-chlorophenoxy)methyl]benzimidazoles as selective neuropeptide Y Y1 receptor antagonists
    H Zarrinmayeh
    Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Med Chem 41:2709-19. 1998
    ..The high selectivity of several BI antagonists for the Y1 versus Y2, Y4, and Y5 receptors was also shown...