Lauren B Marangell

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. pmc Current issues: women and bipolar disorder
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine Houston, Texas, USA
    Dialogues Clin Neurosci 10:229-38. 2008
  2. doi request reprint Comparative pain and mood effects in patients with comorbid fibromyalgia and major depressive disorder: secondary analyses of four pooled randomized controlled trials of duloxetine
    Lauren B Marangell
    Lilly USA, LLC, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Pain 152:31-7. 2011
  3. pmc The functional impact of subsyndromal depressive symptoms in bipolar disorder: data from STEP-BD
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, United States
    J Affect Disord 114:58-67. 2009
  4. ncbi request reprint Case-control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: findings from STEP-BD
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and South Central Mental Illness Research and Education Core, Department of Veterans Affairs, Houston, Tex, USA
    J Clin Psychiatry 69:916-22. 2008
  5. ncbi request reprint A 1-year pilot study of vagus nerve stimulation in treatment-resistant rapid-cycling bipolar disorder
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, and Department of Veterans Affairs, Houston, Texas, USA
    J Clin Psychiatry 69:183-9. 2008
  6. ncbi request reprint Omega-3 fatty acids in bipolar disorder: clinical and research considerations
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA
    Prostaglandins Leukot Essent Fatty Acids 75:315-21. 2006
  7. doi request reprint A pragmatic 12-week, randomized trial of duloxetine versus generic selective serotonin-reuptake inhibitors in the treatment of adult outpatients in a moderate-to-severe depressive episode
    James Michael Martinez
    Lilly USA, LLC, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Int Clin Psychopharmacol 27:17-26. 2012
  8. doi request reprint A randomized placebo-controlled trial of duloxetine in patients with major depressive disorder and associated painful physical symptoms
    Paula J Gaynor
    Eli Lilly and Company, Indianapolis, IN, USA
    Curr Med Res Opin 27:1849-58. 2011
  9. ncbi request reprint Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and the Department of Veterans Affairs, VISN 16 MIRECC, Houston, TX 77030, USA
    Bipolar Disord 8:566-75. 2006
  10. ncbi request reprint Baseline predictors of serious adverse events at one year among patients with bipolar disorder in STEP-BD
    James M Martinez
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Ben Taub Hospital, Houston, TX 77030, USA
    Psychiatr Serv 56:1541-8. 2005

Collaborators

Detail Information

Publications47

  1. pmc Current issues: women and bipolar disorder
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine Houston, Texas, USA
    Dialogues Clin Neurosci 10:229-38. 2008
    ..In order to best address these issues, clinicians must be familiar with the data and collaborate with the patient to assess risks and benefits for the individual women and her family...
  2. doi request reprint Comparative pain and mood effects in patients with comorbid fibromyalgia and major depressive disorder: secondary analyses of four pooled randomized controlled trials of duloxetine
    Lauren B Marangell
    Lilly USA, LLC, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Pain 152:31-7. 2011
    ..Hence, both direct and indirect analgesic and antidepressant properties appear to be relevant for the treatment of these comorbid patients with duloxetine...
  3. pmc The functional impact of subsyndromal depressive symptoms in bipolar disorder: data from STEP-BD
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, United States
    J Affect Disord 114:58-67. 2009
    ..This report describes baseline characteristics and functional outcomes of subjects who have prospectively observed subsyndromal symptoms after a major depressive episode (MDE)...
  4. ncbi request reprint Case-control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: findings from STEP-BD
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and South Central Mental Illness Research and Education Core, Department of Veterans Affairs, Houston, Tex, USA
    J Clin Psychiatry 69:916-22. 2008
    ....
  5. ncbi request reprint A 1-year pilot study of vagus nerve stimulation in treatment-resistant rapid-cycling bipolar disorder
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, and Department of Veterans Affairs, Houston, Texas, USA
    J Clin Psychiatry 69:183-9. 2008
    ..The aim of the present study was to investigate the efficacy of VNS in a group of patients with treatment-resistant rapid-cycling bipolar disorder (RCBD) who were excluded from previous trials...
  6. ncbi request reprint Omega-3 fatty acids in bipolar disorder: clinical and research considerations
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA
    Prostaglandins Leukot Essent Fatty Acids 75:315-21. 2006
    ..Our pilot trial of DHA in women who plan to stop conventional psychotropics in order to conceive suggests that such trials are feasible...
  7. doi request reprint A pragmatic 12-week, randomized trial of duloxetine versus generic selective serotonin-reuptake inhibitors in the treatment of adult outpatients in a moderate-to-severe depressive episode
    James Michael Martinez
    Lilly USA, LLC, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Int Clin Psychopharmacol 27:17-26. 2012
    ..Study demographics suggest a more generalizable racial and ethnic population than is typical in randomized clinical trials...
  8. doi request reprint A randomized placebo-controlled trial of duloxetine in patients with major depressive disorder and associated painful physical symptoms
    Paula J Gaynor
    Eli Lilly and Company, Indianapolis, IN, USA
    Curr Med Res Opin 27:1849-58. 2011
    ..Duloxetine has demonstrated efficacy in treating both MDD and certain other painful conditions. This randomized, double-blind clinical trial assessed the effects of duloxetine in patients with both MDD and MDD-associated physical pain...
  9. ncbi request reprint Prospective predictors of suicide and suicide attempts in 1,556 patients with bipolar disorders followed for up to 2 years
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and the Department of Veterans Affairs, VISN 16 MIRECC, Houston, TX 77030, USA
    Bipolar Disord 8:566-75. 2006
    ....
  10. ncbi request reprint Baseline predictors of serious adverse events at one year among patients with bipolar disorder in STEP-BD
    James M Martinez
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine, Ben Taub Hospital, Houston, TX 77030, USA
    Psychiatr Serv 56:1541-8. 2005
    ..Little is known about serious adverse events that occur in the context of clinical care for bipolar disorder. This study examined predictors of serious adverse events in a large cohort of patients with bipolar disorder...
  11. ncbi request reprint The importance of subsyndromal symptoms in bipolar disorder
    Lauren B Marangell
    Mood Disorders Center, Baylor College of Medicine, and the South Central Mental Illness Research, Education, and Clinical Center of the Department of Veterans Affairs, Houston, Tex, USA
    J Clin Psychiatry 65:24-7. 2004
    ..In addition, the use of subsyndromal symptoms to broaden the diagnostic criteria for bipolar disorder is receiving increased attention. This article reviews and discusses these important issues...
  12. ncbi request reprint Relationship between major depressive disorder and associated painful physical symptoms: analysis of data from two pooled placebo-controlled, randomized studies of duloxetine
    Michael J Robinson
    aEli Lilly and Company, Indianapolis bStrategic Alliances, inVentiv Health Clinical, LLC, Indianapolis, Indiana cDepartment of Psychiatry, University of Texas Health Science Center, Houston, Texas dUniversity of South Florida College of Medicine, Tampa, Florida, USA eLilly Research Laboratories Japan, Eli Lilly Japan K K, Kobe, Japan
    Int Clin Psychopharmacol 28:330-8. 2013
    ....
  13. pmc Prescription patterns of psychotropic medications in elderly compared with younger participants who achieved a "recovered" status in the systematic treatment enhancement program for bipolar disorder
    Rayan K Al Jurdi
    Department of Psychiatry, Baylor College of Medicine, Houston, Texas, USA
    Am J Geriatr Psychiatry 16:922-33. 2008
    ..This study compares prescription patterns between young adults and elderly with bipolar disorder who achieved a recovery status during the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)...
  14. ncbi request reprint Omega-3 fatty acids for the prevention of postpartum depression: negative data from a preliminary, open-label pilot study
    Lauren B Marangell
    Department of Psychiatry, Baylor College of Medicine, Houston, Texas 77030, USA
    Depress Anxiety 19:20-3. 2004
    ..Controlled studies are lacking...
  15. ncbi request reprint The efficacy and tolerability of duloxetine in the treatment of anxious versus non-anxious depression: a post-hoc analysis of an open-label outpatient study
    Maurizio Fava
    Department of Psychiatry, Massachusetts General Hospital, Boston, MA, and Menninger Department of Psychiatry, Baylor College of Medicine, Houston, TX, USA
    Ann Clin Psychiatry 19:187-95. 2007
    ..This study compares the efficacy and tolerability of 12 weeks of open-label duloxetine in adult outpatients with anxious versus non-anxious depression...
  16. ncbi request reprint Lamotrigine treatment of bipolar disorder: data from the first 500 patients in STEP-BD
    Lauren B Marangell
    Mood Disorders Program, Department of Psychiatry, Baylor College of Medicine, Houston, TX 77030, USA
    Bipolar Disord 6:139-43. 2004
    ..To describe the frequency and correlates of lamotrigine therapy among the first 500 patients enrolled into the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD) study...
  17. doi request reprint Brain-derived neurotrophic factor in generalized anxiety disorder: results from a duloxetine clinical trial
    Susan Ball
    Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Prog Neuropsychopharmacol Biol Psychiatry 43:217-21. 2013
    ..The objective of this study was to examine the relationship between baseline BDNF level and treatment response in patients with GAD...
  18. ncbi request reprint Olanzapine in the treatment of apathy in previously depressed participants maintained with selective serotonin reuptake inhibitors: an open-label, flexible-dose study
    Lauren B Marangell
    Mood Disorders Center, Department of Psychiatry, Baylor College of Medicine, Houston, Tex 77030, USA
    J Clin Psychiatry 63:391-5. 2002
    ..We report a clinical trial of olanzapine in the treatment of prominent apathy in the absence of depression in patients on long-term treatment with selective serotonin reuptake inhibitors (SSRIs) for nonpsychotic major depression...
  19. ncbi request reprint A double-blind, placebo-controlled study of the omega-3 fatty acid docosahexaenoic acid in the treatment of major depression
    Lauren B Marangell
    Mood Disorders Center, Department of Psychiatry, Baylor College of Medicine, Suite 560, 6655 Travis Road, Houston, TX 77030, USA
    Am J Psychiatry 160:996-8. 2003
    ..This study was an evaluation of the omega-3 fatty acid docosahexaenoic acid (DHA) for the treatment of major depression...
  20. ncbi request reprint Vagus nerve stimulation: current use and potential applications in child and adolescent psychiatry
    James M Martinez
    Menninger Department of Psychiatry, Baylor College of Medicine, 6655 Travis Road, Suite 560, Houston, TX 77030, USA
    Child Adolesc Psychiatr Clin N Am 14:177-91, viii. 2005
    ..This intervention also holds promise as a potential treatment in children and adolescents, although research is currently lacking...
  21. doi request reprint Duloxetine versus placebo in the treatment of major depressive disorder and associated painful physical symptoms: a replication study
    Paula J Gaynor
    Eli Lilly and Company, Indianapolis, IN, USA
    Curr Med Res Opin 27:1859-67. 2011
    ..Duloxetine has demonstrated efficacy in treating MDD and other certain painful conditions; this study specifically evaluated patients with both MDD and MDD-associated pain...
  22. doi request reprint Assessment of depressive symptoms and functional outcomes in patients with major depressive disorder treated with duloxetine versus placebo: primary outcomes from two trials conducted under the same protocol
    Tina Marie Myers Oakes
    Lilly USA, LLC, Indianapolis, Indiana 46201, USA
    Hum Psychopharmacol 27:47-56. 2012
    ..Return of functional ability is a central goal in the treatment of major depressive disorder. We conducted two trials with the same protocol that was designed to assess functioning after 8 Weeks of treatment with duloxetine...
  23. ncbi request reprint Use of treatment algorithms for depression
    Madhukar H Trivedi
    Mood Disorders Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Clin Psychiatry 67:1458-65. 2006
  24. ncbi request reprint Clinical and functional outcomes of patients who experience partial response to citalopram: secondary analysis of STAR*D
    Ellen B Dennehy
    DENNEHY Eli Lilly and Company, Indianapolis, IN, and Purdue University, West Lafayette, IN MARANGELL Eli Lilly and Company and The University of Texas Health Science Center, Houston, TX MARTINEZ Eli Lilly and Company BALASUBRAMANI and WISNIEWSKI Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA
    J Psychiatr Pract 20:178-87. 2014
    ....
  25. ncbi request reprint Vagus nerve stimulation (VNS) for major depressive episodes: one year outcomes
    Lauren B Marangell
    Department of Psychiatry, Baylor College of Medicine, One Baylor Plaza, BCM 350, Houston, TX 77030, USA
    Biol Psychiatry 51:280-7. 2002
    ..This open, naturalistic follow-up study was conducted to determine whether the initial promising effects were sustained, and whether changes in function would be observed...
  26. ncbi request reprint A cross-national relationship between sugar consumption and major depression?
    Arthur N Westover
    Mood Disorders Center MDOC, Department of Psychiatry, Baylor College of Medicine, Houston, Texas, USA
    Depress Anxiety 16:118-20. 2002
    ..Possible relationships between sugar consumption, beta-endorphins, and oxidative stress are discussed...
  27. doi request reprint Comprehensive review of factors implicated in the heterogeneity of response in depression
    Gebra Cuyun Carter
    Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
    Depress Anxiety 29:340-54. 2012
    ..The goal of this study was to review the literature and attempt to identify nongenetic factors potentially predictive of overall response to depression treatments...
  28. ncbi request reprint Two-year outcome of vagus nerve stimulation (VNS) for treatment of major depressive episodes
    Ziad Nahas
    Brain Stimulation Laboratory, Department of Psychiatry, Medical University of South Carolina, Charleston, SC 29403, USA
    J Clin Psychiatry 66:1097-104. 2005
    ..We examined the effects of adjunctive VNS over 24 months in this cohort...
  29. ncbi request reprint A one-year comparison of vagus nerve stimulation with treatment as usual for treatment-resistant depression
    Mark S George
    Department of Psychiatry, Medical University of South Carolina, 67 President Street 502 N, Charleston, SC 29425, USA
    Biol Psychiatry 58:364-73. 2005
    ..To better understand these effects on long-term outcome, we compared 12-month VNS+TAU outcomes with those of a comparable TRD group...
  30. ncbi request reprint Effects of 12 months of vagus nerve stimulation in treatment-resistant depression: a naturalistic study
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:355-63. 2005
    ..The need for effective, long-term treatment for recurrent or chronic, treatment-resistant depression is well established...
  31. ncbi request reprint Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone
    Andrew A Nierenberg
    Massachusetts General Hospital Bipolar Clinic and Research Program, Suite 580, 50 Staniford Street, Boston, MA 02114, USA
    Am J Psychiatry 163:210-6. 2006
    ..This study represents the first randomized trial of competing options for treatment-resistant bipolar depression and assesses the effectiveness and safety of antidepressant augmentation with lamotrigine, inositol, and risperidone...
  32. ncbi request reprint Brief report: paroxetine in younger and adult individuals at high risk for suicide
    Mark S Bauer
    Department of Psychiatry, Brown University, USA
    Psychopharmacol Bull 39:31-7. 2006
    ..In fact, the younger group showed a trend for decreased suicidality (P = .13). Thus, increased suicidality risk with paroxetine exposure does not extend to this other high-risk mood disordered population, even among younger individuals...
  33. ncbi request reprint Vagus nerve stimulation for treatment-resistant depression: a randomized, controlled acute phase trial
    A John Rush
    Department of Psychiatry, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA
    Biol Psychiatry 58:347-54. 2005
    ..Vagus nerve stimulation (VNS) alters both concentrations of neurotransmitters or their metabolites and functional activity of central nervous system regions dysregulated in mood disorders. An open trial has suggested efficacy...
  34. ncbi request reprint Long-term implications of early onset in bipolar disorder: data from the first 1000 participants in the systematic treatment enhancement program for bipolar disorder (STEP-BD)
    Roy H Perlis
    Partners Bipolar Treatment Center at Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Biol Psychiatry 55:875-81. 2004
    ..Early onset of mood symptoms in bipolar disorder has been associated with poor outcome in many studies; however, the factors that might contribute to poor outcome have not been adequately investigated...
  35. ncbi request reprint Are antidepressants associated with new-onset suicidality in bipolar disorder? A prospective study of participants in the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Mark S Bauer
    Providence Veterans Affairs Medical Center and the Department of Psychiatry and Human Behavior, Brown University, VAMC 116R, 830 Chalkstone Avenue, Providence, R I 02908 4799, USA
    J Clin Psychiatry 67:48-55. 2006
    ..However, few data are available to inform the suicidality risk assessment of antidepressant use specifically in bipolar disorder...
  36. ncbi request reprint Current suicide ideation and prior suicide attempts of bipolar patients as influences on caregiver burden
    Cheryl A Chessick
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, Colorado 80220, USA
    Suicide Life Threat Behav 37:482-91. 2007
    ..Levels of depression in caregivers varied with whether the caregiver was a spouse or a parent, and whether patients had a history of suicide attempts, current suicidal ideation, or both...
  37. ncbi request reprint Durability of antidepressant response to vagus nerve stimulation (VNS)
    Harold A Sackeim
    Departments of Biological Psychiatry, New York State Psychiatric Institute, New York, NY 10032, USA
    Int J Neuropsychopharmacol 10:817-26. 2007
    ..Yet patients who showed substantial clinical benefit maintained the improvement at remarkably high rates. This durability of benefit was not attributable to alterations in other treatments...
  38. ncbi request reprint Predictors of recurrence in bipolar disorder: primary outcomes from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP-BD)
    Roy H Perlis
    Bipolar Clinical and Research Program, Massachusetts General Hospital, ACC 812, 15 Parkman Street, Boston, MA 02114, USA
    Am J Psychiatry 163:217-24. 2006
    ..The authors looked for the features associated with risk of recurrence...
  39. pmc Psychosocial treatments for bipolar depression: a 1-year randomized trial from the Systematic Treatment Enhancement Program
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Arch Gen Psychiatry 64:419-26. 2007
    ..Psychosocial interventions have been shown to enhance pharmacotherapy outcomes in bipolar disorder...
  40. pmc Intensive psychosocial intervention enhances functioning in patients with bipolar depression: results from a 9-month randomized controlled trial
    David J Miklowitz
    Department of Psychology, University of Colorado, Boulder, CO 80309 0345, USA
    Am J Psychiatry 164:1340-7. 2007
    ..In a randomized trial, the authors examined the impact of intensive psychosocial treatment plus pharmacotherapy on the functional outcomes of patients with bipolar disorder over the 9 months following a depressive episode...
  41. ncbi request reprint Effectiveness of adjunctive antidepressant treatment for bipolar depression
    Gary S Sachs
    Bipolar Clinic and Research Program, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    N Engl J Med 356:1711-22. 2007
    ..Our study was designed to determine whether adjunctive antidepressant therapy reduces symptoms of bipolar depression without increasing the risk of mania...
  42. pmc Increased rate of non-right-handedness in patients with bipolar disorder
    Cecylia Nowakowska
    J Clin Psychiatry 69:866-7. 2008
  43. ncbi request reprint Overweight and obesity in bipolar disorders
    Po W Wang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Room 2117, CA 94305 5723, USA
    J Psychiatr Res 40:762-4. 2006
  44. pmc Whole-genome association study of bipolar disorder
    P Sklar
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Mol Psychiatry 13:558-69. 2008
    ..Given the heritability of BP disorder, the lack of agreement between studies emphasizes that susceptibility alleles are likely to be modest in effect size and require even larger samples for detection...
  45. ncbi request reprint Gender differences in bipolar disorder: retrospective data from the first 500 STEP-BD participants
    Claudia F Baldassano
    Bipolar Disorders Program, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA, USA
    Bipolar Disord 7:465-70. 2005
    ..To examine gender differences in a large sample of patients with bipolar illness...
  46. ncbi request reprint Serotonin gene polymorphisms and bipolar I disorder: focus on the serotonin transporter
    Hader A Mansour
    Department of Psychiatry, University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, 3811 O Hara Street, Pittsburgh, PA 15213, U S A
    Ann Med 37:590-602. 2005
    ..Our analyses do not support association between SLC6A4 and BDI families. Further studies using sub-groups of BDI are worthwhile...
  47. ncbi request reprint How blind is double-blind? A study of fish oil versus placebo
    Karen E Damico
    Psychopharmacology Research Laboratory, Center for the Development of Novel and Natural Treatments for Mood Disorders, McLean Hospital, Belmont, MA 02478, USA
    Prostaglandins Leukot Essent Fatty Acids 66:393-5. 2002
    ..The results suggest that altering subjects' expectations could further improve the validity of the double-blind...