- Prediction of CYP3A-mediated drug-drug interactions using human hepatocytes suspended in human plasmaJialin Mao
Department of Drug Disposition, Eli Lilly and Co Lilly Corporate Center, Indianapolis, IN 46285, USA
Drug Metab Dispos 39:591-602. 2011..Thus, HHSHP produced accurate DDI predictions with a simple IC(50) determined at a single incubation time regardless of the inhibition mechanism; further if needed, the mechanism(s) of inhibition can be identified...
- Predictions of cytochrome P450-mediated drug-drug interactions using cryopreserved human hepatocytes: comparison of plasma and protein-free media incubation conditionsJialin Mao
Drug Disposition, Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN 46285, USA
Drug Metab Dispos 40:706-16. 2012..In conclusion, the HHSHP system proved to be a simple, accurate predictor of DDIs for three major P450s and superior to the protein-free approach...