Xia Li

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Dehydration anorexia is attenuated in oxytocin-deficient mice
    Linda Rinaman
    University of Pittsburgh, Department of Neuroscience, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1791-9. 2005
  2. ncbi request reprint Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
    X Li
    Eli Lilly and Co, Lilly Research Laboratories, Indianapolis, IN 46285 0510, USA
    Neuropharmacology 40:1028-33. 2001
  3. ncbi request reprint Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice
    Xia Li
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285 0510, USA
    J Pharmacol Exp Ther 319:254-9. 2006
  4. ncbi request reprint Enhancement of antidepressant potency by a potentiator of AMPA receptors
    Xia Li
    Neuroscience Discovery Research, Eli Lilly and Co, Lilly Research Laboratories, Corporate Center, Indianapolis, Indiana, USA
    Cell Mol Neurobiol 23:419-30. 2003
  5. doi request reprint Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression
    Donald R Gehlert
    Neuroscience and Endocrine Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 329:429-38. 2009
  6. doi request reprint N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link betw
    Matthew J Fell
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, DC0510, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 336:165-77. 2011
  7. ncbi request reprint In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders
    Andrew Alt
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Psychopharmacology (Berl) 185:240-7. 2006
  8. ncbi request reprint A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disorders
    Jeffrey M Witkin
    Psychiatric Drug Discovery, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Trends Pharmacol Sci 26:609-17. 2005
  9. ncbi request reprint Decreases in nestlet shredding of mice by serotonin uptake inhibitors: comparison with marble burying
    Xia Li
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Life Sci 78:1933-9. 2006
  10. doi request reprint New approaches to the pharmacological management of major depressive disorder
    Jeffrey M Witkin
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Adv Pharmacol 57:347-79. 2009

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Dehydration anorexia is attenuated in oxytocin-deficient mice
    Linda Rinaman
    University of Pittsburgh, Department of Neuroscience, 446 Crawford Hall, Pittsburgh, PA 15260, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1791-9. 2005
    ..These findings support the view that OT-containing projections from the hypothalamus to the hindbrain are necessary for the full expression of compensatory behavioral and physiological responses to dehydration...
  2. ncbi request reprint Antidepressant-like actions of an AMPA receptor potentiator (LY392098)
    X Li
    Eli Lilly and Co, Lilly Research Laboratories, Indianapolis, IN 46285 0510, USA
    Neuropharmacology 40:1028-33. 2001
    ..These findings indicate that biarylpropylsulfonamides, exemplified by LY392098, may represent a novel class of antidepressants...
  3. ncbi request reprint Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice
    Xia Li
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285 0510, USA
    J Pharmacol Exp Ther 319:254-9. 2006
    ..This mechanism may not only provide a novel approach to the therapeutic management of depressive disorders but also may be useful in the augmentation of effects of traditional antidepressant agents...
  4. ncbi request reprint Enhancement of antidepressant potency by a potentiator of AMPA receptors
    Xia Li
    Neuroscience Discovery Research, Eli Lilly and Co, Lilly Research Laboratories, Corporate Center, Indianapolis, Indiana, USA
    Cell Mol Neurobiol 23:419-30. 2003
    ....
  5. doi request reprint Preclinical evaluation of melanin-concentrating hormone receptor 1 antagonism for the treatment of obesity and depression
    Donald R Gehlert
    Neuroscience and Endocrine Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 329:429-38. 2009
    ..Thus, GW803430 produces robust antiobesity and antidepressant-like effects in rats and mice at doses that compete for central MCHR1 in vivo. As such, MCHR1 should be considered as a promising target for future drug discovery efforts...
  6. doi request reprint N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link betw
    Matthew J Fell
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, DC0510, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 336:165-77. 2011
    ..In addition, we provide evidence that sleep EEG and CSF t-MeHA might function as viable biomarker approaches to facilitate the translational development of THIIC and other mGlu2 potentiators...
  7. ncbi request reprint In vitro and in vivo studies in rats with LY293558 suggest AMPA/kainate receptor blockade as a novel potential mechanism for the therapeutic treatment of anxiety disorders
    Andrew Alt
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Psychopharmacology (Berl) 185:240-7. 2006
    ..Although convergent evidence exists for a role of glutamate in the regulation of anxiety, the involvement of specific glutamate receptor subtypes has yet to be defined...
  8. ncbi request reprint A therapeutic role for cannabinoid CB1 receptor antagonists in major depressive disorders
    Jeffrey M Witkin
    Psychiatric Drug Discovery, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Trends Pharmacol Sci 26:609-17. 2005
    ..Thus, CB1 receptor antagonism might constitute an integrated pharmacotherapeutic approach that impacts the affective, cognitive, appetitive and motivational neuronal networks involved in mood disorders...
  9. ncbi request reprint Decreases in nestlet shredding of mice by serotonin uptake inhibitors: comparison with marble burying
    Xia Li
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Life Sci 78:1933-9. 2006
    ....
  10. doi request reprint New approaches to the pharmacological management of major depressive disorder
    Jeffrey M Witkin
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Adv Pharmacol 57:347-79. 2009
    ..Accumulating evidence supports the idea that amplification of AMPA receptor function is a critical link in the transduction processes involved antidepressant effects...
  11. pmc The CB1 receptor antagonist SR141716A selectively increases monoaminergic neurotransmission in the medial prefrontal cortex: implications for therapeutic actions
    Eleni T Tzavara
    Eli Lilly and Company, Lilly Corporate Center, DC0510, Neuroscience Discovery Research, Indianapolis, IN 46285 0510, USA
    Br J Pharmacol 138:544-53. 2003
    ....
  12. ncbi request reprint Further evaluation of the neuropharmacological determinants of the antidepressant-like effects of curcumin
    Jeffrey M Witkin
    Psychiatry Drug Discovery, Lilly Research Labs, Indianapolis, IN 46285 0510, USA
    CNS Neurol Disord Drug Targets 12:498-505. 2013
    ..The scientific and patient communities await the full scale clinical evaluation of a sufficiently bioavailable curcumin analog in major depressive disorder. ..
  13. ncbi request reprint Curcumin, an active constiuent of the ancient medicinal herb Curcuma longa L.: some uses and the establishment and biological basis of medical efficacy
    Jeffrey M Witkin
    Psychiatric Drug Discovery, Lilly Research Laboratories, Indianapolis, IN 46285 0510, USA
    CNS Neurol Disord Drug Targets 12:487-97. 2013
    ..Although multiple approaches to this problem are being examined, a solution to the bioavailability issue will be needed to ensure appropriate tissue exposures of curcumin in clinical investigation. Progress in this regard is underway. ..
  14. ncbi request reprint A rapid punishment procedure for detection of anxiolytic compounds in mice
    Jeffrey M Witkin
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Psychopharmacology (Berl) 172:52-7. 2004
    ..The use of mice in these tests has been limited, but the utility of this species in drug discovery and for neurobiological inquiry would benefit from a rapid, reliable method...
  15. pmc Levo-tetrahydropalmatine inhibits cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats
    Zheng Xiong Xi
    Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropharmacology 53:771-82. 2007
    ..Together, the present data, combined with previous findings, support the potential use of l-THP for treatment of cocaine addiction...
  16. ncbi request reprint Antidepressant-like effects of sarsasapogenin from Anemarrhena asphodeloides BUNGE (Liliaceae)
    Li Xiang Ren
    School of Pharmacy, Shenyang Pharmaceutical University, China
    Biol Pharm Bull 29:2304-6. 2006
    ..Moreover, sarsasapogenin showed a monoamine oxidase inhibitory activity in the mouse brain. These findings suggest that the antidepressant activity of sarsasapogenin may involve the central monoaminergic neurotransmitter systems...
  17. doi request reprint Ginsenoside Rg1 protects neurons from hypoxic-ischemic injury possibly by inhibiting Ca2+ influx through NMDA receptors and L-type voltage-dependent Ca2+ channels
    Yun Feng Zhang
    Department of Neuropharmacology, Institute of Nautical Medicine, Nantong University, 19 Qixiu Road, Nantong, Jiangsu, 226001, China
    Eur J Pharmacol 586:90-9. 2008
    ....
  18. ncbi request reprint The influence of carvedilol on atrial connexin 40 after myocardial infarction
    Feng Cao
    Department of Cardiology, Renmin Hospital of Wuhan University, China
    Acta Cardiol 63:303-8. 2008
    ....
  19. pmc Posttraumatic secondary brain insults exacerbates neuronal injury by altering metabotropic glutamate receptors
    Zhou Fei
    Department of Neurosurgery, Xijing Hospital, Fourth Military Medical University, Xi an, 710032, PR China
    BMC Neurosci 8:96. 2007
    ....
  20. ncbi request reprint [Effects of recombinant human bone morphogenic protein-2 and hyaluronic acid on invasion of brain glioma in vivo]
    Xiang Zhang
    The Neurosurgical Institute of PLA, Xijing Hospital, The Fourth Military Medical University, Xi an 710032, China
    Zhonghua Yi Xue Za Zhi 82:90-3. 2002
    ..To investigate the effects of recombinant human bone morphogenic protein-2 (rhBMP-2) and hyaluronic acid (HA) on the invasion and metastasis of rat brain glioma in vivo...
  21. ncbi request reprint Cannabinoid CB1 receptor antagonists attenuate cocaine's rewarding effects: experiments with self-administration and brain-stimulation reward in rats
    Zheng Xiong Xi
    Neuropsychopharmacology Section, Chemical Biology Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, MD 21224, USA
    Neuropsychopharmacology 33:1735-45. 2008
    ..Thus, AM 251 or other more potent CB1 receptor antagonists deserve further study as potentially effective anti-cocaine medications...
  22. ncbi request reprint Effect of Qi-protecting powder (Huqi San) on expression of c-jun, c-fos and c-myc in diethylnitrosamine-mediated hepatocarcinogenesis
    Xia Li
    Pathophysiological Department, Capital Medical University, Beijing 100069, China
    World J Gastroenterol 13:4192-8. 2007
    ....
  23. pmc The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABA and glutamate, but not dopamine, in rats
    Xia Li
    Intramural Research Program, National Institute on Drug Abuse, NIH, DHHS, Baltimore, MD 21224, USA
    Neuropharmacology 54:542-51. 2008
    ..In contrast to its modulatory effect on GABA and glutamate, the mGluR7 receptor does not appear to modulate NAc DA release...
  24. ncbi request reprint Sodium ingestion in oxytocin knockout mice
    Regis R Vollmer
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Exp Neurol 202:441-8. 2006
    ..It appears that OT pathways may be more critical in controlling NaCl intake over brief intervals when an animal is quickly compensating for a dehydrating stimulus...
  25. ncbi request reprint Tumor cells with B7.1 and transmembrane anchored staphylococcal enterotoxin A generate effective antitumor immunity
    Shao Yan Si
    State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital, Fourth Military Medical University, Xi an, Shanxi Province, China
    Biochem Biophys Res Commun 347:208-14. 2006
    ..1 (B16-B7.1) and B16/SEAtm (B16-SEAtm), and supported the feasibility and effectiveness of the dual-modified tumor cell vaccine with superantigen and co-stimulatory molecule...
  26. ncbi request reprint Centrally administered oxytocin elicits exaggerated grooming in oxytocin null mice
    Janet A Amico
    Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Pharmacol Biochem Behav 78:333-9. 2004
    ..The results indicate that the chronic absence of OT in null mice leads to an increase in OT receptor responsiveness that contributes to the augmented grooming activity elicited by centrally administered OT...
  27. ncbi request reprint Enhanced corticosterone concentrations and attenuated Fos expression in the medial amygdala of female oxytocin knockout mice exposed to psychogenic stress
    Rose C Mantella
    Department of Pharmaceutical Sciences, University of Pittsburgh, 904 Salk Hall, Pittsburgh, PA 15261, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1494-504. 2004
    ..Our findings indicate heightened stress-induced corticosterone release in female OT knockout mice. Therefore, the results suggest that OT pathways play a role in attenuating the HPA axis response to psychogenic stress in female mice...
  28. ncbi request reprint Rosiglitazone combined with insulin preserves islet beta cell function in adult-onset latent autoimmune diabetes (LADA)
    Zhiguang Zhou
    Institute of Metabolism and Endocrinology, Second Xiangya Hospital, Central South University, Changsha, China
    Diabetes Metab Res Rev 21:203-8. 2005
    ..Therefore, we hypothesized that LADA patients might benefit from thiazolidinediones treatment...
  29. ncbi request reprint Prenatal stress causes gender-dependent neuronal loss and oxidative stress in rat hippocampus
    Zhongliang Zhu
    Department of Physiology, Xi an Jiaotong University Medical College, Xi an, China
    J Neurosci Res 78:837-44. 2004
    ..These data suggest that prenatal stress can cause oxidative stress and consequent damage to neurons, leading to neuronal loss in the brain of offspring during development...
  30. pmc Expression profiling of murine acute promyelocytic leukemia cells reveals multiple model-dependent progression signatures
    Matthew J Walter
    Division of Oncology, Section of Stem Cell Biology, Campus Box 8007, 660 South Euclid Ave, St Louis, MO 63110 1093, USA
    Mol Cell Biol 24:10882-93. 2004
    ..The two models exhibited distinct gene expression profiles, suggesting that the dominant molecular signatures of murine acute promyelocytic leukemia can be influenced by several independent progression events...
  31. ncbi request reprint Paraquat induces selective dopaminergic nigrostriatal degeneration in aging C57BL/6 mice
    Xia Li
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
    Chin Med J (Engl) 118:1357-61. 2005
    ..Aging is an accepted risk factor for idiopathic Parkinson's disease. The aim of this study was to test the hypothesis that paraquat could induce PD-like nigrostriatal dopaminergic degeneration in aging C57BL/6 mice...
  32. ncbi request reprint Neuroprotective effects of Polygonum multiflorum on nigrostriatal dopaminergic degeneration induced by paraquat and maneb in mice
    Xia Li
    Division of Natural Products Chemistry, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Pharmacol Biochem Behav 82:345-52. 2005
    ..The present findings suggest that PME has a beneficial influence on parkinsonism induced by PQMB and that the effects of PME are attributable to some substance(s) included in the ethanol-soluble fraction of PME (PME-I)...
  33. ncbi request reprint [Exogenous nitric oxide inhibits the proliferation of mouse neural progenitor cells]
    Xiang Zhang
    Institute of Neurosurgery of People s Liberation Army, Xijing Hospital, Fourth Military Medical University, Xi an 710032, China
    Zhonghua Yi Xue Za Zhi 83:1259-61. 2003
    ..To explore the inhibitive effect of exogenous nitric oxide (NO) on the proliferation of mouse neural progenitor cells (NPCs)...
  34. ncbi request reprint Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs
    Kristina E Hill
    Division of Gastroenterology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Am J Clin Nutr 77:1484-8. 2003
    ..On the basis of in vitro studies, the antioxidant nutrients vitamins E and C are postulated to interact in vivo...
  35. ncbi request reprint Ascorbic acid spares alpha-tocopherol and decreases lipid peroxidation in neuronal cells
    Xia Li
    Department of Medicine, Vanderbilt University School of Medicine, 715 Preston Research Building II, 2220 Pierce Ave, Nashville, TN 37232 6303, USA
    Biochem Biophys Res Commun 305:656-61. 2003
    ..These results show that neuronal cells concentrate ascorbate, and that intracellular ascorbate, either directly or through sparing of alpha-tocopherol, protects them against oxidant stress...
  36. pmc Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/J mice
    Masashi Inoue
    Laboratory of Cellular Neurobiology, School of Life Science, Tokyo University of Pharmacy and Life Science, Hachioji, Tokyo 192 0392, Japan
    J Neurosci 24:2296-303. 2004
    ..This study describes the range of ligand sensitivity of the T1R3 receptor using an in vivo approach and, to our knowledge, is the first genetic mapping study of activity in gustatory nerves...