Research Topics
| Atsushi KuriharaSummaryAffiliation: Eli Lilly and Company Country: USA Publications
| Collaborators
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Detail Information
Publications
Preclinical bridging studies: understanding dried blood spot and plasma exposure profilesEnaksha R Wickremsinhe
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
Bioanalysis 5:159-70. 2013....
Validating regulatory-compliant wide dynamic range bioanalytical assays using chip-based nanoelectrospray tandem mass spectrometryEnaksha R Wickremsinhe
Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, IN 46285, USA
Rapid Commun Mass Spectrom 19:47-56. 2005..This technology offers the possibility for increased throughput for studies supporting drug development by providing fast data turnaround for assays conforming to regulatory guidelines and GLPs...- Stereoselective metabolism of prasugrel in humans using a novel chiral liquid chromatography-tandem mass spectrometry methodEnaksha R Wickremsinhe
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Drug Metab Dispos 35:917-21. 2007..The ratios of the R-138727 stereoisomers were consistent among subjects, regardless of the dose or time of sample collection or whether the blood was sampled after the first dose or after 4 weeks of therapy... - Dried blood spot sampling: coupling bioanalytical feasibility, blood-plasma partitioning and transferability to in vivo preclinical studiesEnaksha R Wickremsinhe
Lilly Research Laboratories, Eli Lilly and Company, IN, USA
Bioanalysis 3:1635-46. 2011..The adoption of dried blood spot (DBS) sampling and analysis to support drug discovery and development requires the understanding of its bioanalytical feasibility as well as the distribution of the analyte in blood... - Quantification of gemcitabine incorporation into human DNA by LC/MS/MS as a surrogate measure for target engagementEnaksha R Wickremsinhe
Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Anal Chem 82:6576-83. 2010..Results are presented which confirm that the ratio of dFdC to dG in DNA isolated from tumor cells incubated with dFdC increases with increased exposure to the drug and that dFdC can also be quantified from DNA extracted from blood... - Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humansNagy A Farid
Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Clin Pharmacol 50:126-42. 2010..Current literature shows that greater ADP-mediated IPA is associated with significantly better clinical outcomes for patients with acute coronary syndrome... - The disposition of prasugrel, a novel thienopyridine, in humansNagy A Farid
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Drug Metab Dispos 35:1096-104. 2007..Total radioactivity was higher in plasma than in blood, suggesting limited penetration of prasugrel metabolites into red blood cells. Approximately 70% of the dose was excreted in the urine and 25% in the feces... - Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450Jessica L Fayer Rehmel
Department of Drug Disposition, Eli Lilly and Company, Lilly Corporate Center DC0714, Indianapolis, IN 46285, USA
Drug Metab Dispos 34:600-7. 2006..These K(i) values exceed circulating concentrations in humans by 3.8- to 43-fold. Therefore, neither R-95913 nor R-138727 is expected to substantially inhibit the P450-mediated metabolism of coadministered drugs... - Inhibitory effects of angiotensin receptor blockers on CYP2C9 activity in human liver microsomesEmi Kamiyama
Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co, Ltd, Tokyo, Japan
Drug Metab Pharmacokinet 22:267-75. 2007.... - Excitation and circular dichroism spectra of (-)-(3aS, 7aS)-2-chalcogena-trans-hydrindans(Ch = S, Se, Te): SAC and SAC-CI calculationsYasushi Honda
Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1 1 Minami Osawa, Hachioji shi, Tokyo 192 0397, Japan
J Comput Chem 29:612-21. 2008..Our calculations predict the triplet states that account for the spectral shapes, indicating importance of the spin-orbit interaction effects for the accurate reproduction of the experimental spectra of the telluride... - Tissue distribution of humanized anti-human Fas monoclonal antibody (R-125224) based on fas antigen-antibody reaction in collagen-induced arthritis monkeysMotoko Saito
Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Co, Ltd, 1 2 58, Hiromachi, Shinagawa ku, Tokyo, 140 8710, Japan
Life Sci 80:2005-14. 2007..51+/-0.08 and 0.60+/-0.11 nM, respectively, which were similar to those values in human lymphocytes and hepatocytes, demonstrating that R-125224 cross-reacts with the monkey Fas antigen... - Brain insulin impairs amyloid-beta(1-40) clearance from the brainTakeshi Shiiki
Drug Metabolism and Pharmacokinetics Research Laboratories, Sankyo Company, Shinagawa ku, Tokyo 140 8710, Japan
J Neurosci 24:9632-7. 2004..In conclusion, the present study has demonstrated the involvement of a proteolytic degradation process and an insulin-sensitive process in cerebral Abeta(1-40) clearance in the rat...