R M Kramer

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi Cytosolic phospholipase A2 (cPLA2) and lipid mediator release in the brain
    R M Kramer
    Lilly Research Laboratories, Indianapolis, IN 46285 0444, USA
    J Lipid Mediat Cell Signal 14:3-7. 1996
  2. ncbi Structure, function and regulation of Ca2+-sensitive cytosolic phospholipase A2 (cPLA2)
    R M Kramer
    Cardiovascular Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    FEBS Lett 410:49-53. 1997
  3. ncbi p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2
    R M Kramer
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Biol Chem 271:27723-9. 1996
  4. ncbi Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE
    S Currie
    Lilly Research Laboratories, Indianapolis, IN 46285
    Biochem J 304:923-8. 1994
  5. ncbi Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine
    R T Pickard
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Biol Chem 271:19225-31. 1996
  6. ncbi Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2
    R T Pickard
    Lilly Research Laboratory, Indianapolis, Indiana 46285, USA
    J Biol Chem 274:8823-31. 1999
  7. ncbi Structure and properties of a secretable phospholipase A2 from human platelets
    R M Kramer
    Lilly Research Laboratories, Indianapolis, IN
    Adv Exp Med Biol 275:35-53. 1990
  8. ncbi Structure and properties of a human non-pancreatic phospholipase A2
    R M Kramer
    Biogen Inc, Cambridge, Massachusetts 02142
    J Biol Chem 264:5768-75. 1989
  9. ncbi Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells
    A G Borsch-Haubold
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 273:4449-58. 1998
  10. ncbi Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution
    J P Wery
    Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285
    Nature 352:79-82. 1991

Collaborators

  • J D Sharp
  • S Currie
  • A G Borsch-Haubold
  • M H Gelb
  • R T Pickard
  • B A Strifler
  • L J Reynolds
  • A L Tebbe
  • P A Hyslop
  • M R DeFelippis
  • E A Dennis
  • Y K Yee
  • X G Chiou
  • J P Wery
  • D K Clawson
  • D B McClure
  • J L Bobbitt
  • E R Dow
  • T Goodson
  • G Gamboa
  • R W Schevitz
  • R B Hermann

Detail Information

Publications10

  1. ncbi Cytosolic phospholipase A2 (cPLA2) and lipid mediator release in the brain
    R M Kramer
    Lilly Research Laboratories, Indianapolis, IN 46285 0444, USA
    J Lipid Mediat Cell Signal 14:3-7. 1996
    ....
  2. ncbi Structure, function and regulation of Ca2+-sensitive cytosolic phospholipase A2 (cPLA2)
    R M Kramer
    Cardiovascular Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    FEBS Lett 410:49-53. 1997
    ..These products of cPLA2 contribute to inflammatory and degenerative disease states and cPLA2 is therefore an attractive target for the development of novel therapies...
  3. ncbi p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2
    R M Kramer
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Biol Chem 271:27723-9. 1996
    ....
  4. ncbi Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE
    S Currie
    Lilly Research Laboratories, Indianapolis, IN 46285
    Biochem J 304:923-8. 1994
    ..We conclude that in MCII mast cells cPLA2 is activated by kinase-dependent mechanisms and may be responsible for Fc epsilon RI-induced mobilization of arachidonic acid for the generation of LTC4...
  5. ncbi Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine
    R T Pickard
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Biol Chem 271:19225-31. 1996
    ..Our results, supported by circular dichroism, provide evidence that Asp-549 and Arg-200 are critical to the enzyme's function and suggest that the cPLA2 catalytic center is novel...
  6. ncbi Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2
    R T Pickard
    Lilly Research Laboratory, Indianapolis, Indiana 46285, USA
    J Biol Chem 274:8823-31. 1999
    ..Mutagenesis shows strong dependence on these residues for catalytic activity of all three enzymes...
  7. ncbi Structure and properties of a secretable phospholipase A2 from human platelets
    R M Kramer
    Lilly Research Laboratories, Indianapolis, IN
    Adv Exp Med Biol 275:35-53. 1990
  8. ncbi Structure and properties of a human non-pancreatic phospholipase A2
    R M Kramer
    Biogen Inc, Cambridge, Massachusetts 02142
    J Biol Chem 264:5768-75. 1989
    ....
  9. ncbi Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells
    A G Borsch-Haubold
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 273:4449-58. 1998
    ....
  10. ncbi Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution
    J P Wery
    Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285
    Nature 352:79-82. 1991
    ..2 A resolution of recombinant human rheumatoid arthritic synovial fluid PLA2. This may aid the development of potent and specific inhibitors of this enzyme using structure-based design...