R M Kramer

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Cytosolic phospholipase A2 (cPLA2) and lipid mediator release in the brain
    R M Kramer
    Lilly Research Laboratories, Indianapolis, IN 46285 0444, USA
    J Lipid Mediat Cell Signal 14:3-7. 1996
  2. ncbi request reprint Structure, function and regulation of Ca2+-sensitive cytosolic phospholipase A2 (cPLA2)
    R M Kramer
    Cardiovascular Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    FEBS Lett 410:49-53. 1997
  3. ncbi request reprint p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2
    R M Kramer
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Biol Chem 271:27723-9. 1996
  4. pmc Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE
    S Currie
    Lilly Research Laboratories, Indianapolis, IN 46285
    Biochem J 304:923-8. 1994
  5. ncbi request reprint Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine
    R T Pickard
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Biol Chem 271:19225-31. 1996
  6. ncbi request reprint Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2
    R T Pickard
    Lilly Research Laboratory, Indianapolis, Indiana 46285, USA
    J Biol Chem 274:8823-31. 1999
  7. ncbi request reprint Structure and properties of a secretable phospholipase A2 from human platelets
    R M Kramer
    Lilly Research Laboratories, Indianapolis, IN
    Adv Exp Med Biol 275:35-53. 1990
  8. ncbi request reprint Structure and properties of a human non-pancreatic phospholipase A2
    R M Kramer
    Biogen Inc, Cambridge, Massachusetts 02142
    J Biol Chem 264:5768-75. 1989
  9. ncbi request reprint Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells
    A G Borsch-Haubold
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 273:4449-58. 1998
  10. ncbi request reprint Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution
    J P Wery
    Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285
    Nature 352:79-82. 1991

Collaborators

  • J D Sharp
  • S Currie
  • M H Gelb
  • A G Borsch-Haubold
  • R T Pickard
  • B A Strifler
  • X G Chiou
  • L J Reynolds
  • E A Dennis
  • M R DeFelippis
  • P A Hyslop
  • A L Tebbe
  • Y K Yee
  • J P Wery
  • G Gamboa
  • R B Hermann
  • D B McClure
  • T Goodson
  • E R Dow
  • R W Schevitz
  • J L Bobbitt
  • D K Clawson

Detail Information

Publications10

  1. ncbi request reprint Cytosolic phospholipase A2 (cPLA2) and lipid mediator release in the brain
    R M Kramer
    Lilly Research Laboratories, Indianapolis, IN 46285 0444, USA
    J Lipid Mediat Cell Signal 14:3-7. 1996
    ....
  2. ncbi request reprint Structure, function and regulation of Ca2+-sensitive cytosolic phospholipase A2 (cPLA2)
    R M Kramer
    Cardiovascular Research, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    FEBS Lett 410:49-53. 1997
    ..These products of cPLA2 contribute to inflammatory and degenerative disease states and cPLA2 is therefore an attractive target for the development of novel therapies...
  3. ncbi request reprint p38 mitogen-activated protein kinase phosphorylates cytosolic phospholipase A2 (cPLA2) in thrombin-stimulated platelets. Evidence that proline-directed phosphorylation is not required for mobilization of arachidonic acid by cPLA2
    R M Kramer
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Biol Chem 271:27723-9. 1996
    ....
  4. pmc Phosphorylation and activation of Ca(2+)-sensitive cytosolic phospholipase A2 in MCII mast cells mediated by high-affinity Fc receptor for IgE
    S Currie
    Lilly Research Laboratories, Indianapolis, IN 46285
    Biochem J 304:923-8. 1994
    ..We conclude that in MCII mast cells cPLA2 is activated by kinase-dependent mechanisms and may be responsible for Fc epsilon RI-induced mobilization of arachidonic acid for the generation of LTC4...
  5. ncbi request reprint Identification of essential residues for the catalytic function of 85-kDa cytosolic phospholipase A2. Probing the role of histidine, aspartic acid, cysteine, and arginine
    R T Pickard
    Lilly Research Laboratories, Indianapolis, Indiana 46285, USA
    J Biol Chem 271:19225-31. 1996
    ..Our results, supported by circular dichroism, provide evidence that Asp-549 and Arg-200 are critical to the enzyme's function and suggest that the cPLA2 catalytic center is novel...
  6. ncbi request reprint Molecular cloning of two new human paralogs of 85-kDa cytosolic phospholipase A2
    R T Pickard
    Lilly Research Laboratory, Indianapolis, Indiana 46285, USA
    J Biol Chem 274:8823-31. 1999
    ..Mutagenesis shows strong dependence on these residues for catalytic activity of all three enzymes...
  7. ncbi request reprint Structure and properties of a secretable phospholipase A2 from human platelets
    R M Kramer
    Lilly Research Laboratories, Indianapolis, IN
    Adv Exp Med Biol 275:35-53. 1990
  8. ncbi request reprint Structure and properties of a human non-pancreatic phospholipase A2
    R M Kramer
    Biogen Inc, Cambridge, Massachusetts 02142
    J Biol Chem 264:5768-75. 1989
    ....
  9. ncbi request reprint Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells
    A G Borsch-Haubold
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 273:4449-58. 1998
    ....
  10. ncbi request reprint Structure of recombinant human rheumatoid arthritic synovial fluid phospholipase A2 at 2.2 A resolution
    J P Wery
    Lilly Research Laboratories, Lilly Corporate Center, Eli Lilly and Company, Indianapolis, Indiana 46285
    Nature 352:79-82. 1991
    ..2 A resolution of recombinant human rheumatoid arthritic synovial fluid PLA2. This may aid the development of potent and specific inhibitors of this enzyme using structure-based design...