Akihiko S Kato

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators
    Douglas A Schober
    Discovery Neuroscience Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 286:13134-42. 2011
  2. ncbi Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 68:1082-96. 2010
  3. ncbi Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology
    Martin B Gill
    Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 31:6928-38. 2011
  4. ncbi AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform
    Martin B Gill
    Neuroscience Discovery Research and Clinical Investigation, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Eur J Neurosci 35:182-94. 2012
  5. ncbi TARPs differentially decorate AMPA receptors to specify neuropharmacology
    Akihiko S Kato
    Department of Neuroscience, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Trends Neurosci 33:241-8. 2010
  6. ncbi Pharmacological regulation of ion channels by auxiliary subunits
    Akihiko S Kato
    Neuroscience Discovery, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Curr Opin Drug Discov Devel 10:565-72. 2007
  7. ncbi AMPA receptor subunit-specific regulation by a distinct family of type II TARPs
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 59:986-96. 2008

Collaborators

Detail Information

Publications7

  1. ncbi Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators
    Douglas A Schober
    Discovery Neuroscience Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 286:13134-42. 2011
    ..These studies demonstrate that accessory proteins define AMPA receptor pharmacology by functionally linking allosteric AMPA receptor potentiator and antagonist sites...
  2. ncbi Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 68:1082-96. 2010
    ..Thus, γ-8 and CNIH-2 functionally interact with common hippocampal AMPA receptor complexes to modulate synergistically kinetics and pharmacology...
  3. ncbi Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology
    Martin B Gill
    Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 31:6928-38. 2011
    ..Together, these data suggest that CNIH-2 modulates neuronal AMPA receptor auxiliary subunit assembly by regulating the number of TARPs within an AMPA receptor complex to modulate receptor gating and pharmacology...
  4. ncbi AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform
    Martin B Gill
    Neuroscience Discovery Research and Clinical Investigation, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Eur J Neurosci 35:182-94. 2012
    ..Together, these data demonstrate that the modulation of AMPA receptors by CNIH-2 depends upon the TARP isoform composition within the receptor complex...
  5. ncbi TARPs differentially decorate AMPA receptors to specify neuropharmacology
    Akihiko S Kato
    Department of Neuroscience, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Trends Neurosci 33:241-8. 2010
    ..TARPs emerge as vital components of excitatory synapses that participate both in signal transduction and in neuropsychiatric disorders...
  6. ncbi Pharmacological regulation of ion channels by auxiliary subunits
    Akihiko S Kato
    Neuroscience Discovery, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Curr Opin Drug Discov Devel 10:565-72. 2007
    ..The recent molecular characterization of neuronal glutamate receptor ion channel complexes identified auxiliary subunits and associated proteins that may provide new targets for treating psychiatric and neurodegenerative diseases...
  7. ncbi AMPA receptor subunit-specific regulation by a distinct family of type II TARPs
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 59:986-96. 2008
    ..We also find that gamma-7 regulation of GluR2 is dictated by mRNA editing. These data establish gamma-5 and gamma-7 as a separate family of "type II TARPs" that impart distinct physiological features to specific AMPA receptors...