Akihiko S Kato

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. pmc Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators
    Douglas A Schober
    Discovery Neuroscience Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 286:13134-42. 2011
  2. doi Glutamate receptor δ2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cγ, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons
    Akihiko S Kato
    Lilly Research Laboratory, Indianapolis, Indiana 46285, USA
    J Neurosci 32:15296-308. 2012
  3. pmc Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 68:1082-96. 2010
  4. doi Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology
    Martin B Gill
    Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 31:6928-38. 2011
  5. doi AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform
    Martin B Gill
    Neuroscience Discovery Research and Clinical Investigation, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Eur J Neurosci 35:182-94. 2012
  6. doi TARPs differentially decorate AMPA receptors to specify neuropharmacology
    Akihiko S Kato
    Department of Neuroscience, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Trends Neurosci 33:241-8. 2010
  7. doi AMPA receptor subunit-specific regulation by a distinct family of type II TARPs
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 59:986-96. 2008
  8. ncbi Pharmacological regulation of ion channels by auxiliary subunits
    Akihiko S Kato
    Neuroscience Discovery, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Curr Opin Drug Discov Devel 10:565-72. 2007

Collaborators

Detail Information

Publications8

  1. pmc Transmembrane AMPA receptor regulatory proteins and cornichon-2 allosterically regulate AMPA receptor antagonists and potentiators
    Douglas A Schober
    Discovery Neuroscience Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Biol Chem 286:13134-42. 2011
    ..These studies demonstrate that accessory proteins define AMPA receptor pharmacology by functionally linking allosteric AMPA receptor potentiator and antagonist sites...
  2. doi Glutamate receptor δ2 associates with metabotropic glutamate receptor 1 (mGluR1), protein kinase Cγ, and canonical transient receptor potential 3 and regulates mGluR1-mediated synaptic transmission in cerebellar Purkinje neurons
    Akihiko S Kato
    Lilly Research Laboratory, Indianapolis, Indiana 46285, USA
    J Neurosci 32:15296-308. 2012
    ....
  3. pmc Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 68:1082-96. 2010
    ..Thus, γ-8 and CNIH-2 functionally interact with common hippocampal AMPA receptor complexes to modulate synergistically kinetics and pharmacology...
  4. doi Cornichon-2 modulates AMPA receptor-transmembrane AMPA receptor regulatory protein assembly to dictate gating and pharmacology
    Martin B Gill
    Neuroscience Discovery Research, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurosci 31:6928-38. 2011
    ..Together, these data suggest that CNIH-2 modulates neuronal AMPA receptor auxiliary subunit assembly by regulating the number of TARPs within an AMPA receptor complex to modulate receptor gating and pharmacology...
  5. doi AMPA receptor modulation by cornichon-2 dictated by transmembrane AMPA receptor regulatory protein isoform
    Martin B Gill
    Neuroscience Discovery Research and Clinical Investigation, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Eur J Neurosci 35:182-94. 2012
    ..Together, these data demonstrate that the modulation of AMPA receptors by CNIH-2 depends upon the TARP isoform composition within the receptor complex...
  6. doi TARPs differentially decorate AMPA receptors to specify neuropharmacology
    Akihiko S Kato
    Department of Neuroscience, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Trends Neurosci 33:241-8. 2010
    ..TARPs emerge as vital components of excitatory synapses that participate both in signal transduction and in neuropsychiatric disorders...
  7. doi AMPA receptor subunit-specific regulation by a distinct family of type II TARPs
    Akihiko S Kato
    Department of Neuroscience, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Neuron 59:986-96. 2008
    ..We also find that gamma-7 regulation of GluR2 is dictated by mRNA editing. These data establish gamma-5 and gamma-7 as a separate family of "type II TARPs" that impart distinct physiological features to specific AMPA receptors...
  8. ncbi Pharmacological regulation of ion channels by auxiliary subunits
    Akihiko S Kato
    Neuroscience Discovery, Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Curr Opin Drug Discov Devel 10:565-72. 2007
    ..The recent molecular characterization of neuronal glutamate receptor ion channel complexes identified auxiliary subunits and associated proteins that may provide new targets for treating psychiatric and neurodegenerative diseases...