- Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1Hsiu Chiung Yang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Neurochem 91:1249-59. 2004..It does not appear to be a significant species specificity to this cleavage...
- Design and synthesis of statine-containing BACE inhibitorsJingdan Hu
Eli Lilly and Company, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
Bioorg Med Chem Lett 13:4335-9. 2003..In addition, computational analysis and the X-ray structure of BACE-inhibitor 38 are discussed...
- Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SARJason Lamar
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Bioorg Med Chem Lett 14:239-43. 2004..The promising inhibitors emerging from this SAR investigation, 12 and 17 demonstrated very good enzyme potency (IC(50)=45 nM) and cellular activity (IC(50)=0.4 microM)...