Jingdan Hu

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1
    Hsiu Chiung Yang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurochem 91:1249-59. 2004
  2. ncbi request reprint Design and synthesis of statine-containing BACE inhibitors
    Jingdan Hu
    Eli Lilly and Company, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 13:4335-9. 2003
  3. ncbi request reprint Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR
    Jason Lamar
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 14:239-43. 2004

Collaborators

Detail Information

Publications3

  1. ncbi request reprint Biochemical and kinetic characterization of BACE1: investigation into the putative species-specificity for beta- and beta'-cleavage sites by human and murine BACE1
    Hsiu Chiung Yang
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Neurochem 91:1249-59. 2004
    ..It does not appear to be a significant species specificity to this cleavage...
  2. ncbi request reprint Design and synthesis of statine-containing BACE inhibitors
    Jingdan Hu
    Eli Lilly and Company, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 13:4335-9. 2003
    ..In addition, computational analysis and the X-ray structure of BACE-inhibitor 38 are discussed...
  3. ncbi request reprint Phe*-Ala-based pentapeptide mimetics are BACE inhibitors: P2 and P3 SAR
    Jason Lamar
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Bioorg Med Chem Lett 14:239-43. 2004
    ..The promising inhibitors emerging from this SAR investigation, 12 and 17 demonstrated very good enzyme potency (IC(50)=45 nM) and cellular activity (IC(50)=0.4 microM)...