Wherly P Hoffman

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Analysis of rodent growth data in toxicology studies
    Wherly P Hoffman
    Statistics and Information Sciences, Lilly Research Laboratories, Eli Lilly and Company, Drop Code GL43, 2001 West Main Street, Greenfield, Indiana 46140, USA
    Toxicol Sci 66:313-9. 2002
  2. ncbi request reprint A protocol for the in vitro micronucleus test. I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity
    Michael L Garriott
    Toxicology Division, Lilly Research Laboratories, Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Mutat Res 517:123-34. 2002
  3. ncbi request reprint A protocol for the in vitro micronucleus test. II. Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity
    J Barry Phelps
    Toxicology Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Mutat Res 521:103-12. 2002
  4. ncbi request reprint Relative cytotoxicity values at the lowest effective concentration for 12 positive chemicals in the in vitro micronucleus test utilizing Chinese hamster ovary cells
    J Barry Phelps
    Toxicology Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Mutat Res 561:153-8. 2004
  5. doi request reprint Quantitative assessment of cumulative carcinogenic risk for multiple genotoxic impurities in a new drug substance
    Joel P Bercu
    Eli Lilly and Company, Lilly Research Laboratories, 2001 W Main Street, Greenfield, IN 46140, USA
    Regul Toxicol Pharmacol 51:270-7. 2008
  6. doi request reprint Overall type I error rate and power of multiple Dunnett's tests on rodent body weights in toxicology studies
    Wherly P Hoffman
    Global Statistical Sciences, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biopharm Stat 18:883-900. 2008
  7. ncbi request reprint Relative percent cell survival and positive response in the in vitro micronucleus test
    J Barry Phelps
    Mutat Res 537:115-6. 2003
  8. ncbi request reprint Respiratory function in rats restrained for extended periods: assessment of the effects of bethanecol
    David Harris
    Department of Pharmacology, Quintiles Limited, Heriot Watt University Research Park, Riccarton, Edinburgh EH14 4AP, UK
    J Pharmacol Toxicol Methods 52:83-9. 2005

Collaborators

  • J Barry Phelps
  • Michael L Garriott
  • Joel P Bercu
  • David Harris
  • Susanne Gillies
  • Alison Templeton
  • Leslie Patmore
  • Mary Jeanne Kallman
  • Joanne Price
  • Rebeccah Bodine
  • Cindy Lee
  • Ronald K Wolff
  • Ross Young
  • Lynne Anderson
  • Mags Graham
  • Fiona Munro
  • Kirsty Paterson
  • Gill Low
  • Sue McKendrick

Detail Information

Publications8

  1. ncbi request reprint Analysis of rodent growth data in toxicology studies
    Wherly P Hoffman
    Statistics and Information Sciences, Lilly Research Laboratories, Eli Lilly and Company, Drop Code GL43, 2001 West Main Street, Greenfield, Indiana 46140, USA
    Toxicol Sci 66:313-9. 2002
    ..Data from a mouse carcinogenicity study are included to illustrate this repeated-measures ANOVA approach to analyzing growth data in contrast with the one-factor ANOVA approach...
  2. ncbi request reprint A protocol for the in vitro micronucleus test. I. Contributions to the development of a protocol suitable for regulatory submissions from an examination of 16 chemicals with different mechanisms of action and different levels of activity
    Michael L Garriott
    Toxicology Division, Lilly Research Laboratories, Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Mutat Res 517:123-34. 2002
    ....
  3. ncbi request reprint A protocol for the in vitro micronucleus test. II. Contributions to the validation of a protocol suitable for regulatory submissions from an examination of 10 chemicals with different mechanisms of action and different levels of activity
    J Barry Phelps
    Toxicology Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Mutat Res 521:103-12. 2002
    ....
  4. ncbi request reprint Relative cytotoxicity values at the lowest effective concentration for 12 positive chemicals in the in vitro micronucleus test utilizing Chinese hamster ovary cells
    J Barry Phelps
    Toxicology Division, Lilly Research Laboratories, A Division of Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
    Mutat Res 561:153-8. 2004
  5. doi request reprint Quantitative assessment of cumulative carcinogenic risk for multiple genotoxic impurities in a new drug substance
    Joel P Bercu
    Eli Lilly and Company, Lilly Research Laboratories, 2001 W Main Street, Greenfield, IN 46140, USA
    Regul Toxicol Pharmacol 51:270-7. 2008
    ..Findings based on probabilistic analysis here can be very useful in making appropriate decisions about risk management of multiple genotoxic impurities measured in the final drug substance...
  6. doi request reprint Overall type I error rate and power of multiple Dunnett's tests on rodent body weights in toxicology studies
    Wherly P Hoffman
    Global Statistical Sciences, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    J Biopharm Stat 18:883-900. 2008
    ..These results provide guidance to managing multiplicity of body weight analysis of general toxicology studies...
  7. ncbi request reprint Relative percent cell survival and positive response in the in vitro micronucleus test
    J Barry Phelps
    Mutat Res 537:115-6. 2003
  8. ncbi request reprint Respiratory function in rats restrained for extended periods: assessment of the effects of bethanecol
    David Harris
    Department of Pharmacology, Quintiles Limited, Heriot Watt University Research Park, Riccarton, Edinburgh EH14 4AP, UK
    J Pharmacol Toxicol Methods 52:83-9. 2005
    ..Previously, animals have been placed in plethysmography chambers for short durations. This study investigates the possibility of restraining animals in chambers for a longer duration to assess respiratory function over extended periods...