C C Felder

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Cannabinoid receptors and their endogenous agonists
    C C Felder
    Neuroscience Discovery, ELI LILLY RESEARCH LABORATORY, Indianapolis, Indiana 46285, USA
    Annu Rev Pharmacol Toxicol 38:179-200. 1998
  2. doi request reprint Scintillation proximity assay
    Steven D Kahl
    Lilly Research Laboratories, Indianapolis, Indiana, USA
    Curr Protoc Neurosci . 2005
  3. ncbi request reprint Strategic Research Institute G-Protein-Coupled Receptors Drug Discovery World Summit
    Christian C Felder
    Eli Lilly Research Laboratories, Neuroscience Division, Indianapolis, IN, USA
    Expert Opin Investig Drugs 13:1071-4. 2004
  4. ncbi request reprint Elucidating the role of muscarinic receptors in psychosis
    C C Felder
    Neuroscience Division, Eli Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Life Sci 68:2605-13. 2001
  5. ncbi request reprint Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice
    F P Bymaster
    Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Life Sci 68:2473-9. 2001
  6. ncbi request reprint Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice
    E T Tzavara
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Mol Psychiatry 8:673-9. 2003
  7. ncbi request reprint Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo
    F P Bymaster
    Neuroscience Research Division, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Brain Res 916:165-71. 2001
  8. ncbi request reprint Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay
    N W Delapp
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 289:946-55. 1999
  9. ncbi request reprint Muscarinic agonist-mediated increases in serum corticosterone levels are abolished in m(2) muscarinic acetylcholine receptor knockout mice
    S K Hemrick-Luecke
    Neuroscience Division, Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 303:99-103. 2002
  10. ncbi request reprint The endocannabinoid nervous system: unique opportunities for therapeutic intervention
    A C Porter
    Neuroscience Division, Drop 0510, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Pharmacol Ther 90:45-60. 2001

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Cannabinoid receptors and their endogenous agonists
    C C Felder
    Neuroscience Discovery, ELI LILLY RESEARCH LABORATORY, Indianapolis, Indiana 46285, USA
    Annu Rev Pharmacol Toxicol 38:179-200. 1998
    ....
  2. doi request reprint Scintillation proximity assay
    Steven D Kahl
    Lilly Research Laboratories, Indianapolis, Indiana, USA
    Curr Protoc Neurosci . 2005
    ..This unit identifies potential uses of the technology for the measurement of receptor-ligand binding, cAMP accumulation, GTP binding to heterotrimeric G proteins, protease activity and cellular uptake...
  3. ncbi request reprint Strategic Research Institute G-Protein-Coupled Receptors Drug Discovery World Summit
    Christian C Felder
    Eli Lilly Research Laboratories, Neuroscience Division, Indianapolis, IN, USA
    Expert Opin Investig Drugs 13:1071-4. 2004
    ..GPCRs continue to be an attractive platform for drug discovery...
  4. ncbi request reprint Elucidating the role of muscarinic receptors in psychosis
    C C Felder
    Neuroscience Division, Eli Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Life Sci 68:2605-13. 2001
    ..These findings support a role for the development of M1 and M4 receptor agonists for diseases in which symptoms include cognitive impairment and psychotic behaviors...
  5. ncbi request reprint Investigations into the physiological role of muscarinic M2 and M4 muscarinic and M4 receptor subtypes using receptor knockout mice
    F P Bymaster
    Neuroscience Research Division, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285 0510, USA
    Life Sci 68:2473-9. 2001
    ..The data demonstrate the usefulness of knockout mice in determining the physiological function of peripheral and central muscarinic receptors...
  6. ncbi request reprint Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice
    E T Tzavara
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
    Mol Psychiatry 8:673-9. 2003
    ..Together these results suggest a crucial role for muscarinic M2 and M4 receptors in the tonic and phasic regulation of acetylcholine efflux in the hippocampus as well as in cognitive processes...
  7. ncbi request reprint Receptor reserve of phosphoinositide-coupled muscarinic receptors in mouse hippocampus in vivo
    F P Bymaster
    Neuroscience Research Division, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Brain Res 916:165-71. 2001
    ..Since pilocarpine is a relatively weak partial agonist, these data suggest a substantial level of receptor reserve for the PI response in mouse hippocampus...
  8. ncbi request reprint Determination of [35S]guanosine-5'-O-(3-thio)triphosphate binding mediated by cholinergic muscarinic receptors in membranes from Chinese hamster ovary cells and rat striatum using an anti-G protein scintillation proximity assay
    N W Delapp
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
    J Pharmacol Exp Ther 289:946-55. 1999
    ..Antibody capture GTPgamma35S binding using scintillation proximity assay technology provides a convenient, productive alternative to immunoprecipitation for exploration of receptor-G protein interaction in cells and tissues...
  9. ncbi request reprint Muscarinic agonist-mediated increases in serum corticosterone levels are abolished in m(2) muscarinic acetylcholine receptor knockout mice
    S K Hemrick-Luecke
    Neuroscience Division, Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    J Pharmacol Exp Ther 303:99-103. 2002
    ..These data suggest that the muscarinic M(2) receptor subtype mediates muscarinic agonist-induced activation of the hypothalamic-pituitary-adrenocortical axis in mice...
  10. ncbi request reprint The endocannabinoid nervous system: unique opportunities for therapeutic intervention
    A C Porter
    Neuroscience Division, Drop 0510, Lilly Research Laboratories, Indianapolis, IN 46285, USA
    Pharmacol Ther 90:45-60. 2001
    ..This new knowledge may facilitate the development of cannabinoid receptor-targeted therapeutics with improved safety and efficacy profiles...
  11. doi request reprint N-(4-((2-(trifluoromethyl)-3-hydroxy-4-(isobutyryl)phenoxy)methyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide (THIIC), a novel metabotropic glutamate 2 potentiator with potential anxiolytic/antidepressant properties: in vivo profiling suggests a link betw
    Matthew J Fell
    Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, DC0510, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 336:165-77. 2011
    ..In addition, we provide evidence that sleep EEG and CSF t-MeHA might function as viable biomarker approaches to facilitate the translational development of THIIC and other mGlu2 potentiators...
  12. ncbi request reprint Muscarinic mechanisms of antipsychotic atypicality
    Frank P Bymaster
    Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Prog Neuropsychopharmacol Biol Psychiatry 27:1125-43. 2003
    ..However, olanzapine significantly occupies central muscarinic receptors in humans. Overall, the role of muscarinic receptors in the antipsychotic effects of clozapine and olanzapine is controversial and complex...
  13. ncbi request reprint Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity
    Frank P Bymaster
    Neuroscience Research Division, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, USA
    Eur J Neurosci 17:1403-10. 2003
    ..Muscarinic M1 receptors appear to be the only muscarinic receptor subtype mediating seizures...
  14. ncbi request reprint Use of M1-M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system
    Frank P Bymaster
    Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
    Neurochem Res 28:437-42. 2003
    ..M4 mAChRs modulate dopamine activity in motor tracts and act as inhibitory autoreceptors in striatum. Thus, as elucidated by gene targeting technology, mAChRs have widespread and manifold functions in the periphery and brain...
  15. ncbi request reprint M1 muscarinic receptor signaling in mouse hippocampus and cortex
    Amy C Porter
    Lilly Research Laboratories, Neuroscience Research Division, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Brain Res 944:82-9. 2002
    ..These findings support a role for the M1 receptor subtype as the primary G(alpha)(q)/11-coupled muscarinic receptor in mouse hippocampus and cortex...
  16. pmc Identification of a high-affinity binding site involved in the transport of endocannabinoids
    S A Moore
    Eli Lilly and Company, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285 0510, USA
    Proc Natl Acad Sci U S A 102:17852-7. 2005
    ....
  17. ncbi request reprint The muscarinic agonist xanomeline increases monoamine release and immediate early gene expression in the rat prefrontal cortex
    K W Perry
    Eli Lilly and Company Research Laboratories, Neuroscience Research Division, Lilly Corporate Center, Indianapolis, IN 46285-0510, USA
    Biol Psychiatry 49:716-25. 2001
    ..Based on the antipsychotic-like activity of xanomeline in Alzheimer's patients and the similarity to atypical antipsychotic agents, we suggest that xanomeline may be a novel antipsychotic agent...
  18. ncbi request reprint Role of the cholinergic muscarinic system in bipolar disorder and related mechanism of action of antipsychotic agents
    F P Bymaster
    Neuroscience Research Division, Lilly Research Laboratories, Indianapolis, IN 46285 0510, USA
    Mol Psychiatry 7:S57-63. 2002
    ..Olanzapine may normalize mood due to antidepressant-like activities, such as 5-HT(2A) receptor antagonism and increasing cortical norepinephrine and dopamine...
  19. ncbi request reprint A current review of olanzapine's safety in the geriatric patient: from pre-clinical pharmacology to clinical data
    J S Kennedy
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Int J Geriatr Psychiatry 16:S33-61. 2001
    ....
  20. ncbi request reprint Pharmacological characterization of endocannabinoid transport and fatty acid amide hydrolase inhibitors
    Amy K Dickason-Chesterfield
    Eli Lilly and Company, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285, USA
    Cell Mol Neurobiol 26:407-23. 2006
    ....
  21. doi request reprint Selective muscarinic receptor agonist xanomeline as a novel treatment approach for schizophrenia
    Anantha Shekhar
    Department of Psychiatry, Indiana University School of Medicine, 1111 West 10th St, Suite 313, Indianapolis, IN 46202, USA
    Am J Psychiatry 165:1033-9. 2008
    ..The authors studied xanomeline, a relatively selective muscarinic type 1 and type 4 (M(1) and M(4)) receptor agonist, to determine if this agent is effective in the treatment of schizophrenia...
  22. ncbi request reprint Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor
    Amy C Porter
    Lilly Research Laboratories, Neuroscience Division, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN, USA
    J Pharmacol Exp Ther 301:1020-4. 2002
    ..As a potential endogenous antagonist at the CB1 receptor, virodhamine adds a new form of regulation to the endocannabinoid system...
  23. doi request reprint Pharmacological characterization of LY593093, an M1 muscarinic acetylcholine receptor-selective partial orthosteric agonist
    Marla L Watt
    Lilly Research Laboratories, Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN 46285, USA
    J Pharmacol Exp Ther 338:622-32. 2011
    ..This compound demonstrates modest to no activity at the other muscarinic receptor subtypes, stimulates Gα(q)-coupled signaling events as well as β-arrestin recruitment, and displays significant efficacy in in vivo models of cognition...
  24. ncbi request reprint Evaluation of muscarinic agonist-induced analgesia in muscarinic acetylcholine receptor knockout mice
    Alokesh Duttaroy
    Laboratory of Bioorganic Chemistry, National Institute of Diabetes Digestive and Kidney Diseases, Bethesda, Maryland 20892 0810, USA
    Mol Pharmacol 62:1084-93. 2002
    ..These findings should be of considerable relevance for the development of receptor subtype-selective muscarinic agonists as novel analgesic drugs...
  25. doi request reprint New insights into the function of M4 muscarinic acetylcholine receptors gained using a novel allosteric modulator and a DREADD (designer receptor exclusively activated by a designer drug)
    Vindhya Nawaratne
    Drug Discovery Biology Laboratory, Monash Institute of Pharmaceutical Sciences, Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia
    Mol Pharmacol 74:1119-31. 2008
    ..These results provide conclusive evidence for the retention of a functional allosteric site on the M4 DREADD and highlight a role for residues Tyr113 and Ala203 in the transmission of cooperativity...
  26. pmc Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain
    Arieh Moussaieff
    Department of Medicinal Chemistry and Natural Products, Medical Faculty, Hebrew University of Jerusalem, 91120, Jerusalem, Israel
    FASEB J 22:3024-34. 2008
    ..Furthermore, the biochemical and pharmacological effects of IA may provide a biological basis for deeply rooted cultural and religious traditions...
  27. pmc Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents
    Garth Terry
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuroimage 41:690-8. 2008
    ..Radiometabolites of [11C]MePPEP in brain caused distribution volume to be overestimated by approximately 13%...
  28. ncbi request reprint The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain
    Fumihiko Yasuno
    Molecular Imaging Branch, National Institute of Mental Health, Bethesda, MD 20892 2035, USA
    Neuropsychopharmacology 33:259-69. 2008
    ..These promising results in monkey justify studying this radioligand in human subjects...
  29. ncbi request reprint Muscarinic receptor subtypes mediating central and peripheral antinociception studied with muscarinic receptor knockout mice: a review
    Jurgen Wess
    Laboratory of Bioorganic Chemistry, Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, Bldg 8A, Room B1A 05, 8 Center Drive MSC 0810, Bethesda, MD 20892 0810, USA
    Life Sci 72:2047-54. 2003
    ..Our results highlight the usefulness of muscarinic receptor mutant mice to shed light on the functional roles of acetylcholine released from both neuronal and non-neuronal cells...