Aldemar Degroot

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests
    Aldemar Degroot
    Department of Psychology, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Brain Res 949:60-70. 2002
  2. ncbi request reprint Anxiety is functionally segregated within the septo-hippocampal system
    Aldemar Degroot
    Department of Psychology, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Brain Res 1001:60-71. 2004
  3. ncbi request reprint Glucose increases hippocampal extracellular acetylcholine levels upon activation of septal GABA receptors
    Aldemar Degroot
    Department of Psychology, University of Alberta, AB, Edmonton, Canada
    Brain Res 979:71-7. 2003
  4. ncbi request reprint Genetic deletion of muscarinic M4 receptors is anxiolytic in the shock-probe burying model
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN, 46285 0510, USA
    Eur J Pharmacol 531:183-6. 2006
  5. ncbi request reprint Fluoxetine disrupts the integration of anxiety and aversive memories
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285 0510, USA
    Neuropsychopharmacology 30:391-400. 2005
  6. ncbi request reprint Genetic deletion and pharmacological blockade of CB1 receptors modulates anxiety in the shock-probe burying test
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN, 46285 0510, USA
    Eur J Neurosci 20:1059-64. 2004
  7. ncbi request reprint Acute exposure to a novel object during consolidation enhances cognition
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285 0510, USA
    Neuroreport 16:63-7. 2005
  8. ncbi request reprint Genetic deletion of CB1 receptors improves non-associative learning
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285 0510, USA
    Behav Brain Res 162:161-4. 2005
  9. ncbi request reprint Exposure to an elevated platform increases plasma corticosterone and hippocampal acetylcholine in the rat: reversal by chlordiazepoxide
    Aldemar Degroot
    Neuroscience Discovery Research, Eli Lilly and Company, Lilly Corporate Center DC0510, Indianapolis, IN, 46285 0510, USA
    Eur J Pharmacol 493:103-9. 2004
  10. ncbi request reprint CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN, USA
    Mol Pharmacol 70:1236-45. 2006

Detail Information

Publications10

  1. ncbi request reprint Dorsal and ventral hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests
    Aldemar Degroot
    Department of Psychology, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Brain Res 949:60-70. 2002
    ..Overall, the results suggest that cholinergic stimulation in the dorsal and ventral hippocampus modulate anxiety, but that only the ventral hippocampal cholinergic system is involved in the passive avoidance of painful stimuli...
  2. ncbi request reprint Anxiety is functionally segregated within the septo-hippocampal system
    Aldemar Degroot
    Department of Psychology, University of Alberta, Edmonton, Alberta, Canada T6G 2E9
    Brain Res 1001:60-71. 2004
    ..Collectively, the data suggest that the control of specific anxiety reactions is functionally segregated within different aspects of the septo-hippocampal system...
  3. ncbi request reprint Glucose increases hippocampal extracellular acetylcholine levels upon activation of septal GABA receptors
    Aldemar Degroot
    Department of Psychology, University of Alberta, AB, Edmonton, Canada
    Brain Res 979:71-7. 2003
    ..Thus, glucose increases hippocampal extracellular ACh levels when the ACh system is inhibited, an effect that likely contributes to the effects of glucose on memory...
  4. ncbi request reprint Genetic deletion of muscarinic M4 receptors is anxiolytic in the shock-probe burying model
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN, 46285 0510, USA
    Eur J Pharmacol 531:183-6. 2006
    ..Therefore, muscarinic M4 receptors are of particular significance in anxiety modulation that seems dissociated from changes in long-term memory...
  5. ncbi request reprint Fluoxetine disrupts the integration of anxiety and aversive memories
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285 0510, USA
    Neuropsychopharmacology 30:391-400. 2005
    ..This reduces the emotional impact of aversive memories, thereby opposing consequent anxiety...
  6. ncbi request reprint Genetic deletion and pharmacological blockade of CB1 receptors modulates anxiety in the shock-probe burying test
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN, 46285 0510, USA
    Eur J Neurosci 20:1059-64. 2004
    ..Collectively, these results suggest that CB1 receptor blockade reduces some, but not all, aspects of anxiety. The decrease in probe contacts induced by CB1 receptor blockade may be due to enhanced cognition...
  7. ncbi request reprint Acute exposure to a novel object during consolidation enhances cognition
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285 0510, USA
    Neuroreport 16:63-7. 2005
    ..The data suggest that environmental enrichment during a critical period (consolidation) is sufficient to improve learning and memory. This effect is likely mediated through an enhancement of hippocampal cholinergic neurotransmission...
  8. ncbi request reprint Genetic deletion of CB1 receptors improves non-associative learning
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN 46285 0510, USA
    Behav Brain Res 162:161-4. 2005
    ..We conclude that CB1 receptor gene invalidation improves habituation tentatively through an increase in cholinergic neurotransmission...
  9. ncbi request reprint Exposure to an elevated platform increases plasma corticosterone and hippocampal acetylcholine in the rat: reversal by chlordiazepoxide
    Aldemar Degroot
    Neuroscience Discovery Research, Eli Lilly and Company, Lilly Corporate Center DC0510, Indianapolis, IN, 46285 0510, USA
    Eur J Pharmacol 493:103-9. 2004
    ..These results provide direct evidence for the importance of the hippocampal cholinergic system in stress and provide validation for the elevated platform as a model of stress...
  10. ncbi request reprint CB1 receptor antagonism increases hippocampal acetylcholine release: site and mechanism of action
    Aldemar Degroot
    Eli Lilly and Company, Lilly Corporate Center, Neuroscience Discovery Research, Indianapolis, IN, USA
    Mol Pharmacol 70:1236-45. 2006
    ....