Ying Chen

Summary

Affiliation: Eli Lilly and Company
Country: USA

Publications

  1. ncbi request reprint The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices
    Ying Chen
    Lilly Research Centre, Eli Lilly and Co Ltd, Erl Wood Manor, Sunninghill Road, Surrey GU20 6PH, Windlesham, UK
    Neuropharmacology 45:334-44. 2003
  2. pmc Partial agonists for α4β2 nicotinic receptors stimulate dopaminergic neuron firing with relatively enhanced maximal effects
    Ying Chen
    Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK Eli Lilly and Co Erl Wood Manor, Windlesham, Surrey, UK
    Br J Pharmacol 165:1006-16. 2012
  3. pmc GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area
    Ying Chen
    Eli Lilly and Co Ltd, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH
    Br J Pharmacol 144:926-32. 2005
  4. ncbi request reprint The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia
    Dennis R Grayson
    Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, 60612, USA
    Pharmacol Ther 111:272-86. 2006
  5. ncbi request reprint A practical synthesis of 2-((1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino)-5- fluoronicotinic acid
    Xin Wang
    Chemical Process R and D, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 1799, USA
    J Org Chem 71:4021-3. 2006
  6. ncbi request reprint Control of muscle regeneration in the Xenopus tadpole tail by Pax7
    Ying Chen
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Development 133:2303-13. 2006
  7. pmc Organic cation transporters are determinants of oxaliplatin cytotoxicity
    Shuzhong Zhang
    Department of Biopharmaceutical Sciences, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94158, USA
    Cancer Res 66:8847-57. 2006
  8. ncbi request reprint Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway
    Gregory D Salinas
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 281:40164-73. 2006
  9. pmc Regeneration of neural crest derivatives in the Xenopus tadpole tail
    Gufa Lin
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, UK
    BMC Dev Biol 7:56. 2007
  10. ncbi request reprint Induction of the reelin promoter by retinoic acid is mediated by Sp1
    Ying Chen
    Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Psychiatric Institute, Chicago, Illinois 60612, USA
    J Neurochem 103:650-65. 2007

Collaborators

  • Lisa M Broad
  • E Sher
  • Rajiv Sharma
  • Erminio Costa
  • ILYA B BEZPROZVANNY
  • R Zwart
  • Xiao Chun Chen
  • Dennis R Grayson
  • Li Min Chen
  • Yuan Gui Zhu
  • Fang Fang
  • Jian Shi
  • Gufa Lin
  • Gregory D Salinas
  • Xin Wang
  • Shuzhong Zhang
  • Alessandro Guidotti
  • Peggy C Stolt
  • Jai Sung Noh
  • Yi can Zhou
  • Liping Zhang
  • Juan Yang
  • Yong Hua Ji
  • Jin Chen
  • Ping Zheng
  • Yan Hong Duan
  • Hui Qiong He
  • Xue Qin Shu
  • Rong Zhao
  • Jian Wei Zhang
  • Jonathan M W Slack
  • Leah L Lagpacan
  • Mike Martinelli
  • Jeffrey D Singer
  • Takafumi Komori
  • Liang Huang
  • Xin Chen
  • Marija Kundakovic
  • Leigh A Needleman
  • Stephen J Lippard
  • Robert Larsen
  • Kathleen M Giacomini
  • Erbo Dong
  • Min Li
  • Shawn Eisenberg
  • Katherine S Lovejoy
  • Anna Lapuk
  • Richard Crockett
  • Ben Zhi
  • Paul Reider
  • Yan Shu
  • Justina D Gonzales
  • Joe W Gray
  • Leslie A C Blair
  • John Marshall
  • Jean Baum
  • John Ng
  • James E Shima
  • Xiaomei Jia
  • Stephen C Blacklow
  • Pingsheng Liu
  • Hans H Bock
  • Marin Veldic
  • Joachim Herz
  • Alain A Salvacion
  • Chao Hui Zhao
  • Li an Zhu
  • Chun Huang
  • Ying Lu
  • Karin N Westlund

Detail Information

Publications22

  1. ncbi request reprint The nicotinic alpha 4 beta 2 receptor selective agonist, TC-2559, increases dopamine neuronal activity in the ventral tegmental area of rat midbrain slices
    Ying Chen
    Lilly Research Centre, Eli Lilly and Co Ltd, Erl Wood Manor, Sunninghill Road, Surrey GU20 6PH, Windlesham, UK
    Neuropharmacology 45:334-44. 2003
    ....
  2. pmc Partial agonists for α4β2 nicotinic receptors stimulate dopaminergic neuron firing with relatively enhanced maximal effects
    Ying Chen
    Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK Eli Lilly and Co Erl Wood Manor, Windlesham, Surrey, UK
    Br J Pharmacol 165:1006-16. 2012
    ..We assessed the extent of α4β2 partial agonist-induced increase of firing rate in dopaminergic neurons and evaluated the influence of receptor reserve...
  3. pmc GABA(B) receptor modulators potentiate baclofen-induced depression of dopamine neuron activity in the rat ventral tegmental area
    Ying Chen
    Eli Lilly and Co Ltd, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey GU20 6PH
    Br J Pharmacol 144:926-32. 2005
    ..This finding suggests a therapeutic potential for GABA(B) potentiators for the treatment of diseases associated with a hyperfunctional mesocorticolimbic system...
  4. ncbi request reprint The human reelin gene: transcription factors (+), repressors (-) and the methylation switch (+/-) in schizophrenia
    Dennis R Grayson
    Department of Psychiatry, The Psychiatric Institute, College of Medicine, University of Illinois at Chicago, 1601 W Taylor St, 60612, USA
    Pharmacol Ther 111:272-86. 2006
    ....
  5. ncbi request reprint A practical synthesis of 2-((1H-pyrrolo[2,3-b]pyridine-4-yl)methylamino)-5- fluoronicotinic acid
    Xin Wang
    Chemical Process R and D, Amgen Inc, One Amgen Center Drive, Thousand Oaks, California 91320 1799, USA
    J Org Chem 71:4021-3. 2006
    ..A highly selective monodechlorination of 2,6-dichloro-5-fluoronicotinic acid was discovered to afford the nicotinic acid 3. The two building blocks 2 and 3 were then coupled to complete the preparation of 1...
  6. ncbi request reprint Control of muscle regeneration in the Xenopus tadpole tail by Pax7
    Ying Chen
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath BA2 7AY, UK
    Development 133:2303-13. 2006
    ..This shows that inhibition of pax7 action does not prevent differentiation of satellite cells to myofibres, but it does prevent their maintenance as a stem cell population...
  7. pmc Organic cation transporters are determinants of oxaliplatin cytotoxicity
    Shuzhong Zhang
    Department of Biopharmaceutical Sciences, Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94158, USA
    Cancer Res 66:8847-57. 2006
    ..The development of new anticancer drugs, specifically targeted to OCTs, represents a novel strategy for targeted drug therapy. The results of the present structure-activity studies indicate specific tactics for realizing this goal...
  8. ncbi request reprint Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway
    Gregory D Salinas
    Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, Rhode Island 02912, USA
    J Biol Chem 281:40164-73. 2006
    ..Together our data demonstrate that actinfilin acts as a scaffold, linking GluR6 to the Cul3 ubiquitin ligase to provide a novel mechanism for kainate receptor degradation...
  9. pmc Regeneration of neural crest derivatives in the Xenopus tadpole tail
    Gufa Lin
    Centre for Regenerative Medicine, Department of Biology and Biochemistry, University of Bath, Bath, UK
    BMC Dev Biol 7:56. 2007
    ..The regeneration of the neural crest derivatives has not previously been examined and is described in this paper...
  10. ncbi request reprint Induction of the reelin promoter by retinoic acid is mediated by Sp1
    Ying Chen
    Department of Psychiatry, College of Medicine, University of Illinois at Chicago, Psychiatric Institute, Chicago, Illinois 60612, USA
    J Neurochem 103:650-65. 2007
    ..The data suggest that while the Pax6 site plays a role in modulating reelin expression, it is not absolutely required for induction by RA...
  11. pmc Inhibition of martentoxin on neuronal BK channel subtype (alpha+beta4): implications for a novel interaction model
    Jian Shi
    Graduate School of the Chinese Academy of Sciences, Institute of Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, 200031, People s Republic of China
    Biophys J 94:3706-13. 2008
    ..Therefore, this research not only sheds light on a unique ligand for neuronal BK channels (alpha+beta4), but also highlights a novel model approach for the interaction between K(+) channels and specific-ligands...
  12. ncbi request reprint Differential modulation by the GABAB receptor allosteric potentiator 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)-phenol (CGP7930) of synaptic transmission in the rat hippocampal CA1 area
    Ying Chen
    School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK GU2 7XH
    J Pharmacol Exp Ther 317:1170-7. 2006
    ..This finding provides a synaptic mechanism to support the hypothesis that GABAB potentiators may be a better therapeutic alternative than GABAB agonists for central nervous system disorders...
  13. ncbi request reprint Reelin modulates NMDA receptor activity in cortical neurons
    Ying Chen
    Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 25:8209-16. 2005
    ..Thus, Reelin may physiologically modulate learning and memory by modulating NMDA receptor functions...
  14. ncbi request reprint Actinfilin, a brain-specific actin-binding protein in postsynaptic density
    Ying Chen
    Department of Physiology, School of Medicine, Johns Hopkins University, 725 N Wolfe Street, Baltimore, MD 21205, USA
    J Biol Chem 277:30495-501. 2002
    ..The results showed the postsynaptic density distribution of actinfilin. Together, these results indicate that actinfilin may be a key player in the actin-based neuronal function...
  15. ncbi request reprint Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons
    Xiao Chun Chen
    Fujian Institute of Geriatrics, Union Hospital, Fujian Medical University, Fuzhou 350001, China
    Acta Pharmacol Sin 23:829-34. 2002
    ..To explore the possible mechanism of the ginsenoside Rg1 in protecting substantia nigra neurons from 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-induced apoptosis in C57BL mice...
  16. ncbi request reprint [Possible mechanisms of the protective effect of ginsenoside Rg1 on apoptosis in substantia nigra neurons]
    Ying Chen
    Fujian Institute of Geriatrics, Union Hospital of Fujian Medical Univisity, Fuzhou 350001, China
    Yao Xue Xue Bao 37:249-52. 2002
    ..To investigate the role of ginsenoside Rg1 in preventing against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced apoptosis of the substantia nigra neurons in the mouse model of Parkinson's disease (PD)...
  17. ncbi request reprint Ginsenoside Rg1 attenuates dopamine-induced apoptosis in PC12 cells by suppressing oxidative stress
    Xiao Chun Chen
    Fujian Institute of Geriatrics, the Affiliated Union Hospital of Fujian Medical University, No 29, Xinquan Road, Fuzhou, PO 350001, China
    Eur J Pharmacol 473:1-7. 2003
    ..These results suggested that ginsenoside Rg1 may attenuate dopamine-induced apoptotic cell death through suppression of intracellular oxidative stress, and that it may rescue or protect dopamine neurons in Parkinson's disease...
  18. ncbi request reprint Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and Reelin signal transduction
    Peggy C Stolt
    Department of Pathology, Harvard Medical School, Brigham and Womens Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 280:9671-7. 2005
    ....
  19. ncbi request reprint Ginsenoside Rg1 reduces MPTP-induced substantia nigra neuron loss by suppressing oxidative stress
    Xiao Chun Chen
    Fujian Institute of Geriatrics, Union Hospital, Fujian Medical University, Fuzhou 350001, China
    Acta Pharmacol Sin 26:56-62. 2005
    ..To investigate the effect of ginsenoside Rg1, an effective ingredient from ginsenoside, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced substantia nigra neuron lesion...
  20. pmc DNA methyltransferase 1 regulates reelin mRNA expression in mouse primary cortical cultures
    Jai Sung Noh
    Psychiatric Institute, Department of Psychiatry, College of Medicine, University of Illinois, 1601 West Taylor Street, Chicago, IL 60612, USA
    Proc Natl Acad Sci U S A 102:1749-54. 2005
    ..These data support the hypothesis that the reduced amounts of reelin and GAD67 mRNAs documented in postmortem schizophrenia brain may be the consequence of a Dnmt1-mediated hypermethylation of the corresponding promoters...
  21. ncbi request reprint Interactions between CAP70 and actinfilin are important for integrity of actin cytoskeleton structures in neurons
    Ying Chen
    Department of Neuroscience and High Throughput Biology Center, Johns Hopkins University School of Medicine, BRB311, Baltimore, MD 21205, USA
    Neuropharmacology 49:1026-41. 2005
    ..Mutation of actinfilin lacking the ability to interact with CAP70 abolished the effect by CAP70. The evidence suggests a role of actinfilin and possible regulation by scaffolding proteins...
  22. ncbi request reprint Group I metabotropic glutamate receptor antagonists block secondary thermal hyperalgesia in rats with knee joint inflammation
    Liping Zhang
    Department of Anatomy and Neurosciences, University of Texas Medical Branch, Galveston, Texas 77555 1043, USA
    J Pharmacol Exp Ther 300:149-56. 2002
    ....