Research Topics
Genomes and Genes | Guoqing CaoSummaryAffiliation: Eli Lilly and Company Country: USA Publications
| Collaborators
|
Detail Information
Publications
Phospholipid transfer protein is regulated by liver X receptors in vivoGuoqing Cao
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 277:39561-5. 2002..We conclude that PLTP is a direct target gene of LXRs in vivo and plays an important role in LXR agonist-mediated HDL cholesterol and size increase in mice...- Liver X receptors as potential therapeutic targets for multiple diseasesGuoqing Cao
Division of Cardiovascular Discovery, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Drug News Perspect 17:35-41. 2004..This review intends to summarize the most recent progress in the field and provide an assessment of LXRs as potential therapeutic targets... - Characterization of HSCD5, a novel human stearoyl-CoA desaturase unique to primatesJian Wang
Cardiovascular Division, Lilly Research Labs, Eli Lilly and Company, DC 0343, Indianapolis, IN 46285, USA
Biochem Biophys Res Commun 332:735-42. 2005..These data suggested that hSCD5 plays a role distinct from that of hSCD1 during development and in normal physiological conditions... - Liver X receptor-mediated gene regulation and cholesterol homeostasis in brain: relevance to Alzheimer's disease therapeuticsGuoqing Cao
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Curr Alzheimer Res 4:179-84. 2007..Taken together, these findings suggest that brain-penetrable LXR agonists or modulators may be useful therapeutic agents for the treatment and (or) prevention of Alzheimer's disease... - Identification and characterization of hamster stearoyl-CoA desaturase isoformsJian Wang
Cardiovascular and Diabetes Drug Discovery, Lilly Research Labs, Lilly Corporate Center, Indianapolis, IN 46285, USA
Lipids 43:197-205. 2008..Very low levels of hmSCD3 mRNA can be detected in the tissues tested. This report is the first description of three SCD isoforms in the hamster and will provide useful tools in the further study of fatty acids metabolism in this species... 
Evacetrapib is a novel, potent, and selective inhibitor of cholesteryl ester transfer protein that elevates HDL cholesterol without inducing aldosterone or increasing blood pressureGuoqing Cao
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Lipid Res 52:2169-76. 2011..Our data indicate that evacetrapib is a potent and selective CETP inhibitor without torcetrapib-like off-target liabilities. Evacetrapib is currently in phase II clinical development...- Glycerolipid acyltransferases in triglyceride metabolism and energy homeostasis-potential as drug targetsGuoqing Cao
Lilly Research Laboratories, 359 Merrill Street, Indianapolis, IN 46285, USA
Endocr Metab Immune Disord Drug Targets 12:197-206. 2012.... - Further LDL cholesterol lowering through targeting PCSK9 for coronary artery diseaseGuoqing Cao
Lilly Research Laboratories, Indianapolis, IN 46285, USA
Endocr Metab Immune Disord Drug Targets 8:238-43. 2008..We review here the current understanding of PCSK9 and its potential as a therapeutic target through which to reduce LDL cholesterol for prevention and treatment of coronary heart disease... - Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesisGuoqing Cao
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 278:1131-6. 2003..These data not only suggest that LXRs are novel targets for diabetes but also reveal an unanticipated role for these receptors, further linking lipid and glucose metabolism... - Coadministration of a liver X receptor agonist and a peroxisome proliferator activator receptor-alpha agonist in Mice: effects of nuclear receptor interplay on high-density lipoprotein and triglyceride metabolism in vivoThomas P Beyer
Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
J Pharmacol Exp Ther 309:861-8. 2004..Liver lipoprotein lipase expression was additively increased upon LXR agonist and PPARalpha agonist coadministration. Our studies mark the first exploration of nuclear receptor interplay on lipid homeostasis in vivo... - Liver X receptors (LXRs) regulate apolipoprotein AIV-implications of the antiatherosclerotic effect of LXR agonistsYu Liang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
Mol Endocrinol 18:2000-10. 2004..In addition, we identified a functional LXR-responsive element at 3' end enhancer region of mouse ApoAIV gene. We conclude that ApoAIV is a direct target gene of LXRs that may contribute to the antiatherogenic effect of LXR activation... - A liver X receptor and retinoid X receptor heterodimer mediates apolipoprotein E expression, secretion and cholesterol homeostasis in astrocytesYu Liang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Neurochem 88:623-34. 2004..LXR/RXR agonists may have significant impact on the pathogenesis of multiple neurological diseases, including AD... 
Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivoRobert J Schmidt
Lilly Research Laboratories, Eli Lilly and Company, Cardiovascular Research, 355 Merrill Street, Indianapolis, IN 46285, USA
Biochem Biophys Res Commun 370:634-40. 2008..Taken together, our studies indicate that secreted PCSK9 can potentially impact extrahepatic tissue cholesterol homeostasis by regulating extrahepatic tissue LDLR levels...- Liver X receptor and retinoic X receptor mediated ABCA1 regulation and cholesterol efflux in macrophage cells-messenger RNA measured by branched DNA technologyYouyan Zhang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Mol Genet Metab 77:150-8. 2002.... - Hepatic peroxisomal fatty acid beta-oxidation is regulated by liver X receptor alphaTonghuan Hu
Lilly Research Laboratories, Department of Cardiovascular Research, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
Endocrinology 146:5380-7. 2005.... - A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activityRobert J Schmidt
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Lipid Res 47:1037-44. 2006..Our data thus provide a molecular basis for the hypocholesterolemic activity of the 15-ketosterol and further suggest its potential antiatherosclerotic benefit as an LXR agonist... - A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptorJeffrey Thomas
Department of Cardiovascular Research, Eli Lilly and Co, Indianapolis, Indiana 46285, USA
J Biol Chem 278:2403-10. 2003..These findings provide not only an unexpected mechanism by which fenofibrate inhibits lipogenesis but also the basis for examination of the pharmacology of an LXR ligand in humans... - Enlargement of high density lipoprotein in mice via liver X receptor activation requires apolipoprotein E and is abolished by cholesteryl ester transfer protein expressionXian Cheng Jiang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
J Biol Chem 278:49072-8. 2003..Our studies provide direct evidence that apoE and CETP are intimately involved in the accumulation of the enlarged HDL (HDL1 or HDLc) particles in mice... - Identification and characterization of a major liver lysophosphatidylcholine acyltransferaseYang Zhao
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Biol Chem 283:8258-65. 2008.... - Development of a quantitative biochemical and cellular sphingomyelin synthase assay using mass spectrometryYanqun Chen
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Anal Biochem 438:61-6. 2013..The establishment of quantitative biochemical and cellular SMS assays may help to facilitate the discovery of novel SMS1- or SMS2-specific inhibitors... - Role of ubiquitination in PCSK9-mediated low-density lipoprotein receptor degradationYanqun Chen
Department of Endocrine Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Biochem Biophys Res Commun 415:515-8. 2011..Furthermore, LDLR protein carrying mutations in the C-terminal ubiquitination sites was resistant to PCSK9-mediated degradation. Our data suggest that the ubiquitination system is involved in PCSK9-induced LDLR degradation... - Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosisYue Wei Qian
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Lipid Res 48:1488-98. 2007.... - The microsomal cardiolipin remodeling enzyme acyl-CoA lysocardiolipin acyltransferase is an acyltransferase of multiple anionic lysophospholipidsYang Zhao
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Lipid Res 50:945-56. 2009..Our studies provide the molecular basis for future investigations of the physiological function of ALCAT1 and offer evidence of critical amino acids involved in substrate binding for the family of glycerolipid acyltransferases... - Fenofibrate treatment increases human serum proprotein convertase subtilisin kexin type 9 levelsJason S Troutt
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Lipid Res 51:345-51. 2010.... - A novel splicing variant of proprotein convertase subtilisin/kexin type 9Robert J Schmidt
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285, USA
DNA Cell Biol 27:183-9. 2008..Both N425S and A443T mutants were processed normally, secreted, and reduced LDLR levels. However, the physiological function of this novel splicing variant of PCSK9 has yet to be determined... - Development of a novel sandwich ELISA for measuring cell lysate ABCA1 protein levelsJason S Troutt
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Lipids 45:757-64. 2010..Together, these results suggest that the sandwich ELISA may be a sensitive and effective method for quantitating ABCA1 protein levels... - A natural product ligand of the oxysterol receptor, liver X receptorKelli S Bramlett
Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46060, USA
J Pharmacol Exp Ther 307:291-6. 2003.... - Atorvastatin increases human serum levels of proprotein convertase subtilisin/kexin type 9Holly E Careskey
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Lipid Res 49:394-8. 2008..These results suggest that the addition of a PCSK9 inhibitor to statin therapy may result in even further LDL-C decreases... - AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferaseYan Qun Chen
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Biol Chem 283:10048-57. 2008..Our data indicate that AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4... - An apolipoprotein A-I mimetic dose-dependently increases the formation of prebeta1 HDL in human plasmaJason S Troutt
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Lipid Res 49:581-7. 2008.... - Genetic disorders associated with ATP binding cassette cholesterol transportersThomas P Burris
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Mol Genet Metab 77:13-20. 2002..This summary provides an overview and discussion of the most recent progress that includes molecular mechanism and regulation of cholesterol transport mediated by these ABC transporters... - Peroxisome proliferator-activated receptor alpha agonists regulate cholesterol ester transfer proteinThomas P Beyer
Cardiovascular Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Lipids 43:611-8. 2008..We conclude that PPARalpha agonists upregulate CETP expression and activity and may play an important role in PPARalpha (agonist mediated HDL cholesterol homeostasis in humans... - Serum proprotein convertase subtilisin kexin type 9 is correlated directly with serum LDL cholesterolWilliam E Alborn
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
Clin Chem 53:1814-9. 2007..Relatively little is known about PCSK9 in human serum... - Effects of currently prescribed LDL-C-lowering drugs on PCSK9 and implications for the next generation of LDL-C-lowering agentsRobert J Konrad
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Lipids Health Dis 10:38. 2011.... - The acyl coenzymeA:monoacylglycerol acyltransferase 3 (MGAT3) gene is a pseudogene in mice but encodes a functional enzyme in ratsYong Gang Yue
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Lipids 46:513-20. 2011..Our results thus provide the molecular basis to understand the relative functional role of MGAT2 and MGAT3 and also for future exploration of MGAT3 function in animal models... - Niacin mediates lipolysis in adipose tissue through its G-protein coupled receptor HM74AYouyan Zhang
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Biochem Biophys Res Commun 334:729-32. 2005..Our results provided direct evidence indicating that HM74A, but not HM74, was sufficient to mediate anti-lipolytic effect of niacin in adipose tissue... - Circulating human hepcidin-25 concentrations display a diurnal rhythm, increase with prolonged fasting, and are reduced by growth hormone administrationJason S Troutt
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Clin Chem 58:1225-32. 2012.... - Dual-monoclonal, sandwich immunoassay specific for glucose-dependent insulinotropic peptide1-42, the active form of the incretin hormoneJason S Troutt
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
Clin Chem 57:849-55. 2011..There is currently no described monoclonal antibody-based sandwich immunoassay to quantify concentrations of GIP(1-42), the active form of the peptide... - Adipose tissue-specific CETP expression in mice: impact on plasma lipoprotein metabolismHongwen Zhou
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY 11203, USA
J Lipid Res 47:2011-9. 2006..Moreover, adipose tissue CETP expression changes triglyceride and cholesterol content and the size of adipocytes... - Inhibition of sphingomyelin synthase (SMS) affects intracellular sphingomyelin accumulation and plasma membrane lipid organizationZhiqiang Li
Department of Anatomy and Cell Biology, State University of New York Downstate Medical Center, 450 Clarkson Ave Box 5, Brooklyn, NY 11203, USA
Biochim Biophys Acta 1771:1186-94. 2007....