Research Topics
| Haya Ascher-SvanumSummaryAffiliation: Eli Lilly and Company Country: USA Publications
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Detail Information
Publications
The burden of depressive symptoms in the long-term treatment of patients with schizophreniaRobert R Conley
Maryland Psychiatric Research Center, University of Maryland at Baltimore, School of Medicine, USA
Schizophr Res 90:186-97. 2007..To prospectively measure the link between depressive symptoms and functional outcomes in the long-term treatment of people with schizophrenia...
The cost of relapse and the predictors of relapse in the treatment of schizophreniaHaya Ascher-Svanum
US Outcomes Research, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
BMC Psychiatry 10:2. 2010..To assess the direct cost of relapse and the predictors of relapse during the treatment of patients with schizophrenia in the United States...
Cost-effectiveness of olanzapine vs. aripiprazole in the treatment of schizophreniaHaya Ascher-Svanum
Eli Lilly and Company, Lilly Corporate Center, DC 4133, Indianapolis, IN 46285, USA
Curr Med Res Opin 27:115-22. 2011..The objective of this study was to compare the cost-effectiveness of olanzapine to aripiprazole in the treatment of schizophrenia from the perspective of public payers in the United States...
Cost-effectiveness of several atypical antipsychotics in orally disintegrating tablets compared with standard oral tablets in the treatment of schizophrenia in the United StatesHaya Ascher-Svanum
Eli Lilly and Company, Indianapolis, IN, USA
J Med Econ 15:531-47. 2012..The study also compared olanzapine ODT with risperidone and aripiprazole, two other atypical antipsychotics available in both ODT and SOT formulations...
Methodological issues in assessing changes in costs pre- and post-medication switch: a schizophrenia study exampleDouglas E Faries
Lilly USA, LLC, Indianapolis, Indiana, USA
Cost Eff Resour Alloc 7:11. 2009..Given the importance of quality economic research on the cost of switching treatments, thorough sensitivity analyses should be performed to identify the impact of crisis events around the time of medication change...
Item response analysis of the Positive and Negative Syndrome ScaleDarcy A Santor
School of Psychology, University of Ottawa, Ottawa, Canada, and The Provincial Centre of Excellence for Child and Youth Mental Health, Ottawa, Ontario, Canada
BMC Psychiatry 7:66. 2007....
Reasons for discontinuation and continuation of antipsychotics in the treatment of schizophrenia from patient and clinician perspectivesHaya Ascher-Svanum
Eli Lilly and Company, Indianapolis, IN 46285, USA
Curr Med Res Opin 26:2403-10. 2010..To identify reasons for discontinuation and continuation of antipsychotic medications in the treatment of schizophrenia from the patients' and their clinicians' perspectives...
Assessing the infrequent oral supplementation of olanzapine long-acting injection in the treatment of schizophreniaH Ascher-Svanum
Lilly Corporate Center, DC 4133, Eli Lilly and Company, Indianapolis, IN 46285, USA
Eur Psychiatry 26:313-9. 2011..This post-hoc analysis assessed supplementation of olanzapine long-acting injection (olanzapine-LAI) with oral olanzapine...
Involvement in the US criminal justice system and cost implications for persons treated for schizophreniaHaya Ascher-Svanum
Eli Lilly and Company, Indianapolis, IN, USA
BMC Psychiatry 10:11. 2010..This study assessed the prevalence of encounters with the criminal justice system, encounter types, and the estimated cost attributable to these encounters in the one-year treatment of persons with schizophrenia...
Patient education about schizophrenia: initial expectations and later satisfactionH Ascher-Svanum
Roudebush VA Medical Center, Indiana University School of Medicine, Indianapolis, Indiana, USA
Issues Ment Health Nurs 22:325-33. 2001..Content areas that were rated less helpful included prevalence of schizophrenia, its psychosocial rehabilitation, and use of community resources. Implications for clinical practice in patient education are identified and discussed...
Clinical, functional, and economic ramifications of early nonresponse to antipsychotics in the naturalistic treatment of schizophreniaHaya Ascher-Svanum
Eli Lilly and Company, Indianapolis, IN 46285, USA
Schizophr Bull 34:1163-71. 2008..This study assessed the predictive accuracy of early nonresponse to treatment and its clinical, functional, and economic ramifications in the naturalistic treatment of predominately chronic outpatients treated for schizophrenia...
Treatment patterns and clinical characteristics prior to initiating depot typical antipsychotics for nonadherent schizophrenia patientsHaya Ascher-Svanum
Eli Lilly and Company, Indianapolis, IN, USA
BMC Psychiatry 9:46. 2009....
Cost-effectiveness model comparing olanzapine and other oral atypical antipsychotics in the treatment of schizophrenia in the United StatesNicolas M Furiak
Eli Lilly and Company, Indianapolis, IN, USA
Cost Eff Resour Alloc 7:4. 2009..Olanzapine may, therefore, be a cost-effective therapeutic option for patients with schizophrenia...
Clinical comparability of schizophrenia patients at two public mental health systemsHaya Ascher-Svanum
Eli Lilly and Company, Indianapolis, Indiana, USA
Adm Policy Ment Health 30:231-45. 2003....
A prospective study of risk factors for nonadherence with antipsychotic medication in the treatment of schizophreniaHaya Ascher-Svanum
Eli Lilly and Co, Lilly Corporate Center, Indianapolis, IN 46285, USA
J Clin Psychiatry 67:1114-23. 2006..This study aimed to prospectively identify the best single predictor and the best set of predictors of risk for nonadherence with anti-psychotic medication in the treatment of patients with schizophrenia...
The rate, pattern, and cost of use of antiparkinsonian agents among patients treated for schizophrenia in a managed care settingHaya Ascher-Svanum
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Ind 46285, USA
Am J Manag Care 10:20-4. 2004..To examine the use and economic cost of antiparkinsonian agents during the medication management of patients diagnosed with schizophrenic disorders in a naturalistic healthcare setting...
Medication adherence and long-term functional outcomes in the treatment of schizophrenia in usual careHaya Ascher-Svanum
Eli Lilly and Co, Indianapolis, Ind, USA
J Clin Psychiatry 67:453-60. 2006....
Acute weight gain, gender, and therapeutic response to antipsychotics in the treatment of patients with schizophreniaHaya Ascher-Svanum
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana
BMC Psychiatry 5:3. 2005..This study assessed the impact of acute treatment-emergent weight gain on clinical and functional outcomes of patients with schizophrenia by patient gender and antipsychotic treatment (olanzapine or haloperidol)...
Time to discontinuation of atypical versus typical antipsychotics in the naturalistic treatment of schizophreniaHaya Ascher-Svanum
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana, USA
BMC Psychiatry 6:8. 2006..This naturalistic study compares atypical and typical antipsychotics on time to all-cause medication discontinuation, a recognized index of medication effectiveness in the treatment of schizophrenia...
Weight gain as a prognostic indicator of therapeutic improvement during acute treatment of schizophrenia with placebo or active antipsychoticHaya Ascher-Svanum
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
J Psychopharmacol 19:110-7. 2005..88, p 0.05). Treatment-emergent weight gain appears to be an important marker of symptom reduction, and may not be exclusively attributable to pharmacological perturbations...
Challenging the assumption that improvement in functional outcomes is delayed relative to improvement in symptoms in the treatment of schizophreniaBruce J Kinon
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Schizophr Res 118:176-82. 2010..In this study, we assessed the effects of early response/non-response to an atypical antipsychotic across multiple outcome measures...
Randomized, double-blind 6-month comparison of olanzapine and quetiapine in patients with schizophrenia or schizoaffective disorder with prominent negative symptoms and poor functioningBruce J Kinon
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
J Clin Psychopharmacol 26:453-61. 2006..Greater improvement in positive symptoms and a greater study completion rate may hold relevance to enhanced functional outcomes observed after OLZ therapy...
Early response to antipsychotic drug therapy as a clinical marker of subsequent response in the treatment of schizophreniaBruce J Kinon
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Neuropsychopharmacology 35:581-90. 2010....
Predicting response to atypical antipsychotics based on early response in the treatment of schizophreniaBruce J Kinon
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
Schizophr Res 102:230-40. 2008..To test whether early onset of response to antipsychotic medications accurately predicts subsequent response in the treatment of patients with schizophrenia...
Predictors of switching antipsychotic medications in the treatment of schizophreniaAllen W Nyhuis
Eli Lilly and Company, Indianapolis, IN USA
BMC Psychiatry 10:75. 2010..To identify patient characteristics and early changes in patients' clinical status that best predict subsequent switching of antipsychotic agents in the long-term treatment of schizophrenia...
Identification of early changes in specific symptoms that predict longer-term response to atypical antipsychotics in the treatment of patients with schizophreniaStephen J Ruberg
Eli Lilly and Company, Indianapolis, IN, USA
BMC Psychiatry 11:23. 2011..To identify a simple decision tree using early symptom change to predict response to atypical antipsychotic therapy in patients with (Diagnostic and Statistical Manual, Fourth Edition, Text Revised) chronic schizophrenia...
Responses to antipsychotic therapy among patients with schizophrenia or schizoaffective disorder and either predominant or prominent negative symptomsVirginia L Stauffer
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Schizophr Res 134:195-201. 2012..This distinction, incorporating an evaluation of the presence of positive, affective, and extrapyramidal symptoms, may therefore not have prognostic implications for the responsiveness of patients' negative symptoms to treatment...
Antipsychotic monotherapy and polypharmacy in the naturalistic treatment of schizophrenia with atypical antipsychoticsDouglas Faries
Outcomes Research, Eli Lilly and Company, Indianapolis, Indiana, USA
BMC Psychiatry 5:26. 2005..This study assessed the annual rate and duration of antipsychotic monotherapy and its inverse, antipsychotic polypharmacy, among schizophrenia patients initiated on commonly used atypical antipsychotic medications...
Cost-effectiveness of olanzapine as first-line treatment for schizophrenia: results from a randomized, open-label, 1-year trialSandra L Tunis
US Medical Division, Eli Lilly and Company, Indianapolis, IN 46285, USA
Value Health 9:77-89. 2006..029). CONCLUSIONS: Approaches that integrate costs, effectiveness, and treatment patterns are important for providing optimal information regarding the value of first-line antipsychotic options for schizophrenia...
Switching from risperidone to olanzapine in a one-year, randomized, open-label effectiveness study of schizophreniaDouglas E Faries
Eli Lilly and Co, Lilly Research Laboratories, Indianapolis, IN 46285, USA
Curr Med Res Opin 24:1399-405. 2008..Switching medications is common in the treatment of schizophrenia. This study examines the effectiveness of olanzapine therapy following a clinically warranted switch from risperidone during treatment of patients with schizophrenia...
Clinical and economic ramifications of switching antipsychotics in the treatment of schizophreniaDouglas E Faries
US Statistics, Lilly USA, LLC, Indianapolis, IN, USA
BMC Psychiatry 9:54. 2009..The goal of this research was to assess the clinical and economic ramifications of switching antipsychotics during outpatient management of schizophrenia...
Early response to antipsychotic therapy as a clinical marker of subsequent response in the treatment of patients with first-episode psychosisVirginia L Stauffer
Eli Lilly and Company, Indianapolis, IN 46285, USA
Psychiatry Res 187:42-8. 2011..As had been seen in the treatment of patients with chronic schizophrenia, early non-response was a robust predictor of subsequent non-response in the treatment of patients with first-episode psychosis...
Cost-effectiveness of olanzapine long-acting injection in the treatment of patients with schizophrenia in the United States: a micro-simulation economic decision modelNicolas M Furiak
Medical Decision Modeling Inc, Indianapolis, IN, USA
Curr Med Res Opin 27:713-30. 2011....
Early response predicts subsequent response to olanzapine long-acting injection in a randomized, double-blind clinical trial of treatment for schizophreniaHaya Ascher-Svanum
Global Health Outcomes, Eli Lilly and Company, USA
BMC Psychiatry 11:152. 2011..This study assessed whether early response predicted later response when using a long-acting injection (LAI) antipsychotic...
A 24-week randomized study of olanzapine versus ziprasidone in the treatment of schizophrenia or schizoaffective disorder in patients with prominent depressive symptomsBruce J Kinon
Eli Lilly and Company, Indianapolis, IN 46285, USA
J Clin Psychopharmacol 26:157-62. 2006..The objective of this study is to compare olanzapine with ziprasidone therapy in patients with schizophrenia or schizoaffective disorder and experiencing depressive symptoms...
Tardive dyskinesia and the 3-year course of schizophrenia: results from a large, prospective, naturalistic studyHaya Ascher-Svanum
U S Outcomes Research, Eli Lilly and Co, Lilly Corporate Center, DC 4133, Indianapolis, IN 46285, USA
J Clin Psychiatry 69:1580-8. 2008..The objective of this study was to compare the 3-year course of schizophrenia between persons with tardive dyskinesia (TD) and persons without TD on multiple outcome measures...
Analysis of treatment effectiveness in longitudinal observational dataDouglas Faries
Outcomes Research, Eli Lilly and Company, Indianapolis, Indiana, USA
J Biopharm Stat 17:809-26. 2007..Marginal structural models are a promising approach to estimation of causal treatment effects in such data...
Improved outcomes following a switch to olanzapine treatment from risperidone treatment in a 1-year naturalistic study of schizophrenia patients in JapanWenyu Ye
Eli Lilly Japan K K, Kobe, Japan
Psychiatry Clin Neurosci 66:313-21. 2012..This study assessed clinical and functional outcomes following a switch from risperidone to olanzapine in a 1-year naturalistic study of schizophrenia patients in Japan...
The relationship, structure and profiles of schizophrenia measurements: a post-hoc analysis of the baseline measures from a randomized clinical trialLei Chen
Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
BMC Psychiatry 11:203. 2011..In this exploratory study, we characterized the relationships among six clinical, functional, cognitive, and quality-of-life measures, identifying a parsimonious set of measurements...
Cost of antipsychotic polypharmacy in the treatment of schizophreniaBaojin Zhu
Eli Lilly and Company, Indianapolis, Indiana, USA
BMC Psychiatry 8:19. 2008..This study compared the costs of antipsychotic polypharmacy for patients who initiated on 1 of the 3 most commonly prescribed atypical antipsychotics - olanzapine, quetiapine, or risperidone...
Optimal thresholds of early response to atypical antipsychotics: application of signal detection methodsLei Chen
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, DC 4133, Indianapolis, IN 46285, USA
Schizophr Res 113:34-40. 2009..Identify the optimal magnitude of response to antipsychotic medication at various early time points that best predicts subsequent non-response at 8 weeks...
Time to discontinuation of depot and oral first-generation antipsychotics in the usual care of schizophreniaBaojin Zhu
Eli Lilly and Company, Lilly Corporate Center Drop 4133, Indianapolis, IN 46285, USA
Psychiatr Serv 59:315-7. 2008..This study compared the time to discontinuation for any reason of first-generation antipsychotics--in oral versus depot formulation--in the usual care of schizophrenia...
Trajectories of response to treatment with atypical antipsychotic medication in patients with schizophrenia pooled from 6 double-blind, randomized clinical trialsVirginia Stauffer
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
Schizophr Res 130:11-9. 2011..Most patients had modest and sustained improvements during atypical antipsychotic treatment, regardless of their baseline illness severity, representing a partial response to currently available treatments...
Effects of olanzapine long-acting injection on levels of functioning among acutely ill patients with schizophreniaMichael M Witte
Lilly USA, LLC, Indianapolis, IN 46285, USA
Curr Med Res Opin 28:315-23. 2012..To assess the effects of olanzapine long-acting injection (olanzapine-LAI) on levels of functioning in acutely ill patients with schizophrenia...
Costs of treating patients with schizophrenia who have illness-related crisis eventsBaojin Zhu
Eli Lilly and Company, Indianapolis, USA
BMC Psychiatry 8:72. 2008..This naturalistic prospective study assessed the association of recent crises with mental health treatment costs among persons receiving treatment for schizophrenia...
Early onset of antipsychotic action in schizophrenia: evaluating the possibility of shorter acute efficacy trialsBruce J Kinon
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
J Clin Psychopharmacol 30:286-9. 2010..Early response to antipsychotic treatment discriminated AD from placebo. Reducing placebo-controlled clinical trials from 6 weeks to 2 to 4 weeks was found to be a viable option for efficacy identification in acutely ill patients...
Longer time to antipsychotic treatment discontinuation for any cause is associated with better functional outcomes for patients with schizophrenia, schizophreniform disorder, or schizoaffective disorderEduardo Dunayevich
Outcomes Research, Eli Lilly and Co, Indianapolis, IN, USA
J Clin Psychiatry 68:1163-71. 2007..This study examines whether longer time to all-cause medication discontinuation is also linked to better functional outcomes...
The temporal relationship between symptom change and treatment discontinuation in a pooled analysis of 4 schizophrenia trialsBruce J Kinon
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA
J Clin Psychopharmacol 28:544-9. 2008..Early improvement in positive or depressive/anxiety symptoms is especially predictive of treatment persistence...
Maintenance of response with atypical antipsychotics in the treatment of schizophrenia: a post-hoc analysis of 5 double-blind, randomized clinical trialsVirginia Stauffer
Lilly Research Laboratories, Indianapolis, IN, USA
BMC Psychiatry 9:13. 2009..This post-hoc analysis describes maintenance of response over 24 or 28 weeks in people treated for schizophrenia with olanzapine, risperidone, quetiapine, ziprasidone, or aripiprazole...
Change in level of productivity in the treatment of schizophrenia with olanzapine or other antipsychoticsHong Liu-Seifert
Lilly Research Laboratories, Indianapolis, Indiana, USA
BMC Psychiatry 11:87. 2011..We also assessed the links between productivity level and other clinical outcomes...
Sustained favorable long-term outcome in the treatment of schizophrenia: a 3-year prospective observational studyGebra B Cuyún Carter
Eli Lilly and Company, Global Health Outcomes, Indianapolis, IN 46285, USA
BMC Psychiatry 11:143. 2011....
Assessing the value of antipsychotics for treating schizophrenia: the importance of evaluating and interpreting the clinical significance of individual service costsSandra L Tunis
US Medical Division, Eli Lilly and Company, Indianapolis, Indiana, USA
Pharmacoeconomics 22:1-8. 2004....
Cost-effectiveness of early responders versus early nonresponders to atypical antipsychotic therapyXiaomei Peng
Eli Lilly and Company, Indianapolis, Indiana, USA
Clinicoecon Outcomes Res 3:79-87. 2011....
Medication patterns and costs associated with olanzapine and other atypical antipsychotics in the treatment of bipolar disorderBaojin Zhu
Eli Lilly and Company Lilly Research Laboratories, Indianapolis, IN, USA
Curr Med Res Opin 23:2805-14. 2007..Atypical antipsychotics are playing an increasing role in the treatment of bipolar disorder. The objective of this study was to assess the medication treatment patterns and costs associated with different atypical antipsychotics...
Construct validity of 2 measures to assess reasons for antipsychotic discontinuation and continuation from patients' and clinicians' perspectives in a clinical trialDouglas Faries
Eli Lilly and Company, Lilly Corporate Center, DC 5024, Indianapolis, IN 46285, USA
BMC Med Res Methodol 12:142. 2012....
Adherence and persistence to typical and atypical antipsychotics in the naturalistic treatment of patients with schizophreniaHaya Ascher-Svanum
Eli Lilly and Company, Outcomes Research, Indianapolis, IN, USA
Patient Prefer Adherence 2:67-77. 2008..To compare adherence and persistence to typical versus atypical antipsychotics and between specific atypical agents in the usual care of schizophrenia and to examine the association between adherence and persistence...
Long-term healthcare costs and functional outcomes associated with lack of remission in schizophrenia: a post-hoc analysis of a prospective observational studyVirginia S Haynes
Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA
BMC Psychiatry 12:222. 2012..This post-hoc analysis of a 3-year study compared the costs of mental health services and functional outcomes between individuals with schizophrenia who met or did not meet cross-sectional symptom remission at study enrollment...
Comparison of patients undergoing switching versus augmentation of antipsychotic medications during treatment for schizophreniaHaya Ascher-Svanum
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
Neuropsychiatr Dis Treat 8:113-8. 2012..Current findings are consistent with physicians' stated reasons for switching versus augmenting antipsychotics in the treatment of schizophrenia. Confirmation of these findings requires further research...
Patient perception of medication benefit and early treatment discontinuation in a 1-year study of patients with schizophreniaHong Liu-Seifert
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
Patient Prefer Adherence 1:9-17. 2007..Associations of patient beliefs about medication with clinical psychopathology and their life satisfaction were also assessed...
Reviewing CATIE for clinicians: balancing benefit and risk using evidence-based medicine toolsJamie Karagianis
Eli Lilly Canada Inc, Toronto, Ontario, Canada
Curr Med Res Opin 23:2551-7. 2007....
Decline in hospitalization risk and health care cost after initiation of depot antipsychotics in the treatment of schizophreniaXiaomei Peng
Eli Lilly and Company, Indianapolis, IN, USA
Clinicoecon Outcomes Res 3:9-14. 2011..To assess change in hospitalization and cost of care from 6 months pre- to 6 months post-initiation on any depot antipsychotic among schizophrenia patients...
Treatment-completion rates with olanzapine long-acting injection versus risperidone long-acting injection in a 12-month, open-label treatment of schizophrenia: indirect, exploratory comparisonsHaya Ascher-Svanum
Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
Int J Gen Med 5:391-8. 2012....
Treatment of schizophrenia with long-acting fluphenazine, haloperidol, or risperidoneMark Olfson
Division of Clinical and Genetic Epidemiology, New York State Psychiatric Institute, New York, NY, USA
Schizophr Bull 33:1379-87. 2007..This study compares 3 cohorts of patients with schizophrenia before, during, and after initiating treatment with fluphenazine decanoate (FD), haloperidol decanoate (HD), or long-acting injectable risperidone (LAR)...
Characteristics and use patterns of patients taking first-generation depot antipsychotics or oral antipsychotics for schizophreniaLizheng Shi
Department of Health Systems Management, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St, Suite 1900, New Orleans, LA 70112, USA
Psychiatr Serv 58:482-8. 2007....
Classifying patients by antipsychotic adherence patterns using latent class analysis: characteristics of nonadherent groups in the California Medicaid (Medi-Cal) programJeonghoon Ahn
University of Southern California, Los Angeles, CA, USA
Value Health 11:48-56. 2008..This study identifies latent classes defined by varying degrees of adherence to antipsychotic drug therapy and examines the sociodemographic, clinical, and resource utilization correlates associated with membership in each adherence class...
Antipsychotic treatment discontinuation among individuals with schizophrenia and co-occurring substance useDavid A Smelson
J Clin Psychopharmacol 26:666-7. 2006
