Gregory A Elder

Summary

Country: USA

Publications

  1. pmc Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells
    Rita De Gasperi
    Neurology Service, James J, Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA
    BMC Biochem 13:28. 2012
  2. pmc Blast exposure induces post-traumatic stress disorder-related traits in a rat model of mild traumatic brain injury
    Gregory A Elder
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    J Neurotrauma 29:2564-75. 2012
  3. doi request reprint Blast-induced mild traumatic brain injury
    Gregory A Elder
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychiatr Clin North Am 33:757-81. 2010
  4. doi request reprint Blast-related mild traumatic brain injury: mechanisms of injury and impact on clinical care
    Gregory A Elder
    James J Peters Department of Veterans Affairs Medical Center, Rehabilitation Medicine Service, Bronx, NY, USA
    Mt Sinai J Med 76:111-8. 2009
  5. pmc Presenilin transgenic mice as models of Alzheimer's disease
    Gregory A Elder
    Neurology Service 3E16, James J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA
    Brain Struct Funct 214:127-43. 2010
  6. pmc Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations
    Miguel A Gama Sosa
    Research and Development, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA
    Am J Pathol 176:353-68. 2010
  7. doi request reprint Modeling human neurodegenerative diseases in transgenic systems
    Miguel A Gama Sosa
    Research and Development Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Hum Genet 131:535-63. 2012
  8. pmc Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling
    Rita De Gasperi
    Research and Development James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Dev Dyn 237:2405-14. 2008
  9. ncbi request reprint Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact
    Miguel A Gama Sosa
    Department of Psychiatry, Mount Sinai School of Medicine of New York University, New York, NY, USA
    Cell Res 17:619-26. 2007
  10. pmc Acute blast injury reduces brain abeta in two rodent species
    Rita De Gasperi
    Research and Development Service, James J Peters Department of Veterans Affairs Medical Center Bronx, NY, USA Department of Psychiatry, Mount Sinai School of Medicine New York, NY, USA Friedman Brain Institute, Mount Sinai School of Medicine New York, NY, USA
    Front Neurol 3:177. 2012

Collaborators

  • Miguel A Gama Sosa
  • Dara L Dickstein
  • Steven T DeKosky
  • Sam Gandy
  • Susan L Wearne
  • Rita De Gasperi
  • Miguel A Gama Sosa
  • Patrick R Hof
  • Gissel M Perez
  • Eric Maudlin-Jeronimo
  • Michael C Shaughness
  • Aaron A Hall
  • Soong Ho Kim
  • Richard M McCarron
  • Madhusoodana P Nambiar
  • Stephen T Ahlers
  • John W Steele
  • Zuzanna Naumowicz
  • Stella Dracheva
  • Joseph D Buxbaum
  • Lucia Notterpek
  • Kenneth L Davis
  • Jingjun Li
  • Victor L Friedrich
  • Paul H Wen
  • Anne B Rocher
  • Tom Curran

Detail Information

Publications16

  1. pmc Presenilin-1 regulates the constitutive turnover of the fibronectin matrix in endothelial cells
    Rita De Gasperi
    Neurology Service, James J, Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA
    BMC Biochem 13:28. 2012
    ....
  2. pmc Blast exposure induces post-traumatic stress disorder-related traits in a rat model of mild traumatic brain injury
    Gregory A Elder
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    J Neurotrauma 29:2564-75. 2012
    ..These studies have implications for understanding the relationship of PTSD to mTBI in the population of veterans returning from the wars in Iraq and Afghanistan...
  3. doi request reprint Blast-induced mild traumatic brain injury
    Gregory A Elder
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY 10468, USA
    Psychiatr Clin North Am 33:757-81. 2010
    ..At present, the relationship is unclear. Resolution of these issues will affect both treatment strategies and strategies for the protection of troops in the field...
  4. doi request reprint Blast-related mild traumatic brain injury: mechanisms of injury and impact on clinical care
    Gregory A Elder
    James J Peters Department of Veterans Affairs Medical Center, Rehabilitation Medicine Service, Bronx, NY, USA
    Mt Sinai J Med 76:111-8. 2009
    ..The high rates of mild traumatic brain injury and posttraumatic stress disorder in the current operations are of significant concern for the long-term health of US veterans with associated economic implications...
  5. pmc Presenilin transgenic mice as models of Alzheimer's disease
    Gregory A Elder
    Neurology Service 3E16, James J Peters Department of Veterans Affairs Medical Center, 130 West Kingsbridge Road, Bronx, NY, 10468, USA
    Brain Struct Funct 214:127-43. 2010
    ..The relevance of PS transgenic mice as models of AD is discussed...
  6. pmc Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations
    Miguel A Gama Sosa
    Research and Development, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York, USA
    Am J Pathol 176:353-68. 2010
    ..These studies thus have implications for the role of neuronal to vascular signaling in the pathogenesis of the vascular pathology associated with AD...
  7. doi request reprint Modeling human neurodegenerative diseases in transgenic systems
    Miguel A Gama Sosa
    Research and Development Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Hum Genet 131:535-63. 2012
    ....
  8. pmc Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signaling
    Rita De Gasperi
    Research and Development James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Dev Dyn 237:2405-14. 2008
    ..Unlike reeler mice the preplate splits in Psen1-/- brain. Thus cortical development in Psen1-/- mice fails only after splitting of the preplate and is not due to an intrinsic failure of reelin signaling...
  9. ncbi request reprint Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact
    Miguel A Gama Sosa
    Department of Psychiatry, Mount Sinai School of Medicine of New York University, New York, NY, USA
    Cell Res 17:619-26. 2007
    ..These apparently opposing effects could reflect differential cellular interactions needed for the proper development of the brain...
  10. pmc Acute blast injury reduces brain abeta in two rodent species
    Rita De Gasperi
    Research and Development Service, James J Peters Department of Veterans Affairs Medical Center Bronx, NY, USA Department of Psychiatry, Mount Sinai School of Medicine New York, NY, USA Friedman Brain Institute, Mount Sinai School of Medicine New York, NY, USA
    Front Neurol 3:177. 2012
    ..These studies have implications for understanding the nature of blast injury to the brain. They also suggest that strategies aimed at lowering Aβ production may not be effective for treating acute blast injury to the brain...
  11. pmc Transgenic mouse models of Alzheimer's disease
    Gregory A Elder
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY, USA
    Mt Sinai J Med 77:69-81. 2010
    ..These models will, without a doubt, continue to play central roles in preclinical testing and be used as tools for developing insights into the biological basis of Alzheimer's disease...
  12. pmc The IRG mouse: a two-color fluorescent reporter for assessing Cre-mediated recombination and imaging complex cellular relationships in situ
    Rita De Gasperi
    Research and Development, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Genesis 46:308-17. 2008
    ..IRG mice should provide a versatile tool for analyzing complex cellular relationships in both neural and nonneural tissues...
  13. doi request reprint Animal transgenesis: an overview
    Miguel A Gama Sosa
    Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY, 10029, USA
    Brain Struct Funct 214:91-109. 2010
    ....
  14. pmc PERIPHERAL MYELIN PROTEIN-22 IS EXPRESSED IN CNS MYELIN
    Rita De Gasperi
    Research and Development, James J Peters Department of Veterans Affairs Medical Center, Bronx, New York 10468, USA
    Transl Neurosci 1:282-285. 2010
    ....
  15. pmc Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease
    Rita De Gasperi
    Neurology Service, James J Peters Department of Veterans Affairs Medical Center, Bronx, NY 10468, USA
    Mol Neurodegener 5:38. 2010
    ..Here we investigated whether Psen1 might regulate hypoxic responses by modulating induction of the transcription factor hypoxia inducible factor 1-α (HIF-1α)...
  16. ncbi request reprint Research update: neurogenesis in adult brain and neuropsychiatric disorders
    Gregory A Elder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Mt Sinai J Med 73:931-40. 2006
    ..While obstacles remain to both approaches, stem-cell-based therapies remain an area of intense research interest...