Michael Grundman

Summary

Affiliation: Elan Pharmaceuticals
Country: USA

Publications

  1. ncbi Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)
    Irina Mikolaenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Neuropathol Exp Neurol 64:156-62. 2005
  2. doi A quarter century of advancing treatment for Alzheimer's disease with Leon J. Thal
    Michael Grundman
    Alzheimer s Disease Clinical Development Program, Elan Pharmaceuticals, Inc, San Francisco, CA, USA
    Alzheimers Dement 4:S51-5. 2008
  3. pmc The oldest old and the 90+ Study
    Claudia H Kawas
    Department of Neurology, Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA, USA
    Alzheimers Dement 4:S56-9. 2008
  4. pmc Alzheimer disease pathology and longitudinal cognitive performance in the oldest-old with no dementia
    Archana B Balasubramanian
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA
    Neurology 79:915-21. 2012
  5. pmc Disability in the oldest-old: incidence and risk factors in the 90+ study
    Daniel J Berlau
    Department of Neurology, University of California Irvine, CA 92697, USA
    Am J Geriatr Psychiatry 20:159-68. 2012
  6. pmc Cognitive impairment in nondemented oldest-old: prevalence and relationship to cardiovascular risk factors
    Carrie B Peltz
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA
    Alzheimers Dement 8:87-94. 2012
  7. pmc Dementia incidence continues to increase with age in the oldest old: the 90+ study
    Maria M Corrada
    Department of Neurology, University of California, Irvine, CA 92697 1400, USA
    Ann Neurol 67:114-21. 2010
  8. pmc Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA, USA
    Alzheimers Dement 7:35-52. 2011
  9. ncbi Synaptic proteins, neuropathology and cognitive status in the oldest-old
    Elizabeth Head
    Institute of Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurobiol Aging 30:1125-34. 2009
  10. pmc Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old
    B Adar Kravitz
    Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA, USA
    Alzheimers Dement 5:318-23. 2009

Collaborators

Detail Information

Publications36

  1. ncbi Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA)
    Irina Mikolaenko
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    J Neuropathol Exp Neurol 64:156-62. 2005
    ..Finally, the coexistence of Abeta amyloid and alpha-synuclein pathology in AD brains suggests that the pathogenic mechanism/s leading to the accumulation of Abeta and alpha-synuclein may be similar...
  2. doi A quarter century of advancing treatment for Alzheimer's disease with Leon J. Thal
    Michael Grundman
    Alzheimer s Disease Clinical Development Program, Elan Pharmaceuticals, Inc, San Francisco, CA, USA
    Alzheimers Dement 4:S51-5. 2008
  3. pmc The oldest old and the 90+ Study
    Claudia H Kawas
    Department of Neurology, Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA, USA
    Alzheimers Dement 4:S56-9. 2008
    ..Through our collective efforts, we will continue the scientific work that Leon so strongly supported...
  4. pmc Alzheimer disease pathology and longitudinal cognitive performance in the oldest-old with no dementia
    Archana B Balasubramanian
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA
    Neurology 79:915-21. 2012
    ..The purpose of this study was to compare longitudinal cognitive performance in oldest-old individuals without dementia with and without AD neuropathology...
  5. pmc Disability in the oldest-old: incidence and risk factors in the 90+ study
    Daniel J Berlau
    Department of Neurology, University of California Irvine, CA 92697, USA
    Am J Geriatr Psychiatry 20:159-68. 2012
    ..To measure the incidence of disability in individuals aged 90 years and older and examine factors that may increase risk of disability...
  6. pmc Cognitive impairment in nondemented oldest-old: prevalence and relationship to cardiovascular risk factors
    Carrie B Peltz
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, USA
    Alzheimers Dement 8:87-94. 2012
    ..To determine the prevalence and types of cognitive impairment in a sample of nondemented participants aged ≥90 (the oldest-old) and to examine the relationships between cognitive impairment and cardiovascular risk factors...
  7. pmc Dementia incidence continues to increase with age in the oldest old: the 90+ study
    Maria M Corrada
    Department of Neurology, University of California, Irvine, CA 92697 1400, USA
    Ann Neurol 67:114-21. 2010
    ..Here, we estimate age- and sex-specific incidence rates of all-cause dementia in people aged 90 years and older, including estimates for centenarians...
  8. pmc Operationalizing diagnostic criteria for Alzheimer's disease and other age-related cognitive impairment-Part 2
    Sudha Seshadri
    Department of Neurology, Boston University School of Medicine, MA, USA
    Alzheimers Dement 7:35-52. 2011
    ..Improved accuracy in the clinical diagnosis of AD is anticipated with the addition of molecular and structural biomarkers in the next generation of epidemiological studies...
  9. ncbi Synaptic proteins, neuropathology and cognitive status in the oldest-old
    Elizabeth Head
    Institute of Brain Aging and Dementia, University of California, Irvine, CA 92697 4540, USA
    Neurobiol Aging 30:1125-34. 2009
    ..Frontal cortex SYN protein levels may protect neuronal function in oldest-old individuals and reflect compensatory responses that may be involved with maintaining cognition...
  10. pmc Elevated C-reactive protein levels are associated with prevalent dementia in the oldest-old
    B Adar Kravitz
    Department of Neurobiology and Behavior, University of California at Irvine, Irvine, CA, USA
    Alzheimers Dement 5:318-23. 2009
    ..Using a cross-sectional design, we examined whether high levels of serum CRP are associated with increased odds of prevalent dementia in the oldest-old...
  11. pmc Apolipoprotein E genotype, dementia, and mortality in the oldest old: the 90+ Study
    Maria M Corrada
    Department of Neurology, University of California Irvine, CA, USA
    Alzheimers Dement 9:12-8. 2013
    ....
  12. pmc Incidence of dementia in oldest-old with amnestic MCI and other cognitive impairments
    Carrie B Peltz
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA, USA
    Neurology 77:1906-12. 2011
    ..To examine the incidence of dementia among the oldest-old people with normal cognition and different types of cognitive impairment...
  13. pmc A population-based clinicopathological study in the oldest-old: the 90+ study
    Maria M Corrada
    Department of Neurology, University of California, Irvine, Irvine, CA 92697 1400, USA
    Curr Alzheimer Res 9:709-17. 2012
    ....
  14. pmc APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old
    Daniel J Berlau
    Institute of Brain Aging and Dementia, University of California Irvine, Irvine, CA 92697 1400, USA
    Neurology 72:829-34. 2009
    ..This would predict, even with advanced age, that APOE2 carriers would be less likely to have dementia and less likely to meet pathologic criteria for AD...
  15. pmc High levels of serum C-reactive protein are associated with greater risk of all-cause mortality, but not dementia, in the oldest-old: results from The 90+ Study
    B Adar Kravitz
    Department of Neurobiology and Behavior, University of California at Irvine, Irvine, California, USA
    J Am Geriatr Soc 57:641-6. 2009
    ..To evaluate whether high levels of C-reactive protein (CRP) in serum are associated with greater risk of all-cause dementia or mortality in the oldest-old...
  16. pmc Alzheimer's and dementia in the oldest-old: a century of challenges
    Claudia H Kawas
    Department of Neurology, University of California, Irvine, CA 92697 4540, USA
    Curr Alzheimer Res 3:411-9. 2006
    ....
  17. doi Poor physical performance and dementia in the oldest old: the 90+ study
    Szofia S Bullain
    Department of Neurology, University of California, Irvine, CA 92967, USA
    JAMA Neurol 70:107-13. 2013
    ..To examine the cross-sectional relationship between physical performance and dementia in the oldest old (those ≥ 90 years of age)...
  18. pmc Amyloid imaging and cognitive decline in nondemented oldest-old: the 90+ Study
    Claudia H Kawas
    Department of Neurology, University of California, Irvine, Irvine, CA, USA
    Alzheimers Dement 9:199-203. 2013
    ..The goal of this study was to examine cross-sectional and longitudinal associations between cognitive performance and beta amyloid (Aβ) load determined by florbetapir F18 positron emission tomography (PET) in nondemented oldest-old...
  19. pmc Non-alcoholic beverage and caffeine consumption and mortality: the Leisure World Cohort Study
    Annlia Paganini-Hill
    Department of Preventive Medicine, Keck School of Medicine of the University of Southern California, CA, USA
    Prev Med 44:305-10. 2007
    ..To examine the effects of non-alcoholic beverage and caffeine consumption on all-cause mortality in older adults...
  20. pmc Abnormal EEGs in cognitively and physically healthy oldest old: findings from the 90+ study
    Carrie Brumback Peltz
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California 92697 1400, USA
    J Clin Neurophysiol 27:292-5. 2010
    ..The high rates of EEG abnormalities found in these physically and cognitively healthy participants prompt reappraisal of pathologic significance in this unique population...
  21. pmc The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease
    Guy M McKhann
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Alzheimers Dement 7:263-9. 2011
    ..Much work lies ahead for validating the biomarker diagnosis of AD dementia...
  22. pmc Diagnosing dementia in the oldest-old
    Carrie Brumback-Peltz
    Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, CA 92697 4540, United States
    Maturitas 70:164-8. 2011
    ..More research is necessary in the oldest-old to better understand the etiologies of dementia in this age group, and factors that may affect the expression of disease as we age...
  23. pmc Sensitivity and specificity of the mini-mental state examination for identifying dementia in the oldest-old: the 90+ study
    Kristin Kahle-Wrobleski
    Institute of Brain Aging and Dementia, University of California at Irvine, Irvine, California 92697, USA
    J Am Geriatr Soc 55:284-9. 2007
    ..To evaluate the sensitivity and specificity of the Mini-Mental State Examination (MMSE) in identifying dementia in the oldest-old when stratified by age and education...
  24. ncbi Estrogen replacement therapy, Alzheimer's disease, and mild cognitive impairment
    Ruth A Mulnard
    Departments of Neurology, and Neurobiology and Behavior, University of California Irvine, Gillespie NRF, Room 1113, Irvine, CA 92697 4540, USA
    Curr Neurol Neurosci Rep 4:368-73. 2004
    ..Additional basic and clinical investigations are necessary to examine different forms and dosages of estrogens, other populations, and the relevance of timing and duration of exposure...
  25. pmc DRD4 genotype predicts longevity in mouse and human
    Deborah L Grady
    Department of Biological Chemistry, College of Medicine, University of California, Irvine, California 92697, USA
    J Neurosci 33:286-91. 2013
    ..These results support the hypothesis that DRD4 gene variants contribute to longevity in humans and in mice, and suggest that this effect is mediated by shaping behavioral responses to the environment...
  26. pmc Temporoparietal hypometabolism in frontotemporal lobar degeneration and associated imaging diagnostic errors
    Kyle B Womack
    Department of Neurology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 9129, USA
    Arch Neurol 68:329-37. 2011
    ....
  27. pmc Medications and diet: protective factors for AD?
    Claudia H Kawas
    Department of Neurology, Institute for Brain Aging and Dementia, University of California Irvine, 1121 Gillespie, Irvine, CA 92627 4540, USA
    Alzheimer Dis Assoc Disord 20:S89-96. 2006
    ..At present, there is insufficient evidence to make public health recommendations, but these studies can provide potentially important clues and new avenues for clinical and laboratory research...
  28. pmc Association of body mass index and weight change with all-cause mortality in the elderly
    Maria M Corrada
    Department of Neurology, School of Medicine, University of California, Irvine, 92697 1400, USA
    Am J Epidemiol 163:938-49. 2006
    ..This study highlights the influence on older-age mortality risk of being overweight or obese in young adulthood and underweight or obese in later life...
  29. ncbi Clinical practice. Early Alzheimer's disease
    Claudia H Kawas
    Institute for Brain Aging and Dementia and the Departments of Neurology and Neurobiology and Behavior, University of California, Irvine, CA 92697 4540, USA
    N Engl J Med 349:1056-63. 2003
  30. ncbi Neuronal localization of C1q in preclinical Alzheimer's disease
    Maria I Fonseca
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    Neurobiol Dis 15:40-6. 2004
    ..Thus, it is possible that this neuronal-associated C1q reflects an early, but transient, response to injury that may modulate the progression of neurological dysfunction in AD...
  31. ncbi Informed consent for Alzheimer's disease clinical trials: a survey of clinical investigators
    Jason H T Karlawish
    Internal Ethics Committee of the Alzheimer s Disease Cooperative Study
    IRB 24:1-5. 2002
  32. ncbi Hippocampal neurons in pre-clinical Alzheimer's disease
    Mark J West
    Department of Neurobiology, Institute of Anatomy, Building 234, University Park, Aarhus 8000, Denmark
    Neurobiol Aging 25:1205-12. 2004
    ..However, we did not observe a significant loss of neurons in CA1 or any of the other subdivisions of the hippocampus in preclinical AD...
  33. ncbi Depressive symptoms, sex, and risk for Alzheimer's disease
    Gloria Dal Forno
    Clinical Neurosciences, University Campus BioMedico and Associazione Fatebenefratelli per la Ricerca A Fa R, Via dei Compositori 130 132, 00128 Rome, Italy
    Ann Neurol 57:381-7. 2005
    ..We conclude that the impact of depressive symptoms on risk for dementia and AD may vary with sex. Further studies assessing separately the role of depression as a risk factor in men and women are necessary...
  34. ncbi Survival following dementia onset: Alzheimer's disease and vascular dementia
    Annette L Fitzpatrick
    Department of Epidemiology, University of Washington, Seattle, WA 98115, USA
    J Neurol Sci 229:43-9. 2005
    ..4 years for mixed dementia, and 11.0 years for matched controls with normal cognition. While persons with VaD died primarily from cerebrovascular disease, those with AD/mixed dementia died more frequently from dementia/failure to thrive...
  35. pmc Diet and the risk for Alzheimer's disease
    Claudia H Kawas
    Ann Neurol 59:877-9. 2006
  36. ncbi Immune reactive cells in senile plaques and cognitive decline in Alzheimer's disease
    Anne K Vehmas
    Department of Pathology, Neuropathology Division, The Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 558, Baltimore, MD 21205 2196, USA
    Neurobiol Aging 24:321-31. 2003
    ..Tau immunoreactivity appears as the strongest morphological correlate of dementia...