E C Ebert

Summary

Country: USA

Publications

  1. ncbi request reprint Endogenous inhibitory cytokines repress TNFalpha secretion
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Cell Immunol 237:106-14. 2005
  2. ncbi request reprint Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription
    Ellen C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Cell Immunol 241:7-13. 2006
  3. pmc Activation antigens on colonic T cells in inflammatory bowel disease: effects of IL-10
    E C Ebert
    Crohn s and Colitis Center of New Jersey, NJ, USA
    Clin Exp Immunol 140:157-65. 2005
  4. pmc Interleukin-12 up-regulates perforin- and Fas-mediated lymphokine-activated killer activity by intestinal intraepithelial lymphocytes
    E C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Clin Exp Immunol 138:259-65. 2004
  5. ncbi request reprint Hypoxic liver injury
    Ellen C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Mayo Clin Proc 81:1232-6. 2006
  6. ncbi request reprint Esophageal disease in scleroderma
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    J Clin Gastroenterol 40:769-75. 2006
  7. ncbi request reprint Autoantibodies against human tropomyosin isoform 5 in ulcerative colitis destroys colonic epithelial cells through antibody and complement-mediated lysis
    Ellen C Ebert
    Crohn s and Colitis Center of NJ, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB 478, New Brunswick, NJ 08903, USA
    Cell Immunol 244:43-9. 2006
  8. pmc Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through Fas ligand
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Immunology 124:33-41. 2008
  9. ncbi request reprint Mesenchymal cells stimulate human intestinal intraepithelial lymphocytes
    A I Roberts
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick 08903, USA
    Gastroenterology 113:144-50. 1997
  10. pmc Non-response to infliximab may be due to innate neutralizing anti-tumour necrosis factor-alpha antibodies
    E C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Clin Exp Immunol 154:325-31. 2008

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Endogenous inhibitory cytokines repress TNFalpha secretion
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Cell Immunol 237:106-14. 2005
    ..Keeping TNFalpha levels low is critical to the non-inflammatory steady-state...
  2. ncbi request reprint Human intestinal intraepithelial lymphocytes keep TNF alpha levels low by cell uptake and feedback inhibition of transcription
    Ellen C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Cell Immunol 241:7-13. 2006
    ..Their release of TNFalpha, a cytokine that is toxic to the epithelium, is likely to be tightly regulated. This study documents a novel mechanism to keep TNFalpha levels low with stimuli that cause large fluctuations in IFNgamma release...
  3. pmc Activation antigens on colonic T cells in inflammatory bowel disease: effects of IL-10
    E C Ebert
    Crohn s and Colitis Center of New Jersey, NJ, USA
    Clin Exp Immunol 140:157-65. 2005
    ..In summary, LPLs from active IBD, but not from disease controls, express activation antigens that stimulate naïve T cells, a process that is reduced by IL-10. This may contribute to perpetuation of the inflammation...
  4. pmc Interleukin-12 up-regulates perforin- and Fas-mediated lymphokine-activated killer activity by intestinal intraepithelial lymphocytes
    E C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Clin Exp Immunol 138:259-65. 2004
    ..This study shows that LAK activity, carried out by the CD94(+) IELs, involves perforin, FL and TNF-alpha. IL-12 up-regulates the first two mechanisms of action, showing for the first time its effect on FL production and lytic activity...
  5. ncbi request reprint Hypoxic liver injury
    Ellen C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Mayo Clin Proc 81:1232-6. 2006
    ..Imaging studies reveal hypoechoic or hypodense lesions that resolve completely with reversal of the initiating event. Treatment and prognosis depend on the underlyIng disease...
  6. ncbi request reprint Esophageal disease in scleroderma
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    J Clin Gastroenterol 40:769-75. 2006
    ..This review of the literature highlights many areas of uncertainty in the diagnosis and treatment of esophageal disease in PSS that can be addressed in clinical studies...
  7. ncbi request reprint Autoantibodies against human tropomyosin isoform 5 in ulcerative colitis destroys colonic epithelial cells through antibody and complement-mediated lysis
    Ellen C Ebert
    Crohn s and Colitis Center of NJ, Department of Medicine, UMDNJ Robert Wood Johnson Medical School, 1 Robert Wood Johnson Place, MEB 478, New Brunswick, NJ 08903, USA
    Cell Immunol 244:43-9. 2006
    ..These antibodies may be pathogenic in UC...
  8. pmc Dissection of spontaneous cytotoxicity by human intestinal intraepithelial lymphocytes: MIC on colon cancer triggers NKG2D-mediated lysis through Fas ligand
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Immunology 124:33-41. 2008
    ..This unidirectional FasL-mediated cytotoxicity of IELs against HT-29 cells, triggered through NKG2D, is unique and is likely to be a property of those CD8+ tumour-infiltrating lymphocytes that phenotypically resemble IELs...
  9. ncbi request reprint Mesenchymal cells stimulate human intestinal intraepithelial lymphocytes
    A I Roberts
    Department of Medicine, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick 08903, USA
    Gastroenterology 113:144-50. 1997
    ..CONCLUSIONS: Optimal IEL growth depends on their contact with mesenchymal cells, an interaction that is mediated by VLA-4 and MHC class I. In mucosal immunity, basement membrane myofibroblasts likely serve this role...
  10. pmc Non-response to infliximab may be due to innate neutralizing anti-tumour necrosis factor-alpha antibodies
    E C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Clin Exp Immunol 154:325-31. 2008
    ..Any TNF-alpha-mediated disease process would be neutralized by intrinsic antibodies, so that the disease is likely to be driven by non-TNF-alpha-mediated events...
  11. ncbi request reprint NKG2D receptors induced by IL-15 costimulate CD28-negative effector CTL in the tissue microenvironment
    A I Roberts
    Department of Medicine, University of Medicine and Dentistry of New Jersey, New Brunswick, NJ 08903, USA
    J Immunol 167:5527-30. 2001
    ..Uncontrolled secretion of IL-15 could lead to excessive induction of NKG2D and thus contribute to the development of autoimmune disease by facilitating the activation of autoreactive T cells...
  12. pmc Patients with inflammatory bowel disease may have a transforming growth factor-beta-, interleukin (IL)-2- or IL-10-deficient state induced by intrinsic neutralizing antibodies
    E C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Clin Exp Immunol 155:65-71. 2009
    ..This study shows that about one-third of IBD patients may have a relative deficiency of TGF-beta, IL-2 or IL-10 due to an increase in neutralizing antibodies in their sera...
  13. doi request reprint Antibody to tropomyosin isoform 5 and complement induce the lysis of colonocytes in ulcerative colitis
    Ellen C Ebert
    Department of Medicine and Physiology, Robert Wood Johnson Medical School, University of Medicine and Dentistry of New Jersey, Crohn s and Colitis Center of NJ, New Brunswick, New Jersey 08903, USA
    Am J Gastroenterol 104:2996-3003. 2009
    ..Antibodies against hTM5 are found both in the sera and in the mucosa of patients with ulcerative colitis (UC) but not Crohn's disease (CD). We investigated whether anti-hTM5 autoantibodies are pathogenic...
  14. pmc Spontaneous cytotoxicity of intestinal intraepithelial lymphocytes: clues to the mechanism
    A I Roberts
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick 08903 0019
    Clin Exp Immunol 94:527-32. 1993
    ..Few IEL expressed Fc receptors for IgG. This study describes further differences between the SC activities of IEL and PBL...
  15. pmc Activation of human intraepithelial lymphocytes reduces CD3 expression
    E C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Clin Exp Immunol 132:424-9. 2003
    ..Little apoptosis was found. The partial activation of IELs in response to PHA and CD3 ligation, as manifested by diminished [Ca2+]i, resulted in a decline in CD3 expression...
  16. pmc IL-15 converts human intestinal intraepithelial lymphocytes to CD94 producers of IFN-gamma and IL-10, the latter promoting Fas ligand-mediated cytotoxicity
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Immunology 115:118-26. 2005
    ..This study shows that IL-15 induces the development of CD94(+) IELs containing IFN-gamma and IL-10, and that endogenous IL-10 promotes FL-mediated cytotoxicity...
  17. pmc Integrin alpha1beta1 (VLA-1) mediates adhesion of activated intraepithelial lymphocytes to collagen
    A I Roberts
    Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, NY, USA
    Immunology 97:679-85. 1999
    ..Therefore, IELs bind collagen through integrin alpha1beta1 after protein kinase C activation. Adhesion is modulated by divalent cations...
  18. pmc Interleukin 21 up-regulates perforin-mediated cytotoxic activity of human intra-epithelial lymphocytes
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ, USA
    Immunology 127:206-15. 2009
    ..This functional profile is unique to human IELs, emphasizing that they are a distinct compartment of lymphocytes and that IL-21 may promote their role in tumour immunosurveillance...
  19. doi request reprint Infliximab and the TNF-alpha system
    Ellen C Ebert
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Am J Physiol Gastrointest Liver Physiol 296:G612-20. 2009
    ..In addition, infliximab caused a rise in c-Jun amino-terminal kinase phosphorylation by monocytes. Thus infliximab manipulates the TNF-alpha system to promote its anti-TNF-alpha effects...
  20. doi request reprint Human intestinal intraepithelial lymphocytes and epithelial cells coinduce interleukin-8 production through the CD2-CD58 interaction
    Ellen C Ebert
    University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Am J Physiol Gastrointest Liver Physiol 296:G671-7. 2009
    ..In summary, the synergistic synthesis of IL-8 occurs when IELs are stimulated through the CD2 pathway by CD58 on HT-29 cells, resulting in TNF-alpha release that, in turn, augments IL-8 synthesis and CD58 expression by the HT-29 cells...
  21. pmc IL-10 enhances IL-2-induced proliferation and cytotoxicity by human intestinal lymphocytes
    E C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Clin Exp Immunol 119:426-32. 2000
    ..In conclusion, IL-10 blocking of proinflammatory cytokine secretion probably reduces intestinal inflammation. IL-10 augmentation of IL-2-induced cytotoxicity may help to maintain host defence...
  22. ncbi request reprint Lamina propria lymphocytes produce interferon-gamma and develop suppressor activity in response to lactoglobulin
    E C Ebert
    Department of Medicine, Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA
    Dig Dis Sci 46:661-7. 2001
    ..In summary, LPLs first respond to lactoglobulin by proliferation and IFN-gamma production, then by development of antigen nonspecific suppression...
  23. pmc Massive interleukin-12-induced interferon-gamma production by interleukin-15-stimulated lamina propria lymphocytes followed by down-regulation of the interleukin-12 receptor
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Immunology 124:453-60. 2008
    ..This study demonstrates the early and massive IFN-gamma response of LPL to IL-12 and IL-15, providing the tools to deal with a pathogen. The down-regulation of IL-12 receptors may curtail any excess damaging inflammation...
  24. ncbi request reprint Gastric and enteric involvement in progressive systemic sclerosis
    Ellen C Ebert
    UMDNJ Robert Wood Johnson Medical School, One Robert Wood Johnson Place, New Brunswick, NJ, USA
    J Clin Gastroenterol 42:5-12. 2008
    ..Treatments include biofeedback, sacral nerve stimulation, and surgery. PSS involves the gastrointestinal tract from the mouth to the anus. Studies are needed to define effective treatments in these diseases, which cause great morbidity...
  25. pmc CD2 activation of human lamina propria lymphocytes reduces CD3 responsiveness
    Ellen C Ebert
    Department of Medicine, UMDNJ Robert Wood Johnson Medical School, New Brunswick, NJ 08903, USA
    Immunology 117:71-7. 2006
    ..This study shows that LPLs are constitutively activated through CD2, that they preferentially recognize CD58 on monocytes and that CD2 stimulation leads to CD3 hyporesponsiveness...
  26. ncbi request reprint TCR specificity dictates CD94/NKG2A expression by human CTL
    Bana Jabri
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Immunity 17:487-99. 2002
    ..These findings suggest that TCR antigenic specificity dictates NKG2A commitment, which critically regulates subsequent activation of CTL...
  27. ncbi request reprint Coordinated induction by IL15 of a TCR-independent NKG2D signaling pathway converts CTL into lymphokine-activated killer cells in celiac disease
    Bertrand Meresse
    Department of Pathology, University of Chicago, IL 60637, USA
    Immunity 21:357-66. 2004
    ....