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Genomes and Genes | Aaron VinikSummaryAffiliation: Eastern Virginia Medical School Country: USA Publications
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Publications
The conductor of the autonomic orchestraAaron I Vinik
Department of Medicine, Eastern Virginia Medical School, Strelitz Diabetes and Neuroendocrine Center, Division of Endocrinology and Metabolism Norfolk, VA, USA
Front Endocrinol (Lausanne) 3:71. 2012..Ultimately methods to reset the hypothalamus and the inflammatory cascade are needed if we are to impact the care of patients with this compendium of conditions...- The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndromeAnne Klibanski
Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
Pituitary 13:266-86. 2010..Panel opinions, based on the level of available scientific evidence, were polled. Finally, their views were compared with those of surveyed community-based endocrinologists and neurosurgeons... - Loss of RAGE defense: a cause of Charcot neuroarthropathy?Kara A Witzke
Department of Kinesiology, California State University San Marcos, San Marcos, California, USA
Diabetes Care 34:1617-21. 2011..This study investigated the relationship between circulating soluble receptor for advanced glycation end products (sRAGE) and parameters of bone health in patients with Charcot neuroarthropathy (CNA)... 
Cardiovascular autonomic neuropathy: diagnosis and managementAaron I Vinik
Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
Curr Diab Rep 6:424-30. 2006..Currently, no specific therapeutic strategies can be recommended for cardiac autonomic neuropathy, but management of hyperglycemia and the use of angiotensin-converting enzyme inhibitors and beta blockers should be instituted...- Diabetic neuropathies: clinical manifestations and current treatment optionsAaron Vinik
Strelitz Diabetes Institutes, Norfolk, VA 23510, USA
Nat Clin Pract Endocrinol Metab 2:269-81. 2006..Preventive strategies and patient education still remain key factors in reducing complication rates and mortality... - The role of PPARs in the microvascular dysfunction in diabetesAaron Vinik
Strelitz Diabetes Institute, Eastern Virginia Medical School, Norfolk, VA 23510, United States
Vascul Pharmacol 45:54-64. 2006..In this respect, the combinations of PPARalpha, PPARbeta and PPARgamma may better serve the unique requirements for improving the microvascular defect in diabetes... - Pioglitazone treatment improves nitrosative stress in type 2 diabetesAaron I Vinik
Department of Internal Medicine, The Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, VA 23510, USA
Diabetes Care 29:869-76. 2006..The purpose of this study was to determine the effect of 24 weeks of treatment with 45 mg/day pioglitazone on peripheral skin blood flow (SkBF) and skin nitric oxide (NO) production in vivo in patients with type 2 diabetes... - Diabetic autonomic neuropathyAaron I Vinik
Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk 23510, USA
Diabetes Care 26:1553-79. 2003..Finally, knowledge of early autonomic dysfunction can encourage patient and physician to improve metabolic control and to use therapies such as ACE inhibitors and beta-blockers, proven to be effective for patients with CAN... - The metabolic basis of atherogenic dyslipidemiaAaron I Vinik
The Leonard R Strelitz Diabetes Research Institute, Eastern Virginia Medical School, Norfolk 23510, USA
Clin Cornerstone 7:27-35. 2005..Rimonabant has shown promise in attacking atherogenic dyslipidemia from several vantage points by affecting glucose, HDL-C, triglycerides, and waist circumference in patients who are prone to atherogenic dyslipidemia... - The protein kinase C-beta inhibitor, ruboxistaurin, for the treatment of diabetic microvascular complicationsAaron Vinik
The Strelitz Diabetes Institute, Eastern Virginia Medical School, Norfolk, VA 23510, USA
Expert Opin Investig Drugs 14:1547-59. 2005.... - Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trialAaron I Vinik
Eastern Virginia Medical School, Norfolk, 23510, USA
Clin Ther 27:1164-80. 2005..The aim of this study was to assess the effects of ruboxistaurin (RBX) mesylate on nerve function and sensory symptoms in patients with diabetes mellitus (DM) and diabetic peripheral neuropathy (DPN)... - Antibodies to neuronal structures: innocent bystanders or neurotoxins?Aaron I Vinik
Department of Internal Medicine, The Strelitz Diabetes Institute, Norfolk, VA, USA
Diabetes Care 28:2067-72. 2005 - Diabetic cardiovascular autonomic neuropathyAaron I Vinik
Strelitz Diabetes Research Institute, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
Circulation 115:387-97. 2007 - Adding insulin glargine versus rosiglitazone: health-related quality-of-life impact in type 2 diabetesAaron I Vinik
Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, VA 23510, USA
Diabetes Care 30:795-800. 2007..We sought to assess health-related quality of life (HRQOL) in patients with type 2 diabetes treated with insulin glargine or rosiglitazone as add-on therapy to sulfonylurea plus metformin... - Autonomic imbalance: prophet of doom or scope for hope?A I Vinik
Eastern Virginia Medical School, Strelitz Diabetes Research Center and Neuroendocrine Unit, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
Diabet Med 28:643-51. 2011..In addition, conditions of autonomic imbalance associated with cardiovascular risk are discussed. Potential treatment for restoration of autonomic balance is outlined... 
Measuring the relationship of quality of life and health status, including tumor burden, symptoms, and biochemical measures in patients with neuroendocrine tumorsEtta Vinik
Neuroendocrine Unit, Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
Endocrinol Metab Clin North Am 40:97-109, viii. 2011....- New and emerging syndromes due to neuroendocrine tumorsAaron I Vinik
Eastern Virginia Medical School, Strelitz Diabetes Center, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
Endocrinol Metab Clin North Am 40:19-63, vii. 2011..For these reasons a high index of suspicion is needed, and it is important to understand the pathophysiology of each tumor to decide which biochemical markers are more useful and when they should be used... - The approach to the management of the patient with neuropathic painAaron Vinik
Department of Internal Medicine, Eastern Virginia Medical School, Strelitz Diabetes Center and Neuroendocrine Unit at Norfolk, Norfolk, Virginia 23510, USA
J Clin Endocrinol Metab 95:4802-11. 2010.... - Neuroendocrine tumors: a critical appraisal of management strategiesAaron I Vinik
Research and Neuroendocrine Unit, Eastern Virginia Medical School Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Norfolk, VA 23510, USA
Pancreas 39:801-18. 2010..It will examine the differences in opinions between expert faculty and community physicians... - Biochemical testing for neuroendocrine tumorsAaron I Vinik
Eastern Virginia Medical School, Strelitz Diabetes Research Center, Norfolk, VA 23510, USA
Pancreas 38:876-89. 2009..There is also a specific description of the properties of the most important biochemical markers and 2 complications, bone metastasis and carcinoid heart disease, from the biochemical point of view... - Diabetic neuropathy in older adultsAaron I Vinik
Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
Clin Geriatr Med 24:407-35, v. 2008..Ultimately agents that address large fiber dysfunction will be essential to reduce the gross impairment of quality of life and activities of daily living that neuropathy visits older people who have diabetes... - Advancing therapy in type 2 diabetes mellitus with early, comprehensive progression from oral agents to insulin therapyAaron Vinik
Strelitz Diabetes Research Institute, Eastern Virginia Medical School, Norfolk, Virginia, USA
Clin Ther 29:1236-53. 2007..Patients at different stages of disease may benefit from the early introduction of intensive glycemic control... - Advancing therapy in type 2 diabetes mellitus with early, comprehensive progression from oral agents to insulin therapyAaron Vinik
Strefitz Diabetes Research Institute, Eastern Virginia Medical School, Norfolk, Virginia, USA
Clin Ther 29:1236-53. 2007..Patients at different stages of disease may benefit from the early introduction of intensive glycemic control... - Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled studiesAaron I Vinik
Diabetes Institute, Eastern Virginia Medical School, 855 West Bramdleton, Norfolk, VA 23510, USA
Pain 128:169-79. 2007..Compared with placebo, lamotrigine (300 and 400 mg daily) was inconsistently effective for pain associated with diabetic neuropathy but was generally safe and well tolerated... - Rosiglitazone treatment increases nitric oxide production in human peripheral skin: a controlled clinical trial in patients with type 2 diabetes mellitusAaron I Vinik
The Leonard R Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, VA 23529, USA
J Diabetes Complications 17:279-85. 2003..This provides further evidence for the beneficial effects of rosiglitazone on nontraditional cardiovascular risk factors associated with T2DM... - Methods for evaluation of peripheral neurovascular dysfunctionA I Vinik
The Leonard Strelitz Diabetes Research Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk 23510, USA
Diabetes Technol Ther 3:29-50. 2001..A combination of microdialysis and iontophoresis techniques can be useful in assessment of the pharmacokinetics of polar and nonpolar agents and the physiology and pathophysiology of the skin neurovascular system... - Platelet dysfunction in type 2 diabetesA I Vinik
Department of Medicine and Pathology Anatomy Neurobiology, the Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, Virginia, USA
Diabetes Care 24:1476-85. 2001..Thus, the defects in insulin action in diabetes create a milieu of disordered platelet activity conducive to macrovascular and microvascular events... - Management of neuropathy and foot problems in diabetic patientsAaron I Vinik
Strelitz Diabetes Institutes, Departments of Internal Medicine and Pathology Neurobiology, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
Clin Cornerstone 5:38-55. 2003..Patient education and preventive strategies, however, are still the best ways to treat the complications of neuropathy and reduce the amputation rate... - Focal entrapment neuropathies in diabetesAaron Vinik
The Diabetes Institute, Eastern Virginia Medical School, Norfolk, VA 23510, USA
Diabetes Care 27:1783-8. 2004 - Diabetic neuropathiesA I Vinik
Department of Internal Medicine, The Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
Med Clin North Am 88:947-99, xi. 2004..The ability to manage successfully the many different manifestations of diabetic neuropathy depends ultimately on success in uncovering the pathogenic processes underlying this disorder... - A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathyCarolina M Casellini
Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, Virginia, USA
Diabetes Care 30:896-902. 2007..We investigate the effects of the isoform-selective PKC-beta inhibitor ruboxistaurin mesylate on neurovascular function and other measures of DPN... - Quality of life and objective measures of diabetic neuropathy in a prospective placebo-controlled trial of ruboxistaurin and topiramateAmanda Boyd
Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, USA
J Diabetes Sci Technol 5:714-22. 2011..We aimed to determine if the Norfolk QOL-DN could be used to capture changes in QOL that correlate with nerve fiber-specific objective measures in a placebo-controlled trial of two agents that affect different nerve fibers... - The Reg family member INGAP is a marker of endocrine patterning in the embryonic pancreasNatasha S Hamblet
Department of Internal Medicine, The Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, VA 23510, USA
Pancreas 36:1-9. 2008..Adult islet neogenesis is believed to recapitulate elements of pancreatic endocrine development. Identifying factors that regulate islet neogenesis-associated protein (INGAP) gene activity could provide links to pancreas development... - Change in cutaneous perfusion following 10 weeks of aerobic training in Type 2 diabetesSheri R Colberg
Old Dominion University, Norfolk, VA 23529, USA
J Diabetes Complications 19:276-83. 2005..Thus, moderate aerobic training for only 10 weeks does not appear to reverse the impairment in cutaneous perfusion of the foot dorsum in response local heating in a Type 2 diabetic population... - The effect of an aerobic exercise training program on quality of life in type 2 diabetesD Robb Holton
Department of Exercise Science, Sport, Physical Education, and Recreation, Old Dominion University, Norfolk, Virginia 23529, USA
Diabetes Educ 29:837-46. 2003..In addition, neither training nor the presence of type 2 diabetes significantly affected the physical or mental component scores on the QOL survey... - Pdx-1 regulation of the INGAP promoter involves sequestration of NeuroD into a non-DNA-binding complexDavid A Taylor-Fishwick
Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
Pancreas 39:64-70. 2010..Islet neogenesis-associated protein (INGAP) can enhance beta-cell mass to offset progression of diabetes. Identifying how transcription factors regulate INGAP gene expression could reveal key checkpoints governing islet neogenesis... - Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocinDavid A Taylor-Fishwick
Department of Internal Medicine, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, 23510 Virginia, USA
J Endocrinol 190:729-37. 2006..The INGAP transgenic mouse provides a new model to uncover factors that are protective to diabetes onset and biomarkers to track beta-cell pathology... - Effect of a single bout of prior moderate exercise on cutaneous perfusion in type 2 diabetesSheri R Colberg
ESPER Department, Old Dominion University, Norfolk, VA 23529, USA
Diabetes Care 29:2316-8. 2006 - Update: metabolic and cardiovascular consequences of bariatric surgeryDonald W Richardson
Department of Medicine, L R Strelitz Diabetes Center for Endocrinology and Metabolism, L R Strelitz Diabetes Research Institute, Eastern Virginia Medical School, 855 West Brambleton Boulevard, Norfolk, VA 23510, USA
Endocrinol Metab Clin North Am 40:81-96, viii. 2011..Data suggest that some of these patients may be better served by bariatric surgery... - Cloning genomic INGAP: a Reg-related family member with distinct transcriptional regulation sitesDavid A Taylor-Fishwick
Department of Medicine, The Leonard Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
Biochim Biophys Acta 1638:83-9. 2003..Comparison of transcription factor binding sites in INGAP to the related gene RegIIIdelta exposes potential sites for differential gene regulation... - Intramuscular injection of islet neogenesis-associated protein peptide stimulates pancreatic islet neogenesis in healthy dogsGary L Pittenger
Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23510, USA
Pancreas 34:103-11. 2007..Islet neogenesis- associated protein (INGAP) stimulates islet neogenesis; therefore, we hypothesized that it would stimulate islet neogenesis in dogs... - Cutaneous blood flow in type 2 diabetic individuals after an acute bout of maximal exerciseSheri R Colberg
ESPER Department, Old Dominion University, Norfolk, Virginia 23529, USA
Diabetes Care 26:1883-8. 2003..Thus, we hypothesized that a prior acute bout of maximal exercise would also have positive effects on postexercise blood flow... - Chronic exercise is associated with enhanced cutaneous blood flow in type 2 diabetesSheri R Colberg
Department of Exercise Science, Physical Education, and Recreation (ESPER, Old Dominion University, Norfolk, VA 23529, USA
J Diabetes Complications 16:139-45. 2002..As such, regular physical activity may be an invaluable tool in the prevention and reversal of defective skin vasodilation and resultant foot ulcers so common in diabetes... - PDX-1 can repress stimulus-induced activation of the INGAP promoterDavid A Taylor-Fishwick
Department of Medicine, Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
J Endocrinol 188:611-21. 2006..These findings implicate PDX-1 in a possible feedback loop to block unbridled islet expansion... - Pancreatic islet immunoreactivity to the Reg protein INGAPDavid A Taylor-Fishwick
Department of Medicine, Eastern Virginia Medical School, 855 W Brambleton Ave, Norfolk, VA, USA
J Histochem Cytochem 56:183-91. 2008..These findings reveal that INGAP and/or related group 3 Reg proteins have a conserved expression in the pancreatic islet... - The role of islet neogeneis-associated protein (INGAP) in pancreatic islet neogenesisGary L Pittenger
The Strelitz Diabetes Center, Department of Internal Medicine, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
Curr Protein Pept Sci 10:37-45. 2009..The peptide has been tested in human clinical trials, with success being reported. The evidence points to INGAP as a major factor in stimulating islet neogenesis, and, therefore, may play a significant therapeutic role in diabetes... - Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastasesMatthew E Bourcier
Strelitz Diabetes Center and Neuroendocrine Unit, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
J Clin Endocrinol Metab 94:3157-62. 2009..A continuous infusion of octreotide lowered the blood glucose levels further. He required diazoxide, a thiazide diuretic, phenytoin, and a constant infusion of glucose to control the hypoglycemia and elevated insulin levels... - Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patientsGary L Pittenger
Department of Internal Medicine, The Strelitz Diabetes Institutes, Norfolk, Virginia 23510, USA
Diabetes Care 27:1974-9. 2004..Small-fiber neuropathies may be symptomatic yet escape detection by standard tests. We hypothesized that morphologic changes in intraepidermal nerves would correlate with clinical measures of small-fiber neuropathy... - Diagnosis and management of diabetic autonomic neuropathyAaron I Vinik
Strelitz Diabetes Research Institutes, Departments of Internal Medicine and Anatomy/Neurobiology, Eastern Virginia Medical School, Norfolk, VA, USA
Compr Ther 29:130-45. 2003..The diagnosis confers an attenuated life expectancy, but much can be done to alleviate symptoms and to address the underlying disorder... - Sural sensory action potential identifies diabetic peripheral neuropathy responders to therapyAaron I Vinik
Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, 23510, USA
Muscle Nerve 32:619-25. 2005..004; OR = 0.896). For patients with abnormal VDT, preserved sural SNAP identifies a patient population with less severe DPN who may respond to therapeutic intervention in clinical trials... - Metabolic implications of obesity: before and after gastric bypassDonald W Richardson
L R Strelitz Diabetes Institute, Eastern Virginia Medical School, 855 West Brambleton Boulevard, Norfolk, VA 23510, USA
Gastroenterol Clin North Am 34:9-24. 2005..This article evaluates the metabolic consequences of obesity and highlights which of these are amenable to correction with weight reduction achieved by gastric bypass... - Development of the Norfolk quality of life tool for assessing patients with neuroendocrine tumorsEtta Vinik
Department of Medicine, Strelitz Diabetes Research Center and Neuroendocrine Unit, Eastern Virginia Medical School, Norfolk 23510, VA, USA
Pancreas 38:e87-95. 2009..To develop a disease-specific questionnaire for identifying domains having the greatest impact on the quality of life (QOL) of patients with neuroendocrine tumors (NETS)... - Clinical case seminar: hypoglycemia after pancreas transplantation: association with allograft nesidiodysplasia and expression of islet neogenesis-associated peptideCrispin Semakula
Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Clin Endocrinol Metab 87:3548-54. 2002..Reported cases of adult nesidioblastosis are reviewed. The significance of nesidioblastosis in the context of pancreas transplantation and possible mechanisms of posttransplant hypoglycemia are discussed... - Exercise status affects skin perfusion via prostaglandin, nitric oxide, and EDHF pathways in diabetesSheri R Colberg
ESPER Department, Old Dominion University, Norfolk, VA 23529, USA
Microvasc Res 77:120-4. 2009..These results suggest that regular exercise may exhibit the greatest effect on the normal functioning of these vasodilatory pathways, although diabetes and a sedentary state together may somewhat alter their relative importance... - Effect of an 8-week resistance training program on cutaneous perfusion in type 2 diabetesSheri R Colberg
ESPER Department, Old Dominion University, Norfolk, VA 23529, USA
Microvasc Res 71:121-7. 2006.... - Autonomic function in sleep apnea patients: increased heart rate variability except during REM sleep in obese patientsErica B Reynolds
Eastern Virginia Medical School, Sentara Norfolk General Hospital, Norfolk, USA
Sleep Breath 11:53-60. 2007..The decrease in HRV during REM sleep in the obese apnea patients suggests the possibility of an autonomic dysfunction in this subgroup... - Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathySheri R Colberg
Old Dominion University, Norfolk, Virginia 23529, USA
Diabetes Care 26:986-90. 2003.... - Metabolic complications of bariatric surgery: diagnosis and management issuesM Elizabeth Mason
Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
Gastroenterol Clin North Am 34:25-33. 2005..Neuropathy, acute Wemicke's encephalopathy and vitamin A deficiency also occur. Prevention, diagnosis,and treatment of these disorders are necessary parts of lifelong care after bariatric surgery... - Nerve growth factor and diabetic neuropathyGary Pittenger
The Leonard Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Exp Diabesity Res 4:271-85. 2003..It seems reasonable to anticipate that neurotrophic factor therapy, specifically targeted at different nerve fiber populations, might enter the therapeutic armamentarium... - Etiology and treatment of erectile failure in diabetes mellitusDonald Richardson
Leonard R Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
Curr Diab Rep 2:501-9. 2002.... - Diabetes and macrovascular diseaseAaron Vinik
Virginia Medical School and the Leonard R. Strelitz Diabetes Institutes, 855 West Brambleton Avenue Eastern, Norfolk, VA 23510, USA
J Diabetes Complications 16:235-45. 2002..If this is done, this emerging epidemic of macrovascular disease will be contained... - CLINICAL REVIEW: Use of antiepileptic drugs in the treatment of chronic painful diabetic neuropathyAaron Vinik
Diabetes Research Institute, 855 West Brambleton Avenue, Norfolk, Virginia 23510, USA
J Clin Endocrinol Metab 90:4936-45. 2005..Decreased physical activity, increased fatigue, and mood and sleep problems may result... - The development and validation of the Norfolk QOL-DN, a new measure of patients' perception of the effects of diabetes and diabetic neuropathyEtta J Vinik
Leonard R. Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
Diabetes Technol Ther 7:497-508. 2005..05) higher than either of the two control groups (i.e., greater impairment). The positive scores for the DC group in the ADL and autonomic domains suggest that diabetes per se impacts these aspects of QOL... - Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behaviorThomas M O'Dorisio
Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
Pancreas 39:611-6. 2010..Existing pancreastatin assays, which depend on antibodies that cross-react in varying percents with the larger prohormone, may lack sensitivity and specificity to detect small changes in neuroendocrine tumor volume... - Diabetic peripheral neuropathy: how reliable is a homemade 1-g monofilament for screening?Matthew E Bourcier
Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
J Fam Pract 55:505-8. 2006 - Diabetic autonomic neuropathyAaron I Vinik
Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Semin Neurol 23:365-72. 2003..There are studies in progress that suggest that autonomic nerves can be induced to regenerate, and the future for patients with diabetic autonomic neuropathy is brighter... - Diabetic neuropathy in older adultsKara A Witzke
Department of Health, Physical Education, and Exercise Science, Norfolk State University, 700 Park Ave, Norfolk, VA 23504, USA
Rev Endocr Metab Disord 6:117-27. 2005 - Diabetic nerve conduction abnormalities in the primary care settingAaron I Vinik
The Leonard Strelitz Diabetes Research Institutes, Departments of Internal Medicine and Pathology/Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia, USA
Diabetes Technol Ther 8:654-62. 2006..These findings have important implications for the clinical and epidemiological evaluation of DPN... - Neuropathy: new concepts in evaluation and treatmentAaron I Vinik
Strelitz Diabetes Research Institute, Eastern Virginia Medical School, Norfolk 23510, USA
South Med J 95:21-3. 2002 - Median and ulnar nerve conduction measurements in patients with symptoms of diabetic peripheral neuropathy using the NC-stat systemAaron I Vinik
The Leonard Strelitz Diabetes Research Institutes, Departments of Internal Medicine and Pathology/Anatomy/Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia, USA
Diabetes Technol Ther 6:816-24. 2004..The widespread availability of the NC-stat system may provide a robust and objective method for identifying DPN and other neuropathies in patients with diabetes... - Reversal of phrenic nerve palsy with topiramateAmanda L Rice
Department of Internal Medicine, Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, VA 23510, USA
J Diabetes Complications 21:63-7. 2007..Topiramate may prove to be an effective agent in the treatment of nonremitting diaphragmatic paralysis and regrowth of intraepidermal nerve fibers... - Prevention of the complications of diabetesAaron I Vinik
Diabetes Research Institute, Eastern Virginia Medical School, Norfolk, USA
Am J Manag Care 9:S63-80; quiz S81-4. 2003.... - Advances in diabetes for the millennium: new treatments for diabetic neuropathiesAaron I Vinik
The Leonard Strelitz Diabetes Institute, Norfolk, Virginia, USA
MedGenMed 6:13. 2004..If attention is directed toward a pathogenetic approach, much can be done to alleviate the symptoms, alleviate the mitigation of quality of life, and now it would seem to address the underlying biological disturbance... - Clinical manifestations and current treatment options for diabetic neuropathiesCarolina M Casellini
The Leonard Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
Endocr Pract 13:550-66. 2007..To review the clinical manifestations and current treatment options for diabetic neuropathies, one of the most common complications of diabetes mellitus... - Effects of 8 weeks of flexibility and resistance training in older adults with type 2 diabetesMatthew T Herriott
ESPER Department, Old Dominion University, Norfolk, VA 23529, USA
Diabetes Care 27:2988-9. 2004 - Advances in diabetes for the millennium: toward a cure for diabetesAaron I Vinik
The Leonard Strelitz Diabetes Institute, Norfolk, Virginia, USA
MedGenMed 6:12. 2004.... - A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J miceLawrence Rosenberg
Department of Surgery, McGill University, Montreal, Quebec, Canada
Ann Surg 240:875-84. 2004.... - Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administrationBrian F Johnson
Pfizer Research, Groton, Connecticut, USA
Diabetes Care 27:448-54. 2004..There was no change in resting diastolic filling rates in either group. CONCLUSIONS: Diabetic patients with neuropathy have LV abnormalities that can be stabilized and partially reversed by ARI treatment... - The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysisRaelene E Maser
Department of Medical Technology, University of Delaware, Newark, Delaware 19716, USA
Diabetes Care 26:1895-901. 2003..To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes... - Safety and effectiveness of topiramate for the management of painful diabetic peripheral neuropathy in an open-label extension studyPeter D Donofrio
Department of Neurology, Wake Forest University School of Medicine, Winston Salem, NC 21757, USA
Clin Ther 27:1420-31. 2005..The aim of this study was to further assess the long-term safety and effectiveness of open-label topiramate therapy in subjects with moderately to severely painful diabetic peripheral neuropathy (DPN)... - Diabetes-related complications, glycemic control, and falls in older adultsAnn V Schwartz
Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107 1762, USA
Diabetes Care 31:391-6. 2008..We determined whether diabetes-related complications or treatments are associated with risk of falls in older diabetic adults... - Pathophysiology and treatment of diabetic peripheral neuropathy: the case for diabetic neurovascular function as an essential componentKeri A Kles
Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
Curr Diabetes Rev 2:131-45. 2006.... - Diabetes, peripheral neuropathy, and old age disabilityHelaine E Resnick
MedStar Research Institute, 108 Irving Street NW, Annex 5, Washington, DC 20010, USA
Muscle Nerve 25:43-50. 2002..Interventions aimed at reducing the impact of diabetes-associated disability in old age may have the greatest impact among people with peripheral neuropathy... - Validation of serum versus plasma measurements of chromogranin a levels in patients with carcinoid tumors: lack of correlation between absolute chromogranin a levels and symptom frequencyEugene A Woltering
Section of Surgical Endocrinology, Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
Pancreas 33:250-4. 2006.... - The relationship of reduced peripheral nerve function and diabetes with physical performance in older white and black adults: the Health, Aging, and Body Composition (Health ABC) studyElsa S Strotmeyer
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Diabetes Care 31:1767-72. 2008..Poor peripheral nerve function is prevalent in diabetes and older populations, and it has great potential to contribute to poor physical performance...