Aaron Vinik

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. pmc A 70-year-old male with peripheral neuropathy, ataxia and antigliadin antibodies shows improvement in neuropathy, but not ataxia, after intravenous immunoglobulin and gluten-free diet
    Dharshan Anandacoomaraswamy
    Department of Internal Medicine, Coney Island Hospital, Brooklyn, NY, USA
    J Multidiscip Healthc 1:93-6. 2008
  2. pmc Guidelines in the management of diabetic nerve pain: clinical utility of pregabalin
    Aaron I Vinik
    Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA, USA
    Diabetes Metab Syndr Obes 6:57-78. 2013
  3. pmc Cardiac autonomic imbalance in newly diagnosed and established diabetes is associated with markers of adipose tissue inflammation
    DAVID C LIEB
    Division of Endocrinology and Metabolism, Department of Medicine, Eastern Virginia Medical School, Strelitz Diabetes Center for Endocrine and Metabolic Disorders, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Exp Diabetes Res 2012:878760. 2012
  4. ncbi request reprint Diabetic neuropathy
    Aaron I Vinik
    Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA Electronic address
    Endocrinol Metab Clin North Am 42:747-87. 2013
  5. doi request reprint Diabetic autonomic neuropathy
    Aaron I Vinik
    Eastern Virginia Medical School, Strelitz Diabetes Center, Division of Endocrinology and Metabolism, Eastern Virginia Medical School, Norfolk, VA, USA Electronic address
    Handb Clin Neurol 117:279-94. 2013
  6. doi request reprint Neurovascular function and sudorimetry in health and disease
    Aaron I Vinik
    Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA 23510, USA
    Curr Diab Rep 13:517-32. 2013
  7. doi request reprint Relationship between pain relief and improvements in patient function/quality of life in patients with painful diabetic peripheral neuropathy or postherpetic neuralgia treated with pregabalin
    Aaron Vinik
    Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Clin Ther 35:612-23. 2013
  8. pmc The conductor of the autonomic orchestra
    Aaron I Vinik
    Department of Medicine, Eastern Virginia Medical School, Strelitz Diabetes and Neuroendocrine Center, Division of Endocrinology and Metabolism Norfolk, VA, USA
    Front Endocrinol (Lausanne) 3:71. 2012
  9. pmc The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome
    Anne Klibanski
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Pituitary 13:266-86. 2010
  10. ncbi request reprint Cardiovascular autonomic neuropathy: diagnosis and management
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Curr Diab Rep 6:424-30. 2006

Detail Information

Publications98

  1. pmc A 70-year-old male with peripheral neuropathy, ataxia and antigliadin antibodies shows improvement in neuropathy, but not ataxia, after intravenous immunoglobulin and gluten-free diet
    Dharshan Anandacoomaraswamy
    Department of Internal Medicine, Coney Island Hospital, Brooklyn, NY, USA
    J Multidiscip Healthc 1:93-6. 2008
    ..This case illustrates the need to test for celiac disease in patients with idiopathic ataxia and peripheral neuropathy and the need for alternative therapies for ataxia...
  2. pmc Guidelines in the management of diabetic nerve pain: clinical utility of pregabalin
    Aaron I Vinik
    Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA, USA
    Diabetes Metab Syndr Obes 6:57-78. 2013
    ..Thus, this review attempts to give a more balanced view of the management of pain in the diabetic patient with neuropathy and in particular the role of pregabalin...
  3. pmc Cardiac autonomic imbalance in newly diagnosed and established diabetes is associated with markers of adipose tissue inflammation
    DAVID C LIEB
    Division of Endocrinology and Metabolism, Department of Medicine, Eastern Virginia Medical School, Strelitz Diabetes Center for Endocrine and Metabolic Disorders, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Exp Diabetes Res 2012:878760. 2012
    ..Cardiac autonomic imbalance predicts increased cardiovascular risk and mortality. We studied the relationship between cardiac autonomic imbalance and adipose tissue-derived inflammation in newly diagnosed and established type 2 diabetes...
  4. ncbi request reprint Diabetic neuropathy
    Aaron I Vinik
    Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA Electronic address
    Endocrinol Metab Clin North Am 42:747-87. 2013
    ..A review of the clinical assessment and treatment algorithms for diabetic neuropathy, painful neuropathy, and autonomic dysfunction is provided. ..
  5. doi request reprint Diabetic autonomic neuropathy
    Aaron I Vinik
    Eastern Virginia Medical School, Strelitz Diabetes Center, Division of Endocrinology and Metabolism, Eastern Virginia Medical School, Norfolk, VA, USA Electronic address
    Handb Clin Neurol 117:279-94. 2013
    ..Restoration of dopaminergic tone suppresses the sympathetic dominance and reduces cardiovascular events and mortality by close to 50%. Cinderella's slipper can now be worn! ..
  6. doi request reprint Neurovascular function and sudorimetry in health and disease
    Aaron I Vinik
    Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Eastern Virginia Medical School, Norfolk, VA 23510, USA
    Curr Diab Rep 13:517-32. 2013
    ....
  7. doi request reprint Relationship between pain relief and improvements in patient function/quality of life in patients with painful diabetic peripheral neuropathy or postherpetic neuralgia treated with pregabalin
    Aaron Vinik
    Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Clin Ther 35:612-23. 2013
    ..It is unclear, for example, whether pregabalin has a direct independent effect on patient function/QoL or whether improvements in function/QoL are an indirect consequent of pain relief...
  8. pmc The conductor of the autonomic orchestra
    Aaron I Vinik
    Department of Medicine, Eastern Virginia Medical School, Strelitz Diabetes and Neuroendocrine Center, Division of Endocrinology and Metabolism Norfolk, VA, USA
    Front Endocrinol (Lausanne) 3:71. 2012
    ..Ultimately methods to reset the hypothalamus and the inflammatory cascade are needed if we are to impact the care of patients with this compendium of conditions...
  9. pmc The endocrine tumor summit 2008: appraising therapeutic approaches for acromegaly and carcinoid syndrome
    Anne Klibanski
    Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA
    Pituitary 13:266-86. 2010
    ..Panel opinions, based on the level of available scientific evidence, were polled. Finally, their views were compared with those of surveyed community-based endocrinologists and neurosurgeons...
  10. ncbi request reprint Cardiovascular autonomic neuropathy: diagnosis and management
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Curr Diab Rep 6:424-30. 2006
    ..Currently, no specific therapeutic strategies can be recommended for cardiac autonomic neuropathy, but management of hyperglycemia and the use of angiotensin-converting enzyme inhibitors and beta blockers should be instituted...
  11. ncbi request reprint Advancing therapy in type 2 diabetes mellitus with early, comprehensive progression from oral agents to insulin therapy
    Aaron Vinik
    Strefitz Diabetes Research Institute, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Clin Ther 29:1236-53. 2007
    ..Patients at different stages of disease may benefit from the early introduction of intensive glycemic control...
  12. ncbi request reprint Diabetic neuropathies: clinical manifestations and current treatment options
    Aaron Vinik
    Strelitz Diabetes Institutes, Norfolk, VA 23510, USA
    Nat Clin Pract Endocrinol Metab 2:269-81. 2006
    ..Preventive strategies and patient education still remain key factors in reducing complication rates and mortality...
  13. ncbi request reprint The role of PPARs in the microvascular dysfunction in diabetes
    Aaron Vinik
    Strelitz Diabetes Institute, Eastern Virginia Medical School, Norfolk, VA 23510, United States
    Vascul Pharmacol 45:54-64. 2006
    ..In this respect, the combinations of PPARalpha, PPARbeta and PPARgamma may better serve the unique requirements for improving the microvascular defect in diabetes...
  14. ncbi request reprint Pioglitazone treatment improves nitrosative stress in type 2 diabetes
    Aaron I Vinik
    Department of Internal Medicine, The Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, VA 23510, USA
    Diabetes Care 29:869-76. 2006
    ..The purpose of this study was to determine the effect of 24 weeks of treatment with 45 mg/day pioglitazone on peripheral skin blood flow (SkBF) and skin nitric oxide (NO) production in vivo in patients with type 2 diabetes...
  15. ncbi request reprint The metabolic basis of atherogenic dyslipidemia
    Aaron I Vinik
    The Leonard R Strelitz Diabetes Research Institute, Eastern Virginia Medical School, Norfolk 23510, USA
    Clin Cornerstone 7:27-35. 2005
    ..Rimonabant has shown promise in attacking atherogenic dyslipidemia from several vantage points by affecting glucose, HDL-C, triglycerides, and waist circumference in patients who are prone to atherogenic dyslipidemia...
  16. ncbi request reprint The protein kinase C-beta inhibitor, ruboxistaurin, for the treatment of diabetic microvascular complications
    Aaron Vinik
    The Strelitz Diabetes Institute, Eastern Virginia Medical School, Norfolk, VA 23510, USA
    Expert Opin Investig Drugs 14:1547-59. 2005
    ....
  17. ncbi request reprint Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C beta-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial
    Aaron I Vinik
    Eastern Virginia Medical School, Norfolk, 23510, USA
    Clin Ther 27:1164-80. 2005
    ..The aim of this study was to assess the effects of ruboxistaurin (RBX) mesylate on nerve function and sensory symptoms in patients with diabetes mellitus (DM) and diabetic peripheral neuropathy (DPN)...
  18. ncbi request reprint Lamotrigine for treatment of pain associated with diabetic neuropathy: results of two randomized, double-blind, placebo-controlled studies
    Aaron I Vinik
    Diabetes Institute, Eastern Virginia Medical School, 855 West Bramdleton, Norfolk, VA 23510, USA
    Pain 128:169-79. 2007
    ..Compared with placebo, lamotrigine (300 and 400 mg daily) was inconsistently effective for pain associated with diabetic neuropathy but was generally safe and well tolerated...
  19. ncbi request reprint Diabetic cardiovascular autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institute, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Circulation 115:387-97. 2007
  20. ncbi request reprint Adding insulin glargine versus rosiglitazone: health-related quality-of-life impact in type 2 diabetes
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, VA 23510, USA
    Diabetes Care 30:795-800. 2007
    ..We sought to assess health-related quality of life (HRQOL) in patients with type 2 diabetes treated with insulin glargine or rosiglitazone as add-on therapy to sulfonylurea plus metformin...
  21. pmc Autonomic imbalance: prophet of doom or scope for hope?
    A I Vinik
    Eastern Virginia Medical School, Strelitz Diabetes Research Center and Neuroendocrine Unit, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Diabet Med 28:643-51. 2011
    ..In addition, conditions of autonomic imbalance associated with cardiovascular risk are discussed. Potential treatment for restoration of autonomic balance is outlined...
  22. doi request reprint Measuring the relationship of quality of life and health status, including tumor burden, symptoms, and biochemical measures in patients with neuroendocrine tumors
    Etta Vinik
    Neuroendocrine Unit, Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Endocrinol Metab Clin North Am 40:97-109, viii. 2011
    ....
  23. doi request reprint New and emerging syndromes due to neuroendocrine tumors
    Aaron I Vinik
    Eastern Virginia Medical School, Strelitz Diabetes Center, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Endocrinol Metab Clin North Am 40:19-63, vii. 2011
    ..For these reasons a high index of suspicion is needed, and it is important to understand the pathophysiology of each tumor to decide which biochemical markers are more useful and when they should be used...
  24. doi request reprint The approach to the management of the patient with neuropathic pain
    Aaron Vinik
    Department of Internal Medicine, Eastern Virginia Medical School, Strelitz Diabetes Center and Neuroendocrine Unit at Norfolk, Norfolk, Virginia 23510, USA
    J Clin Endocrinol Metab 95:4802-11. 2010
    ....
  25. ncbi request reprint Neuroendocrine tumors: a critical appraisal of management strategies
    Aaron I Vinik
    Research and Neuroendocrine Unit, Eastern Virginia Medical School Strelitz Diabetes Center for Endocrine and Metabolic Disorders, Norfolk, VA 23510, USA
    Pancreas 39:801-18. 2010
    ..It will examine the differences in opinions between expert faculty and community physicians...
  26. doi request reprint Biochemical testing for neuroendocrine tumors
    Aaron I Vinik
    Eastern Virginia Medical School, Strelitz Diabetes Research Center, Norfolk, VA 23510, USA
    Pancreas 38:876-89. 2009
    ..There is also a specific description of the properties of the most important biochemical markers and 2 complications, bone metastasis and carcinoid heart disease, from the biochemical point of view...
  27. pmc Diabetic neuropathy in older adults
    Aaron I Vinik
    Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Clin Geriatr Med 24:407-35, v. 2008
    ..Ultimately agents that address large fiber dysfunction will be essential to reduce the gross impairment of quality of life and activities of daily living that neuropathy visits older people who have diabetes...
  28. ncbi request reprint Advancing therapy in type 2 diabetes mellitus with early, comprehensive progression from oral agents to insulin therapy
    Aaron Vinik
    Strelitz Diabetes Research Institute, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Clin Ther 29:1236-53. 2007
    ..Patients at different stages of disease may benefit from the early introduction of intensive glycemic control...
  29. ncbi request reprint Antibodies to neuronal structures: innocent bystanders or neurotoxins?
    Aaron I Vinik
    Department of Internal Medicine, The Strelitz Diabetes Institute, Norfolk, VA, USA
    Diabetes Care 28:2067-72. 2005
  30. pmc Loss of RAGE defense: a cause of Charcot neuroarthropathy?
    Kara A Witzke
    Department of Kinesiology, California State University San Marcos, San Marcos, California, USA
    Diabetes Care 34:1617-21. 2011
    ..This study investigated the relationship between circulating soluble receptor for advanced glycation end products (sRAGE) and parameters of bone health in patients with Charcot neuroarthropathy (CNA)...
  31. ncbi request reprint Diabetic neuropathies
    A I Vinik
    Department of Internal Medicine, The Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Med Clin North Am 88:947-99, xi. 2004
    ..The ability to manage successfully the many different manifestations of diabetic neuropathy depends ultimately on success in uncovering the pathogenic processes underlying this disorder...
  32. ncbi request reprint Diabetic autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk 23510, USA
    Diabetes Care 26:1553-79. 2003
    ..Finally, knowledge of early autonomic dysfunction can encourage patient and physician to improve metabolic control and to use therapies such as ACE inhibitors and beta-blockers, proven to be effective for patients with CAN...
  33. ncbi request reprint Focal entrapment neuropathies in diabetes
    Aaron Vinik
    The Diabetes Institute, Eastern Virginia Medical School, Norfolk, VA 23510, USA
    Diabetes Care 27:1783-8. 2004
  34. ncbi request reprint Management of neuropathy and foot problems in diabetic patients
    Aaron I Vinik
    Strelitz Diabetes Institutes, Departments of Internal Medicine and Pathology Neurobiology, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Clin Cornerstone 5:38-55. 2003
    ..Patient education and preventive strategies, however, are still the best ways to treat the complications of neuropathy and reduce the amputation rate...
  35. ncbi request reprint Rosiglitazone treatment increases nitric oxide production in human peripheral skin: a controlled clinical trial in patients with type 2 diabetes mellitus
    Aaron I Vinik
    The Leonard R Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, VA 23529, USA
    J Diabetes Complications 17:279-85. 2003
    ..This provides further evidence for the beneficial effects of rosiglitazone on nontraditional cardiovascular risk factors associated with T2DM...
  36. ncbi request reprint Methods for evaluation of peripheral neurovascular dysfunction
    A I Vinik
    The Leonard Strelitz Diabetes Research Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk 23510, USA
    Diabetes Technol Ther 3:29-50. 2001
    ..A combination of microdialysis and iontophoresis techniques can be useful in assessment of the pharmacokinetics of polar and nonpolar agents and the physiology and pathophysiology of the skin neurovascular system...
  37. ncbi request reprint Platelet dysfunction in type 2 diabetes
    A I Vinik
    Department of Medicine and Pathology Anatomy Neurobiology, the Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Diabetes Care 24:1476-85. 2001
    ..Thus, the defects in insulin action in diabetes create a milieu of disordered platelet activity conducive to macrovascular and microvascular events...
  38. ncbi request reprint A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase C-beta inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy
    Carolina M Casellini
    Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Diabetes Care 30:896-902. 2007
    ..We investigate the effects of the isoform-selective PKC-beta inhibitor ruboxistaurin mesylate on neurovascular function and other measures of DPN...
  39. pmc Quality of life and objective measures of diabetic neuropathy in a prospective placebo-controlled trial of ruboxistaurin and topiramate
    Amanda Boyd
    Department of Internal Medicine, Strelitz Diabetes Center, Eastern Virginia Medical School, Norfolk, Virginia, USA
    J Diabetes Sci Technol 5:714-22. 2011
    ..We aimed to determine if the Norfolk QOL-DN could be used to capture changes in QOL that correlate with nerve fiber-specific objective measures in a placebo-controlled trial of two agents that affect different nerve fibers...
  40. doi request reprint The Reg family member INGAP is a marker of endocrine patterning in the embryonic pancreas
    Natasha S Hamblet
    Department of Internal Medicine, The Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, VA 23510, USA
    Pancreas 36:1-9. 2008
    ..Adult islet neogenesis is believed to recapitulate elements of pancreatic endocrine development. Identifying factors that regulate islet neogenesis-associated protein (INGAP) gene activity could provide links to pancreas development...
  41. ncbi request reprint Change in cutaneous perfusion following 10 weeks of aerobic training in Type 2 diabetes
    Sheri R Colberg
    Old Dominion University, Norfolk, VA 23529, USA
    J Diabetes Complications 19:276-83. 2005
    ..Thus, moderate aerobic training for only 10 weeks does not appear to reverse the impairment in cutaneous perfusion of the foot dorsum in response local heating in a Type 2 diabetic population...
  42. ncbi request reprint The effect of an aerobic exercise training program on quality of life in type 2 diabetes
    D Robb Holton
    Department of Exercise Science, Sport, Physical Education, and Recreation, Old Dominion University, Norfolk, Virginia 23529, USA
    Diabetes Educ 29:837-46. 2003
    ..The purpose of this study was to determine the effect of 10 weeks of moderate aerobic exercise training on quality of life (QOL) and selected physiological parameters in previously sedentary persons with diabetes...
  43. doi request reprint Pdx-1 regulation of the INGAP promoter involves sequestration of NeuroD into a non-DNA-binding complex
    David A Taylor-Fishwick
    Department of Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    Pancreas 39:64-70. 2010
    ..Islet neogenesis-associated protein (INGAP) can enhance beta-cell mass to offset progression of diabetes. Identifying how transcription factors regulate INGAP gene expression could reveal key checkpoints governing islet neogenesis...
  44. pmc Pancreatic islet immunoreactivity to the Reg protein INGAP
    David A Taylor-Fishwick
    Department of Medicine, Eastern Virginia Medical School, 855 W Brambleton Ave, Norfolk, VA, USA
    J Histochem Cytochem 56:183-91. 2008
    ..These findings reveal that INGAP and/or related group 3 Reg proteins have a conserved expression in the pancreatic islet...
  45. doi request reprint Successful control of intractable hypoglycemia using rapamycin in an 86-year-old man with a pancreatic insulin-secreting islet cell tumor and metastases
    Matthew E Bourcier
    Strelitz Diabetes Center and Neuroendocrine Unit, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
    J Clin Endocrinol Metab 94:3157-62. 2009
    ..A continuous infusion of octreotide lowered the blood glucose levels further. He required diazoxide, a thiazide diuretic, phenytoin, and a constant infusion of glucose to control the hypoglycemia and elevated insulin levels...
  46. ncbi request reprint Diagnosis and management of diabetic autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Departments of Internal Medicine and Anatomy Neurobiology, Eastern Virginia Medical School, Norfolk, VA, USA
    Compr Ther 29:130-45. 2003
    ..The diagnosis confers an attenuated life expectancy, but much can be done to alleviate symptoms and to address the underlying disorder...
  47. ncbi request reprint Intraepidermal nerve fibers are indicators of small-fiber neuropathy in both diabetic and nondiabetic patients
    Gary L Pittenger
    Department of Internal Medicine, The Strelitz Diabetes Institutes, Norfolk, Virginia 23510, USA
    Diabetes Care 27:1974-9. 2004
    ..Small-fiber neuropathies may be symptomatic yet escape detection by standard tests. We hypothesized that morphologic changes in intraepidermal nerves would correlate with clinical measures of small-fiber neuropathy...
  48. ncbi request reprint Intramuscular injection of islet neogenesis-associated protein peptide stimulates pancreatic islet neogenesis in healthy dogs
    Gary L Pittenger
    Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA 23510, USA
    Pancreas 34:103-11. 2007
    ..Islet neogenesis- associated protein (INGAP) stimulates islet neogenesis; therefore, we hypothesized that it would stimulate islet neogenesis in dogs...
  49. doi request reprint Development of the Norfolk quality of life tool for assessing patients with neuroendocrine tumors
    Etta Vinik
    Department of Medicine, Strelitz Diabetes Research Center and Neuroendocrine Unit, Eastern Virginia Medical School, Norfolk 23510, VA, USA
    Pancreas 38:e87-95. 2009
    ..To develop a disease-specific questionnaire for identifying domains having the greatest impact on the quality of life (QOL) of patients with neuroendocrine tumors (NETS)...
  50. ncbi request reprint Metabolic implications of obesity: before and after gastric bypass
    Donald W Richardson
    L R Strelitz Diabetes Institute, Eastern Virginia Medical School, 855 West Brambleton Boulevard, Norfolk, VA 23510, USA
    Gastroenterol Clin North Am 34:9-24. 2005
    ..This article evaluates the metabolic consequences of obesity and highlights which of these are amenable to correction with weight reduction achieved by gastric bypass...
  51. ncbi request reprint The role of islet neogeneis-associated protein (INGAP) in pancreatic islet neogenesis
    Gary L Pittenger
    The Strelitz Diabetes Center, Department of Internal Medicine, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Curr Protein Pept Sci 10:37-45. 2009
    ..The peptide has been tested in human clinical trials, with success being reported. The evidence points to INGAP as a major factor in stimulating islet neogenesis, and, therefore, may play a significant therapeutic role in diabetes...
  52. ncbi request reprint Sural sensory action potential identifies diabetic peripheral neuropathy responders to therapy
    Aaron I Vinik
    Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, 23510, USA
    Muscle Nerve 32:619-25. 2005
    ..004; OR = 0.896). For patients with abnormal VDT, preserved sural SNAP identifies a patient population with less severe DPN who may respond to therapeutic intervention in clinical trials...
  53. ncbi request reprint PDX-1 can repress stimulus-induced activation of the INGAP promoter
    David A Taylor-Fishwick
    Department of Medicine, Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
    J Endocrinol 188:611-21. 2006
    ..These findings implicate PDX-1 in a possible feedback loop to block unbridled islet expansion...
  54. ncbi request reprint Chronic exercise is associated with enhanced cutaneous blood flow in type 2 diabetes
    Sheri R Colberg
    Department of Exercise Science, Physical Education, and Recreation ESPER, Old Dominion University, Norfolk, VA 23529, USA
    J Diabetes Complications 16:139-45. 2002
    ..As such, regular physical activity may be an invaluable tool in the prevention and reversal of defective skin vasodilation and resultant foot ulcers so common in diabetes...
  55. ncbi request reprint Cutaneous blood flow in type 2 diabetic individuals after an acute bout of maximal exercise
    Sheri R Colberg
    ESPER Department, Old Dominion University, Norfolk, Virginia 23529, USA
    Diabetes Care 26:1883-8. 2003
    ..Thus, we hypothesized that a prior acute bout of maximal exercise would also have positive effects on postexercise blood flow...
  56. ncbi request reprint Islet neogenesis associated protein transgenic mice are resistant to hyperglycemia induced by streptozotocin
    David A Taylor-Fishwick
    Department of Internal Medicine, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, 23510 Virginia, USA
    J Endocrinol 190:729-37. 2006
    ..The INGAP transgenic mouse provides a new model to uncover factors that are protective to diabetes onset and biomarkers to track beta-cell pathology...
  57. ncbi request reprint Effect of a single bout of prior moderate exercise on cutaneous perfusion in type 2 diabetes
    Sheri R Colberg
    ESPER Department, Old Dominion University, Norfolk, VA 23529, USA
    Diabetes Care 29:2316-8. 2006
  58. ncbi request reprint Cloning genomic INGAP: a Reg-related family member with distinct transcriptional regulation sites
    David A Taylor-Fishwick
    Department of Medicine, The Leonard Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Biochim Biophys Acta 1638:83-9. 2003
    ..Comparison of transcription factor binding sites in INGAP to the related gene RegIIIdelta exposes potential sites for differential gene regulation...
  59. doi request reprint Update: metabolic and cardiovascular consequences of bariatric surgery
    Donald W Richardson
    Department of Medicine, L R Strelitz Diabetes Center for Endocrinology and Metabolism, L R Strelitz Diabetes Research Institute, Eastern Virginia Medical School, 855 West Brambleton Boulevard, Norfolk, VA 23510, USA
    Endocrinol Metab Clin North Am 40:81-96, viii. 2011
    ..Data suggest that some of these patients may be better served by bariatric surgery...
  60. ncbi request reprint Clinical case seminar: hypoglycemia after pancreas transplantation: association with allograft nesidiodysplasia and expression of islet neogenesis-associated peptide
    Crispin Semakula
    Division of Endocrinology and Diabetes, Department of Medicine, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Clin Endocrinol Metab 87:3548-54. 2002
    ..Reported cases of adult nesidioblastosis are reviewed. The significance of nesidioblastosis in the context of pancreas transplantation and possible mechanisms of posttransplant hypoglycemia are discussed...
  61. ncbi request reprint Use of heart rate reserve and rating of perceived exertion to prescribe exercise intensity in diabetic autonomic neuropathy
    Sheri R Colberg
    Old Dominion University, Norfolk, Virginia 23529, USA
    Diabetes Care 26:986-90. 2003
    ....
  62. ncbi request reprint Exercise status affects skin perfusion via prostaglandin, nitric oxide, and EDHF pathways in diabetes
    Sheri R Colberg
    ESPER Department, Old Dominion University, Norfolk, VA 23529, USA
    Microvasc Res 77:120-4. 2009
    ..These results suggest that regular exercise may exhibit the greatest effect on the normal functioning of these vasodilatory pathways, although diabetes and a sedentary state together may somewhat alter their relative importance...
  63. ncbi request reprint Metabolic complications of bariatric surgery: diagnosis and management issues
    M Elizabeth Mason
    Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 West Brambleton Avenue, Norfolk, VA 23510, USA
    Gastroenterol Clin North Am 34:25-33. 2005
    ..Neuropathy, acute Wemicke's encephalopathy and vitamin A deficiency also occur. Prevention, diagnosis,and treatment of these disorders are necessary parts of lifelong care after bariatric surgery...
  64. ncbi request reprint Effect of an 8-week resistance training program on cutaneous perfusion in type 2 diabetes
    Sheri R Colberg
    ESPER Department, Old Dominion University, Norfolk, VA 23529, USA
    Microvasc Res 71:121-7. 2006
    ....
  65. ncbi request reprint Autonomic function in sleep apnea patients: increased heart rate variability except during REM sleep in obese patients
    Erica B Reynolds
    Eastern Virginia Medical School, Sentara Norfolk General Hospital, Norfolk, USA
    Sleep Breath 11:53-60. 2007
    ..The decrease in HRV during REM sleep in the obese apnea patients suggests the possibility of an autonomic dysfunction in this subgroup...
  66. ncbi request reprint Prediction of pregabalin-mediated pain response by severity of sleep disturbance in patients with painful diabetic neuropathy and post-herpetic neuralgia
    Aaron Vinik
    Eastern Virginia Medical School, Norfolk, Virginia, USA
    Pain Med 15:661-70. 2014
    ..To evaluate the predictive value of disturbed sleep on the ability of pregabalin to reduce pain associated with diabetic peripheral neuropathy (DPN) and post-herpetic neuralgia (PHN)...
  67. pmc Nerve growth factor and diabetic neuropathy
    Gary Pittenger
    The Leonard Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
    Exp Diabesity Res 4:271-85. 2003
    ..It seems reasonable to anticipate that neurotrophic factor therapy, specifically targeted at different nerve fiber populations, might enter the therapeutic armamentarium...
  68. ncbi request reprint CLINICAL REVIEW: Use of antiepileptic drugs in the treatment of chronic painful diabetic neuropathy
    Aaron Vinik
    Diabetes Research Institute, 855 West Brambleton Avenue, Norfolk, Virginia 23510, USA
    J Clin Endocrinol Metab 90:4936-45. 2005
    ..Decreased physical activity, increased fatigue, and mood and sleep problems may result...
  69. ncbi request reprint Etiology and treatment of erectile failure in diabetes mellitus
    Donald Richardson
    Leonard R Strelitz Diabetes Institutes, Eastern Virginia Medical School, 855 W Brambleton Avenue, Norfolk, VA 23510, USA
    Curr Diab Rep 2:501-9. 2002
    ....
  70. ncbi request reprint Diabetes and macrovascular disease
    Aaron Vinik
    Virginia Medical School and the Leonard R Strelitz Diabetes Institutes, 855 West Brambleton Avenue Eastern, Norfolk, VA 23510, USA
    J Diabetes Complications 16:235-45. 2002
    ..If this is done, this emerging epidemic of macrovascular disease will be contained...
  71. ncbi request reprint Diabetic peripheral neuropathy: how reliable is a homemade 1-g monofilament for screening?
    Matthew E Bourcier
    Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, VA, USA
    J Fam Pract 55:505-8. 2006
  72. ncbi request reprint Development of a highly sensitive and specific carboxy-terminal human pancreastatin assay to monitor neuroendocrine tumor behavior
    Thomas M O'Dorisio
    Department of Internal Medicine, University of Iowa Hospitals and Clinics, Iowa City, IA, USA
    Pancreas 39:611-6. 2010
    ..Existing pancreastatin assays, which depend on antibodies that cross-react in varying percents with the larger prohormone, may lack sensitivity and specificity to detect small changes in neuroendocrine tumor volume...
  73. ncbi request reprint Diabetic autonomic neuropathy
    Aaron I Vinik
    Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
    Semin Neurol 23:365-72. 2003
    ..There are studies in progress that suggest that autonomic nerves can be induced to regenerate, and the future for patients with diabetic autonomic neuropathy is brighter...
  74. ncbi request reprint The development and validation of the Norfolk QOL-DN, a new measure of patients' perception of the effects of diabetes and diabetic neuropathy
    Etta J Vinik
    Leonard R Strelitz Diabetes Institutes, Department of Internal Medicine, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Diabetes Technol Ther 7:497-508. 2005
    ..This study was designed to develop and validate a patient-reported outcomes measure, sensitive to the different features of diabetic neuropathy (DN)-small fiber, large fiber, and autonomic nerve function...
  75. pmc Effect of bromocriptine-QR (a quick-release formulation of bromocriptine mesylate) on major adverse cardiovascular events in type 2 diabetes subjects
    J Michael Gaziano
    Divisions of Aging, Cardiology, Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Am Heart Assoc 1:e002279. 2012
    ....
  76. ncbi request reprint Reversal of phrenic nerve palsy with topiramate
    Amanda L Rice
    Department of Internal Medicine, Strelitz Diabetes Institutes, Eastern Virginia Medical School, Norfolk, VA 23510, USA
    J Diabetes Complications 21:63-7. 2007
    ..Topiramate may prove to be an effective agent in the treatment of nonremitting diaphragmatic paralysis and regrowth of intraepidermal nerve fibers...
  77. ncbi request reprint Median and ulnar nerve conduction measurements in patients with symptoms of diabetic peripheral neuropathy using the NC-stat system
    Aaron I Vinik
    The Leonard Strelitz Diabetes Research Institutes, Departments of Internal Medicine and Pathology Anatomy Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Diabetes Technol Ther 6:816-24. 2004
    ..Advanced point-of-service NCS systems, already widely used in the assessment of entrapment neuropathies, may address these issues in the arena of diabetes...
  78. ncbi request reprint Diabetic nerve conduction abnormalities in the primary care setting
    Aaron I Vinik
    The Leonard Strelitz Diabetes Research Institutes, Departments of Internal Medicine and Pathology Neurobiology, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Diabetes Technol Ther 8:654-62. 2006
    ..The purpose of this study was to utilize automated NCS technology to characterize nerve conduction of patients with diabetes in primary care settings...
  79. ncbi request reprint Neuropathy: new concepts in evaluation and treatment
    Aaron I Vinik
    Strelitz Diabetes Research Institute, Eastern Virginia Medical School, Norfolk 23510, USA
    South Med J 95:21-3. 2002
  80. ncbi request reprint Diabetic neuropathy in older adults
    Kara A Witzke
    Department of Health, Physical Education, and Exercise Science, Norfolk State University, 700 Park Ave, Norfolk, VA 23504, USA
    Rev Endocr Metab Disord 6:117-27. 2005
  81. ncbi request reprint Prevention of the complications of diabetes
    Aaron I Vinik
    Diabetes Research Institute, Eastern Virginia Medical School, Norfolk, USA
    Am J Manag Care 9:S63-80; quiz S81-4. 2003
    ....
  82. ncbi request reprint Clinical manifestations and current treatment options for diabetic neuropathies
    Carolina M Casellini
    The Leonard Strelitz Diabetes Research Institutes, Eastern Virginia Medical School, Norfolk, Virginia 23510, USA
    Endocr Pract 13:550-66. 2007
    ..To review the clinical manifestations and current treatment options for diabetic neuropathies, one of the most common complications of diabetes mellitus...
  83. ncbi request reprint Effects of 8 weeks of flexibility and resistance training in older adults with type 2 diabetes
    Matthew T Herriott
    ESPER Department, Old Dominion University, Norfolk, VA 23529, USA
    Diabetes Care 27:2988-9. 2004
  84. pmc Advances in diabetes for the millennium: new treatments for diabetic neuropathies
    Aaron I Vinik
    The Leonard Strelitz Diabetes Institute, Norfolk, Virginia, USA
    MedGenMed 6:13. 2004
    ..If attention is directed toward a pathogenetic approach, much can be done to alleviate the symptoms, alleviate the mitigation of quality of life, and now it would seem to address the underlying biological disturbance...
  85. pmc Advances in diabetes for the millennium: toward a cure for diabetes
    Aaron I Vinik
    The Leonard Strelitz Diabetes Institute, Norfolk, Virginia, USA
    MedGenMed 6:12. 2004
    ....
  86. ncbi request reprint Safety and effectiveness of topiramate for the management of painful diabetic peripheral neuropathy in an open-label extension study
    Peter D Donofrio
    Department of Neurology, Wake Forest University School of Medicine, Winston Salem, NC 21757, USA
    Clin Ther 27:1420-31. 2005
    ..The aim of this study was to further assess the long-term safety and effectiveness of open-label topiramate therapy in subjects with moderately to severely painful diabetic peripheral neuropathy (DPN)...
  87. ncbi request reprint Pathophysiology and treatment of diabetic peripheral neuropathy: the case for diabetic neurovascular function as an essential component
    Keri A Kles
    Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA
    Curr Diabetes Rev 2:131-45. 2006
    ....
  88. pmc Diabetes-related complications, glycemic control, and falls in older adults
    Ann V Schwartz
    Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California 94107 1762, USA
    Diabetes Care 31:391-6. 2008
    ..We determined whether diabetes-related complications or treatments are associated with risk of falls in older diabetic adults...
  89. ncbi request reprint The association between cardiovascular autonomic neuropathy and mortality in individuals with diabetes: a meta-analysis
    Raelene E Maser
    Department of Medical Technology, University of Delaware, Newark, Delaware 19716, USA
    Diabetes Care 26:1895-901. 2003
    ..To examine by meta-analysis the relationship between cardiovascular autonomic neuropathy (CAN) and risk of mortality in individuals with diabetes...
  90. pmc A pentadecapeptide fragment of islet neogenesis-associated protein increases beta-cell mass and reverses diabetes in C57BL/6J mice
    Lawrence Rosenberg
    Department of Surgery, McGill University, Montreal, Quebec, Canada
    Ann Surg 240:875-84. 2004
    ....
  91. ncbi request reprint Cardiac abnormalities in diabetic patients with neuropathy: effects of aldose reductase inhibitor administration
    Brian F Johnson
    Pfizer Research, Groton, Connecticut, USA
    Diabetes Care 27:448-54. 2004
    ..The goal of this study was to determine whether treatment with an aldose reductase inhibitor (ARI) has beneficial effects on asymptomatic cardiac abnormalities in diabetic patients with neuropathy...
  92. ncbi request reprint Validation of serum versus plasma measurements of chromogranin a levels in patients with carcinoid tumors: lack of correlation between absolute chromogranin a levels and symptom frequency
    Eugene A Woltering
    Section of Surgical Endocrinology, Department of Surgery, Louisiana State University Health Sciences Center, New Orleans, LA, USA
    Pancreas 33:250-4. 2006
    ....
  93. ncbi request reprint Diabetes, peripheral neuropathy, and old age disability
    Helaine E Resnick
    MedStar Research Institute, 108 Irving Street NW, Annex 5, Washington, DC 20010, USA
    Muscle Nerve 25:43-50. 2002
    ..Interventions aimed at reducing the impact of diabetes-associated disability in old age may have the greatest impact among people with peripheral neuropathy...
  94. pmc The relationship of reduced peripheral nerve function and diabetes with physical performance in older white and black adults: the Health, Aging, and Body Composition (Health ABC) study
    Elsa S Strotmeyer
    Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Diabetes Care 31:1767-72. 2008
    ..Poor peripheral nerve function is prevalent in diabetes and older populations, and it has great potential to contribute to poor physical performance...