Research Topics
| Lut Van DammeSummaryAffiliation: Eastern Virginia Medical School Country: USA Publications
| Collaborators |
Detail Information
Publications
Overcoming recruitment challenges: lessons learned from a safety and feasibility study of a diaphragm/microbicide combination in South AfricaGreg Guest
J Acquir Immune Defic Syndr 45:481-2. 2007- Penile application of dextrin sulphate gel (Emmelle)Lut Van Damme
Institute of Tropical Medicine, Antwerp, Belgium
Contraception 66:133-6. 2002..Results from laboratory evaluations, genital examinations, and adverse events reports showed that 4% DS gel administered topically to the penis was well tolerated when compared with placebo... - Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trialLut Van Damme
Institute of Tropical Medicine, Antwerp, Belgium
Lancet 360:971-7. 2002..Results of studies of its effectiveness in prevention of HIV-1 infection in women have been inconclusive. We aimed to assess effectiveness of this vaginal gel... - Clinical microbicide research: an overviewLut Van Damme
CONRAD, Arlington, VA 22209, USA
Trop Med Int Health 9:1290-6. 2004..In the 1990s most research was done with spermicides, mainly nonoxynol-9. Since the results of the COL-1492 trial became available, new products were evaluated and some of them are now in phase III trials... 
Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmissionLut Van Damme
CONRAD, Arlington, VA, USA
N Engl J Med 359:463-72. 2008..Women make up more than 50% of adults living with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa. Thus, female-initiated HIV prevention methods are urgently needed...- Safety trial of the vaginal microbicide cellulose sulfate gel in HIV-positive menVicky Jespers
Institute of Tropical Medicine, Antwerp, Belgium
Sex Transm Dis 34:519-22. 2007..Cellulose sulfate (CS) is a promising vaginal microbicide. Because men will be exposed to the microbicide when engaging in vaginal intercourse, safety and acceptability need to be assessed in men... 
Performance of a rapid and simple HIV testing algorithm in a multicenter phase III microbicide clinical trialTania Crucitti
HIV STI Reference Laboratory, Institute of Tropical Medicine, 155 Nationalestraat, 2000 Antwerp, Belgium
Clin Vaccine Immunol 18:1480-5. 2011..We conclude that HIV testing algorithms, including only R/S assays, are suitable for use in clinical trials, provided that adequate quality assurance procedures are in place...- Vaginal microbicides can interfere with nucleic acid amplification tests used for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae infectionTania Crucitti
HIV STD Research and Intervention Unit, Institute of Tropical Medicine, 155 Nationalestraat, 2000 Antwerp, Belgium
Diagn Microbiol Infect Dis 57:97-9. 2007..We therefore recommend that the effects of microbicide gels on diagnostic assays of sexually transmitted infections be established before starting up clinical studies... - Obtaining valid laboratory data in clinical trials conducted in resource diverse settings: lessons learned from a microbicide phase III clinical trialTania Crucitti
HIV STI Reference Laboratory, Institute of Tropical Medicine, Antwerp, Belgium
PLoS ONE 5:e13592. 2010..This paper describes the design and outcomes of a laboratory quality assurance program which was implemented during a phase III clinical trial evaluating the efficacy of the candidate microbicide Cellulose Sulfate 6% (CS) [1]... - Safety and acceptability of penile application of 2 candidate topical microbicides: BufferGel and PRO 2000 Gel: 3 randomized trials in healthy low-risk men and HIV-positive menStephen R Tabet
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 33:476-83. 2003.... - Changes in sexual behavior during a safety and feasibility trial of a microbicide/diaphragm combination: an integrated qualitative and quantitative analysisGreg Guest
Family Health International, Durham, NC 27713, USA
AIDS Educ Prev 19:310-20. 2007..Data suggest this is because of increased partner involvement, increased negotiating power afforded by study participation, and provision of free condoms perceived to be of high quality... - Microbicide drug candidates to prevent HIV infectionJan Balzarini
Rega Institute for Medical Research, K U Leuven, B 3000 Leuven, Belgium
Lancet 369:787-97. 2007..We review different categories of microbicide drugs and lead compounds, their mechanism of action, current status of development, and progress in phase III trials... - Structural accelerated failure time models for the effects of observed exposures on repeated events in a clinical trialAn Vandebosch
Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281 S9, B 9000 Ghent, Belgium
Stat Med 24:1029-46. 2005..We discuss the logical constraints imposed by this model choice as well as new challenges posed on recensoring... - Intravaginal and intrarectal microbicides to prevent HIV infectionJan Balzarini
Rega Institute for Medical Research, Leuven, Belgium
CMAJ 172:461-4. 2005 - A dose-ranging phase I study of dextrin sulphate, a vaginal microbicide, in HIV-negative and HIV-positive female volunteersSheena McCormack
Medical Research Council Clinical Trials Unit, London, UK
Sex Transm Dis 32:765-70. 2005..Part A was a randomized, placebo-controlled, double-blind, 3-arm trial (DS4%, DS1%, placebo) in HIV-negative women. In part B, HIV-positive women received DS4% and HIV-negative women were randomized to DS4% or no gel... - Expanded Phase I safety and acceptability study of 6% cellulose sulfate vaginal gelIsaac M Malonza
Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
AIDS 19:2157-63. 2005..An expanded Phase I trial was performed to assess the safety and acceptability of 6% cellulose sulfate gel (CS) in comparison with K-Y Jelly...