Lut Van Damme

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. ncbi request reprint Overcoming recruitment challenges: lessons learned from a safety and feasibility study of a diaphragm/microbicide combination in South Africa
    Greg Guest
    J Acquir Immune Defic Syndr 45:481-2. 2007
  2. ncbi request reprint Penile application of dextrin sulphate gel (Emmelle)
    Lut Van Damme
    Institute of Tropical Medicine, Antwerp, Belgium
    Contraception 66:133-6. 2002
  3. ncbi request reprint Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial
    Lut Van Damme
    Institute of Tropical Medicine, Antwerp, Belgium
    Lancet 360:971-7. 2002
  4. ncbi request reprint Clinical microbicide research: an overview
    Lut Van Damme
    CONRAD, Arlington, VA 22209, USA
    Trop Med Int Health 9:1290-6. 2004
  5. doi request reprint Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission
    Lut Van Damme
    CONRAD, Arlington, VA, USA
    N Engl J Med 359:463-72. 2008
  6. ncbi request reprint Safety trial of the vaginal microbicide cellulose sulfate gel in HIV-positive men
    Vicky Jespers
    Institute of Tropical Medicine, Antwerp, Belgium
    Sex Transm Dis 34:519-22. 2007
  7. pmc Performance of a rapid and simple HIV testing algorithm in a multicenter phase III microbicide clinical trial
    Tania Crucitti
    HIV STI Reference Laboratory, Institute of Tropical Medicine, 155 Nationalestraat, 2000 Antwerp, Belgium
    Clin Vaccine Immunol 18:1480-5. 2011
  8. ncbi request reprint Vaginal microbicides can interfere with nucleic acid amplification tests used for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae infection
    Tania Crucitti
    HIV STD Research and Intervention Unit, Institute of Tropical Medicine, 155 Nationalestraat, 2000 Antwerp, Belgium
    Diagn Microbiol Infect Dis 57:97-9. 2007
  9. doi request reprint The evolving design and methods for trials evaluating the safety of candidate vaginal microbicides: a systematic review
    Vicky Jespers
    From the Unit of Epidemiology and Control of HIV STD, Institute of Tropical Medicine, Antwerp, Belgium Clinical Trial Service and Epidemiological Studies Units, University of Oxford, Oxford, United Kingdom Kirby Institute, University of New South Wales, Sydney, Australia and Bill and Melinda Gates Foundation, Seattle, WA
    Sex Transm Dis 40:729-36. 2013
  10. pmc Obtaining valid laboratory data in clinical trials conducted in resource diverse settings: lessons learned from a microbicide phase III clinical trial
    Tania Crucitti
    HIV STI Reference Laboratory, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 5:e13592. 2010

Detail Information

Publications17

  1. ncbi request reprint Overcoming recruitment challenges: lessons learned from a safety and feasibility study of a diaphragm/microbicide combination in South Africa
    Greg Guest
    J Acquir Immune Defic Syndr 45:481-2. 2007
  2. ncbi request reprint Penile application of dextrin sulphate gel (Emmelle)
    Lut Van Damme
    Institute of Tropical Medicine, Antwerp, Belgium
    Contraception 66:133-6. 2002
    ..Results from laboratory evaluations, genital examinations, and adverse events reports showed that 4% DS gel administered topically to the penis was well tolerated when compared with placebo...
  3. ncbi request reprint Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial
    Lut Van Damme
    Institute of Tropical Medicine, Antwerp, Belgium
    Lancet 360:971-7. 2002
    ..Results of studies of its effectiveness in prevention of HIV-1 infection in women have been inconclusive. We aimed to assess effectiveness of this vaginal gel...
  4. ncbi request reprint Clinical microbicide research: an overview
    Lut Van Damme
    CONRAD, Arlington, VA 22209, USA
    Trop Med Int Health 9:1290-6. 2004
    ..In the 1990s most research was done with spermicides, mainly nonoxynol-9. Since the results of the COL-1492 trial became available, new products were evaluated and some of them are now in phase III trials...
  5. doi request reprint Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission
    Lut Van Damme
    CONRAD, Arlington, VA, USA
    N Engl J Med 359:463-72. 2008
    ..Women make up more than 50% of adults living with human immunodeficiency virus (HIV) infection or the acquired immunodeficiency syndrome (AIDS) in sub-Saharan Africa. Thus, female-initiated HIV prevention methods are urgently needed...
  6. ncbi request reprint Safety trial of the vaginal microbicide cellulose sulfate gel in HIV-positive men
    Vicky Jespers
    Institute of Tropical Medicine, Antwerp, Belgium
    Sex Transm Dis 34:519-22. 2007
    ..Cellulose sulfate (CS) is a promising vaginal microbicide. Because men will be exposed to the microbicide when engaging in vaginal intercourse, safety and acceptability need to be assessed in men...
  7. pmc Performance of a rapid and simple HIV testing algorithm in a multicenter phase III microbicide clinical trial
    Tania Crucitti
    HIV STI Reference Laboratory, Institute of Tropical Medicine, 155 Nationalestraat, 2000 Antwerp, Belgium
    Clin Vaccine Immunol 18:1480-5. 2011
    ..We conclude that HIV testing algorithms, including only R/S assays, are suitable for use in clinical trials, provided that adequate quality assurance procedures are in place...
  8. ncbi request reprint Vaginal microbicides can interfere with nucleic acid amplification tests used for the diagnosis of Chlamydia trachomatis and Neisseria gonorrhoeae infection
    Tania Crucitti
    HIV STD Research and Intervention Unit, Institute of Tropical Medicine, 155 Nationalestraat, 2000 Antwerp, Belgium
    Diagn Microbiol Infect Dis 57:97-9. 2007
    ..We therefore recommend that the effects of microbicide gels on diagnostic assays of sexually transmitted infections be established before starting up clinical studies...
  9. doi request reprint The evolving design and methods for trials evaluating the safety of candidate vaginal microbicides: a systematic review
    Vicky Jespers
    From the Unit of Epidemiology and Control of HIV STD, Institute of Tropical Medicine, Antwerp, Belgium Clinical Trial Service and Epidemiological Studies Units, University of Oxford, Oxford, United Kingdom Kirby Institute, University of New South Wales, Sydney, Australia and Bill and Melinda Gates Foundation, Seattle, WA
    Sex Transm Dis 40:729-36. 2013
    ..Here, we propose a stepwise clinical assessment that can be used for future guidance. ..
  10. pmc Obtaining valid laboratory data in clinical trials conducted in resource diverse settings: lessons learned from a microbicide phase III clinical trial
    Tania Crucitti
    HIV STI Reference Laboratory, Institute of Tropical Medicine, Antwerp, Belgium
    PLoS ONE 5:e13592. 2010
    ..This paper describes the design and outcomes of a laboratory quality assurance program which was implemented during a phase III clinical trial evaluating the efficacy of the candidate microbicide Cellulose Sulfate 6% (CS) [1]...
  11. ncbi request reprint Safety and acceptability of penile application of 2 candidate topical microbicides: BufferGel and PRO 2000 Gel: 3 randomized trials in healthy low-risk men and HIV-positive men
    Stephen R Tabet
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 33:476-83. 2003
    ....
  12. ncbi request reprint Structural accelerated failure time models for the effects of observed exposures on repeated events in a clinical trial
    An Vandebosch
    Department of Applied Mathematics and Computer Science, Ghent University, Krijgslaan 281 S9, B 9000 Ghent, Belgium
    Stat Med 24:1029-46. 2005
    ..We discuss the logical constraints imposed by this model choice as well as new challenges posed on recensoring...
  13. ncbi request reprint Changes in sexual behavior during a safety and feasibility trial of a microbicide/diaphragm combination: an integrated qualitative and quantitative analysis
    Greg Guest
    Family Health International, Durham, NC 27713, USA
    AIDS Educ Prev 19:310-20. 2007
    ..Data suggest this is because of increased partner involvement, increased negotiating power afforded by study participation, and provision of free condoms perceived to be of high quality...
  14. ncbi request reprint Microbicide drug candidates to prevent HIV infection
    Jan Balzarini
    Rega Institute for Medical Research, K U Leuven, B 3000 Leuven, Belgium
    Lancet 369:787-97. 2007
    ..We review different categories of microbicide drugs and lead compounds, their mechanism of action, current status of development, and progress in phase III trials...
  15. pmc Intravaginal and intrarectal microbicides to prevent HIV infection
    Jan Balzarini
    Rega Institute for Medical Research, Leuven, Belgium
    CMAJ 172:461-4. 2005
  16. ncbi request reprint Expanded Phase I safety and acceptability study of 6% cellulose sulfate vaginal gel
    Isaac M Malonza
    Department of Reproductive Health and Research, World Health Organization, Geneva, Switzerland
    AIDS 19:2157-63. 2005
    ..An expanded Phase I trial was performed to assess the safety and acceptability of 6% cellulose sulfate gel (CS) in comparison with K-Y Jelly...
  17. ncbi request reprint A dose-ranging phase I study of dextrin sulphate, a vaginal microbicide, in HIV-negative and HIV-positive female volunteers
    Sheena McCormack
    Medical Research Council Clinical Trials Unit, London, UK
    Sex Transm Dis 32:765-70. 2005
    ..Part A was a randomized, placebo-controlled, double-blind, 3-arm trial (DS4%, DS1%, placebo) in HIV-negative women. In part B, HIV-positive women received DS4% and HIV-negative women were randomized to DS4% or no gel...