- Staphylococcus aureus surface protein SdrE binds complement regulator factor H as an immune evasion tacticJulia A Sharp
Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia, United States of America
PLoS ONE 7:e38407. 2012..Thus, we report the first identification of a S. aureus protein associated with the staphylococcal surface that binds factor H as an immune evasion mechanism...
- Disruption of the alternative pathway convertase occurs at the staphylococcal surface via the acquisition of factor H by Staphylococcus aureusJulia A Sharp
Department of Pediatrics, Eastern Virginia Medical School, Norfolk, VA 23501 1980, USA
Mol Immunol 48:683-90. 2011..aureus surface inhibits complement-mediated opsonization via disruption of the alternative pathway convertase; thus, we report an immune-evasion mechanism not previously described for S. aureus...
- Complement inhibition significantly decreases red blood cell lysis in a rat model of acute intravascular hemolysisTushar A Shah
Department of Pediatrics, Eastern Virginia Medical School, Norfolk, Virginia Children s Specialty Group, Norfolk, Virginia Children s Hospital of the King s Daughters, Norfolk, Virginia
Transfusion 54:2892-900. 2014..Prevention of acute hemolytic transfusion reactions is a worldwide concern. The objective of this study was to develop a simple rat model of complement-mediated acute intravascular hemolysis...