OLIVER SEMMES

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. pmc SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers
    Christine Laronga
    Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia and the Virginia Prostate Center, Norfolk, VA, USA
    Dis Markers 19:229-38. 2003
  2. pmc Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer
    Lifang Yang
    Leroy T Canoles Cancer Research Center, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Mol Cell Proteomics 10:M110.007294. 2011
  3. pmc The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin
    S Mehdi Belgnaoui
    Department of Microbiology and Molecular Cell Biology, Cancer Biology and Infectious Disease Research Center, Eastern Virginia Medical School, Norfolk, Virgina 23508, USA
    J Biol Chem 285:32897-905. 2010
  4. pmc Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity
    Xin Guo
    Department of Microbiology and Molecular Cell Biology, Cancer Biology and Infectious Disease Research Center, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 285:33348-57. 2010
  5. pmc HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase
    Sarah S Durkin
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 283:36311-20. 2008
  6. pmc Phosphorylation regulates human T-cell leukemia virus type 1 Rex function
    Matthew Kesic
    Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA
    Retrovirology 6:105. 2009
  7. pmc A proteomic study of TAR-RNA binding protein (TRBP)-associated factors
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Cell Biosci 1:9. 2011
  8. pmc A Bayesian network approach to feature selection in mass spectrometry data
    Karl W Kuschner
    Department of Physics, The College of William and Mary, Williamsburg, VA, USA
    BMC Bioinformatics 11:177. 2010
  9. pmc Computational protein biomarker prediction: a case study for prostate cancer
    Michael Wagner
    Cincinnati Children s Hospital Research Foundation and Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45229, USA
    BMC Bioinformatics 5:26. 2004
  10. pmc Adult T cell leukemia: a tale of two T cells
    O John Semmes
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    J Clin Invest 116:858-60. 2006

Collaborators

Detail Information

Publications16

  1. pmc SELDI-TOF serum profiling for prognostic and diagnostic classification of breast cancers
    Christine Laronga
    Department of Surgery, Eastern Virginia Medical School, Norfolk, Virginia and the Virginia Prostate Center, Norfolk, VA, USA
    Dis Markers 19:229-38. 2003
    ..These initial results indicate the utility of protein profiling approaches for developing new diagnostic and prognostic assays for breast cancers...
  2. pmc Targeted identification of metastasis-associated cell-surface sialoglycoproteins in prostate cancer
    Lifang Yang
    Leroy T Canoles Cancer Research Center, Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    Mol Cell Proteomics 10:M110.007294. 2011
    ..Our approach effectively targeted surface sialoglycoproteins and efficiently identified proteins that underlie the metastatic potential of the ML2 cells...
  3. pmc The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin
    S Mehdi Belgnaoui
    Department of Microbiology and Molecular Cell Biology, Cancer Biology and Infectious Disease Research Center, Eastern Virginia Medical School, Norfolk, Virgina 23508, USA
    J Biol Chem 285:32897-905. 2010
    ..These data support a model for virus-induced genomic instability in which viral oncogene-induced damage-independent foci compete with normal cellular DNA damage response...
  4. pmc Interdependent phosphorylation within the kinase domain T-loop Regulates CHK2 activity
    Xin Guo
    Department of Microbiology and Molecular Cell Biology, Cancer Biology and Infectious Disease Research Center, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 285:33348-57. 2010
    ..The results demonstrate that a complex interdependent network of phosphorylation events within the T-loop exchange region regulates dimerization/autophosphorylation, kinase activation, and chromatin targeting/egress of Chk2...
  5. pmc HTLV-1 Tax oncoprotein subverts the cellular DNA damage response via binding to DNA-dependent protein kinase
    Sarah S Durkin
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, Virginia 23507, USA
    J Biol Chem 283:36311-20. 2008
    ..We also describe a novel interaction between DNA-PK and Chk2 that requires Tax. We propose that Tax binds to and stabilizes a protein complex with DNA-PK and Chk2, resulting in a saturation of DNA-PK-mediated damage repair response...
  6. pmc Phosphorylation regulates human T-cell leukemia virus type 1 Rex function
    Matthew Kesic
    Center for Retrovirus Research, The Ohio State University, Columbus, OH 43210, USA
    Retrovirology 6:105. 2009
    ..HTLV-1 Rex (Rex-1) is a phosphoprotein and general protein kinase inhibition correlates with reduced function. Therefore, it has been proposed that Rex-1 function may be regulated through site-specific phosphorylation...
  7. pmc A proteomic study of TAR-RNA binding protein (TRBP)-associated factors
    Ya Hui Chi
    Molecular Virology Section, Laboratory of Molecular Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Cell Biosci 1:9. 2011
    ..abstract:..
  8. pmc A Bayesian network approach to feature selection in mass spectrometry data
    Karl W Kuschner
    Department of Physics, The College of William and Mary, Williamsburg, VA, USA
    BMC Bioinformatics 11:177. 2010
    ....
  9. pmc Computational protein biomarker prediction: a case study for prostate cancer
    Michael Wagner
    Cincinnati Children s Hospital Research Foundation and Department of Biomedical Engineering, University of Cincinnati, Cincinnati, OH 45229, USA
    BMC Bioinformatics 5:26. 2004
    ..Our overall goal is to implicate peaks that have a high likelihood of being biologically linked to a given disease state, and thus to narrow the search for biomarker candidates...
  10. pmc Adult T cell leukemia: a tale of two T cells
    O John Semmes
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, Virginia 23501, USA
    J Clin Invest 116:858-60. 2006
    ..This finding provides a molecular-based mechanism for the restriction of the leukemic phenotype to the CD4+ T cell subtype...
  11. ncbi request reprint Application of mass spectrometry to the discovery of biomarkers for detection of prostate cancer
    O John Semmes
    Department of Microbiology and Molecular Cell Biology, Center for Biomedical Proteomics, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk 23507, USA
    J Cell Biochem 98:496-503. 2006
    ..The development of newer proteomic strategies for use in future applications is also discussed...
  12. ncbi request reprint Discrete serum protein signatures discriminate between human retrovirus-associated hematologic and neurologic disease
    O J Semmes
    Department of Microbiology and Molecular Cell Biology, Eastern Virginia Medical School, Norfolk, VA, USA
    Leukemia 19:1229-38. 2005
    ..9 and 11.9 kDa) of haproglobin-2. To the best of our knowledge, this is the first application of protein profiling to distinguish between two disease states resulting from a single infectious agent...
  13. ncbi request reprint Evaluation of serum protein profiling by surface-enhanced laser desorption/ionization time-of-flight mass spectrometry for the detection of prostate cancer: I. Assessment of platform reproducibility
    O John Semmes
    Department of Microbiology and Molecular Cell Biology, Virginia Prostate Center, Eastern Virginia Medical School, Norfolk, VA 23507, USA
    Clin Chem 51:102-12. 2005
    ..This report describes the first stage of a National Cancer Institute/Early Detection Research Network-sponsored multiinstitutional evaluation and validation of this approach for detection of prostate cancer...
  14. pmc Physical and in silico approaches identify DNA-PK in a Tax DNA-damage response interactome
    Emad Ramadan
    George L, Wright Center for Biomedical Proteomics, Eastern Virginia Medical School, Norfolk, VA, USA
    Retrovirology 5:92. 2008
    ..To date we have mapped 250 cellular components within this interactome. Here we present our approach to prioritizing these interactions via an in silico culling process...
  15. ncbi request reprint Feature extraction in the analysis of proteomic mass spectra
    Xuena Wang
    State University of New York, Stony Brook, NY, USA
    Proteomics 6:2095-100. 2006
    ..T., Somers, K. D., Cazares, L. H., Malik, G. et al.., Clin. Cancer Res. 2004, 10, 1625-1632] revealed that the new feature extraction method would yield consistent and highly discriminatory biomarkers...
  16. ncbi request reprint Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response
    Susan J Marriott
    Baylor College of Medicine, Department of Molecular Virology and Microbiology, One Baylor Plaza, Houston, TX 77030, USA
    Oncogene 24:5986-95. 2005
    ..The contribution of these activities to genome instability and cellular transformation will be discussed...

Research Grants13

  1. HTLV-1 Tax Disrupts DNA Damage Repair-Response Complexes
    OLIVER SEMMES; Fiscal Year: 2009
    ..Elucidation of this cause and effect model will contribute significantly to our understanding of HTLV-1-mediated disease. ..
  2. EARLY DETECTION OF CANCER BY AFFINITY MASS SPECTROMETRY
    OLIVER SEMMES; Fiscal Year: 2007
    ..Our unique team of investigators from basic sciences, mathematical sciences and the clinical arena supply the needed expertise to continue our work in biomarker development. ..
  3. HTLV-1 Tax Disrupts DNA Damage Repair-Response Complexes
    OLIVER SEMMES; Fiscal Year: 2007
    ..Elucidation of this cause and effect model will contribute significantly to our understanding of HTLV-1-mediated disease. ..
  4. HTLV-1 Tax Disrupts DNA Damage Repair-Response Complexes
    OLIVER SEMMES; Fiscal Year: 2006
    ..Elucidation of this cause and effect model will contribute significantly to our understanding of HTLV-1-mediated disease. ..
  5. HTLV-1 Tax Disrupts DNA Damage Repair-Response Complexes
    OLIVER SEMMES; Fiscal Year: 2005
    ..Elucidation of this cause and effect model will contribute significantly to our understanding of HTLV-1-mediated disease. ..
  6. Typhoon 9410 Gel/Blot Imager
    OLIVER SEMMES; Fiscal Year: 2004
    ..Additionally, several investigators will be able to undertake new avenues of investigation using the Typhoon's features. ..
  7. HTLV-1 Tax Disrupts DNA Damage Repair-Response Complexes
    OLIVER SEMMES; Fiscal Year: 2009
    ..Elucidation of this cause and effect model will contribute significantly to our understanding of HTLV-1-mediated disease. ..