Research Topics
| C K MauckSummaryAffiliation: Eastern Virginia Medical School Country: USA Publications
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Detail Information
Publications
Colposcopy: still useful in microbicide safety trials?Christine K Mauck
CONRAD, Arlington, VA, USA
Sex Transm Dis 39:465-9. 2012..This reanalysis of 9 safety studies determined the impact of omitting colposcopy on the number of findings detected and assessed whether colposcopy was useful in identifying nonoxynol-9 (N-9) as an unsafe product in one study...
Introduction: background, issues, and recommendations from the conferenceChristine Mauck
CONRAD, Eastern Virginia Medical School, 1611 N. Kent Street, Suite 806, Arlington, VA 22209, USA
J Acquir Immune Defic Syndr 37:S143-9. 2004- Biomarkers of semen in the vagina: applications in clinical trials of contraception and prevention of sexually transmitted pathogens including HIVChristine K Mauck
CONRAD, Eastern Virginia Medical School EVMS, Arlington, VA 22209, USA
Contraception 75:407-19. 2007.... - Vaginal distribution of Replens and K-Y Jelly using three imaging techniquesChristine K Mauck
CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
Contraception 77:195-204. 2008..Determination of vaginal distribution is important to the development of potential vaginal microbicidal or spermicidal products... - Noncomparative contraceptive efficacy of cellulose sulfate gelChristine K Mauck
CONRAD, Eastern Virginia Medical School EVMS, Arlington, Virginia 22209, USA
Obstet Gynecol 111:739-46. 2008..To estimate the 6-month cumulative probability of pregnancy, short-term adverse effects, and acceptability of cellulose sulfate vaginal contraceptive gel... - Using objective markers to assess participant behavior in HIV prevention trials of vaginal microbicidesChristine K Mauck
CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
J Acquir Immune Defic Syndr 49:64-9. 2008..Resources and funding should be mobilized to develop and validate markers of sexual behavior and product use as a high priority in vaginal microbicide research... - Six-day randomized safety trial of intravaginal lime juiceChristine K Mauck
CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
J Acquir Immune Defic Syndr 49:243-50. 2008..In vitro data suggest that lime juice is virucidal, but only at cytotoxic concentrations. This is the first controlled, randomized safety trial of lime juice applied to the human vagina... - Biomarkers of semen exposureChristine K Mauck
CONRAD Eastern Virginia Medical School, Arlington, Virginia 22209, USA
Sex Transm Dis 36:S81-3. 2009.... - Biomarkers for evaluating vaginal microbicides and contraceptives: discovery and early validationChristine K Mauck
CONRAD Eastern Virginia Medical School, Arlington, Virginia 22209, USA
Sex Transm Dis 36:S73-5. 2009..Although the meeting was held 2 years ago, the material reviewed and conclusions drawn are still relevant... - Reddy female condom: functional performance of a 90-mm shaft length in two clinical studiesChristine Mauck
CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
Contraception 83:466-71. 2011..We report on the functional performance, safety and acceptability of the 90-mm Reddy female condom in two clinical trials, one in Los Angeles, CA, and one in Pune, Maharashtra, India... 
FemCap with removal strap: ease of removal, safety and acceptabilityChristine K Mauck
CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
Contraception 73:59-64. 2006..This trial assessed whether the new design reduced removal difficulties and had any effects on dislodgment, genital pain/discomfort, safety, and acceptability...- Lea's Shield: colposcopic and microbiological testing during 8 weeks of useChristine K Mauck
CONRAD, Eastern Virginia Medical School, Department of Obstetrics and Gynecology, Arlington, VA 22209, USA
Contraception 72:53-9. 2005.... - The use of colposcopy in assessing vaginal irritation in researchC K Mauck
AIDS 14:2221-7. 2000.... - Cellulose sulfate: tolerance and acceptability of penile applicationC Mauck
CONRAD Program, Arlington, VA, USA
Contraception 64:377-81. 2001.... - Diaphragms in clinical trials: is clinician fitting necessary?Christine Mauck
CONRAD, 1611 Kent Street, No 806, Arlington, VA 22209, USA
Contraception 69:263-6. 2004..Being able to provide the same size device to all women would greatly simplify supplying the device and training the clinicians, provided that it does not compromise effectiveness... - Single and multiple exposure tolerance study of polystyrene sulfonate gel: a phase I safety and colposcopy studyChristine K Mauck
CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Suite 806, Arlington 22209, USA
Contraception 70:77-83. 2004..To evaluate symptoms and signs of genital irritation, vaginal leakage and acceptability of polystyrene sulfonate (PSS), which is being studied as a vaginal contraceptive and microbicide... - Male tolerance study of 1% C31GChristine K Mauck
CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Suite 806, Arlington, VA 22209, USA
Contraception 70:221-5. 2004..C31G is being studied as a vaginal contraceptive and microbicide. This study was conducted to ensure that male partners of the women in future trials of C31G will not be subjected to an undue risk of penile irritation... - A phase I comparative postcoital testing study of three concentrations of C31GChristine K Mauck
CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Suite 806, Arlington, VA 22209, USA
Contraception 70:227-31. 2004..5%, 1.0% and 1.7%, administered as a 3.5-mL dose of a vaginal gel to prevent sperm from entering mid-cycle cervical mucus. Irritation of the genitalia and acceptability were also assessed... - A randomized Phase I vaginal safety study of three concentrations of C31G vs. Extra Strength Gynol IIChristine K Mauck
CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Arlington, VA 22209, USA
Contraception 70:233-40. 2004..C31G is an antimicrobial and spermicidal agent that contains two surface-active compounds, cetyl betaine and myristamine oxide. It is being developed as a vaginal microbicide and contraceptive... - Safety evaluation of 1% tenofovir gel in healthy menJ L Schwartz
Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
Int J STD AIDS 20:384-6. 2009..TFV gel applied to the penis for seven days was well tolerated locally and systemically and it is unlikely that male partners exposed to small amounts of TFV gel will experience significant genital or systemic toxicity... - Fourteen-day safety and acceptability study of 6% cellulose sulfate gel: a randomized double-blind Phase I safety studyJill L Schwartz
Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
Contraception 74:133-40. 2006..Cellulose sulfate (CS) is a noncytotoxic antifertility agent that exhibits in vitro antimicrobial activity against sexually transmitted pathogens, including HIV... - Male tolerance of ACIDFORM gelJill L Schwartz
CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
Contraception 71:443-6. 2005..This study was conducted to make certain that males will not be subjected to an unacceptable risk of penile irritation as a result of exposure to the product in future studies... - Vaginal distribution of two volumes of the novel microbicide gel cellulose sulfate (2.5 and 3.5 mL)Kurt T Barnhart
Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
Contraception 72:65-70. 2005..Most linear spreading took place in the first 5 min after insertion, although lateral spreading continued to increase with time especially when ambulation took place. Leakage and gel was not a significant problem at either volume... - Vaginal microbicides: a novel approach to preventing sexual transmission of HIVGustavo Doncel
CONRAD, Eastern Virginia Medical School, 601 Colley Avenue, Norfolk, VA 23507, USA
Curr HIV/AIDS Rep 1:25-32. 2004..This review is based on a previous work, which has been updated to contain new information, especially regarding microbicide candidates in preclinical and clinical stages of development... - Overview of why hormones may be an issueChristine Mauck
CONRAD Arlington, VA, USA
J Acquir Immune Defic Syndr 38:S11-2. 2005 - Safety and acceptability of penile application of 2 candidate topical microbicides: BufferGel and PRO 2000 Gel: 3 randomized trials in healthy low-risk men and HIV-positive menStephen R Tabet
Department of Medicine, University of Washington, Seattle, WA 98104, USA
J Acquir Immune Defic Syndr 33:476-83. 2003.... - A randomized six-day safety study of an antiretroviral microbicide candidate UC781, a non-nucleoside reverse transcriptase inhibitorJill L Schwartz
CONRAD, Eastern Virginia Medical School, Arlington, Virginia 22209, USA
Sex Transm Dis 35:414-9. 2008..This study evaluated the effect of a single dose and 5 additional consecutive daily doses of UC781 gel at concentrations of 0.1%, 0.25%, 1.0%, and 0% on urogenital irritation... - Fourteen-day safety and acceptability study of the universal placebo gelJill L Schwartz
CONRAD, Eastern Virginia Medical School EVMS, Arlington, VA 22209, USA
Contraception 75:136-41. 2007..This study evaluated the effect of the so-called universal placebo compared to the polystyrene sulfonate (PSS) placebo on genital irritation... - A comparison of techniques to assess cervicovaginal irritation and evaluation of the variability between two observersSusan A Ballagh
CONRAD Clinical Research Center, Eastern Virginia Medical School, 601 Colley Avenue, Norfolk, VA 23507, USA
Contraception 70:241-9. 2004..Colposcopy is used to evaluate effects of new vaginal products on cervicovaginal epithelium as part of the US Food and Drug Administration-mandated product approval process, yet few aspects of its use have been investigated... - A pilot clinical trial comparing an acid-buffering formulation (ACIDFORM gel) with metronidazole gel for the treatment of symptomatic bacterial vaginosisJose A Simoes
Department of Obstetrics and Gynaecology, School of Medicine, Universidade Estadual de Campinas (UNICAMP, Campinas, SP, Brazil
Br J Clin Pharmacol 61:211-7. 2006..CONCLUSION: ACIDFORM gel was significantly less effective than high-dose metronidazole gel for the treatment of symptomatic BV... - As the world grows: contraception in the 21st centuryR John Aitken
Discipline of Biological Sciences and ARC Centre of Excellence in Biotechnology and Development, University of Newcastle, Callaghan, New South Wales, Australia
J Clin Invest 118:1330-43. 2008..This Review addresses the contribution that the "omic" revolution can make to the identification of novel contraceptive targets, as well as the progress that has been made for different target molecules under development...