C K Mauck

Summary

Affiliation: Eastern Virginia Medical School
Country: USA

Publications

  1. doi request reprint Colposcopy: still useful in microbicide safety trials?
    Christine K Mauck
    CONRAD, Arlington, VA, USA
    Sex Transm Dis 39:465-9. 2012
  2. ncbi request reprint Introduction: background, issues, and recommendations from the conference
    Christine Mauck
    CONRAD, Eastern Virginia Medical School, 1611 N Kent Street, Suite 806, Arlington, VA 22209, USA
    J Acquir Immune Defic Syndr 37:S143-9. 2004
  3. ncbi request reprint Biomarkers of semen in the vagina: applications in clinical trials of contraception and prevention of sexually transmitted pathogens including HIV
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School EVMS, Arlington, VA 22209, USA
    Contraception 75:407-19. 2007
  4. doi request reprint Vaginal distribution of Replens and K-Y Jelly using three imaging techniques
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Contraception 77:195-204. 2008
  5. doi request reprint Noncomparative contraceptive efficacy of cellulose sulfate gel
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School EVMS, Arlington, Virginia 22209, USA
    Obstet Gynecol 111:739-46. 2008
  6. doi request reprint Using objective markers to assess participant behavior in HIV prevention trials of vaginal microbicides
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    J Acquir Immune Defic Syndr 49:64-9. 2008
  7. doi request reprint Six-day randomized safety trial of intravaginal lime juice
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    J Acquir Immune Defic Syndr 49:243-50. 2008
  8. doi request reprint Biomarkers of semen exposure
    Christine K Mauck
    CONRAD Eastern Virginia Medical School, Arlington, Virginia 22209, USA
    Sex Transm Dis 36:S81-3. 2009
  9. doi request reprint Biomarkers for evaluating vaginal microbicides and contraceptives: discovery and early validation
    Christine K Mauck
    CONRAD Eastern Virginia Medical School, Arlington, Virginia 22209, USA
    Sex Transm Dis 36:S73-5. 2009
  10. doi request reprint Reddy female condom: functional performance of a 90-mm shaft length in two clinical studies
    Christine Mauck
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Contraception 83:466-71. 2011

Detail Information

Publications31

  1. doi request reprint Colposcopy: still useful in microbicide safety trials?
    Christine K Mauck
    CONRAD, Arlington, VA, USA
    Sex Transm Dis 39:465-9. 2012
    ..This reanalysis of 9 safety studies determined the impact of omitting colposcopy on the number of findings detected and assessed whether colposcopy was useful in identifying nonoxynol-9 (N-9) as an unsafe product in one study...
  2. ncbi request reprint Introduction: background, issues, and recommendations from the conference
    Christine Mauck
    CONRAD, Eastern Virginia Medical School, 1611 N Kent Street, Suite 806, Arlington, VA 22209, USA
    J Acquir Immune Defic Syndr 37:S143-9. 2004
  3. ncbi request reprint Biomarkers of semen in the vagina: applications in clinical trials of contraception and prevention of sexually transmitted pathogens including HIV
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School EVMS, Arlington, VA 22209, USA
    Contraception 75:407-19. 2007
    ....
  4. doi request reprint Vaginal distribution of Replens and K-Y Jelly using three imaging techniques
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Contraception 77:195-204. 2008
    ..Determination of vaginal distribution is important to the development of potential vaginal microbicidal or spermicidal products...
  5. doi request reprint Noncomparative contraceptive efficacy of cellulose sulfate gel
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School EVMS, Arlington, Virginia 22209, USA
    Obstet Gynecol 111:739-46. 2008
    ..To estimate the 6-month cumulative probability of pregnancy, short-term adverse effects, and acceptability of cellulose sulfate vaginal contraceptive gel...
  6. doi request reprint Using objective markers to assess participant behavior in HIV prevention trials of vaginal microbicides
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    J Acquir Immune Defic Syndr 49:64-9. 2008
    ..Resources and funding should be mobilized to develop and validate markers of sexual behavior and product use as a high priority in vaginal microbicide research...
  7. doi request reprint Six-day randomized safety trial of intravaginal lime juice
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    J Acquir Immune Defic Syndr 49:243-50. 2008
    ..In vitro data suggest that lime juice is virucidal, but only at cytotoxic concentrations. This is the first controlled, randomized safety trial of lime juice applied to the human vagina...
  8. doi request reprint Biomarkers of semen exposure
    Christine K Mauck
    CONRAD Eastern Virginia Medical School, Arlington, Virginia 22209, USA
    Sex Transm Dis 36:S81-3. 2009
    ....
  9. doi request reprint Biomarkers for evaluating vaginal microbicides and contraceptives: discovery and early validation
    Christine K Mauck
    CONRAD Eastern Virginia Medical School, Arlington, Virginia 22209, USA
    Sex Transm Dis 36:S73-5. 2009
    ..Although the meeting was held 2 years ago, the material reviewed and conclusions drawn are still relevant...
  10. doi request reprint Reddy female condom: functional performance of a 90-mm shaft length in two clinical studies
    Christine Mauck
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Contraception 83:466-71. 2011
    ..We report on the functional performance, safety and acceptability of the 90-mm Reddy female condom in two clinical trials, one in Los Angeles, CA, and one in Pune, Maharashtra, India...
  11. pmc FemCap with removal strap: ease of removal, safety and acceptability
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Contraception 73:59-64. 2006
    ..This trial assessed whether the new design reduced removal difficulties and had any effects on dislodgment, genital pain/discomfort, safety, and acceptability...
  12. ncbi request reprint Lea's Shield: colposcopic and microbiological testing during 8 weeks of use
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, Department of Obstetrics and Gynecology, Arlington, VA 22209, USA
    Contraception 72:53-9. 2005
    ....
  13. ncbi request reprint The use of colposcopy in assessing vaginal irritation in research
    C K Mauck
    AIDS 14:2221-7. 2000
    ....
  14. ncbi request reprint Cellulose sulfate: tolerance and acceptability of penile application
    C Mauck
    CONRAD Program, Arlington, VA, USA
    Contraception 64:377-81. 2001
    ....
  15. ncbi request reprint Diaphragms in clinical trials: is clinician fitting necessary?
    Christine Mauck
    CONRAD, 1611 Kent Street, No 806, Arlington, VA 22209, USA
    Contraception 69:263-6. 2004
    ..Being able to provide the same size device to all women would greatly simplify supplying the device and training the clinicians, provided that it does not compromise effectiveness...
  16. pmc Single and multiple exposure tolerance study of polystyrene sulfonate gel: a phase I safety and colposcopy study
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Suite 806, Arlington 22209, USA
    Contraception 70:77-83. 2004
    ..To evaluate symptoms and signs of genital irritation, vaginal leakage and acceptability of polystyrene sulfonate (PSS), which is being studied as a vaginal contraceptive and microbicide...
  17. ncbi request reprint Male tolerance study of 1% C31G
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Suite 806, Arlington, VA 22209, USA
    Contraception 70:221-5. 2004
    ..C31G is being studied as a vaginal contraceptive and microbicide. This study was conducted to ensure that male partners of the women in future trials of C31G will not be subjected to an undue risk of penile irritation...
  18. ncbi request reprint A phase I comparative postcoital testing study of three concentrations of C31G
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Suite 806, Arlington, VA 22209, USA
    Contraception 70:227-31. 2004
    ..5%, 1.0% and 1.7%, administered as a 3.5-mL dose of a vaginal gel to prevent sperm from entering mid-cycle cervical mucus. Irritation of the genitalia and acceptability were also assessed...
  19. ncbi request reprint A randomized Phase I vaginal safety study of three concentrations of C31G vs. Extra Strength Gynol II
    Christine K Mauck
    CONRAD, Eastern Virginia Medical School, 1611 North Kent Street, Arlington, VA 22209, USA
    Contraception 70:233-40. 2004
    ..C31G is an antimicrobial and spermicidal agent that contains two surface-active compounds, cetyl betaine and myristamine oxide. It is being developed as a vaginal microbicide and contraceptive...
  20. doi request reprint Safety evaluation of 1% tenofovir gel in healthy men
    J L Schwartz
    Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Int J STD AIDS 20:384-6. 2009
    ..TFV gel applied to the penis for seven days was well tolerated locally and systemically and it is unlikely that male partners exposed to small amounts of TFV gel will experience significant genital or systemic toxicity...
  21. ncbi request reprint Fourteen-day safety and acceptability study of 6% cellulose sulfate gel: a randomized double-blind Phase I safety study
    Jill L Schwartz
    Department of Obstetrics and Gynecology, CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Contraception 74:133-40. 2006
    ..Cellulose sulfate (CS) is a noncytotoxic antifertility agent that exhibits in vitro antimicrobial activity against sexually transmitted pathogens, including HIV...
  22. ncbi request reprint Male tolerance of ACIDFORM gel
    Jill L Schwartz
    CONRAD, Eastern Virginia Medical School, Arlington, VA 22209, USA
    Contraception 71:443-6. 2005
    ..This study was conducted to make certain that males will not be subjected to an unacceptable risk of penile irritation as a result of exposure to the product in future studies...
  23. ncbi request reprint Vaginal distribution of two volumes of the novel microbicide gel cellulose sulfate (2.5 and 3.5 mL)
    Kurt T Barnhart
    Department of Obstetrics and Gynecology, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    Contraception 72:65-70. 2005
    ..Most linear spreading took place in the first 5 min after insertion, although lateral spreading continued to increase with time especially when ambulation took place. Leakage and gel was not a significant problem at either volume...
  24. ncbi request reprint Vaginal microbicides: a novel approach to preventing sexual transmission of HIV
    Gustavo Doncel
    CONRAD, Eastern Virginia Medical School, 601 Colley Avenue, Norfolk, VA 23507, USA
    Curr HIV/AIDS Rep 1:25-32. 2004
    ..This review is based on a previous work, which has been updated to contain new information, especially regarding microbicide candidates in preclinical and clinical stages of development...
  25. ncbi request reprint Overview of why hormones may be an issue
    Christine Mauck
    CONRAD Arlington, VA, USA
    J Acquir Immune Defic Syndr 38:S11-2. 2005
  26. ncbi request reprint Safety and acceptability of penile application of 2 candidate topical microbicides: BufferGel and PRO 2000 Gel: 3 randomized trials in healthy low-risk men and HIV-positive men
    Stephen R Tabet
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 33:476-83. 2003
    ....
  27. doi request reprint A randomized six-day safety study of an antiretroviral microbicide candidate UC781, a non-nucleoside reverse transcriptase inhibitor
    Jill L Schwartz
    CONRAD, Eastern Virginia Medical School, Arlington, Virginia 22209, USA
    Sex Transm Dis 35:414-9. 2008
    ..This study evaluated the effect of a single dose and 5 additional consecutive daily doses of UC781 gel at concentrations of 0.1%, 0.25%, 1.0%, and 0% on urogenital irritation...
  28. ncbi request reprint Fourteen-day safety and acceptability study of the universal placebo gel
    Jill L Schwartz
    CONRAD, Eastern Virginia Medical School EVMS, Arlington, VA 22209, USA
    Contraception 75:136-41. 2007
    ..This study evaluated the effect of the so-called universal placebo compared to the polystyrene sulfonate (PSS) placebo on genital irritation...
  29. ncbi request reprint A comparison of techniques to assess cervicovaginal irritation and evaluation of the variability between two observers
    Susan A Ballagh
    CONRAD Clinical Research Center, Eastern Virginia Medical School, 601 Colley Avenue, Norfolk, VA 23507, USA
    Contraception 70:241-9. 2004
    ..Colposcopy is used to evaluate effects of new vaginal products on cervicovaginal epithelium as part of the US Food and Drug Administration-mandated product approval process, yet few aspects of its use have been investigated...
  30. pmc A pilot clinical trial comparing an acid-buffering formulation (ACIDFORM gel) with metronidazole gel for the treatment of symptomatic bacterial vaginosis
    Jose A Simoes
    Department of Obstetrics and Gynaecology, School of Medicine, Universidade Estadual de Campinas UNICAMP, Campinas, SP, Brazil
    Br J Clin Pharmacol 61:211-7. 2006
    ..To compare the effectiveness of an acid-buffering formulation gel (ACIDFORM) with metronidazole gel in the treatment of symptomatic bacterial vaginosis (BV)...
  31. pmc As the world grows: contraception in the 21st century
    R John Aitken
    Discipline of Biological Sciences and ARC Centre of Excellence in Biotechnology and Development, University of Newcastle, Callaghan, New South Wales, Australia
    J Clin Invest 118:1330-43. 2008
    ..This Review addresses the contribution that the "omic" revolution can make to the identification of novel contraceptive targets, as well as the progress that has been made for different target molecules under development...